Hochschule Bonn-Rhein-Sieg
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Ordnung zur Regelung des Auslaufens des Lehr- und Prüfungsangebots für den Bachelorstudiengang Naturwissenschaftliche Forensik B.SC. auf der Grundlage der Prüfungsordnung vom 26.06.2008 in der Fassung der 4. Änderungsordnung vom 24.09.2015 am Campus Rheinbach der Hochschule Bonn-Rhein-Sieg vom 27.04.2023
Get PDFPrüfungsordnung für den Bachelor-Studiengang Informatik, den Bachelor-Studiengang Cyber Security and Privacy, den Bachelor-Studiengang Wirtschaftsinformatik, den Bachelor-Studiengang Informatik dual, den Master-Studiengang Informatik, den Master-Studiengang Cyber Security and Privacy, den Master-Studiengang Autonomous Systems und den Master-Studiengang Visual Computing and Games Technology vom 01.06.2017 in der Fassung der 5. Änderungsordnung am Campus Sankt Augustin der Hochschule Bonn-Rhein-Sieg vom 27.04.2023
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Alkali metal cations modulate the geometry of different binding sites in HCN4 selectivity filter for permeation or block
No full textHyperpolarization-activated cyclic-nucleotide gated (HCN) channels are important for timing biological processes like heartbeat and neuronal firing. Their weak cation selectivity is determined by a filter domain with only two binding sites for K+ and one for Na+. The latter acts as a weak blocker, which is released in combination with a dynamic widening of the filter by K+ ions, giving rise to a mixed K+/Na+ current. Here, we apply molecular dynamics simulations to systematically investigate the interactions of five alkali metal cations with the filter of the open HCN4 pore. Simulations recapitulate experimental data like a low Li+ permeability, considerable Rb+ conductance, a block by Cs+ as well as a punch through of Cs+ ions at high negative voltages. Differential binding of the cation species in specific filter sites is associated with structural adaptations of filter residues. This gives rise to ion coordination by a cation-characteristic number of oxygen atoms from the filter backbone and solvent. This ion/protein interplay prevents Li+, but not Na+, from entry into and further passage through the filter. The site equivalent to S3 in K+ channels emerges as a preferential binding and presumably blocking site for Cs+. Collectively, the data suggest that the weak cation selectivity of HCN channels and their block by Cs+ are determined by restrained cation-generated rearrangements of flexible filter residues
Detection of SARS-CoV2 Antibodies Following Vaccination in Patients with Rheumatic Musculoskeletal Disease (Decodir) – a Report from a Danish Prospective Cohort Study
No full textTeaching Analysis Poll-Verfahren in Deutschland und transformatives Lernen: eine Annäherung
No full textThe Teaching Analysis Poll (TAP) method has become a well-known and popular approach for the qualitative evaluation of academic courses at German universities. Despite its positive reputation, there is a lack of systematic investigation into the assumed benefits. This article presents initial findings from an exploratory online survey conducted among instructors at six German universities who utilized the TAP method. The survey focused on motives, insights gained, and perceived effects of TAP. Emphasis is placed on TAP as a dialogical feedback instrument, shifting the focus from evaluating teaching performance to understanding student learning. The study outlines the flexible TAP process, built around three conversation sequences between instructors, students and Third Space employees. The collected data indicate positive changes in teaching practices and suggest that TAP may potentially foster transformative learning. This analysis lays the groundwork for further research, systematically examining the impacts of TAP at German universities and integrating them into a theoretical framework
