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An example of giving an online lecture utilizing the “Microsoft Teams” –A case of “Pharmacotherapy A”, a specialized subject in the course of Clinical Nutrition, Department of Clinical Dietetics and Human Nutrition, Faculty of Pharmacy and Pharmaceutical Sciences –
Get PDF2019 年度末にはじまった新型コロナウイルスの影響により，感染拡大防止を狙った移動自粛などがはじまり，薬学部医療栄養学科では2020 年度前期に開講する講義のすべてをオンラインで実施することを決断した。城西大学はMicrosoft 社と教育機関向け総合ライセンス契約を提携していることから，業務用チャットサービス「Microsoft Teams」（Teams）を使用したオンライン講義の実施を，「薬物療法学A」の講義で試みた。本稿では，Teams の紹介やその機能である，“チーム”の作成，“チャネル”の設定，“会議”の投稿および“チームメンバー”の設定の実際について報告するほか，学生への周知およびオンライン講義の実際に関しても報告する。報
Studies on Distinctive Education of Josai Junior College to deal with Diversity
Get PDF現在日本における短期大学の多くは、1年次から多様な専門科目に加え、基礎を重視した科目が設置してあり、1年次の後期にはキャリア教育がスタートする仕組みになっている。城西短期大学は、女子教育の短期大学としてスタートしたが、今世紀には共学となり、広く社会人育成の役割を担っている。近年、入学する学生の多くは、2年間の学びを通して職業人としての活躍を希望する学生が 大半であるが、4年制大学へ編入学を希望する日本人学生やアジア圏からの留学生がいるので、 様々な進路希望者が含まれている。このような現状において城西短期大学の個性豊かな教育を実現するための教育に、入口となる「初年次教育」と出口となる「キャリア教育」がどのようにかかわっていくべきか研究を進めている。本稿は第一報である。学長所管研究「ディプロマ・ポリシーから逆算して設計した初年次教育の効果に関する研究」Research on Effectiveness of the First Year Experience planned backward from Diploma Polic
Adverse drug events caused by drugs contraindicated for coadministration reported in the japanese adverse drug event report database and recognized by reporters
Get PDFThe “INTERACTIONS” section of package inserts aims to provide alert-type warnings in clinical practice; however, these also include many drug–drug interactions that occur rarely. Moreover, considering that drug–drug interaction alert systems were created based on package inserts, repeated alerts can lead to alert fatigue. Although investigations have been conducted to determine prescriptions that induce drug–drug interactions, no studies have focused explicitly on the adverse events induced by drug–drug interactions. We, therefore, sought to investigate the true occurrence of adverse events caused by drug pair contraindications for coadministration in routine clinical practice. Toward this, we created a list of drug combinations that were designated as “contraindications for coadministration” and extracted the cases of adverse drug events from the Japanese Adverse Drug Event Report database that occurred due to combined drug usage. We then calculated the reporters’ recognition rate of the drug–drug interactions. Out of the 2121 investigated drug pairs, drug–drug interactions were reported in 43 pairs, 23 of which included an injected drug and many included catecholamines. Warfarin potassium and miconazole (19 reports), azathioprine and febuxostat (11 reports), and warfarin potassium and iguratimod (six reports) were among the 20 most-commonly reported oral medication pairs that were contraindicated for coadministration, for which recognition rates of drug–drug interactions were high. Although these results indicate that only a few drug pair contraindications for coadministration were associated with adverse drug events (43 pairs out of 2121 pairs), it remains necessary to translate these findings into clinical practice.V709210006<Pre 医中誌
ダイ8カイ ジョウサイ ゲンダイセイサク ケンキュウカイ ゴアンナイ チラシ
Get PDF日時：2021年9月17日(金）15：30～17：00 会場：Zoom会議 発表者：酒井 宏平 テーマ：「複数状況の組み合わせを考慮した観光客の避難行動に関する研究」 司会者：ベルタラニチュ・ボシティア
Growth hormone signaling pathway leading to the induction of dna synthesis and proliferation in primary cultured hepatocytes of adult rats
Get PDFBackground: We investigated the signal transduction pathway associated with growth hormone (GH)-stimulated DNA synthesis and proliferation in primary cultured hepatocytes. Methods: Adult rat hepatocytes were isolated from normal livers by two-step in situ collagenase perfusion to facilitate disaggregation of the adult rat liver. Then hepatocytes were cultured in serum-free Williams’ medium E supplemented with GH (1-100 ng/ml) in the presence or absence of test reagents. GH-induced hepatocyte DNA synthesis and proliferation were determined, and the phosphorylation activities of Janus kinase (JAK) 2 (JAK2) (p125 kDa), p95-kDa RTK, and ERK1/2 were measured by western blotting. Results: Hepatocytes grown in serum-free defined medium proliferated within 5 h of culture in the presence of GH (100 ng/ml) in a concentration- and time-dependent manner (EC50 75 ng/ml). These proliferative effects of GH were almost completely blocked by an anti-GH receptor monoclonal antibody (85 ng/ml) and an anti-insulin-like growth factor (IGF)-I receptor monoclonal antibody. In addition, the proliferative effects of GH were significantly blocked by a JAK2 inhibitor (TG101209, 10−6 M), as well as specific signal-transducing inhibitors of phospholipase C (PLC; U-73122, 10−6 M), RTK (AG538, 10−6 M), phosphoinositide 3-kinase (PI3K; LY294002, 10−6 M), mitogen-activated protein kinase kinase/extracellular signal-regulated kinase (MEK/ERK; PD98059, 10−6 M), and mammalian target of rapamycin (mTOR; rapamycin, 10 ng/ml). GH significantly induced the phosphorylations of JAK2 (p125 kDa), p95-kDa IGF-I receptor tyrosine kinase (RTK), and ERK2 in this order according to western blotting analysis. Conclusions: The proliferative action of GH is mediated by two main signaling pathways. One includes activation of the GH receptor/JAK2/PLC/Ca2+ pathway, and the other involves activation of the p95-kDa IGF-I RTK/PI3K/ERK2/mTOR pathway in primary cultures of adult rat hepatocytes.This is an open access journal with with free of charge submission and non-commercial download. At the time of submission, authors will be asked to transfer the copyright to the accepted article to the Journal of Pharmacy and Pharmaceutical Sciences. The author may purchase the copyright for $500 upon which he/she will have the exclusive copyright to the article. Nevertheless, acceptance of a manuscript for publication in the Journal is with the authors' approval of the terms and conditions of the Creative Commons copyright license Creative Common license (Attribution-ShareAlike) License for non-commercial uses
