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Interreligious open theology and human exceptionalism: in conversation with Catherine Keller
No full textNeutrophils plasma membrane lipid order decreases and is required for efficient reutrophil extracellular trap release [Abstract]
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Hypothalamic obesity following craniopharyngioma surgery: what is the role of hypothalamic T2 signal changes in brain MRI?
No full textBackground
Despite hypothalamus-sparing surgical techniques, hypothalamic obesity remains common in childhood craniopharyngioma (cCP) survivors. Emerging evidence suggests a role for hypothalamic inflammation (HI) in obesity development. This study aimed to quantitatively assess post-operative T2 signal intensity (SI) changes, suggestive of inflammation and edema, using MRI and investigate its association with clinical outcomes, including BMI changes, over a one-year period.
Methods
We retrospectively analyzed two cCP cohorts. Diagnostic and post-operative MRIs were evaluated for changes in hypothalamic T2 SI on FLAIR. We assessed clinical and radiological predictors of post-operative T2 SI and examined correlations between ΔT2SI and ΔBMI z-score from pre-operative to 3 months after surgery. A multivariable model was used to evaluate factors influencing BMI z-score change. In a subgroup (n = 40), we compared post-operative T2 SI between patients with and without hypothalamic syndrome at 6 months.
Results
Both left (p < 0.001) and right (p < 0.05) hypothalamic T2 SI increased post-operatively. Higher post-operative T2 SI was associated with increased pre-operative T2 SI, age, less cystic tumors, and higher post-operative Müller grades. ΔT2SI correlated with ΔBMI z-score at 3 months (r = 0.56, 95% CI : 0.29–0.74). ΔT2SI (left) was significantly associated with ΔBMI z-score (β = 1.02, SE = 0.35) after adjusting for baseline variables. Patients with hypothalamic syndrome (n = 17) had higher post-operative T2 SI than those without (n = 23, p < 0.01).
Conclusion
Our data suggests that hypothalamic T2 SI increase is associated with the BMI increase and hypothalamic dysfunction after cCP surgery. These insights enhance our understanding of the pathophysiology underlying post-operative hypothalamic obesity and may inform future preventive and therapeutic strategies
Development of a standardized role script template for simulated participant scenarios - results of a multi-step consensus process in the German-speaking countries = Erstellung eines standardisierten Rollenskript-Templates für den Einsatz von Simulationspersonen – Ergebnisse eines mehrstufigen Konsensverfahrens im deutschsprachigen Raum
No full textAim: The need for a scientifically founded role script template for simulated participants (SPs) arises from the great importance that SPs have for teaching and assessments in the health professions. Stakeholders have thus far developed their own scripts, making usage across institutions and professions difficult. The aim of this research project is therefore to develop an evidence-based, interprofessional role script template for simulated participants.
Method: To integrate the diverse traditions and needs of the professional groups, a multi-stage developmental and consensus process, based on the Delphi method, was conducted by a working group of 19 members over 10 rounds. This process incorporated, among other inputs, the findings of a systematic literature review, feedback from a 24-member interprofessional expert panel, and 11 reviews by experienced SPs.
Results: The template has 13 categories, and its modular structure allows for flexible use in teaching and assessment, vocational training, academic studies, as well as further education and training. The template is designed to be consistently interprofessional and suitable for use in the fields of occupational therapy, midwifery, medicine, speech therapy, nursing science, pharmacy, physiotherapy, psychotherapy, emergency response services, veterinary medicine, and dentistry.
Conclusion: The complex consensus process reflected the heterogeneity of SP practice in the health professions. Nevertheless, experiences were compiled in one template so that it is possible to interchange scripts between the professions and across institutions and to (further) develop them collectively. The next steps are to evaluate the template's usability and its ongoing development in the community of practice
Initial clinical experience with [177Lu]Lu-RTX-2358 radiopharmaceutical therapy targeting fibroblast activation protein: biodistribution, pharmacokinetics, and dosimetry
No full textRezension: Martin Breul, Aaron Langenfeld, Sarah Rosenhauer, Fana Schiefen: Gibt es Gott wirklich? Gründe für den Glauben: ein Streitgespräch. Freiburg i. Br.: Herder, 2022
No full textEP531/#2469 Characteristics and outcome of primary metastatic nasopharyngeal carcinoma in children and young adults: experience of the Gpoh-Npc study group [Abstract]
No full textTreatment effect of intravenous high-dose selenium in sepsis phenotypes: a retrospective analysis of a large multicenter randomized controlled trial
No full textBackground
Treatment effect of high-dose intravenous selenium remains controversial in patients with sepsis or septic shock. Here, we reanalyzed data from the randomized placebo-controlled trial of Sodium Selenite and Procalcitonin Guided Antimicrobial Therapy in Severe Sepsis (SISPCT) to reveal possible treatment differences according to established sepsis phenotypes.
Methods
In this secondary data analysis of the SISPCT trial all 1089 patients of the original study were included. Patients were assigned to one of the four phenotypes by comparing patient variables with the Sepsis Endotyping in Emergency Care (SENECA) validation cohort. Survival analyses were performed using Kaplan–Meier and log-rank tests.
Results
No robust effect of selenium on mortality and other outcome parameters could be determined in any sepsis phenotype. Phenotype frequencies were markedly different in our study cohort compared to previous reports (α: 2.2%, β: 6.3%, γ: 68.0%, δ: 23.4%). Differences in mortality between the respective phenotypes were not significant overall; however, 28-day mortality showed a lower mortality for the α- (20.8%) and β-phenotype (20.3%), followed by the γ- (27.1%), and δ-phenotype (28.5%).
Conclusions
Application of the four sepsis phenotypes to the SISPCT study cohort showed discrete but non-significant mortality differences within 28 days. However, beneficial treatment effects of high-dose intravenous selenium were still not detectable after categorizing the SISPCT study cohort according to four phenotype criteria