263134 research outputs found
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Epigenetische Regulatie van de Cardiomyocytcelcyclus
No full textThis Ph.D. project is built upon the recently published findings from Thienpont, Aronsen, Robinson et al. (JCI 2017) and will contribute to the development of new strategies for enhancing cardiac regeneration and ameliorate disease. The role of the epigenome in determining and maintaining the post-mitotic adult cardiac myocyte phenotype remains to be fully explored and it is important to examine how the epigenome itself can be manipulated to enhance regeneration and ameliorate disease. Considering that the adult myocyte is characterized by an absence of proliferation, it is intriguing and clinically relevant to identify exactly how the cardiac myocyte fate can be reprogrammed so that the inadequate proliferation would be reversed, thereby enabling the repair of the damaged heart. Moreover, the absence of proliferation in the adult heart provides an ideal substrate to examine epigenetic mechanisms independent of cell cycle. The aim of this project is to probe the role of histone methylation in the regulation of cardiac proliferation and in preventing/reversing harmful hypertrophic remodelling. This research will test the notion that the manipulation of histone methylation can be used as a tool to reprogram cardiac myocyte phenotype, and enhance proliferation required for repair.status: Publishe
How emphasizing responsibility practices favors compatibilism
No full textP.F. Strawson’s emphasis on our responsibility practices in ‘Freedom and Resentment’ has been thought to favor compatibilism, but this idea has come under attack. ‘Strawsonian incompatibilists’ agree with Strawson that holding responsible may be unavoidable and a good thing overall, while claiming that this does not entail that we are responsible if determinism is true. My aim is to explain how a Strawsonian emphasis on responsibility practices favors compatibilism. I rely on two key ideas. First, compatibilists and incompatibilists disagree about the meaning of responsibility. Second, we can shed light upon the meaning of responsibility in an indirect way, by starting from the idea that our practices and concept of responsibility have a point. Combining these key ideas, we can ask whether compatibilist or incompatibilist analyses of the meaning of responsibility come out best in the light of Strawson’s hypothesis about the point of having the concept and practices of responsibility, which is roughly that they manifest a basic human demand for good will. Strawsonian incompatibilists are challenged to make sense of the connection between (1) the meaning of responsibility and (2) the point of having the concept of responsibility and the practices structured by it.status: Published onlin
A decade of grade inflation boosted by the COVID-19 pandemic-An empirical analysis of a top European university
No full textsponsorship: Fonds Wetenschappelijk Onderzoek; HORIZON EUROPE Framework Programme (HORIZON EUROPE Framework Programme)status: Publishe
Fragile Masculinities: Vulnerable Bodies, Pain, and 2 the Shaping of Manhood in the Hebrew Bible (forthcoming)
No full textstatus: Accepte
Accelerated H2-norm approximation for time-delay systems with discrete delays
No full textsponsorship: This work was supported by KU Leuven project C14/22/092 and by FWO-Flanders under grant number G.092.721N. (KU Leuven project|C14/22/092, FWO-Flanders|G.092.721N.)status: Accepte
De Rol van Ouderlijk Reflectief Functioneren in Ouderlijke Stress, Autonomie-Relevant Opvoeden, en de Socio-Emotionele Ontwikkeling van Kinderen en Adolescenten
No full textParental reflective functioning is the capacity of parents to envision their child's mental states and their own mental states in relation to their child. Research shows that this capacity plays a crucial role in the socioemotional development of children and adolescents and may buffer against the negative effects of early adversity. Conversely, impairments in this capacity have been linked to higher stress, maladaptive parenting, and socioemotional child and adolescent difficulties. This dissertation examined the role of parental reflective functioning in parents' stress, parenting quality (with a focus on autonomy-relevant parenting), and ultimately the socioemotional development of children and adolescents, including transnational adoptees, a group that has been described to be at higher risk for socioemotional difficulties, due to enhanced rates of early adversity prior to adoption. In this context, we also considered a process of intergenerational transmission of parents' and adolescents' reflective functioning. The current dissertation consists of eight chapters. Chapter 1 (General Introduction) reviews extant literature on parental reflective functioning and its impact on children's development, highlighting gaps and future research opportunities. Chapter 2 examines how parents' reflective capacities, assessed before adoption, moderate the relationship between pre-adoptive adversity and children's socioemotional outcomes four years later. Chapter 3 examines parenting stress in the first four years after adoption, focusing on how parents' self-criticism and children's negative emotionality dynamically contribute to parenting stress. Chapter 4 examines the role of parental reflective functioning in parents' daily stress and autonomy-relevant parenting in two independent samples of community adolescents. Chapter 5 examines day-to-day fluctuations in parental reflective functioning and the evocative roles of adolescents' socioemotional difficulties and parenting stress. Chapter 6 examines the relationship between autonomy-relevant parenting, adolescent reflective functioning, and socioemotional difficulties in adolescence. Chapter 7 presents a longitudinal study exploring how pre-adoptive and early childhood parental reflective functioning relates to the reflective functioning and socioemotional adjustment of transnationally adopted adolescents. Finally, Chapter 8 (General Discussion) integrates the study's main findings, theoretical and clinical implications, study limitations, and suggestions for future research.status: Publishe
Een Belgische studie ter bevordering van de implementatie en effectiviteit van een multifactoriële valpreventie interventie bij thuiswonende oudere personen
No full textApproximately 24 to 40% community-dwelling older people fall annually, of which 21 to 45% recurrently. Many factors contribute to the risk of falling, such as mobility impairment, medication use, environmental issues and risk behavior. Falls are associated with an increased risk of morbidity and mortality and often lead to physical and psychosocial consequences. Falls and related injuries have a huge economic impact on society. Given its proven efficacy as shown by controlled trials, multifactorial fall prevention interventions are recommended as primary strategy. However, poor implementation in daily clinical practice leads to inconclusive results on clinical outcomes. The context is a critical concept to understand variation in implementation and clinical outcomes. Therefore, it is necessary to comprehensively understand the context prior to development and implementation.To date, the context and tailored implementation are neglected in the majority of fall prevention research. Therefore, this BElgian study aims to develop tailored strategies to Enhance the uptake and effectiveness of a Multifactorial fall Prevention intervention in Older communitydWElling peRsons (BE-EMPOWERed).status: Publishe
Perspective Benders decomposition with applications to fixed-charge nonlinear resource allocation
No full textsponsorship: Accepted by Frangioni, Design Analysis Algorithms-Continuous. Funding: K. Yang acknowledges financial support from China Scholarship Council [Grant 202406110031] . This work was also supported by the National Science Fund for Outstanding Young Scholars [Grant 62122093] , the National Natural Science Foundation of China [Grants 72101264, 72431011, and 72421002] , the Science and Technology Innovation Program of Hunan Province [Grant 2023RC3008] , Open Project of Xiangjiang Laboratory [Grant 22XJ02003] , and the University Fundamental Research Fund [Grant 23-ZZCX-JDZ-28] . H. Yang's work is funded by National Natural Science Foundation of China [Grant 72201232 and 72231008] , Guangdong Provincial Key Laboratory of Mathematical Foundations for Artificial Intelligence [Grant 2023B1212010001] , and Shenzhen Key Laboratory of Crowd Intelligence Empowered Low-Carbon Energy Network [Grant ZDSYS20220606100601002] . (China Scholarship Council|202406110031, National Science Fund for Outstanding Young Scholars|62122093, National Natural Science Foundation of China|72201232, National Natural Science Foundation of China|72231008, Science and Technology Innovation Program of Hunan Province|2023RC3008, Open Project of Xiangjiang Laboratory|22XJ02003, University Fundamental Research Fund|23-ZZCX-JDZ-28, Guangdong Provincial Key Laboratory of Mathematical Foundations|2023B1212010001, Shenzhen Key Laboratory of Crowd Intelligence Empowered Low-Carbon Energy Network|ZDSYS20220606100601002)status: Published onlin
Boosting first-line mental health care for adolescents suffering from chronic conditions with mindfulness: Results from a randomized staggered within-subjects design
No full textsponsorship: Fondation Huoshenstatus: Publishe