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Thymolipoma associated with lymphocytosis in a 6-year-old girl: A case report
Get PDFThymolipoma is a benign and rare tumor that could be found at any age. Thymolipoma associated with the
myasthenia gravis, Graves disease, aplastic anemia, and hypogammaglobulinemia was reported previously, but
in this case, thymolipoma is associated with lymphocytosis. A 6-year-old girl was brought to the hospital because
of a chronic cough. Her evaluation revealed a 130 × 160× 160 mm fat-containing soft tissue mass arising from
anterior mediastinum with complete left lung collapse and contralateral mediastinal shift. Her past medical
history showed that she had been evaluated and treated unsuccessfully due to severe lymphocytosis two years
earlier. Her peripheral blood and bone marrow cell morphology were normal; in contrast, blood cell count and
CD flow cytometry showed severe lymphocytosis. The patient’s tumor was excised entirely without any complications, and lymphocytosis resolved during the follow-up period. Because the T lymphocytes are developed in
the thymus, and more than 80% of cells in CD flow cytometry were T lymphocytes, and the lymphocytosis
resolved with tumor removal; therefore, the authors suggested that Thymolipoma could be associated with
lymphocytosis
Microarray analysis identification of key pathways and interaction network of differential gene expressions during osteogenic differentiation
Get PDFBackground: Adult bone marrow-derived mesenchymal stem cells (BM-MSCs) are multipotent stem cells that can
differentiate into three lineages. They are suitable sources for cell-based therapy and regenerative medicine
applications. This study aims to evaluate the hub genes and key pathways of differentially expressed genes (DEGs)
related to osteogenesis by bioinformatics analysis in three different days. The DEGs were derived from the three
different days compared with day 0.
Results: Gene expression profiles of GSE37558 were obtained from the Gene Expression Omnibus (GEO) database.
A total of 4076 DEGs were acquired on days 8, 12, and 25. Gene ontology (GO) enrichment analysis showed that
the non-canonical Wnt signaling pathway and lipopolysaccharide (LPS)-mediated signaling pathway were
commonly upregulated DEGs for all 3 days. KEGG pathway analysis indicated that the PI3K-Akt and focal adhesion
were also commonly upregulated DEGs for all 3 days. Ten hub genes were identified by CytoHubba on days 8, 12,
and 25. Then, we focused on the association of these hub genes with the Wnt pathways that had been enriched
from the protein-protein interaction (PPI) by the Cytoscape plugin MCODE.
Conclusions: These findings suggested further insights into the roles of the PI3K/AKT and Wnt pathways and their
association with osteogenesis. In addition, the stem cell microenvironment via growth factors, extracellular matrix
(ECM), IGF1, IGF2, LPS, and Wnt most likely affect osteogenesis by PI3K/AKT
Effect of exercise training before mating on mRNA expression of breast cancer-related genes in offspring in rats
Get PDFPurpose: Exercise is associated with reduced risk of breast cancer, however, effect of parental
exercise on risk of breast cancer in children has not been studied. Thus, the aim of the present
study was evaluating the effect of aerobic training of parents before pregnancy on the
expression of some of the main genes in breast cancer in breast tissue of their offspring.
Method: Eighteen female and 6 male Sprague Dawley rats were randomly divided into two
exercise training and control group. After training each male mated with 2 females. Parental
aerobic training with moderate intensity was performed running on treadmill for 4 weeks, 5
sessions per week. Finally Pairs 4, 5, and 6 of adult breast tissues was performed to evaluate
the expression of BRCA1, TP53, ER-α, IGF-1 and IGF-1R. Results: We found that prepregnancy moderate aerobic training of mother, especially along with father caused a
significant increase in the mRNA of the BRCA1, P53 and ER-α genes, and a significant
reduction in IGF-1 and IGF-1R. Conclusion: Exercise with moderate intensity before mating
significantly affected the expression of BRCA1, P53, IGF-1, IGF-1R and ER-α genes. So we
suggest that parents regular exercise before pregnancy can reduce the risk of breast cancer in
children
Simultaneous removal of phenol and linear alkylbenzene sulfonate from automotive service station wastewater: Optimization of coupled electrochemical and physical processes
Get PDFThis work investigates the feasibility of the coupled electrochemical (electrocoagulation/flotation) and physical processes
(sedimentation, sand filtration, and activated carbon) for the treatment of automotive service wastewater (ASWW). The
impacts of critical parameters, viz. pH solution, reaction time and current intensity on linear alkylbenzene sulfonate (LAS),
and phenol removal efficiencies as well as energy consumption and operating cost are studied. Central composite design
results reveal that at the optimum conditions, LAS and phenol removal efficiencies, energy consumption and operating cost
are obtained 96.7%, 87.65%, 15.99 Wh, 0.001 US$, respectively. This process reveals a feasible technology for phenol and
LAS removal from ASW
بررسی ارتباط بین خطر اختلالات خوردن و برخی عوامل خطر مرتبط با تغذیه و شاخص های تن سنجی در دانش آموزان دختر مقطع دبیرستان دوره دوم شهر زنجان در سال 1396 (فایل دفاع نهایی)
Get PDFبررسی خصوصیات فیزیکی و شیمیایی چهار مهارکننده ی تیروزیناز قارچی (Naringin, Chrisin, Quercetin, Kaempferol) در محیط In Silico(چکیده طرح تحقیقاتی)
Get PDFبررسی اثرات اسید های چرب امگا3 , 6 و 9 بر بیان پروتئین ErK از مسیر MAPK در رده ی سلولی SK-OV-3 مربوط به سرطان تخمدان (چکیده طرح تحقیقاتی)
Get PDFEpidemiologic assessment of self‑concept and academic self‑efficacy in Iranian high school students: Multilevel analysis
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