Hochschule Bonn-Rhein-Sieg
Publikationsserver der Hochschule Bonn-Rhein-Sieg - pub H-BRSNot a member yet
7939 research outputs found
Sort by
Disturbance of mitochondrial functions caused by N-acetylglutamate and N-acetylmethionine in brain of adolescent rats: Potential relevance in aminoacylase 1 deficiency
No full textArten von Normen
No full textDieses Video aus der Videoreihe „Normen-ABC“ erklärt die Herkunft und Arten von Normen. Es werden Beispiele für Normen von A bis Z gezeigt. Anhand der Planungsnorm für Projektmanagement, der ersten deutschen DIN 1 als Ausführungsnorm und der weltweit verbreiteten Prüfnorm sowie Managementnormen zur Förderung von Nachhaltigkeit wird eine Einordnung im PDCA-Zyklus gezeigt
A framework to assess the role of social cash transfers in building adaptive capacity for climate resilience
No full textClimate change is increasingly affecting vulnerable groups and resulting in dire social and economic consequences, especially for those in the Global South. Managing current and emerging climate-related risks will require increasing individual’s and communities’ resilience, including enhancing absorptive, adaptive, and transformative capacities. Policymakers are now considering the role that social protection policies and programmes can play in building climate resilience by contributing to these capacities. However, there is a limited understanding of the extent to which social protection instruments can influence these three resilience-related capacities. Lack of assessment tools or frameworks might contribute to limited evidence of social protection’s ability to increase climate resilience. In particular, there appear to be no frameworks or tools that help assess the role of social cash transfers (SCT) in building adaptive capacity. Based on a multi-staged literature review, we develop an adaptive capacity outcomes framework (ACOF) that can help assess SCT’s contribution to building adaptive capacity, and, consequently, resilience. The framework is then tested using impact evaluation and assessment reports from SCT programmes in Indonesia, Zambia, Ethiopia, Bangladesh, and Tanzania. The exercise finds that SCTs alone have a limited contribution to adaptive capacity outcomes, but interventions that combine cash transfers with other components such as nutrition or livelihood training show positive impacts. We find that the ACOF can support assessments of SCT’s contribution towards adaptive capacity. It can help build evidence, evaluate impacts, and through further research, can facilitate learning on SCTs' role in increasing climate resilience
Recording Sodium Self-Inhibition of Epithelial Sodium Channels Using Automated Electrophysiology in Xenopus Oocytes
No full textThe epithelial sodium channel (ENaC) is a key regulator of sodium homeostasis that contributes to blood pressure control. ENaC open probability is adjusted by extracellular sodium ions, a mechanism referred to as sodium self-inhibition (SSI). With a growing number of identified ENaC gene variants associated with hypertension, there is an increasing demand for medium- to high-throughput assays allowing the detection of alterations in ENaC activity and SSI. We evaluated a commercially available automated two-electrode voltage-clamp (TEVC) system that records transmembrane currents of ENaC-expressing Xenopus oocytes in 96-well microtiter plates. We employed guinea pig, human and Xenopus laevis ENaC orthologs that display specific magnitudes of SSI. While demonstrating some limitations over traditional TEVC systems with customized perfusion chambers, the automated TEVC system was able to detect the established SSI characteristics of the employed ENaC orthologs. We were able to confirm a reduced SSI in a gene variant, leading to C479R substitution in the human α-ENaC subunit that has been reported in Liddle syndrome. In conclusion, automated TEVC in Xenopus oocytes can detect SSI of ENaC orthologs and variants associated with hypertension. For precise mechanistic and kinetic analyses of SSI, optimization for faster solution exchange rates is recommended
Unterbringung von geflüchteten Menschen: Kommunale Realitäten
No full textWährend ihrer Untersuchung zur Situation von geflüchteten Menschen in kommunalen Unterbringungen beginnt der Krieg in der Ukraine: Im Interview berichten Prof. Dr. Rosenow-Williams, Dr. Alina Bergedick und Dr. Katharina Behmer-Prinz von neuen Herausforderungen und Chancen und geben Einblicke in die Praxis kommunaler Flüchtlingsarbeit
