Jurnal ILMU DASAR
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Production of The Entomopathogenic Fungi Beauveria bassiana using Starch Rich Substrate and Its Infectivity against Tribolium castaneum
Full text linkThe entomopathogenic fungi of Beauveria bassiana is known to infect the Tribolium castaneum pest. Mass production of B. bassiana is currently carried out using alternative media, the amount of conidia produced on alternative media is quite large and can tolerate temperature. This research aims to select alternative media for the propagation of B. bassiana to gain germination, conidia density, and virulence of the best alternative media concentration against the pest of T. castaneum. The method used was a compiled in the Completely Randomized Design (RAL) at all stages of research. In the first stage of alternative media selection consisting of 4 treatments in 6 replications: A (PDA); B (peanuts); C (soybean); D (old coconut meat). The second stage of alternative media infectivity consisting of 5 treatments in 5 replications: positive control (synthesis insecticide); negative control (aquades); 107; 108; 109 spores/ml. The results achieved that alternative media selection given a highest colony diameter is 4.39 cm on soybean, the highest conidia density is 5,61 x 108 spores/ml on peanuts, the highest germinating power is 31.76% on peanuts. Furthermore, the infectivity of alternative media obtained on peanut media had a significant effect on the mortality of T. castaneum (36.00%) at a concentration of 109 spores/ml, LC50 was obtained at 5.6 x 105 spores/ml, and LT50 within 5.42 days. The results indicated that the peanut media was a good propagation medium of B. bassiana and it was necessary to find other alternatives to increase the infectivity of B. bassiana against T. castaneum
Value at Risk with Performing Exponential Generalized Autoregressive Conditional Heteroscedasticity–Generalized Pareto Distribution
Full text linkStocks are an investment that many investors are interested in but often have a high risk. Value at Risk (VaR) is one tool that is often used in risk measurement. In general, financial data fluctuate rapidly so that the variants of the residuals are not constant or heteroscedasticity. The condition of heteroscedasticity is modeled using the ARCH/GARCH model. If there is an asymmetric effect on the data, it is modeled using an asymmetric GARCH model, namely Exponential GARCH (EGARCH). In addition to the impacts of heteroscedasticity and asymmetric events, extreme events in fat distribution tails are modeled using the Extreme Value Theory method, namely the Peaks Over Threshold method with the Generalized Pareto Distribution (GPD) approach. The data in this study is the return data of PT. Indocement Tunggal Prakarsa Tbk (INTP) for the period of March 1, 2013 - October 31, 2018. It was found that the data was heteroscedasticity, asymmetric, and there were also fat distribution tails, so it was modeled using a combination of EGARCH-GPD models. ARIMA ([2], 0, [2,13]) EGARCH (1,1) has the smallest AIC compared to other models, and then we choose it as the best model. The amount of risk with a 95% confidence level obtained with the GPD approach is 0.333% of current investment
Cardioprotective Effect of Chloroform Extract of Arcangelisia flava on Doxorubicin-induced Cardiomyopathy
Full text linkLong-term use of doxorubicin as cancer chemotherapeutic agent would cause tissue toxicity, including cardiotoxicity. Arcangelisia flava is suggested to have cardio protective effect. This study aimed to determine the effect of chloroform extract of A. flava leaves on cardio histopathology of doxorubicin-treated Wistar white male rats. Wistar male rats were divided into four groups (1) control group; (2) doxorubicin 7.5 mg/kgBW intraperitoneally twice (day 1 and 6); (3) doxorubicin + chloroform extract of A. flava leaves 250 mg/kgBW/day orally for 11 days; (4) Chloroform extract of A. flava leaves 250 mg/kgBW/day orallly for 11 days. At the 12th day, the rats were sacrificed; the heart organ was taken to make histopathological preparations and analyzed using HE staining. Vacuolization and necrosis are the parameters used in evaluating this effect. The phytochemical screening was also done to determine the compounds in chloroform extract of A. flava leaves. Based on the HE staining, chloroform extract of A. flava leaves decreased the cardiotoxicity caused by doxorubicin. The phytochemical screening showed that chloroform extract of A. flava leaves contains flavonoid, tannin, alkaloid, and triterpenoid. The cardioprotective effect of chloroform extract of A. flava leaves was suggested to be contributed by the flavonoid, tannin, and triterpenoid
Construction of Three Branches Fractal Trees Using Iterated Function System
Full text linkThere are two types of fractal: natural fractals and fractals set. The examples of natural fractals are trees, leaves, ferns, mountain, and coastlines. One of the examples of fractals set is Pythagorean tree. In the earlier study, the Pythagorean tree has two branches generated through several affine transformations, i.e dilation and rotation. Here, we developed the Pythagorean tree (or fractal tree) with three branches through dilation, translation, and rotation transformation using Iterated Function System (IFS) method. Some values of height and length parameters were selected to ensure the formation of a fractal tree. These parameters affected the branching angle that can result in different fractal tree shape. Some random values of height and length parameters produced several variations of fractal tree. These values influenced the shape of fractal whether it tended to the left, to the right, or symmetrical shape
Increased Interleukin-4 in Farmers With Ascariasis in Rural Jember
Full text linkAscaris lumbricoides is nematode which often infest human in the world. The infestation of A. lumbricoides in the human will trigger the formation of Th2 immune responses through increased interleukin-4 released by innate immune cells. Th2 immune response generates B lymphocyte cells to produce IgE antibodies to eliminate A. lumbricoides. Therefore, IL-4 is a marker of Th2 immune response. The purpose of this study was to determine the prevalence of ascariasis and an increase of IL-4 in planters infested with A. lumbricoides as a marker of Th2 immune response. Our study was observational analytic with cross sectional design. 230 planters who were willing to be involved in the study gave stool samples for the diagnosis of ascariasis. 20 people who were positive for ascariasis and 20 people who were negative selected randomly for blood plasma samples. IL-4 levels in blood plasma were measured using ELISA. Differences in IL4 levels between positive and negative ascariasis were analyzed by the Mann Whitney statistical test with p value ≤ 0.05. The prevalence of ascariasis among planters in rural area of Jember was 16,52% which was included low prevalence. Univariate analysis showed that the mean and median levels of IL-4 ascariasis were greater than those of healthy planters. Mann Whitney test results showed that there were differences in levels of IL-4 between ascariasis and healthy planters (p≤0.05). Increased levels of IL-4 in planters with ascariasis indicate that A. lumbricoides infection triggers the formation of Th2 immune response as a mechanism for eliminating A. lumbricoides. Keywords: Interleukin-4, A. lumbricoides, Th2 immune response
Echinoderms Diversity in Cibuaya Beach Ujung Genteng, West Java
Full text linkThe research about Echinoderms diversity in Cibuaya Beach Ujung Genteng, West Java has been conducted from February to July 2019. It aimed to know diversity index of Echinoderms. It used belt transect method with three stations in the intertidal zone. Sampling technique used purposive sampling. The observation data are included primary data (the number of phylum Echinoderm’s species in the transect) and environmental data (pH, salinity, temperature, depth, current strength, and substrate). The population in this study was all species of Echinoderms found in the intertidal zone. The sample in this study was the species of Echinoderms found in the area of the station. Based on the result, the study obtained 8 species of Echinoderms, consisted of 3 classesand classified into 5 orders, 5 families, and 6 genera. The diversity index is classified as low with the average value of 0.62. The evenness index is classified as low with the average value of 0.37. The dominance index is classified as moderate with the average value of 0.67. Keywords: diversity, echinoderms, cibuaya beach, Ophiuroidea, Echinoidea, Holothuroidea
Electric Field Distribution Analysis of Blood Cancer as a Potential Blood Cancer Therapy
Full text linkBlood cancer causes a significant increase in the concentration of Leukocytes, which can be broken down through dielectrophoresis and electrochemical procedures. Therefore, the electric field plays an important role in the migration of leukocytes to high voltage areas. This is because different electrode arrangements produce varying electric field distributions. Furthermore, this study applied finite element methods to generate electric fields when electrodes with an AC voltage were applied to blood placed in a chamber. Therefore, in this study, variations of mediums and electrode arrangements were investigated, which led to the recommendation of 3 models. The objective was to investigate electrode arrangements that produce optimal electric field distribution for the three models to exhibit a booster of electric field distribution. The maximum electric field is generated close to the electrode (Z=2 mm and Z=92 mm) for any material (i.e. normal blood, B lymphocyte, and T lymphocyte) with values of 22.6 V/m and 23.47 V/m, 22.85 V/m and 22.97 V/m, and 24.88 V/m and 25.01 V/m. Based on principle, lymphocytes in the blood result in positive dielectrophoresis, since they migrate to a higher electric field close to the electrode, with enough input voltage to turn the electrochemical process on the leukocytes into electric current. Furthermore, this study provides new perspectives and ideas, which have not been revealed in previous studies on blood cancer therapy using the electric field of Ag electrode in blood cancer distribution.Keywords: blood cancer, dielectrophoresis, electric field, voltage, electrochemical, and cancer therapy
Kluwek Seed (Pangium edule Reinw) Germination Response to Soaking Time and Concentration of Gibberellin Acid (GA3)
Full text linkKluwek seeds (Pangium edule Reinw.) have a low germination percentage caused by dormancy due to hard seed coat. Kluwek seed germination takes about 1 month. The purpose of this study was to obtain a combination of treatments that were effective in increasing the percentage of kluwek seed germination and reducing the intensity of kluwek seed dormancy. This study used a Completely Randomized Design (CRD) factorial design. The first factor was immersion time (H) consisting of five levels, namely H0: Control (0 hour), H1: 6 hours, H2: 12 hours, H3: 18 hours, and H4: 24 hours and the second factor was giberellin concentration (G) with five levels namely G0: 0 ppm, G1: 25 ppm, G2: 50 ppm, G3: 75 ppm and G4: 100 ppm. Data analysis used Analysis of Variance (Anava) and further tested with Duncans' Multiple Range test (DMRT) at a significant level of 5%. The results obtained showed that the percentage of seed germination without immersion is 6.67%. Soaking using aquades produces an average germination percentage of 28.33%. The most effective treatment was GA3 75 ppm for 24 hours with seed germination of 60%, while the value of dormant intensity is 40%.Keywords: dormancy, germination, gibberellin, kluwek
