Hochschule Bonn-Rhein-Sieg
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Expand - talents, ideas, partnerships
No full textBreaking new ground and setting new trends in research, teaching and transfer - this is what the Hochschule Bonn-Rhein-Sieg (H-BRS) managed to do last year despite the Corona pandemic. Talents, ideas and cooperations have come to fruition in various ways, always in close exchange between applied science, society and business. "expand" is therefore the motto of the annual report of the H-BRS for the year 2021, which has now been published
Introduction of an adhesion factor to cube in cube models and its effect on calculated moduli of particulate composites
Get PDFThe cube in cube approach was used by Paul and Ishai-Cohen to model and derive formulas for filler content dependent Young's moduli of particle filled composites assuming perfect filler matrix adhesion. Their formulas were chosen because of their simplicity, and recalculated using an elementary volume approach which transforms spherical inclusions to cubic inclusions. The EV approach led to expression of the composites moduli that allows introducing an adhesion factor kadh ranging from 0 and 1 to take into account reduced filler matrix adhesion. This adhesion factor scales the edge length of the cubic inclusions, thus reducing the stress transfer area between matrix and filler. Fitting the experimental data with the modified Paul model provides reasonable kadh for PA66, PBT, PP, PE-LD and BR which are in line with their surface energies. Further analysis showed that stiffening only occurs if kadh exceeds [Formula: see text] and depends on the ratio of matrix modulus and filler modulus. The modified model allows for a quick calculation of any particle filled composites for known matrix modulus EM, filler modulus EF, filler volume content vF and adhesion factor kadh. Thus, finite element analysis (FEA) simulations of any particle filled polymer parts as well as materials selection are significantly eased. FEA of cubic and hexagonal EV arrangements show that stress distributions within the EV exhibit more shear stresses if one deviates from the cubic arrangement. At high filler contents the assumption that the property of the EV is representative for the whole composite, holds only for filler volume contents up to 15 or 20% (corresponding to 30 to 40 weight %). Thus, for vast majority of commercially available particulate composites, the modified model can be applied. Furthermore, this indicates that the cube in cube approach reaches two limits: (i) the occurrence of increasing shear stresses at filler contents above 20% due to deviations of EV arrangements or spatial filler distribution from cubic arrangements (singular), and (ii) increasing interaction between particles with the formation of particle network within the matrix violating the EV assumption of their homogeneous dispersion
Correction: Franz et al. Unraveling a Force-Generating Allosteric Pathway of Actomyosin Communication Associated with ADP and Pi Release. Int. J. Mol. Sci. 2021, 22, 104
Get PDFThe author wishes to make the following correction to this paper [...]
Mid- to long-term cardiac magnetic resonance findings in elite athletes recovered from COVID-19 - results from one German Olympic medical center
No full textBackground There is a lack of cardiac magnetic resonance (CMR) data regarding mid- to long-term myocardial damage due to Covid-19 in elite athletes. Objective This study investigated mid-to long-term consequences of myocardial involvement after a Covid-19 infection in elite athletes.
Methods Between January 2020 and October 2021, 27 athletes of the German Olympic centre Rhineland with confirmed Covid-19 infection were analyzed. 9 healthy non-athlete volunteers served as control. CMR was performed in mean 182 days (SD 99) after initial positive test result.
Results CMR did not reveal any signs of acute myocarditis in regard to the current Lake Louise criteria or myocardial damage in any of the 26 elite athletes with previous Covid-19 infection. Nevertheless, 92 % of the athletes experienced a symptomatic course and 54 % reported lasting symptoms for more than 4 weeks. In one male athlete CMR revealed an arrhythmogenic right ventricular cardiomyopathy (ARVC) and this athlete was excluded from the study. Athletes had significantly enlarged left and right ventricle volumes and increased left ventricular myocardial mass in comparison to the healthy control group (LVEDVi 103.4 vs. 91.1 ml/m 2 p=0.031; RVEDVi 104.1 vs. 86.6 ml/m 2 p=0.007; and LVMi 59.0 vs. 46.2 g/m 2 p=0.002).
Conclusion Our findings suggest that the risk for mid-to long-term myocardial damage seems to be very low to negligible in elite athletes. No conclusions can be drawn regarding myocardial injury in the acute phase of infection nor about possible long-term myocardial effects in the general population
Evaluation and generic application scenarios for curved hexahedral adaptive mesh refinement
No full textIn (dynamic) adaptive mesh refinement (AMR) an input mesh is refined or coarsened to the need of the numerical application. This refinement happens with no respect to the originally meshed domain and is therefore limited to the geometrical accuracy of the original input mesh. We presented a novel approach to equip this input mesh with additional geometry information, to allow refinement and high-order cells based on the geometry of the original domain. We already showed a limited implementation of this algorithm. Now we evaluate this prototype with a numerical application and we prove its influence on the accuracy of certain numerical results. To be as practical as possible, we implement the ability to import meshes generated by Gmsh and equip them with the needed geometry information. Furthermore, we improve the mapping algorithm, which maps the geometry information of the boundary of a cell into the cell's volume. With these preliminary steps done, we use out new approach in a simulation of the advection of a concentration along the boundary of a sphere shell and past the boundary of a rotating cylinder. We evaluate the accuracy of our approach in comparison to the conventional refinement of cells to answer our research question: How does the performance and accuracy of the hexahedral curved domain AMR algorithm compare to linear AMR when solving the advection equation with the linear finite volume method? To answer this question, we show the influence of curved AMR on our simulation results and see, that it is even able to outperform far finer linear meshes in terms of accuracy. We also see that the current implementation of this approach is too slow for practical usage. We can therefore prove the benefits of curved AMR in certain, geometry-related application scenarios and show possible improvements to make it more feasible and practical in the future
Let's Go to the Mall: Investigating the Role of User Experience in Customers’ Intention to Use Social Robots in a Shopping Mall
No full textAim of this study is to investigate the effects of user experience (UX) on shopping mall customers’ intention to use a social robot. Therefore, we used a Wizard of Oz approach that enabled data collection in situ. Quantitative data was obtained from a questionnaire completed by shopping mall customers who interacted with a social robot. Data was used in a regression analysis, where user experience factors served as predictors for robot use in retail. The regression model explains up to 23.2% of the variance in customers’ intention to use a social robot. In addition, we collected qualitative data on human-robot-interactions and used the data to complement the interpretation of statistical results. Our findings suggest that only hedonic qualities significantly contribute to the prediction of customers’ intention, that shopping mall customers are reluctant to grant pragmatic qualities to social robots, and that UX evaluation in HRI requires additional predictors
Nanomedicine-based strategies to improve treatment of cutaneous leishmaniasis
No full textNanomedicine strategies were first adapted and successfully translated to clinical application for diseases, such as cancer and diabetes. These strategies would no doubt benefit unmet diseases needs as in the case of leishmaniasis. The latter causes skin sores in the cutaneous form and affects internal organs in the visceral form. Treatment of cutaneous leishmaniasis (CL) aims at accelerating wound healing, reducing scarring and cosmetic morbidity, preventing parasite transmission and relapse. Unfortunately, available treatments show only suboptimal effectiveness and none of them were designed specifically for this disease condition. Tissue regeneration using nano-based devices coupled with drug delivery are currently being used in clinic to address diabetic wounds. Thus, in this review, we analyse the current treatment options and attempt to critically analyse the use of nanomedicine-based strategies to address CL wounds in view of achieving scarless wound healing, targeting secondary bacterial infection and lowering drug toxicity