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Statistical Analysis of Text on National Examination for Registered Dietitian– An example study at the area of “nutrition of carbohydrates” in basic nutrition –
Get PDF計量テキスト分析（テキストマイニングまたはテキストデータマイニング）は，文章や文書，言葉などのテキストデータを単語に分解し，頻度計数や統計手法などのいろいろな分析手法を駆使することでテキストデータ全体を理解するための手法として利用されている。近年，いくつかの国家試験において，試験内容をテキストデータとし，計量テキスト分析することで問題傾向等を研究する試みがなされている。本研究では，計量テキスト分析の管理栄養士国家試験研究への応用性を見出すために，管理栄養士国家試験ガイドラインの基礎栄養学分野「4 炭水化物の栄養」領域の選択肢の文を用いることで検討した。その結果，「4 炭水化物の栄養」領域を勉強する上で重要な専門用語を，単語出現頻度により抽出することができた。さらに，共起ネットワークにより，「4 炭水化物の栄養」領域の大・中項目における優先して学ぶべき領域を明らかにすることができた。また興味深いことに，誤りとなる選択肢の文としての共起関係を明らかにすることができた。これらのことは，計量テキスト分析の管理栄養士国家試験研究への応用が可能であることを示唆する。研究ノート / Research Note
A Study on Contributing to the Local Community by Accepting Foreign Human Resources in Industry-Academia Collaboration - A Specified Skilled Worker Scholarship Concept with a Nursing Care Facilities in the Vicinity of Josai University
Get PDFIn recent years, the shortage of manpower in the nursing care sector has become a serious situ ation. In particular, the ratio of effective job offers in the nursing care sector in Saitama Prefecture in September 2021 was 5.43 times, which is a very serious situation. In response to this situation, Josai University “Bekka (Preparatory Japanese Language Program)” wondered if it would be possible to accept international students through a scholarship program from nursing care facilities. First, for eign students who have received scholarships from nursing care facilities can enroll in “Bekka” as in ternational students and work part-time in the nursing care field during their time. Next, they will improve their Japanese language skills at “Bekka”, and after graduation, they will switch to a Speci fied Skilled Worker visa and work at the facility that provided them with the scholarship as full-time nursing care workers. We wondered if this kind of system could solve the shortage of human re sources in the region. Through some analysis, we found that there was a certain level of need among nursing care facili ties for this concept. It also proved to be beneficial to various stakeholders. This kind of scholarship concept, which not only has social significance but also builds win-win relationships among stakehold ers, should definitely be continued to operate.論文 / Article 編集：城西大学・城西短期大学地域連携センター紀要編集委員
Effects of Oakmoss Components on Extra- and Intracellular Legionella pneumophila and Its Host Acanthamoeba castellanii
Get PDFAcanthamoeba castellanii is a ubiquitous organism found in environmental water. The amoeba is pathogenic to toward humans and is also a reservoir of bacteria of the genus Legionella, a causative agent of legionellosis. Oakmoss, a source of natural fragrance ingredients, and its components are antibacterial agents that are specifically active against the genus Legionella. In the present study, oakmoss and its components were investigated for their inhibitory effects on total (extra- and intracellular) Legionella pneumophila within A. castellanii and on L. pneumophila within A. castellanii. Among the oakmoss components, 3-hydroxy-5-methylphenyl 2,4-dihydroxy-6-methylbenzoate (1), 3-methoxy-5-methylphenyl 2,4-dihydroxy-6-methylbenzoate (2), and 8-(2,4-dihydroxy-6-(2-oxoheptyl)phenoxy)-6-hydroxy-3-pentyl-1H-isochromen-1-one (8) reduced the number of total bacteria (extra- and intracellular) in a test culture and also exhibited high amoebicidal activity against L. pneumophila within A. castellanii at concentrations lower than their IC50 values for A. castellanii. In contrast, 6,8-dihydroxy-3-pentyl-1H-isochromen-1-one (5) reduced the total number of L. pneumophila and, also that of total bacteria after 24 h of treatment (P < 0.05), whereas the compound did not exhibit amoebicidal activity against L. pneumophila within A. castellanii at concentrations lower than its IC50 value against A. castellanii. Thus, it is suggested that these oakmoss components could be good candidates for disinfectants to protect from Legionella infection
Verification of the Status of Issuance of Discharge Information Documents and Use of ‘Okusuritecho’ as Medication Handbook in Community Pharmacies
Get PDFThe activities of community pharmacies include collecting and sharing information about patients' hospitalization histories by checking medication registers, interviewing patients and their families, and providing information from other medical institutions. In 2020, an additional fee was established to provide pharmacies with information in a document form at the time of discharge from the hospital. This study aimed to verify the use of discharge information documents and medication handbooks as medication support for patients visiting community pharmacies after discharge from the hospital. We conducted this study on 97 patients who visited a community pharmacy after discharge from a community hospital between January 2021 and September 2021. In this survey, 17 (17/97) discharge drug information forms were obtained from patients. Surprisingly, 13 of the 17 patients were included in the Medication Book. In addition, information on hospitalization history was obtained from 82 patients and their families. Eleven patients (11/97, 11.3%) were subject to prescription inquiries. Thus, the discharge information documents were not widely used, and the information obtained from patient interviews and medication handbooks was utilized primarily for medication counselling at community pharmacies.This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited
Development of Self-Administered Formulation to Improve the Bioavailability of Leuprorelin Acetate
Get PDFIn recent years, the development of self-injectable formulations has attracted much attention, and the development of formulations to control pharmacokinetics, as well as drug release and migration in the skin, has become an active research area. In the present study, the development of a lipid-based depot formulation containing leuprorelin acetate (LA) as an easily metabolizable drug in the skin was prepared with a novel non-lamellar liquid-crystal-forming lipid of mono-O-(5,9,13-trimethyl-4-tetradecenyl) glycerol ester (MGE). Small-angle X-ray scattering, cryo-transmission electron microscopy, and nuclear magnetic resonance observations showed that the MGE-containing formulations had a face-centered cubic packed micellar structure. In addition, the bioavailability (BA) of LA after subcutaneous injection was significantly improved with the MGE-containing formulation compared with the administration of LA solution. Notably, higher Cmax and faster Tmax were obtained with the MGE-containing formulation, and the BA increased with increasing MGE content in the formulation, suggesting that LA migration into the systemic circulation and its stability might be enhanced by MGE. These results may support the development of self-administered formulations of peptide drugs as well as nucleic acids, which are easily metabolized in the skin.Article number: 785, This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cite
Total Synthesis and Monoamine Oxidase Inhibitory Activities of (±)-Entonalactam A and Its Derivatives
Get PDFThe first total synthesis of isoindolinone (±)-entonalactam A (6), originally obtained from the fungus Entonaema sp., was achieved in 14 steps from commercially available 5-bromovanillin via benzophenone intermediates. Isoindolinone, phthalide, and benzophenone analogues of natural products were also synthesized. The monoamine oxidase (MAO) A and B inhibitory activities were tested. The isoindolinone derivative 30 exhibited inhibition of both MAO-A and -B (IC50 = 17.8 and 15.8 μM, respectively).Published by American Chemical Societ
Verification of the causes of and countermeasures for falls using fall assessment score sheets in a municipal hospital
Get PDFAim. This study aimed to examine the causes and countermeasures concerning falls through evaluating patient falls assessment score sheets at admission and retrospectively examining medication use and biochemical evaluation results.Methods. The medical records of patients hospitalized for 11 months from April 2018 to March 2019 were reviewed anonymously on the basis of medical safety and the safety of medical supplies, and the number of falls was determined. Moreover, the cause and number of falls were reviewed retrospectively based on patient falls assessment score sheets. On assessment of the causes of falls during hospitalization, activity restrictions were noted and physical restraints had been implemented to assist with activities of daily living due to suspected frailty syndrome.Results. As a result of the evaluation of the fall assessment score sheet, 256 patients (90.5%) were aged 65 years or older, and most of the hospitalized patients were elderly. Regarding the history of falls, the number of males aged 65 years or older (136 patients) with a history of falls was approximately 2.7 times that of those without a history (99 patients), and the number of female patients (120 patients) with a history of falls was twice that of those without a history of falls (80 patients). As fall assessment items, it was confirmed that needing assistance for elimination, patient use of accessories, IVs, gastric tubes, drains, and use of wheelchair toilets contributed to the cause of falls. Biochemical evaluations indicated that patients categorized as underweight, based on their body mass index, had lower total protein, albumin, and hemoglobin levels than obese patients.Conclusions. To reduce the occurrence of falls, a patient’s nutritional status and muscle mass should be considered using a falls assessment score sheet at admission. Furthermore, falls may be prevented through evaluating a patient’s nutritional status from a biochemical perspective.This is an open access article distributed in accor-dance with the CC-BY-NC-ND (Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 Inter-national) license. The article can be used by giving appropriate credit and mentioning the license, but only for non-commercial purposes and only in the original version. For further information: https://creati-vecommons.org/licenses/by-nc-nd/4.0/deed.e
Determination of sugars and amino acids in japanese wine using core-shell liquid chromatography tandem electrochemical detection
Get PDFIn this study, sugars (glucose, fructose, and sucrose) and amino acids in plum and yuzu wines were quantified with a new and simple method involving an electrochemical detector (ECD) and core-shell column [S-30/70=St (styrene)/DVB (divinylbenzene)-5TMDAH (tetramethyldiaminohexane)]. Analysis was conducted under the following conditions: A column temperature (40°C), flow rate (0.3 mL/min), injection volume (20 μL), and mobile phase (0.1 mol/L NaOH). Glucose, fructose, and sucrose had retention times of 14.68 min, 16.22 min, and 19.29 min, respectively, when measured using an ECD. When the sugar content was compared among the plum wines, plum wine A had the lowest sugar content. A comparison of the sugar content of the different types of yuzu showed that yuzu wine C had the lowest sugar content. In addition, plum wine C showed higher values of amino acid components (2.27 μmol/mL of alanine, 0.67 μmol/mL of GABA, and 5.28 μmol/mL of glutamic acid) compared with A and B. This straightforward LC technique is reliable in the determination of carbohydrates and amino acid contents in wine, useful criteria for consumers in selecting wines parallel to their ideal health outcomes