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Combined use of deep learning and CAE simulation for design and optimization of pharmaceutical products
Get PDF医薬品適用剤形として汎用される錠剤は，通例，粉体や顆粒の圧縮により製造されている。そのため錠剤内部には応力が残留し，このことが錠剤の重要品質特性（CQAs)に大きな影響を及ぼす。本研究では，モデル錠剤の硬度と崩壊時間をCQAsとし，Drucker-Prager capモデルを利用した有限要素法により残留応力を推算した。応力推定値を予測因子として深層学習とスパースモデリングを適用しCQAの予測を試みた。その結果，いずれのCQAsも高精度に予測され，予測に寄与する応力残留部位を同定することができた。残留応力の強弱は錠剤の処方に依存するが，その分布状態は錠剤形状にとよく影響されることが示唆された。Tablets are popular dosage forms for drug administration, and generally prepared by the compaction of pharmaceutical powders or granules so that various stresses can remain in the inside of tablets. The residual stresses may affect critical quality attributes (CQAs) of tablets, such as a hardness and a disintegration time. In this study, the residual stresses were estimated employing a finite element method incorporating a Drucker-Prager cap model. Hierarchical deep leaning models together with sparse models were applied to the remained stresses for predicting CQAs. As a result, CQAs were predicted with high accuracy as a function of remained stresses. The strength of residual stress was dependent in large part on the components of the formulations, but the distribution bias was mainly attributable to the tablet shape.科学研究費助成事業研究成果報告書 研究種目：基盤研究(C)（一般）, 研究期間：2017～2019, 課題番号：17K08252 研究分野：製剤学, 研究者番号：00130758. 12p
Study on the decor of cancelli in the Early Middle Ages
Get PDFキリスト教の典礼空間において内陣障壁（カンケッリ）は、信徒の空間と聖職者が儀式を行う空間を区別する役割を担っている。本研究は、初期中世の内陣障壁の残存例の現地調査をフランス南東部を中心に行い、作例の形態、材質、装飾、由来する聖堂の歴史などのデータ化、分類、分析を進めた。また、うろこ模様、格子模様、ロゼット模様、組みひも模様など、内陣障壁に特徴的な装飾についての広範囲の資料・文献収集を行い、分析研究を行った。During the Early Middle Ages, the chancel, which separated the priests and the faithful, was considered to be one of the main sanctuary decorations. This study focuses on remnant sculpted chancel fragments, particularly in the South of France and Italy. I studied several specific decorative motifs for this liturgical furniture, including scales, rosettes, and interlaces, examining their origins, meanings, and local particularities.科学研究費助成事業研究成果報告書 研究種目：基盤研究(C)（一般）, 研究期間：2017～2019, 課題番号：17K02321 研究分野：美術史, 研究者番号：60251378. 5p
On The Symbolist Movement in Literature by Arthur Symons : Translations, and Explanatory Notes （Ⅲ） Villiers de l’Ⅰsle-Adam
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Formation and Development of Camara de Comercio e Industria Japonesa do Brasil （CCIJB） - Continuity of the Pre-War and Post-War Activities of CCIJB -
Get PDF本稿では，ブラジル日本商工会議所を取り上げ，戦前の日本経済団体（サンパウロ日本商業会議所1940～1942年）と，戦後の経済団体（サンパウロ日本商業会議所1951年再開，1954年にブラジ日本商工会議所へ名称変更）が，受入国と進出日本企業との間
で果たした調整機能における連続性を明らかにした。その結果，以下の点において，同会議所が連続性を有していることが明らかになった。 戦前・戦後を通じて，日本政府が官民協力型の商業会議所設立・運営を支援してきたことである。 現地経済発展の各
段階で，現地政府と進出日本企業間で生じた問題に対応していることである。 組織整備を行い，日本企業が抱える問題の変化に対応してきたことである。従来，在外日本人経済団体は進出日本企業の団体として扱われてきた。これに対して，本研究はブラジルの場合には，移民者が団体活動に先鞭をつけ，進出日本企業がそれに参加する形で発展したことが特徴であることを明らかにしている。This study analyzes the role of CCIJB through its continuity of the pre-war and postwar activities.JCCIB maintains its continuity on three points; （1）Japanese government provides support to the formation and development of JCCIB, （2）JCCIB has solved the problems occurring between the Brazilian government and Japanese companies, （3）JCCIB has adjusted the problems Japanese companies facing at each Brazilian economic stage by reforming their organization structure. In the case of Brazil, Japanese immigrants contributed in forming JCCIB and later the Japanese companies joined and developed the organization, whereas Japanese companies formed and developed the Japanese Chamber of Commerce in other foreign countries.論
Wasei-M&A as An Approach of Japanese Companies' Globalization - Toward a Right Method of the Performance Evaluation
Get PDF日本企業がグローバル市場の高い成長を自らの業績に取り込もうとする戦略的な動きのひとつとして，近年，和製M&A，つまり日本企業による海外企業の買収が件数・金額ともに増加しているが，社会的には厳しい評価が一般的である。ここでは，和製M
&Aの巧拙について分析した論考を整理しつつ，近年行った有力日本企業の和製M&Aに関する事例研究の成果をもとに新たな考察を進めた。その結果，①和製M&Aの成績は 間言われているほど悪くなく，将来的には日本企業の強みを活かした優良なM&
A実現の可能性が高いこと，②ネガティブ評価の原因となったM&A評価方法については， 事業家視点 による価値評価手法が望ましいこと，の2点の結論が導き出された。この結論に基づいて， 事業家視点 の評価方法のノウハウの確立や，一方で 投
資家視点 の疑問にも答えられるエクイティ・ストーリーの具体的な構築法が，今後の課題としてあげられた（1）。Wasei-M&A, which is a type of M&A conducted by Japanese companies for acquiring foreign companies, has been growing in terms of transaction number and amount. Japanese corporations have strategically aimed at benefiting from higher-pace growth of global markets by initiating Wasei-M&A. But, public eyes including media do not appreciate it positively based on the miserable track records marked by some large-size acquisition deals. This paper reviews previous researches on eveluation of Wasei-M&A and re-visited case studies on major Japanese companies. The results are as follows. Firstly, performance of Wasei-M&A is better than the public views. Furthermore, there could be a number of successful Wasei-M&A if it takes advantage of the strength of the Japanese management. Secondly, business-oriented M&A evaluation method is more suitable for valuing Wasei-M&A than investor-oriented one. Next steps are identified as establishing the know-how of business-oriented M&A evaluation method and clarifying how to make up practical equity story for investors of companies.論
A Study of the High School Baseball Field Management 4.0 Aim at Overcoming a Belief Conflict between Bushido-Baseball and Sports-Baseball
Get PDF本論では現代の高校野球の価値形成において生じている「武士道野球」と「スポーツ野球」の信念対立構造について，構造構成主義に基づいた信念対立解明アプローチによる分析を試みた。これに従い，高校野球フィールドマネジメント4.0における相対可能
性と連携可能性の確保を目指した価値形成の一方法論を考察した。The purpose of this paper attempted to analyze the structure of a belief conflict between Bushido-baseball and Sports-baseball, which was resulting from the value creation
of modern high school baseball. The structure was analyzed by using dissolution approaches for belief conflicts based on a structure constituting principle. Following the results of the analysis, I suggested a unique method of value creation aiming at ensuring cooperation possibility as well as relative possibility concerning high school baseball field management 4.0.論
Differential Equations and Representation Theory : Proceedings of JMM Workshop on Differential Equations and Representation Theory Festschrift in Honor of Toshio Oshima, December 26-27, 2018 Josai University
Get PDFControlled release of a model hydrophilic high molecular weight compound from injectable non-lamellar liquid crystal formulations containing different types of phospholipids
Get PDFSkin offers an easily accessible and convenient site for the administration of drugs. Therefore, the development of injectable formulations with controlled drug release properties are now expected to deliver middle- and large-size biomolecules. In the present study, formulations mainly composed of a novel polyol ester with an isoprenoid side chain; mono-O-(5,9,13-trimethyl-4-tetradecenyl) glycerol ester (MGE), that was capable of forming a non-lamellar liquid crystal (NLLC), were prepared with different types of phospholipid. Then, factors that affected the release of a model entrapped drug, fluorescein-isothiocyanate dextran (FD-4, M.W. 4,000), from the MGE formulations were analyzed with multi-regression analysis. In addition, self-assembly of the NLLC structure was investigated using small-angle X-ray scattering analysis after contacting the MGE formulations with water. NLLC-forming ability of the formulations after s.c. injection into rats was also confirmed using microscopic observations. FD-4 concentrations in blood were determined after s.c. injection of the MGE formulations. The injectable MGE formulations successfully constructed NLLC structures to form a sponge-like gel after contact with water in vitro and in vivo (in rats) as well. In in vitro conditions, the amount of FD-4 released from the formulations was altered by changing the type and concentration of phospholipid in the MGE formulations and can be expressed with parameters such as MGE content and interplanar spacing of the NLLC. A significantly sustained FD-4 level in the blood was observed after s.c. injection of the formulations. These results suggested that injectable MGE formulations may have the potential to achieve controlled release profiles of drugs after s.c. injection.Article 11894