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Nitric oxide inhalation as an interventional rescue therapy for COVID-19-induced acute respiratory distress syndrome
Get PDFCOVID-19 is an emerging disease of public health concern. While there is no specific recommended treatment for COVID-19, nitric oxide has the potential to be of therapeutic value for managing acute respiratory distress syndrome in patients with COVID-19. However, inhaled nitric oxide has not yet been formally evaluated. Given the extent of the COVID-19 pandemic, and the large numbers of hospitalized patients requiring respiratory support, clinical use of inhaled nitric oxide may become an alternate rescue therapy before extracorporeal membrane oxygenation for the management of acute respiratory distress syndrome in patients with COVID-19.2p. Article number: 61Open Access. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing,adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/
Implementing Tax Reductions and Strengthening Social Security and Social Policy from the Double-Dividend of Environmental Tax
Get PDF本稿では、環境税の「二重の配当」について、税収の使い道に焦点を当てて検討を行った。具体的には、税収の使い道の一つとして、減税を想定し、所得税、法人税、消費税、資産課税に焦点を当てて、メリット・デメリットを検討した。さらに、税収の使い道として、社会保険制度を想定し、公的年金制度、公的医療保険制度、介護保険制度、雇用保険制度を挙げ、さらには他の社会政策にも関心を向けて、教育制度、子育て支援、環境政策そのものへの還元についても言及した。各々の使い道については、異なるメリット・デメリットがある。それゆえ、各々を適切に組み合わせて併用する方策が考えられる。また、実際に政策を実行するには、実証分析の結果も併せて検討する必要があるだろう。In this paper, the author examined the double dividend of the environmental tax. Specifically, it assumed that this could be used to implement a reduction in income, corporate, consumption, and property taxes. Another point of focus was how it could be used to improve the social insurance system, specifically the public pension system, public health care insurance system, long-term care insurance system, and employment insurance system.The author also examined other social services and policies that could be strengthened due to the gain in tax revenues stemming from the environmental tax.Various methods of revenue recycling have their advantages and disadvantages; therefore, it is important to take measures to implement them appropriately.In addition, the results of the data analysis should also be considered when implementing future policy of revenue recycling.論
Prolonged Distribution of Tranilast in the Eyes after Topical Application onto Eyelid Skin
Get PDFTranilast, a lipophilic drug with various ophthalmic applications, was used as a model drug to establish the possibility of delivering lipophilic drugs through the eyelid skin. Pharmacokinetics and tissue distribution studies were conducted employing three application methods (topical application onto eyelid skin, eye drops, and intravenous injection in rats) to broaden the significance of delivering drugs through the eyelids. A two-compartment open model analysis was used for intravenous route while a non-compartmental evaluation was used for topical applications to estimate the pharmacokinetic parameters. Eyelid skin application, eye drops, and intravenous administration had mean residence times (MRTs) of 8.07, 1.79, and 3.25 h in the eyeball and 10.8, 1.29, and 2.97 h in the conjunctiva, correspondingly. In the eyeball, topical application of tranilast onto the eyelids corresponded to a 4.5- and 2.5-fold higher MRT compared with eye drops and intravenous administration, respectively. An 8.4- or 3.6-fold higher MRT was observed in the conjunctiva after topical application compared with eye drops or intravenous administration, respectively. This indicated a gradual penetration of tranilast into the eyeball and conjunctiva, subsequently a slow elimination from these target tissues.U813230009<Pre 医中誌
Antitumor Effects and Tumor-specificity of Guaiazulene-3-Carboxylate Derivatives Against Oral Squamous Cell Carcinoma In Vitro
Get PDFAim: The aim of this study was to investigate the antitumor potential of guaiazulene-3-carboxylate derivatives against oral malignant cells. Materials and Methods: Twelve guaiazulene-3-carboxylate derivatives were synthesized by introduction of either with alkyl group [1-5], alkoxy group [6, 7], hydroxyl group [8, 9] or primary amine [10-12] at the end of sidechains. Tumor-specificity (TS) was calculated by the ratio of mean 50% cytotoxic concentration (CC50) against 3 human oral mesenchymal cell lines to that against 4 human oral squamous cell carcinoma (OSCC) cell lines. Potency-selectivity expression (PSE) was calculated by dividing TS value by CC50value against OSCC cell lines. Cell cycle analysis was performed by cell sorter. Results: [6, 7] showed the highest TS and PSE values, and induced the accumulation of both subG1 and G2/M cell populations in HSC-2 OSCC cells. Quantitative structure-activity relationship analysis demonstrated that their tumor-specificity was correlated with chemical descriptors that explain the 3D shape, electric state and ionization potential. Conclusion: Alkoxyl guaiazulene-3-carboxylates [6, 7] can be potential candidates of lead compound for developing novel anticancer drugs.Permission Granted by Publishe
You can conect to the library from anywhere, anytime : New activities of Josai University Mizuta Memorial Library under the Coronavirus Crisis
Get PDF本稿では、新型コロナウイルス感染症対応のための取り組みについて、勤務体制・オンラインサービス・学生アドバイザー、それぞれの担当者より紹介する。日々変化する状況下で、どのように図書館サービスを維持してきたかについて記す
