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Educational Practice Report on the Development of Communication Card Games and Board Games to Activate First-Year Experience (Part 1)
Get PDFMetabolomics techniques applied to Quality evaluation of natural materials. For instance: Corn silk, Green tea, and Asiasarum Root.
Get PDF学位授与機関：城西大学 学位記番号：博甲第111号，学位の種別：博士（薬科学）， 学位授与年月日： 令和6年(2024年)3月18日 (112p.)博士（薬科学）城西大
Research on Risk Avoidance Attempts by Interprofessional Collaborative Practices in a General Hospital
Get PDF学位授与機関：城西大学 学位記番号：博乙第87号，学位の種別：博士（薬学），学位授与年月日： 令和6年(2024年)3月18日 (74p.)博士（薬学）城西大
Development of an Auraptene-Loaded Transdermal Formulation Using Non-ionic Sugar Ester Surfactants
Get PDFAuraptene (Aur) is a naturally occurring monoterpene coumarin ether that exhibits numerous therapeutic properties. Its high lipophilicity and low skin penetration, however, limit its potential application for local and transdermal delivery. Biocompatible non-ionic sugar esters (SEs) possess beneficial properties for the development of transdermal formulations in delivering pharmaceutically challenging molecules such as graphene and Aur. In the present study, we conducted a series of experiments to demonstrate the effect of several previously unstudied SEs on the skin permeation and distribution of Aur by preparing gel- and dispersion-type formulations. Skin permeation and deposition experiments were conducted using a Franz diffusion cell with rat skin as the membrane. The dispersion-type formulations prepared using SEs had higher entrapment efficiency, as well as better skin permeation and retention profiles. The dispersion-type formulation containing sucrose palmitate (sSP) exhibited the highest skin permeation over 8 h. Notably, the enhancement effects on Aur concentration in full-thickness skin after the application of the dispersion-type formulation was higher than those of the control formulation. These results indicated that the prepared formulation has potential for use in the transdermal delivery of Aur in pharmaceutical and cosmetic products
ゲンダイ シャカイ オ ケンコウ デ ユタカ ニ スゴソウ
Get PDF第43回（2024年度）城西大学公開講座 第2回 発表資料（18p.） 開催日時：2024年9月10日（水） 13：45～ 15：30 会場：城西大学23号館209教室 後援：坂戸市・鶴ヶ島市・日高市・川越市・飯能市・東松山市・毛呂山町・越生町・鳩山町・川島町・東秩父村の各教育委員会、埼玉東上地域大学教育プラットフォーム(TJUP)、埼玉新聞社 受講料：無料 修了証書：全4回を受講された方には修了証書を後日郵
Harnessing Arsenic Derivatives and Natural Agents for Enhanced Glioblastoma Therapy
Get PDFGlioblastoma (GBM) is the most common and lethal intracranial tumor in adults. Despite advances in the understanding of the molecular events responsible for disease development and progression, survival rates and mortality statistics for GBM patients have been virtually unchanged for decades and chemotherapeutic drugs used to treat GBM are limited. Arsenic derivatives, known as highly effective anticancer agents for leukemia therapy, has been demonstrated to exhibit cytocidal effects toward GBM cells by inducing cell death, cell cycle arrest, inhibition of migration/invasion, and angiogenesis. Differentiation induction of glioma stem-like cells (GSCs) and inhibition of neurosphere formation have also been attributed to the cytotoxicity of arsenic derivatives. Intriguingly, similar cytotoxic effects against GBM cells and GSCs have also been observed in natural agents such as anthocyanidins, tetrandrine, and bufadienolides. In the current review, we highlight the available data on the molecular mechanisms underlying the multifaceted anticancer activity of arsenic compounds and natural agents against cancer cells, especially focusing on GBM cells and GCSs. We also outline possible strategies for developing anticancer therapy by combining natural agents and arsenic compounds, as well as temozolomide, an alkylating agent used to treat GBM, in terms of improvement of chemotherapy sensitivity and minimization of side effects.p.25 Article number: 2138 Licensee MDPI, Basel, Switzerland.This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/)
