Hochschule Bonn-Rhein-Sieg
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Combination of hydrophobicity and codon usage bias determines sorting of model K+ channel protein to either mitochondria or endoplasmic reticulum
No full textWhen the K+ channel-like protein Kesv from Ectocarpus siliculosus virus 1 is heterologously expressed in mammalian cells, it is sorted to the mitochondria. This targeting can be redirected to the endoplasmic reticulum (ER) by altering the codon usage in distinct regions of the gene or by inserting a triplet of hydrophobic amino acids (AAs) into the protein's C-terminal transmembrane domain (ct-TMD). Systematic variations in the flavor of the inserted AAs and/or its codon usage show that a positive charge in the inserted AA triplet alone serves as strong signal for mitochondria sorting. In cases of neutral AA triplets, mitochondria sorting are favored by a combination of hydrophilic AAs and rarely used codons; sorting to the ER exhibits the inverse dependency. This propensity for ER sorting is particularly high when a common codon follows a rarer one in the AA triplet; mitochondria sorting in contrast is supported by codon uniformity. Since parameters like positive charge, hydrophobic AAs, and common codons are known to facilitate elongation of nascent proteins in the ribosome the data suggest a mechanism in which local changes in elongation velocity and co-translational folding in the ct-TMD influence intracellular protein sorting
Simulation of Pipeline Transport of Carbon Dioxide with Impurities
No full textThe transport of carbon dioxide through pipelines is one of the important components of Carbon dioxide Capture and Storage (CCS) systems that are currently being developed. If high flow rates are desired a transportation in the liquid or supercritical phase is to be preferred. For technical reasons, the transport must stay in that phase, without transitioning to the gaseous state. In this paper, a numerical simulation of the stationary process of carbon dioxide transport with impurities and phase transitions is considered. We use the Homogeneous Equilibrium Model (HEM) and the GERG-2008 thermodynamic equation of state to describe the transport parameters. The algorithms used allow to solve scenarios of carbon dioxide transport in the liquid or supercritical phase, with the detection of approaching the phase transition region. Convergence of the solution algorithms is analyzed in connection with fast and abrupt changes of the equation of state and the enthalpy function in the region of phase transitions
Classification of COVID-19 and lung opacity using vision transformer on chest x-ray images
No full textThere are several recent works which had proposed an automatic computer-aided diagnosis (CAD) deep learning (DL) model to diagnose coronavirus disease 2019 (COVID-19) using chest x-ray images (CXR) to propose a high-accuracy CAD method to detect COVID-19 automatically. In this study, seven different models including Convolutional Neural Network (CNN) models such as VGG-16 and vision transformer (ViT) models, are proposed. The different proposed models are trained with a three-class balanced dataset consisting of 3,000 CXR images consisting of 1,000 CXR images for each class of COVID-19, Normal, and Lung-Opacity. A publicly available dataset to train and test the models is used from Kaggle-COVID-19-Radiography-Dataset. From the experiments, the accuracy of the VGG16 model is 93.44% and ViT's is 92.33%. Besides, the binary classification between two classes of COVID-19 and Normal CXR with a limited number of just 100 images for each class, using a transfer learning technique, with a validation accuracy of 97.5% is proposed
ReDeX - Entwicklung einer reduktiven Behandlungsmethode zur Entfernung von Desinfektionsnebenprodukten und Xenobiotika aus Trinkwasser: Abschlussbericht zum Forschungsvorhaben : Förderung von Forschung an Fachhochschulen mit Unternehmen (FHprofUnt 2018)
No full textBeyond Yield Optimization: The Impact of Organosolv Process Parameters on Lignin Structure
Get PDFWhen optimizing the process parameters of the acidic ethanolic organosolv process, the aim is usually to maximize the delignification and/or lignin purity. However, process parameters such as temperature, time, ethanol and catalyst concentration, respectively, can also be used to vary the structural properties of the obtained organosolv lignin, including the molecular weight and the ratio of aliphatic versus phenolic hydroxyl groups, among others. This review particularly focuses on these influencing factors and establishes a trend analysis between the variation of the process parameters and the effect on lignin structure. Especially when larger data sets are available, as for process temperature and time, correlations between the distribution of depolymerization and condensation reactions are found, which allow direct conclusions on the proportion of lignin's structural features, independent of the diversity of the biomass used. The newfound insights gained from this review can be used to tailor organosolv lignins isolated for a specific application
Key Success Factors for Promoting Business to Business Collaboration between enterprises from Africa and the Global North
No full textThe dawn of the 21st Century has witnessed a tremendous increase in trade pacts among nations, resulting in renewed hopes for sustainable enterprise development in emerging economies worldwide. Ghana and other sub- Saharan African (SSA) countries have signed onto several North-South and South-South free trade agreements with the hope of strengthening their presence in the international trade arena, and to promote economic growth in SSA. For over two decades, however, very little has changed, and many have dashed their high hopes as enterprises continue to struggle in SSA. Not even the African Continental Free Trade Agreement (AfCFTA) could renew the hopes of sceptics. Several studies opined that enterprises in SSA could improve their domestic and international competitiveness by establishing mutually beneficial partnerships with their counterparts from the Global North and South. This study delved into the issues that affect North-South and South-South business collaborations and recommends key success factors that could help promote mutually beneficial cross-border business partnerships. The research includes both literature and empirical information on the key success factors of business partnerships between African enterprises as well as between African enterprises and firms from the Global North. We approached the study qualitatively using a phenomenological research design. Research participants included important stakeholders in Africa and Europe's international trade and sustainable enterprise development ecosystem. The study identified several challenges with the current business collaborations and recommended new ways of making such partnerships more beneficial
Creating Internships in the Absence of the Private Sector
No full textThe differentiation of the higher education sector in Ethiopia has created a new sector of Higher Education Institutions: Universities of Applied Sciences (UAS). Its focus is on educating academically trained experts for regional industries. Close cooperation between industries and UAS is set as a key requirement. However, Ethiopian industries in many regions are not developed enough that those could be considered as active partners for UASs and able to accommodate interns or to provide expert teachers to UAS classes. European UAS structures serve as benchmarks for the Ethiopian Ministry of Education (MoE). Therefore, UAS curricula of study programmes in building-construction, electro-engineering and economic/business/tourism from different European countries build a common ground for Ethiopian UASs. But, due to the lack of industries in the regions, Ethiopian UAS are not able to mirror the European counterparts, where study programmes at bachelor level comprise 70 credits out or 210 credits as practical works, internships and bachelor thesis. - The question is, how can Ethiopian UASs in the absence of companies offer practice-oriented education in their study programmes? This paper refers to the ongoing research, on how to integrate UAS (academic and non-academic) departments at UAS campuses to create internship placements for students in the absence of internship placements in the private sector. Kotebe University of Education (KUE) - as one of the newly founded UAS in Ethiopia - has agreed to act as subject of this try-out
