Hochschule Bonn-Rhein-Sieg
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Discovering single cannabidiol or synergistic antitumor effects of cannabidiol and cytokine-induced killer cells on non-small cell lung cancer cells
No full textIntroduction: A multitude of findings from cell cultures and animal studies are available to support the anti-cancer properties of cannabidiol (CBD). Since CBD acts on multiple molecular targets, its clinical adaptation, especially in combination with cancer immunotherapy regimen remains a serious concern.
Methods: Considering this, we extensively studied the effect of CBD on the cytokine-induced killer (CIK) cell immunotherapy approach using multiple non-small cell lung cancer (NSCLC) cells harboring diverse genotypes.
Results: Our analysis showed that, a) The Transient Receptor Potential Cation Channel Subfamily V Member 2 (TRPV2) channel was intracellularly expressed both in NSCLC cells and CIK cells. b) A synergistic effect of CIK combined with CBD, resulted in a significant increase in tumor lysis and Interferon gamma (IFN-g) production. c) CBD had a preference to elevate the CD25+CD69+ population and the CD62L_CD45RA+terminal effector memory (EMRA) population in NKT-CIK cells, suggesting early-stage activation and effector memory differentiation in CD3+CD56+ CIK cells. Of interest, we observed that CBD enhanced the calcium influx, which was mediated by the TRPV2 channel and elevated phosphor-Extracellular signal-Regulated Kinase (p-ERK) expression directly in CIK cells, whereas ERK selective inhibitor FR180204 inhibited the increasing cytotoxic CIK ability induced by CBD. Further examinations revealed that CBD induced DNA double-strand breaks via upregulation of histone H2AX phosphorylation in NSCLC cells and the migration and invasion ability of NSCLC cells suppressed by CBD were rescued using the TRPV2 antagonist (Tranilast) in the absence of CIK cells. We further investigated the epigenetic effects of this synergy and found that adding CBD to CIK cells decreased the Long Interspersed Nuclear Element-1 (LINE-1) mRNA expression and the global DNA methylation level in NSCLC cells carrying KRAS mutation. We further investigated the epigenetic effects of this synergy and found that adding CBD to CIK cells decreased the Long Interspersed Nuclear Element-1 (LINE-1) mRNA expression and the global DNA methylation level in NSCLC cells carrying KRAS mutation.
Conclusions: Taken together, CBD holds a great potential for treating NSCLC with CIK cell immunotherapy. In addition, we utilized NSCLC with different driver mutations to investigate the efficacy of CBD. Our findings might provide evidence for CBD-personized treatment with NSCLC patients
Selection Performance and Reliability of Eye and Head Gaze Tracking Under Varying Light Conditions
No full textCustomizable Presentation Attack Detection for Improved Resilience of Biometric Applications Using Near-Infrared Skin Detection
No full textDue to their user-friendliness and reliability, biometric systems have taken a central role in everyday digital identity management for all kinds of private, financial and governmental applications with increasing security requirements. A central security aspect of unsupervised biometric authentication systems is the presentation attack detection (PAD) mechanism, which defines the robustness to fake or altered biometric features. Artifacts like photos, artificial fingers, face masks and fake iris contact lenses are a general security threat for all biometric modalities. The Biometric Evaluation Center of the Institute of Safety and Security Research (ISF) at the University of Applied Sciences Bonn-Rhein-Sieg has specialized in the development of a near-infrared (NIR)-based contact-less detection technology that can distinguish between human skin and most artifact materials. This technology is highly adaptable and has already been successfully integrated into fingerprint scanners, face recognition devices and hand vein scanners. In this work, we introduce a cutting-edge, miniaturized near-infrared presentation attack detection (NIR-PAD) device. It includes an innovative signal processing chain and an integrated distance measurement feature to boost both reliability and resilience. We detail the device’s modular configuration and conceptual decisions, highlighting its suitability as a versatile platform for sensor fusion and seamless integration into future biometric systems. This paper elucidates the technological foundations and conceptual framework of the NIR-PAD reference platform, alongside an exploration of its potential applications and prospective enhancements
Making Order in Household Accounting - Digital Invoices as Domestic Work Artifacts
Get PDFThe digitization of financial activities in consumers' lives is increasing, and the digitalization of invoicing processes is expected to play a significant role, although this area is not well understood regarding the private sector. Human-Computer Interaction (HCI) and Computer Supported Cooperative Work (CSCW) research have a long history of analyzing the socio-material and temporal aspects of work practices that are relevant for the domestic domain. The socio-material structuring of invoicing work and the working styles of consumers must be considered when designing effective consumer support systems. In this ethnomethodologically-informed, design-oriented interview study, we followed 17 consumers in their daily practices of dealing with invoices to make the invisible administrative work involved in this process visible. We identified and described the meaningful artifacts that were used in a spatial-temporal process within various storage locations such as input, reminding, intermediate (for postponing cases) buffers, and archive systems. Furthermore, we identified three different working styles that consumers exhibited: direct completion, at the next opportunity, and postpone as far as possible. This study contributes to our understanding of household economics and domestic workplace studies in the tradition of CSCW and has implications for the design of electronic invoicing systems
Enhancing Resilience in Biometric Research: Generation of 3D Synthetic Face Data Using Advanced 3D Character Creation Techniques from High-Fidelity Video Games and Animation
No full textBiometric authentication plays a vital role in various everyday applications with increasing demands for reliability and security. However, the use of real biometric data for research raises privacy concerns and data scarcity issues. A promising approach using synthetic biometric data to address the resulting unbalanced representation and bias, as well as the limited availability of diverse datasets for the development and evaluation of biometric systems, has emerged. Methods for a parameterized generation of highly realistic synthetic data are emerging and the necessary quality metrics to prove that synthetic data can compare to real data are open research tasks. The generation of 3D synthetic face data using game engines’ capabilities of generating varied realistic virtual characters is explored as a possible alternative for generating synthetic face data while maintaining reproducibility and ground truth, as opposed to other creation methods. While synthetic data offer several benefits, including improved resilience against data privacy concerns, the limitations and challenges associated with their usage are addressed. Our work shows concurrent behavior in comparing semi-synthetic data as a digital representation of a real identity with their real datasets. Despite slight asymmetrical performance in comparison with a larger database of real samples, a promising performance in face data authentication is shown, which lays the foundation for further investigations with digital avatars and the creation and analysis of fully synthetic data. Future directions for improving synthetic biometric data generation and their impact on advancing biometrics research are discussed
Verbraucherinformatik: Grundlagen und Anwendungsfelder der digitalen Konsumgesellschaft
Get PDFIn einer Zeit, in der digitale Technologien nahezu jeden Aspekt unseres Lebens durchdringen, ist es unerlässlich, die tieferen Zusammenhänge des digitalen Konsums zu verstehen. Erstmalig bietet dieses open access-Lehrbuch einen Wegweiser durch die vielfältigen Facetten der Digitalisierung des Konsums. Dabei verbindet es die Disziplinen der angewandten Informatik und Verbraucherwissenschaften.
Die Leserinnen und Leser erhalten Einblick in die digitale Konsumlandschaft, ausgehend von der historischen Entwicklung des (digitalen) Konsums. Dazu vermittelt das Lehrbuch zentrale Grundbegriffe und Themen der Verbraucherinformatik und stellt verschiedene Konsumtheorien aus den Disziplinen Wirtschaftswissenschaften, Psychologie und Sozialwissenschaften vor. Praxisnahe Beispiele aus der Digitalisierung bieten Einsichten in unterschiedliche Perspektiven, während vertiefende Textboxen und Selbstreflexionsfragen das Verständnis fördern.
Inhaltlich decken die Autorinnen und Autoren Themen von Datenschutz bis zur Sharing Economy ab und geben insbesondere auch praktische Ansätze für Themen wie Verbraucherschutz und Nachhaltigkeit mit auf den Weg. Die Anwendungs- und Querschnittsthemen der Verbraucherinformatik reichen von der Digitalisierung der Haushalte und Märkte über Fragen des digitalen Verbraucherschutzes bis hin zu zentralen gesellschaftlichen Fragestellungen rund um die Themen Fairness, Verantwortung und Nachhaltigkeit bei der Gestaltung von digitalen Technologien.
Das Buch bietet einen umfassenden Überblick, der sowohl für Studierende der Wirtschafts- und Sozialwissenschaften als auch der angewandten Informatik von bedeutendem Wert ist
Einleitung: Professionalisierung im Verbraucherschutz
Get PDFDas Feld des Verbraucherschutzes unterliegt einem permanenten Wandel. Hatten sich in der Vergangenheit im Bereich der Rechts- oder der Ernährungswissenschaften Ausbildungsgänge oder Spezialisierungsmöglichkeiten für dieses komplexe Berufsfeld entwickelt, so stehen die Akteure angesichts der beschleunigten Marktveränderungen doch immer wieder vor neuen Herausforderungen, die etwa heute auch Kompetenzanforderungen im Bereich des Hackens oder der Algorithmenkontrolle umfassen. Vor diesem Hintergrund gilt es über Verbraucherschutz als Beruf und Berufung genauer nachzudenken und insbesondere die Grenzen und Möglichkeiten der Professionalisierung in diesem Feld zu reflektieren
The impact of gravity on perceived object height
Get PDFAltering posture relative to the direction of gravity, or exposure to microgravity has been shown to affect many aspects of perception, including size perception. Our aims in this study were to investigate whether changes in posture and long-term exposure to microgravity bias the visual perception of object height and to test whether any such biases are accompanied by changes in precision. We also explored the possibility of sex/gender differences. Two cohorts of participants (12 astronauts and 20 controls, 50% women) varied the size of a virtual square in a simulated corridor until it was perceived to match a reference stick held in their hands. Astronauts performed the task before, twice during, and twice after an extended stay onboard the International Space Station. On Earth, they performed the task of sitting upright and lying supine. Earth-bound controls also completed the task five times with test sessions spaced similarly to the astronauts; to simulate the microgravity sessions on the ISS they lay supine. In contrast to earlier studies, we found no immediate effect of microgravity exposure on perceived object height. However, astronauts robustly underestimated the height of the square relative to the haptic reference and these estimates were significantly smaller 60 days or more after their return to Earth. No differences were found in the precision of the astronauts’ judgments. Controls underestimated the height of the square when supine relative to sitting in their first test session (simulating Pre-Flight) but not in later sessions. While these results are largely inconsistent with previous results in the literature, a posture-dependent effect of simulated eye height might provide a unifying explanation. We were unable to make any firm statements related to sex/gender differences. We conclude that no countermeasures are required to mitigate the acute effects of microgravity exposure on object height perception. However, space travelers should be warned about late-emerging and potentially long-lasting changes in this perceptual skill
Time for an Explanation: A Mini-Review of Explainable Physio-Behavioural Time-Series Classification
Get PDFTime-series classification is seeing growing importance as device proliferation has lead to the collection of an abundance of sensor data. Although black-box models, whose internal workings are difficult to understand, are a common choice for this task, their use in safety-critical domains has raised calls for greater transparency. In response, researchers have begun employing explainable artificial intelligence together with physio-behavioural signals in the context of real-world problems. Hence, this paper examines the current literature in this area and contributes principles for future research to overcome the limitations of the reviewed works