Leading & Enlightening Journal UMY
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Dynamic Phenotypic Transitions and Virulence of A. actinomycetemcomitans in Periodontitis
No full textThis study aims to determine the distribution of rough and smooth phenotypes in health and periodontitis, assess the dynamic nature of phenotypic transitions, and correlate culture duration with the production of virulence and adhesion factors. The goal is to elucidate the contribution of these factors to the severity of periodontitis. Isolation of A. actinomycetemcomitans in patients with periodontitis and healthy individuals was observed for its colony morphology using TSBV agar medium as a specific medium for A. actinomycetemcomitans, and comparison of virulence factors, including cytolethal distending toxin (cdtA), leukotoxin (ltx), rcpA, and flp-1, was analyzed using quantitative PCR (qPCR). Morphological observations showed a change from smooth to rough. Measurement of virulence factors uncovered that the rough phenotype was higher than the smooth phenotype for both cdtA and ltx. In addition, the rough phenotype also expressed higher genes in the fimbriae-forming gene than the smooth phenotype. The t-test revealed a significant difference in the change fold of all genes (p < 0.05). Our research found that the rough phenotype was only present in patients with periodontitis; furthermore, the virulence factors, adhesion, and composition of the rough and smooth phenotypes of A. actinomycetemcomitans were significantly different. This may exhibit the high virulence of the rough phenotype in periodontitis, which can contribute to its severity
Mangosteen Peel (Garcinia mangostana) Compounds as MTNR1B Modulators for Gestational Diabetes: In Silico Study
No full textThis study explored mangostin derivatives (3.6-dimethylmangostin, 6-deoxy-gamma-mangostin, and alpha-mangostin) as potential MTNR1B modulators using in silico approaches, through a combination of ADMET profiling and molecular docking simulations. Among the tested compounds, 3.6-dimethylmangostin stood out as the most promising, exhibiting strong binding affinity toward MTNR1B, comparable to the standard ligand ML-1, along with favorable pharmacokinetic parameters. Compared with clinically used anti-diabetic agents such as metformin or sulfonylureas, which act mainly through different molecular pathways, mangostin derivatives may offer complementary benefits by targeting MTNR1B in addition to their known glucose-lowering and insulin-sensitizing effects. In contrast, although 6-deoxy-gamma-mangostin showed the most optimal pharmacokinetic parameters, its interaction with the target receptor was the weakest. These results suggest that 3.6-dimethylmangostin holds significant potential for further exploration in in vitro and in vivo studies aimed at confirming its therapeutic relevance in the treatment of GDM
Barriers to the Implementation of Intelligent Building Systems for Sustainable Development in Developing Countries
No full textThe study explored the industry-based experience of building professionals on the barriers to the implementation of Intelligent Building Systems (IBS) in developing countries, particularly Nigeria. A purposively-sampled expert opinions of the professionals were accessed via well-structured questionnaires. The findings revealed that 29 barriers significantly impede the adoption of IBS in buildings. This is indicated with a mean score (MS) value range of 3.21 ≤ MS ≤ 3.88 and an existing statistical difference of 0.01 ≤ ρ ≤ 0.05 among six (6) barrier items. A 71.65% total variance among the barriers explaining seven (7) principal components of barriers were further established to inhibit IBS in buildings. These included technical-related barriers, legal-related barriers, market-related barriers, regulation-related barriers, and market-maturity barriers. This study provided empirical information on the barriers of IBS to guide policymakers in updating the nation’s building energy efficiency policy, towards sustainable built environment development and national growth in Nigeria
Digitalization of Payments in Urban Society Indonesia
No full textThis research investigates the influence of users' perceptions of usefulness and ease of use on their intention to adopt digital payment methods, with attitude serving as an intervening factor. By employing the Technology Acceptance Model (TAM), this study delivers meaningful input for technology developers and decision-makers to understand the key elements affecting users’ acceptance of digital payment platforms. Primary data for this study were obtained from a questionnaire of 200 urban communities in Indonesia that use digital payments in transactions using non-probability sampling techniques. This study used the SEM-PLS method using SmartPLS 3. The findings indicated that Perceived Usefulness (X1) does not exert a significant influence on Attitude (Y). However, Perceived Usefulness (X1) is known to be able to influence Behavior Intention (Z) directly. Attitude (Y) significantly affects Behavior Intention (Z). Perceived Ease of Use (X2) significantly influences Attitude (Y). Still, it cannot directly influence Behavior Intention (Z), which means that digital payments must be easy to use to shape supportive attitudes toward digital payments and increase intention to use. While enhancing perceived usefulness can directly increase users’ intention to adopt these technologies, improving ease of use is essential for fostering positive attitudes, which in turn shape behavioral intentions
Too Much to Choose: How Product Overload in Retail Leads to Consumer Decision Fatigue?
No full textThe sample used consisted of 300 respondents, selected using purposive sampling techniques. The present study employed a covariance-based structural equation modeling (CB-SEM) approach to analyze the data collected from respondents. The findings indicated that the marketing mix and consumer behavior exert a substantial influence on purchasing decisions, while brand image demonstrated an absence of significant impact. Furthermore, the marketing mix does not exert a substantial influence on customer satisfaction. Consumer behavior and brand image are found to have a significant impact on customer satisfaction. The marketing mix and consumer behavior, which serve as mediators in purchasing decisions, have been demonstrated to exert a significant influence on customer satisfaction. Conversely, brand image, which functions as a mediator in purchasing decisions, has been found to have an insignificant influence on customer satisfaction
Examining the impact of vitality, digital literacy, and transformational leadership on millennial job performance: the mediating role of employee agility in indonesia’s digital sector
No full textThe rapid digital transformation in Indonesia has created pressing challenges for organizations, especially in sustaining consistent employee job performance in highly competitive and constantly changing environments. Many companies struggle to align employee vitality, digital competence, and leadership practices with the agility needed to meet dynamic performance demands, particularly among millennials who dominate the digital workforce. This study investigates the influence of employee vitality, digital literacy, and transformational leadership on job performance, with employee agility as a mediating variable, among millennial employees in Indonesia’s digital industry. A quantitative approach was employed using survey data from 157 millennial employees working in Internet Service Provider (ISP) companies in Batam City. Structural Equation Modeling with SmartPLS 4 was used to test the proposed hypotheses. The findings reveal that employee vitality, digital literacy, and transformational leadership significantly affect job performance. In addition, employee agility mediates these relationships and directly contributes to performance, emphasizing its strategic role in enabling employees to thrive in dynamic digital environment
E-Leadership and Public Service Innovation: A Case Study of Yogyakarta, Indonesia’s Digital Governance Transformation
No full textE-leadership has emerged as an essential concept in contemporary public service management, addressing the growing demands of governance in the digital era. While its applications in the private sector and formal education have been widely acknowledged—particularly in enhancing efficiency and overcoming face-to-face limitations during the COVID-19 pandemic—its adoption in public institutions, especially in developing countries, remains underexplored. This study examines the extent to which e-leadership-based government innovation is implemented in local governments within developing contexts, focusing on Yogyakarta, Indonesia. The novelty of this study lies in its exploration of the intersection between digital transformation and local cultural traditions, a dimension often overlooked in existing e-leadership research. Furthermore, it pioneers the examination of e-leadership’s role in sub-national government innovation, providing new empirical insights into how digital leadership can be localized and harmonized with traditional governance frameworks. By integrating qualitative descriptive methods, the study analyses the readiness of Yogyakarta’s government to adapt digital transformation within culturally rooted administrative practices. Findings reveal that e-leadership-based innovation manifests in three interrelated forms: (1) infrastructure innovation, enabling digital governance systems; (2) institutional and policy transformation, reflecting adaptive leadership in digital policy-making; and (3) cultural innovation, signifying the integration of traditional values with digital practices. These findings contribute to a broader understanding of how e-leadership can serve as a catalyst for inclusive and culturally adaptive digital governance in developing regions, bridging global technological trends with indigenous administrative contexts
E-Government-Based Public Services Through the Pajak Menyapa Portal in Kendari City, Indonesia
No full textThis study examines the implementation of public services at the Kendari City Regional Revenue Agency (Bapenda) through the application of e-government in the digital tax system, with a focus on the Pajak Menyapa Portal. Using a descriptive qualitative design, this study examines the operation of e-government through its portal, specifically the E-PBB feature, which manages online registration, payments, and reporting of regional taxes. The research scope emphasizes service features, user accessibility, and institutional capacity within Bapenda Kendari City. The novelty of this study lies in evaluating the integration of multiple tax services into a single digital platform that simultaneously provides online services for Land and Building Tax, tax on land and building rights acquisition, and independent business tax reporting. This integration represents a novel approach compared to previous studies that have examined e-government separately or in general contexts. The findings revealed that the Pajak Menyapa Portal enhances service efficiency, transparency, and accessibility through a user-friendly interface and real-time payment system. However, challenges remain, including low digital literacy among taxpayers, limited technological infrastructure, and a shortage of competent human resources. Academically, this research contributes to the growing discourse on local e-government innovation and serves as a reference for future studies on digital taxation. Practically, it offers recommendations for strengthening infrastructure, improving human resource competence, and increasing public participation, while providing an evaluation framework that can be replicated in other regions
Development of a Web-Based Music Recommendation System Based on Facial Expression Using a Convolutional Neural Networks Model
No full textThis research presents the development of a web-based music recommendation system that uses facial expression recognition to match songs with users' emotional states. Real-time facial detection and expression classification are conducted in the browser using two CNN models implemented via the face-api.js library. Each classified expression is mapped to a specific music genre, and relevant songs are retrieved using the SoundCloud API. The system was evaluated through two aspects, accuracy and user satisfaction. Accuracy was measured using a dichotomous questionnaire, with results showing that 91% of users agreed that the recommended songs reflected their current emotions. User satisfaction was also assessed using a similar questionnaire and reached 86%, indicating a high level of comfort and relevance in the user experience. Compared to previous studies that used Likert scales, this study offers a different yet equally effective evaluation approach. The findings suggest that integrating facial expression recognition into music recommendation systems can provide a practical and user-friendly way to support emotional regulation through music
Food Inflation and Political Stability: Understanding the Link in Nigeria
No full textThis study examines the complex relationship between food inflation and political stability in Nigeria, a country experiencing significant economic volatility and societal unrest. According to recent data from the National Bureau of Statistics (NBS), food costs are rising at an unprecedented rate, with inflation expected to exceed 40% by early 2024. Using the cost-push theory of inflation as a theoretical lens, the study investigates how insecurity, inadequate infrastructure, climate change, and currency depreciation have disturbed food production and supply systems. These disruptions have significantly reduced household purchasing power, leading to political discontent, civic unrest, and a decline in faith in government institutions. Using a survey approach, data were obtained from 285 respondents in Pategi LGA, Kwara State. ANOVA revealed a significant correlation between food inflation and political instability (p < 0.05). The findings highlight how continuous increases in food prices fuel political discontent, particularly among economically disadvantaged communities. Furthermore, popular cynicism about the success of present government initiatives, such as the Anchor Borrowers Program, underlines the insufficiency of policy solutions. The study suggests that food inflation is more than just an economic concern; it is a powerful political force with the potential to erode democratic governance. The recommendations include proactive, security-driven agriculture policy, infrastructure development, market system reform, and transparent governance practices