Hochschule Bonn-Rhein-Sieg
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Impact of aerosols on photovoltaic energy production using a spectrally resolved model chain: Case study of southern West Africa
No full textA quarter century of usable security and privacy research: transparency, tailorability, and the road ahead
No full textKosten-Nutzen-Modelle für die Rehabilitation – Return on Investment auf der Basis von Patient Reported Outcomes
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Nucleic acids and melanin pigments after exposure to high doses of gamma rays: a biosignature robustness test
No full textThe Role of Marketplaces for the Transformation from Robotic Process Automation to Intelligent Process Automation
No full textThe corporate landscape is experiencing an increasing change in business models due to digitization. An increasing availability of data along the business processes enhance the opportunities for process automation. Technologies such as Robotic Process Automation (RPA) are widely used for business process optimization, but as a side effect an increase in stand-alone solutions and a lack of holistic approaches can be observed. Intelligent Process Automation (IPA) is said to support more complex processes and enable automated decision-making, but due to the lack of connectors makes the implementation difficult. RPA marketplaces can be a bridging technology to help companies implement Intelligent Process Automation. This paper explores the drivers and challenges for the adoption of RPA marketplaces to realize IPA. For this purpose, we conducted ten expert interviews with decision makers and IT staff from the process automation sector
Identification of a Thyroid Hormone Binding Site in Hsp90 with Implications for Its Interaction with Thyroid Hormone Receptor Beta
No full textWhile many proteins are known clients of heat shock protein 90 (Hsp90), it is unclear whether the transcription factor, thyroid hormone receptor beta (TRb), interacts with Hsp90 to control hormonal perception and signaling. Higher Hsp90 expression in mouse fibroblasts was elicited by the addition of triiodothyronine (T3). T3 bound to Hsp90 and enhanced adenosine triphosphate (ATP) binding of Hsp90 due to a specific binding site for T3, as identified by molecular docking experiments. The binding of TRb to Hsp90 was prevented by T3 or by the thyroid mimetic sobetirome. Purified recombinant TRb trapped Hsp90 from cell lysate or purified Hsp90 in pull-down experiments. The affinity of Hsp90 for TRb was 124 nM. Furthermore, T3 induced the release of bound TRb from Hsp90, which was shown by streptavidin-conjugated quantum dot (SAv-QD) masking assay. The data indicate that the T3 interaction with TRb and Hsp90 may be an amplifier of the cellular stress response by blocking Hsp90 activity
Anti-CD40 predominates over anti-CTLA-4 to provide enhanced antitumor response of DC-CIK cells in renal cell carcinoma
No full textCytokine-induced killer cells (CIK) in combination with dendritic cells (DCs) have shown favorable outcomes in renal cell carcinoma (RCC), yet some patients exhibit recurrence or no response to this therapy. In a broader perspective, enhancing the antitumor response of DC-CIK cells may help to address this issue. Considering this, herein, we investigated the effect of anti-CD40 and anti-CTLA-4 antibodies on the antitumor response of DC-CIK cells against RCC cell lines. Our analysis showed that, a) anti-CD40 antibody (G28.5) increased the CD3+CD56+ effector cells of CIK cells by promoting the maturation and activation of DCs, b) G28.5 also increased CTLA-4 expression in CIK cells via DCs, but the increase could be hindered by the CTLA-4 inhibitor (ipilimumab), c) adding ipilimumab was also able to significantly increase the proportion of CD3+CD56+ cells in DC-CIK cells, d) anti-CD40 antibodies predominated over anti-CTLA-4 antibodies for cytotoxicity, apoptotic effect and IFN-g secretion of DC-CIK cells against RCC cells, e) after ipilimumab treatment, the population of Tregs in CIK cells remained unaffected, but ipilimumab combined with G28.5 significantly reduced the expression of CD28 in CIK cells. Taken together, we suggest that the agonistic anti-CD40 antibody rather than CTLA-4 inhibitor may improve the antitumor response of DC-CIK cells, particularly in RCC. In addition, we pointed towards the yet to be known contribution of CD28 in the crosstalk between anti-CTLA-4 and CIK cells
Verwaltungs-Berufsgenossenschaft für gewerbliche Zeitarbeit zuständig: § Landessozialgericht Hamburg, Urteil vom 19. Januar 2022 – L 2 U 50/19, juris
No full textFür Unternehmen der gewerbsmäßigen Arbeitnehmerüberlassung ist auch bei monostruktureller Zeitarbeit nur die Verwaltungs-Berufsgenossenschaft und nicht die Fach-Berufsgenossenschaft zuständig