Journal of Agromedicine and Medical Sciences
Not a member yet
297 research outputs found
Sort by
Analysis of the Relationship between Laboratory Biomarkers and the Severity of COVID-19 at Kaliwates General Hospital Jember
Full text linkCoronavirus Disease 2019 (COVID-19) has become a global health problem since the WHO declared the disease a pandemic. In July 2021, Indonesia experienced a very sharp spike in cases and an increase in mortality due to COVID-19, including at the Kaliwates General Hospital in Jember. Laboratory biomarkers in the form of Neutrophile Lymphpocyte Ratio (NLR), D-dimer, and SpO2 can be a clue to assess the severity of COVID-19 patients. This research is an observational analytical study using a Cross Sectional Study with the aim of knowing the relationship between laboratory biomarkers and the severity of COVID 19 at RSU Kaliwates Jember. This study uses secondary data in the form of medical records of COVID-19 patients during July 2021 with a total of 50 samples. The results of this study were carried out by the Spearman correlation test and it was found that there was a correlation between NLR values ​​and oxygen saturation with the severity of COVID-19, but there was no relationship between D-dimer levels and the severity of COVID-19. The conclusion of this study is that NLR biomarkers and oxygen saturation can be used as predictors of the severity of COVID-19
The Effectiveness of Manual Acupuncture Therapy for Acne Vulgaris: A Case Report
Full text linkAcne vulgaris (AV) is a chronic inflammation of pilosebaceous glands. The clinical presentation of AV can be described as an inflammatory lesion and non-inflammatory lesions. The diagnosis of AV is through clinical evaluations. AV was graded according to clinical severity using Lehmann’s criteria. AV predilection most commonly appears on the face, chest, and back. AV causes the greatest burden between 10 to 30 years old and can cause anxiety and decrease self-confidence, instigating decreased quality of life. Acupuncture is a non-pharmacological treatment modality that is performed using filiform needles at acupuncture points. An 18-year-old woman was diagnosed with a moderate degree of AV based on Lehmann's criteria. She received manual acupuncture acupoints with the needles retained for 30 minutes. The treatment was conducted 2 times a week for a total of 12 treatments. After 12 treatments of acupuncture therapy, the degree of AV was reduced from moderate to mild, with an 81.25% reduction in total lesions. Follow-up was carried out 1 month after the treatment, showing that the effect of acupuncture remained. The acupuncture mechanism works directly on acne lesions by improving microcirculation, reducing proinflammatory reactions, and increasing anti-inflammatory, as well as regulating the HPA axis which can reduce stress and improve hormones. Manual acupuncture can be considered a non-pharmacological therapeutic modality to treat AV with minimal side effects
Case Report: Ranula and Sublingual Glands Extirpation as Intraoral Ranula Procedures
Full text linkRanula is a cystic lesion that develops from saliva extravasation caused by trauma to the sublingual gland or the occurrence of duct blockages. The ranula is divided into intraoral (simple ranula) and plunging ranula. There are several options of methods in the management of ranulas such as sclerotherapy, marsupialization, and extirpation with or without gland removal involved, incision and drainage with intraoral approach, excision lesions with the extra-oral approach. A case of ranula was reported in a girl aged 12 years diagnosed with intraoral ranula (simple ranula). Treatment is done by performing ranula extirpation accompanied by the removal of the sublingual gland and its ducts. The extirpation of the ranula followed by removal of the involved sublingual salivary gland gave satisfactory results with no recurrence until 1 year of follow-up on the management of intra-oral ranula.
Keywords: ranula, simple ranula, intraoral ranul
Predictors Factors of Mortality Hepatocelullar Carcinoma Patients RSD dr. Soebandi Jember 2018-2020
No full textLiver cancer, predominantly Hepatocellular Carcinoma (HCC), is a tumor that originates from hepatocytes and is clinically progressive. In Indonesia, according to the Ministry of Health in 2019, liver cancer is the second most common cancer in men, amounting to 12.4 per 100,000 population with an average death rate of 7.6 per 100,000 population. There are very few studies on HCC in RSD dr. Soebandi Jember. This study aims to determine the characteristics and factors that can be predictors of death in HCC patients. This study uses an observational analytic research type with a case-control research design. The data of this study used secondary data from the medical records of HCC patients at RSD dr. Soebandi Jember, as well as primary data in the form of telephone interviews. The results of this study with a total of 72 samples showed that there was a significant difference between liver cirrhosis and HCC patient mortality within 90 days (p = 0.005), and could be used as a predictor of HCC mortality (OR = 17.15; 95% CI = 1.532-192.017).
Keywords: HCC, predictors of death, HCC mortalit
Ascariasis Detection with IgG4 Using ELISA in Adults at Pasie Nan Tigo Village Padang City
No full textAscariasis is still one of the most common STH infections found in school-age children, but adults may also suffer from this infection. This is due to the fact that the parasite is able to manipulate the host's immune response by increasing the IgG4 levels. The IgG4 technique is a new specific and sensitive method for detecting ascariasis. This study is aimed to determine the prevalence of ascariasis based on IgG4 levels using the ELISA method in adults at Pasie Nan Tigo Village, Padang City. This study is a descriptive study with a cross-sectional design that took place from July 2020 - May 2021 using a multistage random sampling technique where a total of 78 adult respondents in Pasie Nan Tigo Village. Blood samples were taken in order to check their IgG4 levels, using the ELISA at Prodia Laboratory. Data analysis was performed univariately with the purpose of finding the frequency distribution. The results of this study show that from the total of 78 respondents, the majority of age group found is 46-55 years old, namely 28 respondents, the majority of gender is female, namely 65 respondents, 57 respondents were positive for IgG4 where the most sufferers are 17-25 years old (88.9 %) and male (76.9%). The conclusion of this study is most of the respondents were in the age group of 46-55 years and women, there were more than half of the total respondents who detected ascariasis with the most sufferers being the age group of 17-25 years and men.
Keywords: Ascaris lumbricoides, STH, T Cell Regulato
Correlation between the Use of Shared Goods with Pediculosis Capitis among Students in Pondok Pesantren Subulussalam Palembang
Full text linkPediculosis capitis is a parasitic infection caused by the parasite Pediculus humanus var. capitis, which commonly found in densely crowded areas such as boarding schools. It is possible to contract pediculosis capitis by coming into direct or indirect contact with sufferers' hair. The goal of this study was to assess the prevalence of pediculosis capitis in students at Pondok Pesantren Subulussalam Palembang, as well as the association between the use of shared goods and the occurrence of pediculosis capitis. This study is a cross-sectional observational analytic study including 116 students who live permanently in Pondok Pesantren Subulussalam Palembang. A questionnaire was used to collect data, as well as direct observation of hair samples. The Chi-Square test, Fisher's exact test, and logistic regression were used to examine the results. The findings revealed that 35.3% of people had pediculosis capitis, and that there was a significant association between the use of mattresses (p=0.007), combs (p=0.024), and shared veils (p=0.006) and the occurrence of pediculosis capitis. The use of combs (p=0.018) and shared veils (p=0.001) were the most influential variables on the occurrence of pediculosis capitis, according to the results of the logistic regression test. The spread of pediculosis capitis disease is predicted to be reduced and prevented with improved personal hygiene, environment sanitation, and treatment.
Keywords: Pediculosis capitis, boarding schools, Subulussalam, shared good
The Antibacterial Activity of Infusion of Averrhoa bilimbi L Fruits and Cananga odorata Flowers against Frequently Pathogenic Bacteria
Full text linkInfectious diseases due to opportunistic bacteria and pathogens are still a health problem. Transmission can be prevented by using an alcohol-based antiseptic liquid or naturally. Averrhoa bilimbi L. fruit plants and Cananga odorata flowers contain bioactive compounds that can inhibit bacterial growth. This study aimed to analyze the infusion activity of Averrhoa bilimbi fruit and Cananga odorata flower in single and combined dosage forms against several frequently pathogenic bacteria in vitro. This posttest-only experimental study with a control group design used the paper disc diffusion method. Observation parameters were the diameter of the inhibition zone on the test bacteria after infusion treatment of 50%, 75%, and 100% A.bilimbi fruit and 100% C.odora flowers, as well as 70% alcohol. The results showed that the diameter of the inhibition zone in the combination treatment of A.bilimbi and C.odorata infusion was significantly different from that of the single preparation (p<0.05). The combination of 100% A.bilimbi and 100% C.odorata (ratio 1:1) produced the greatest effect and was equivalent to 70% alcohol. The average inhibition of the combination infusion of Staphylococcus aureus (17.36mm) and Staphylococcus epidermidis (17.57mm) was greater than that of Escherichia coli (14.48 mm) and Salmonella enterica serovar Typhi (14.12mm). In conclusion, the infusion of Averrhoa bilimbi fruit and the Cananga odorata flower had antibacterial activity, and the combined preparation produced a better inhibitory effect than the single preparation.
Keywords: antibacterial activity, Averrhoa bilimbi L., Cananga odorata, infusion, single preparation, combination preparatio
The Performance of Hematological Parameters for Diagnosis of Acute Appendicitis in Children
No full textEarly diagnosis of pediatric appendicitis is still difficult to make and 30-40% of cases do not show typical classic symptoms. The negative appendectomy rate and the risk of perforation reach 20% so that new, easy, inexpensive and accurate additional examination is needed. This study aimed to compare platelet distribution width (PDW) and mean platelet volume (MPV) values of appendicitis and control patients. This study is retrospective case control study. Differences in MPV and PDW levels in patients with appendicitis and controls were analyzed with a t-test and determination of sensitivity, specificity and accuracy of the two markers in appendicitis diagnosis were performed by ROC analysis The mean MPV appendicitis was significantly lower (p <0.05) compared to controls (8.3 ± 1.9; 9.2 ± 1.5) while PDW of appendicitis patients did not differ significantly from controls (10.4 ± 1, 4, 10.7 ± 2.4; p> 0.05). AUC MPV as a diagnostic tool for appendicitis 0.619 with a normal limit of 6.6 fl has a sensitivity of 90% and specificity of 30%. MPV can be used for the diagnosis of appendicitis with a normal limit of 6.6 fl having a sensitivity of 90% and specificity of 30%. There was no significant difference between PDW of appendicitis patients with controls. There was no significant difference between MPV levels of patients with simple appendicitis and complications.
Keywords: Appendicitis, MPV, PDW, Platele
Major Burns After Lightning Strikes at Field: Case Report
Full text linkLightning injuries can cause multi-organ damage such as burns, ear damage, and nervous system damage. The type of Burns in this trauma consists of linear or flash burns, punctate burns, thermal injuries, Lichtenburg figures, and combination wounds which are generally superficial and heal faster. Lightning strikes also cause ear damage in the form of perforation of the tympanic membrane, bleeding, and micro fractures in the cochlea. The sequelae in lightning injury survivors consist of permanent brain injury, chronic pain syndrome, peripheral neuropathy, and blindness. This case is a man, 20 years old, working as a farmer, referred to the hospital because he was struck by lightning while working in the middle of the rice fields during heavy rain. There were complaints of pain, heat throughout the body, and decreased hearing in both ears in the anamnesis. Physical examination showed a general condition within normal limits. Local status examination found burns as large as 31.5% of the body area, with 2a degree burns (partial thickness) on the chest, back, upper and lower limbs. Examination of the outer and middle ear revealed no abnormalities. The principle of the treatment refers to the electric burns treatment with initial therapy in fluid resuscitation, evaluation of ECG, adequate analgesia, and wound care. The advanced phase of the treatment focuses on treating the burns and evaluating the hearing loss. Adequate care for nine days showed that the wound was epithelialized by 60% of the total wound area and without any other complaints. This case is essential to be studied considering that Indonesia's natural conditions allow for lightning strikes, especially during the rainy season, so lightning is a threat to farmers as a part of the agro-industrial community.
Keywords: Lightning injuries, burns, agroindustrial 
The LC-MS/MS Profile and Total Phenolic Content of Telang Flower Extract and Roselle as NPC1L1 Inhibitor Candidate: -
No full textInhibition of atherogenesis can be done through several mechanisms, one of which is inhibiting intestinal cholesterol absorption through inhibition of NPC1L1. The activity of Telang flower extract in overcoming various problems of degenerative diseases, especially cardiovascular disease, has been proven by many scientific studies. Likewise, related to the activity of Rosella flowers. Previous research conducted by researchers showed the potential of Rosella flower extract as an LXR agonist, one of the pathways that play a role in NPC1L1 inhibition. The combination of the two extracts is expected to increase its activity as a candidate for NPC1L1 inhibitor. The purpose of this study was based on the results of the determination of total phenolic levels and the characterization of the active compounds with LC MS/MS extracts of telang flower and rosella, which are expected to be developed into further research in vivo to strengthen scientific evidence so that they can be developed into phytopharmaca preparations. Instrumentation analysis method with LC-MS/MS to identify the content of active compounds and determination of total phenolic content with Folin ciocalteu in order to obtain standardized extracts of telang flower and roselle. The results of this study showed that the total phenolic content based on the largest order was purple rosella flower extract (114.129.35 ± 266.20 g GAE), a combination of purple rosella and telang flower extract (101.760.58 ± 116.09 g GAE), telang flower extract (90.477.41 ± 107.38 g GAE) and extract red rosella flowers (84,601.00 ± 266.91 g GAE). The combination of extracts showed reduced total phenolic content compared to the single extract. The phenolic content in each extract affected the total phenolic in the combination of extracts. 8 anthocinin compounds were identified in both the telang flower extract and the rosella flower extract.
Keywords: NPC1L1 inhibitor, telang, extract, Roselle, total phenolics, LC-MS/MS, atherogenesi