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PO118 - Investigating the importance of patient-physician-communication for successful treatment of metastatic breast cancer: the WAVES study [Abstract]
No full textMini-review: From measurement to prediction — a conceptual paradigm shift in assessing overcrowding in pediatric emergency departments since 2021
No full textOvercrowding in pediatric emergency departments (PEDs) is an increasing global challenge. While adult emergency medicine has developed several validated measures to assess overcrowding, pediatric-specific methods remain scarce. In recent years, new approaches have emerged, including the first predictive models capable of anticipating crowding before it occurs. This Mini-Review provides a narrative synthesis of recent conceptual and methodological developments in the measurement and prediction of overcrowding in PEDs, building on the literature published since 2021. It conceptually examines unidimensional metrics, multidimensional scores, and emerging predictive models, emphasizing the shift from retrospective assessment to temporally oriented approaches and the need for pediatric-specific validation and multicenter evaluation
Seltene, aber relevante Komplikationen einer antipsychotischen Therapie mit einem Fokus auf Clozapin
No full textDie Transformation gesellschaftspolitischer Konfliktkonstellationen durch Kommunale Konfliktberatung: Chancen und Herausforderungen
No full textLong-term safety and efficacy of tralokinumab in patients with moderate-to-severe atopic dermatitis treated for up to 6 years: final results from the open-label extension trial ECZTEND
No full textIntroduction
Atopic dermatitis (AD) is a chronic inflammatory skin disease often requiring continuous therapy. The objective with the ECZTEND trial was to assess the long-term safety and efficacy of tralokinumab treatment.
Methods
ECZTEND was a multicountry, open-label, 5-year extension trial conducted from September 2018 to July 2024 in patients (≥ 12 years) with moderate-to-severe AD who had received up to 1 year of tralokinumab treatment in a parent trial. Patients were eligible regardless of previous randomization (tralokinumab or placebo) or treatment response in the parent trial. The primary endpoint was the number of treatment-emergent adverse events (TEAEs) through week 268. Key secondary endpoints were Investigator’s Global Assessment (IGA) and Eczema Area and Severity Index (EASI) through week 248.
Results
In total, 1672 patients were enrolled (4466.2 patient-years of exposure; median 2.6 years). Overall, 68.4% of patients (n = 1143) completed the trial period they consented to; 7.1% (n = 117) discontinued owing to lack of efficacy; and 4.2% (n = 72) owing to adverse events. The TEAE incidence rate was 114.3/100 patient-years with a pattern consistent with that observed in the parent trials albeit at lower rates. The majority (> 97%) of TEAEs were nonserious and of mild or moderate severity. Most (> 80%) were assessed as not related to tralokinumab by the investigator and resolved by the end of the trial. Common TEAEs (≥ 5%) included nasopharyngitis, atopic dermatitis, coronavirus infection, upper respiratory tract infection, conjunctivitis, and headache. The proportions of patients with IGA 0/1 and EASI-75/EASI-90 increased during the first 16 weeks and then remained stable through week 248 at ≥ 50% for IGA 0/1 and EASI-90, and ≥ 80% for EASI-75.
Conclusions
Long-term tralokinumab treatment for up to 6 years (parent trials plus ECZTEND) in patients ≥ 12 years with moderate-to-severe AD was well tolerated and maintained long-term efficacy. A graphical abstract is available for this article
Epidemiology of adult atopic dermatitis in high-burden skin areas: results from a cross-sectional patient survey
No full textSex-specific associations between systemic autoantibodies and allergic sensitization or allergic disease – results from a population-based study
No full textHere, we investigated possible associations between serum AABs and allergies, using data on allergic sensitization and diagnoses of allergic diseases.
Methods: In 331 participants of a population-based study, 5 humoral systemic AABs and 7 AAB screening tests were analyzed. Allergic sensitization was characterized by specific IgE concentrations in serum samples (CAP class ≥ 2); additionally, self-reported diagnoses of allergic diseases were used as exposure variables. Multivariable adjusted logistic regression models were applied to explore the association with AAB test positivity; all analyses were stratified by sex. In a sensitivity analysis, AAB test results were defined as non-normal and normal.
Results: In 46.2% and 37.1% of female and male study participants, respectively, at least one positive AAB test was identified. Allergic sensitization was observed in 23.8% and 29.7% of female and male participants, while 26.2% and 9.3% reported at least one diagnosis of allergic disease, respectively. Positive associations between allergic sensitization and serum AABs were identified in women for rheumatoid factor (RF), antinuclear antibodies (ANA), and at least one positive AAB test; in men, there was some indication for an association with anti-neutrophil cytoplasmic antibody (ANCA) positivity. Self-reported diagnosis of allergic diseases was not significantly associated with the AAB positivity.
Conclusion: In this population-based group of adults, there is evidence for an association between allergic sensitization and systemic AABs, almost exclusively in women. Large prospective studies are needed for confirmation and further investigation of individual AABs
Welcome address for the Annual Conference of the International Society for Research on Textbooks and Educational Media e. V.
No full text
Goals, norms, attitudes, and self-efficacy as predictors of academic dishonesty: two-wave prospective inquiries into additive and multiplicative effects
No full textAlthough students’ achievement goals have been linked to academic dishonesty, more research is needed to clarify mixed findings and identify contextual factors that may influence these linkages. Guided by Expectancy-Value-Cost Theory versus Theory of Planned Behavior predictions, we tested how achievement goals, academic and cheating self-efficacy, injunctive and descriptive norms, and justifying attitudes jointly predict academic dishonesty in a preregistered two-wave study of 856 German university students. Appearance-approach goals, descriptive norms, and justifying attitudes positively related to exam cheating and plagiarism, other associations appeared behavior-specific (work-avoidance related only to plagiarism, cheating self-efficacy related more strongly to exam cheating). No interactions with achievement goals were found, favoring an additive risk structure consistent with the Theory of Planned Behavior. Results point to measurement specificity of both predictor variables and behavior types as one source of mixed findings