38517 research outputs found
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Unbalanced development characteristics and driving mechanisms of regional urban spatial form: a case study of Jiangsu Province, China
Full text linkUnbalanced regional development is widespread, and the imbalance of regional development in developing countries with rapid urbanization is increasingly apparent. This threatens the sustainable development of the region. Promoting the coordinated development of the region has become a hot spot of scientific research and a major practical need. Taking 99 counties of Jiangsu Province China, a typical coastal plain region, as the basic research unit, this paper explores the unbalanced development characteristics of the regional urban spatial form using three indicators: urban spatial expansion size, development intensity, and distribution aggregation degree. Then, their driving mechanisms were evaluated using spatial autocorrelation analysis, Pearson correlation analysis, linear regression, and geographically weighted regression. Our results found that the areas with larger urban spatial expansion size and development intensity were mainly concentrated in southern Jiangsu, where there was a positive spatial correlation between them. We found no agglomeration phenomenon in urban spatial distribution aggregation degree. From the perspective of driving factors: economics was the main driving factor of urban spatial expansion size; urbanization level and urbanization quality were the main driving factors of urban spatial development intensity. Natural landform and urbanization level are the main driving factors of urban spatial distribution aggregation degree. Finally, we discussed the optimization strategy of regional coordinated development. The quality of urbanization development and regional integration should be promoted in Southern Jiangsu. The level of urbanization development should be improved relying on rapid transportation to develop along the axis in central Jiangsu. The economic size should be increased, focusing on the expansion of the urban agglomeration in northern Jiangsu. This study will enrich the perspective of research on the characteristics and mechanisms of regional urban spatial imbalance, and helps to optimize and regulate the imbalance of regional urban development from multiple perspectives
English language teachers in higher education: a different tribe?
Full text linkRecent years have witnessed a heightening of interest in the role of teachers working in EAP (English for Academic Purposes), particularly with regard to defining and debating their professional identity. However, it must be said that most authors have painted a rather dismal picture, when comparing the status and professional standing of English language teachers in Higher Education with that of academics working in other disciplines. Drawing on concepts and sociological models developed by the educationalists Tony Becher, Basil Bernstein and Pierre Bourdieu, this reflective paper proposes a theoretical framework to account for why these differences in status might be so. The paper concludes that EAP as an academic discipline currently faces some significant threats. However, the paper also argues that if EAP practitioners are to gain the professional recognition they desire, then they themselves must strive to trade more explicitly on the forms of capital valued by the academy
Experimental study on seismic vibration control of stockers in wafer and LCD panel fabs
Full text linkAutomated stocker system is widely used in semiconductor and liquid crystal display (LCD) industries for handling and storage of valuable wafers or glass panels. Massive front opening unified pods (foups) containing wafers, or cassettes storing glass panels, are placed in shelf stockers during manufacturing. Although several preventative measures have been taken, during the past earthquakes, substantial financial loss from the industries were reported, and one of the main causes was attributed to collision of the foups or cassettes and shake off from the shelfs. This paper proposes a methodology of incorporating viscous fluid dampers into the stokers to mitigate their seismic response. Unlike conventionally been done in buildings where dampers are placed between adjacent stories, it is proposed to install dampers in between the ceiling and top of the stocker. Such configuration utilizes the large velocity at the stocker top under vibration, resulting in smaller damper size, and enables a leverage mechanism that requires smaller damper force to resist the stocker’s vibration. Both shake table tests and simulation of a full-scale stocker under realistic earthquakes have been conducted. Results indicate that both displacement and acceleration responses of the stocker can be significantly reduced, and dynamic response of the stocker under seismic excitations can be well predicted
ELSA: a new local indicator for spatial association
Full text linkThere are several local indicators of spatial association (LISA) that allow exploration of local patterns in spatial data. Despite numerous situations where categorical variables are encountered, few attempts have been devoted to the development of methods to explore the local spatial pattern in categorical data. To our knowledge, there is no indicator of local spatial association that can be used for both continuous and categorical data. We introduce ELSA, which can be used for exploring and testing local spatial association for continuous and categorical variables. We provide the R-package elsa for making these computations
Classification of single cell types during leukemia therapy using artificial neural networks
Full text linkWe trained artificial neural network (ANN) models to classify peripheral blood mononuclear cells (PBMC) in chronic lymphoid leukemia (CLL) patients. The classification task was to determine differences in gene expression profiles in PBMC pre-treatment (with ibrutinib) and on days 30, 120, 150, and 280 after the start of treatment. Twelve datasets represented clinical samples containing a total 48,016 single cell profiles were used to train and test ANN models to classify the progress of therapy by gene expression changes. The accuracy of ANN classification was >92% in internal cross-validation. External cross-validation, using independent data sets for training and testing, showed the accuracy of classification of post-treatment PBMCs to more than 80%. To the best of our knowledge, this is the first study that has demonstrated the potential of ANNs with 10x single cell gene expression data for detecting the changes during treatment of CLL
Near-ultraviolet circular dichroism and two-dimensional spectroscopy of polypeptides
Full text linkA fully quantitative theory of the relationship between protein conformation and optical spectroscopy would facilitate deeper insights into biophysical and simulation studies of protein dynamics and folding. In contrast to intense bands in the far-ultraviolet, near-UV bands are much weaker and have been challenging to compute theoretically. We report some advances in the accuracy of calculations in the near-UV, which were realised through the consideration of the vibrational structure of the electronic transitions of aromatic side chains
Name-signature lookup system: a security enhancement to named data networking
Full text linkNamed Data Networking (NDN) is a content-centric networking, where the publisher of the packet signs and encapsulates the data packet with a name-content-signature encryption to verify the authenticity and integrity of itself. This scheme can solve many of the security issues inherently compared to IP networking. NDN also support mobility since it hides the point-to-point connection details. However, an extreme attack takes place when an NDN consumer newly connects to a network. A Man-in-the-middle (MITM) malicious node can block the consumer and keep intercepting the interest packets sent out so as to fake the corresponding data packets signed with its own private key. Without knowledge and trust to the network, the NDN consumer can by no means perceive the attack and thus exposed to severe security and privacy hazard. In this paper, the N ame-Signature Lookup System (NSLS) and corresponding Name-Signature Lookup Protocol (NSLP) is introduced to verify packets with their registered genuine publisher even in an untrusted network with the help of embedded keys inside Network Interface Controller (NIC), by which attacks like MITM is eliminated. A theoretical analysis of comparing NSLS with existing security model is provided. Digest algorithm SHA-256 and signature algorithm RSA are used in the NSLP model without specific preference
Natron glass beads reveal Proto-Silk Road between the Mediterranean and China in the 1st millennium BCE
Full text linkNatron-based glass was a vital part of material culture in the Mediterranean and Europe for nearly two millennia, but natron glass found elsewhere on the Eurasian Continent has not received adequate discussion, despite its influence on ancient Asian glass. Here we present a new interpretation of natron glass finds from both the West and the East. After establishing the compositional types and technological sequence of Mediterranean natron glass (eighth-second century BCE) using trace elements, we report the analysis of a mid-1st millennium BCE glass bead from Xinjiang, China, which was likely made with Levantine raw glass, and identify common types of stratified eye beads in Eurasia based on a compositional and typological comparison. Combining these findings, we propose that a considerable number of Mediterranean natron glass products had arrived in East Asia at least by the fifth century BCE, which may have been a contributing factor in the development of native Chinese glass-making. The swift diffusion of natron glass across Eurasia in the 1st millennium BCE was likely facilitated by a three-stage process involving maritime and overland networks and multiple forms of trade and exchange, indicating a highly adaptable and increasingly efficient transcontinental connection along the ‘Proto-Silk Road’
“No future for Libya with Gaddafi”: classical realism, status and revenge in the UK intervention in Libya
Full text linkWhy did Britain intervene in Libya in 2011? Several explanations suggest themselves: security, R2P and status. The article shows that status was a significant motivating factor, and this demonstrates a dynamic that helps to refine a classical realist theory of intervention. The article calls for status to be seen intrinsically and instrumentally, and for more attention to be paid to the related motive of revenge. The findings suggest (though do not prove from a causal standpoint) that status may be a stronger motive than security for state decision-makers. The article’s central empirical argument is that regime change in Libya was not the last stage of Britain’s foreign policy of intervention. Rather, intervention was the last stage in Britain’s status and revenge-driven foreign policy of regime change. Britain saw the Libya crisis as a chance to preserve its great power status and revenge Muammar Gaddafi for past wrongs
Lightweight verification and fine-grained access control in named data networking based on schnorr signature and hash functions
Full text linkNamed Data Networking (NDN) is a new kind of architecture for future Internet, which is exactly satisfied with the rapidly increasing mobile requirement and information-depended applications that dominate today's Internet. However, the current verification-data accessed system is not safe enough to prevent data leakage because no strongly method to resist any device or user to access it. We bring up a lightweight verification based on hash functions and a fine-grained access control based on Schnorr Signature to address the issue seamlessly. The proposed scheme is scalable and protect data confidentiality in a NDN network
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