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Damage control surgery in perforated diverticulitis reduces the stoma rate: a multicentre international retrospective cohort study
No full textLong-term clinical and radiological outcomes of a stemless reverse shoulder implant that is fallen out of favor - stemless nano-reverse shoulder arthroplasty
No full textThe purpose of this study was to assess the long-term results of the stemless onlay Comprehensive Nano reverse total shoulder arthroplasty (rTSA) system.
We evaluated 35 shoulders at an average follow-up of 106 ± 14.6 months (range, 80–135) (follow-up rate 66%). Patients were evaluated via the Constant–Murley scale, the DASH score (Disabilities of the Arm, Shoulder and Hand) and the subjective shoulder value (SSV). Furthermore, a visual analog scale (VAS) for pain intensity was used. The passive glenohumeral range of motion and active total range of motion were recorded.
Radiographic assessment was performed on true antero-posterior and axillary views.
The mean age at surgery was 72.8 ± 6.7 years (range, 47–82). Four patients were revised to a stemmed implant during the follow-up period and were excluded from further assessment. In the remaining group, the Constant score was 82.9 ± 13.1 (range, 40–97), the DASH score was 10.6 ± 17.3 (range, 0–77.5), the SSV was 85.0 ± 18.1 (range, 10–100), and the VAS score for pain was 0.9 ± 1.7/10 (range, 0–7).
The mean active flexion and abduction values were 159.8 ± 13.8 and 155.9 ± 20.1, whereas the active external and internal rotation values averaged 34.8 ± 15.3 and 88.9 ± 7.9, respectively.
Grade I radiolucency lines (RLLs) were found in 4 patients (14.3%). RLLs > 1 mm were not observed. Two patients experienced early varus displacement of the humeral tray with full reintegration without revision. Revisions to a stemmed implant were performed for atraumatic peg breakage of the humeral tray in 2 patients, early septic loosening in one patient and periprosthetic fracture in one patient.
Grade 1 notching was found in 17.9%, and acromion stress fracture was found in 3.6%. Three patients experienced postoperative neurological deficits, with complete recovery in 2 patients.
Compared with published data on stemmed and stemless rTSA, the comprehensive Nano rTSA system in the present study has comparable or even superior clinical outcomes at long-term follow-up. The rates of implant-associated complications and revision, however, are high compared with those reported in the literature
Prediction and risk factors for one year mortality in patients after surgery for pyogenic spondylodiscitis
No full textMarking techniques for target lymph nodes in node-positive breast cancer treated with neoadjuvant therapy in the AXSANA/EUBREAST-03/AGO-B-053 study
No full textE-PS-08-041 Does size and colour matter in computational pathology? First results [Abstract]
No full textMotivationen, Herausforderungen und Werte von Entwickler:innen in DiGA- und Gesundheitsapp-Start-ups - eine qualitative Interviewstudie in Deutschland
No full textOFP-11-011 Stroma AReactive Invasion Front Areas (SARIFA) - a promising prognostic biomarker in muscle-invasive urothelial bladder cancer [Abstract]
No full textOFP-10-002 Hormone-associated subtypes of pulmonary neuroendocrine tumours: correlation with clinicopathological, transcriptional signatures, therapy targets and outcome [Abstract]
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Th17 cells favor migration and invasiveness of cervical cancer cells under hypoxia in an IGF2BP2-dependent manner
No full textHypoxic regions of cervical cancers mediate suppression of the human papillomavirus (HPV) oncoproteins E6 and E7 in an AKT-dependent manner causing oxygen-dependent reversible growth arrest of cancer cells. Furthermore, numbers of T-helper (Th)-17 cells increase during cervical carcinogenesis in cancer tissues, Th17 differentiation is favored by hypoxia and their presence is linked with AKT-dependent therapy resistance, metastases and relapse. As both factors, hypoxia and Th17 cells, are associated with poor prognosis of patients, potential synergistic mechanisms between both are not described so far. In this study, we showed that Th17 cells enhance the expression of hypoxia-related glycolytic enzymes and transporters and functionally favor increased glucose uptake, proliferation and migration of 2D cultures of hypoxic cervical cancer cells as well as invasion of 3D spheroids. As the responsible mediator of increased proliferation, migration and invasion, we identified the RNA-binding protein IGF2BP2 by using small interfering RNAs (siRNAs) for IGF2BP2 as well as small molecule IGF2BP2 inhibitors of the benzamidobenzoic acid class. Consistently, Th17 numbers in cervical cancer biopsies correlated with IGF2BP2 expression associated with lymph node metastases and relapse. Correspondingly, a combination of IGF2BP2 expression and Th17 cell numbers >10/mm2 in situ was associated with reduced recurrence-free survival. In summary, we unraveled a previously unknown molecular mechanism by which Th17 cells promote tumor progression under hypoxic conditions and suggest evaluation of Th17 cells as well as IGF2BP2 as potential target for therapeutic approaches in cervical cancer