Qazvin University of Medical Sciences
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بررسی ویژگی های بالینی و پاراکلینیکی بیماران بستری مبتلا به کووید 19 در مرکز آموزشی درمانی منتخب دانشگاه علوم پزشکی قزوین: یک مطالعه مقطعی
Get PDFبررسی مقایسه ای تعداد ائوزینوفیل های بافتی در درجات متفاوت کارسینوم سلول سنگفرشی و مخاط سالم به روش رنگ آمیزیSirius Red
Get PDFارزیابی خصوصیات فیزیکی-شیمیایی و ضدباکتریایی در شیشه های زیست فعال 68S سنتز و جایگزین شده با عنصر استرانسیوم به روش سل-ژل در شرایط آزمایشگاهی
Get PDFبررسی اثر پیش دارویی با ایبوبروفن بر موفقیت بی حسی بلاک عصب آلوئولار تحتانی در درمان پالپ مولرهای شیری مندیبل با پالپیت برگشت ناپذیر
Get PDFControl of Hyperglycemia Using Differentiated and Undifferentiated Mesenchymal Stem Cells in Rats with Type 1 Diabetes
Get PDFDue to their ability in self-renewing and differentiation into a wide variety of tissues,
mesenchymal stem cells (MSCs) exhibit outstanding potential for regenerative medicine. This
study was aimed at investigating different aspects of MSC therapy in controlling hyperglycemia
in streptozotocin-induced diabetes rats. Using an islet cell differentiation protocol, bone marrow
(BM) MSCs were differentiated into insulin-producing cells (IPCs). The differentiation process
was evaluated by immunocytochemistry, reverse transcriptase PCR, and dithizone staining.
Diabetic animals in 4 diabetic individual groups received normal saline, BM-MSCs,
coadministration of BM-MSCs with supernatant, and IPCs. Blood glucose and insulin levels
were monitored during the experiment. Immunohistochemical analysis of the pancreas was
performed at the end of the experiment. Administration of BM-MSCs could not reverse glucose
and insulin levels in experimental animals as efficiently as cotransplantation of BM-MSCs with
supernatant. The effect of coadministration of BM-MSCs with supernatant and transplantation of
IPCs on controlling hyperglycemia is comparable. Immunohistochemical analysis showed that
number and size of islets per section were significantly increased in groups receiving IPCs and
BM-MSC-supernatant compared to the MSC group of animals. In conclusion, coadministration
of BM-MSCs with supernatant could be used as efficiently as IPC transplantation in controlling
hyperglycemia in diabetic rats
Principles of Cystinosis Transition in Children: A Review
Get PDFChildren with chronic illness need special care during the transition to adolescence and adulthood. Cystinosis is a chronic childhood disease characterized by chronic renal failure and multi-organ involvement. With advances in treatment and kidney transplantation methods, the life expectancy of these patients has been prolonged. Renal transplantation is performed for most of the patients in childhood. These patients are at risk of non-adherence due to multiple drug usage and their chronic disease. As a child enters adulthood, parental care decreases and the patient should learn self-management. So the likelihood of non-compliance and loss of kidney transplant is high in transition time. This article gives a brief overview on transition of cystinosis patients from childhood to adolescence and adulthood
Prevalence and phylogenetic analysis of gastrointestinal helminths (Nematoda: Trichostrongylidae) in ruminant livestock of northwest Iran
Get PDFAbstract: Trichostrongylidae family is considered as a group of gastrointestinal nematodes of ruminants with widespread
distribution in the world. The parasites are the major causes of productivity loss in many countries including Iran. This study was
carried out to determine the distribution of abomasal Trichostrongylidae among livestock of Qazvin, Iran. Totally, 160 abomasum
samples including 83 from sheep, 72 from cattle and 5 from goats were collected from slaughterhouses throughout the Qazvin Province.
The ribosomal DNA internal transcribed spacer 2 (ITS2) region was amplified using PCR followed by sequencing 13 different isolates.
Phylogenetic analysis of the identified sequences was performed using MEGA 7 software. The prevalence rate of the nematodes was
19.4% among the specimens. Also, two spices including Marshallagia marshalli and Teladorsagia circumcincta were identified among
the isolates with M. marshalli at higher frequency. No Trichostrongylus spp. was detected in the region. Since livestock plays a major
role in ecosystem balance and as some species of nematodes have a zoonotic nature, it is necessary to proceed with more comprehensive
epidemiologic studies to clarify the infection rate among the human population living in the regio
Intravenous paracetamol vs intranasal desmopressin for renal colic in the emergency department: A randomized clinical trial
Get PDFObjective. To evaluate the analgesic efficacy of intranasal desmopressin alone vs intravenous paracetamol in patients referred to the emergency department with renal colic. Design. Randomized clinical trial. Setting. This study was conducted in the emergency unit of a university hospital. Subjects. Patients referred to the emergency room with renal colic. Primary Outcome. Effect of intranasal desmopressin in pain relief in comparison with intravenous paracetamol. Methods. In this trial, 240 patients diagnosed with renal colic were randomly divided into two groups to compare the analgesic effect of intravenous paracetamol (15 mg/kg) and intranasal desmopressin spray (40 μg). Pain scores were measured by a numeric rating scale at baseline and after 15, 30, and 60 minutes. Adverse effects and need for rescue analgesic (0.05 mg/kg max 3mg morphine sulphate) were also recorded at the end of the study. Results. Three hundred patients were eligible for the study; however, 240 were included in the final analysis. The patients in the two groups were similar in their baseline characteristics and baseline pain scores. The mean pain score after 15 minutes was more reduced and was clinically significant (>3) in the desmopressin group (P6). Conclusions. Our study showed that intranasal desmopressin is as effective as intravenous paracetamol for renal colic pain management; however, significant clinical reduction in pain score occurred faster with intranasal desmopressin
Spatial distribution of cutaneous anthrax in western Iran from 2009 to 2016: Geographic information system mapping for predicting risk of anthrax outbreaks
Get PDFABSTRACT Objective: To explore the spatial accumulation of diseases and their aggravating factors are essential in all public health. This study attempts to use geographic information system (GIS) to provide more information about the incidence and future of anthrax.
Methods: Patients were diagnosed with anthrax in Kurdistan Province from 2009 to 2016. Data was then exported into ArcGIS software version 9 and the required layers for years and areas were added.Final map for each year was drawn up, pointing out the hot spots and predicting its future pattern.
Results: Most cases were reported in females (57 cases, 54.80 %), and the lower body limbs were most affected (63 cases, 60.57%). The highest numbers of incidences were related to the cities of Marivan, Saqez and Divandareh, with more concentration in the central parts of the province, rather than borderline areas. The highest percentage of the probable incidence of the disease was in Sanandaj (57.74%) with a potential susceptible area of 1 729.12 km2 and then in Saqez (54.36%) with a potential area of 2 422.4 km2.
Conclusions: A vast area of Kurdistan Province is high risk for new cases of anthrax. Therefore, it is important to scale up the surveillance system in the province
Isolation and molecular identification of acanthamoeba and naegleria from agricultural water canal in qazvin, iran
Get PDFBackground: Free-living amoeba (FLA) are widely distributed in different environmental sources. The most genera of the amoeba are Acanthamoeba, Naegleria and Vermamoeba.
The most common consequences of the infections in immune-deficient and immunocompetent persons are amoebic encephalitis and keratitis. The aim of this study was to
investigate the presence of Acanthamoeba spp. and Naegleria spp., isolated from the main
agricultural water canal in Qazvin.
Methods: Totally, 120 water specimens were collected and later the specimens were
cultured and cloned to identify positive samples. PCR amplification and sequencing
were carried out to identify the isolated species as well as the genotypes of amoeba.
Results: According to morphological surveys, 41.7% (50/120) of water specimens were
positive for FLA. Molecular analysis revealed that 68.6% and 31.4% of Acanthamoeba
specimens were identified as T3 and T4 genotypes, respectively. Also, two species of
Naegleria named as N. lovaniensis (57.1%) and Naegleria spp. (42.8%) were identified. The
results of pathogenicity assays demonstrated that 38.5% of T3 and 61.5% of T4 genotypes of Acanthamoeba were highly pathogenic parasites.
Conclusion: The water flowing in the agricultural canal of the area is contaminated
with potential pathogenic FLA, therefore, it is recommended that more attention to be
paid towards proper treatment of water sources to prevent possible risk of the disease