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Healthy healthcare: opportunities and pitfalls of designing and conducting research and practice in healthcare settings?
Get PDFA ban on plastic wet wipes may lead to more river pollution, not less
No full textWipes could be framed as plastic free and biodegradable, sending a false message that it's ok to flush them
Error in sequential action: an evaluation of a competence model
Get PDFThe Wisconsin Card Sorting Test (WCST) is commonly used to assess executive (dys-)function, particularly in neuropsychological patients. Performance on the test typically yields two types of error: perseverative errors, where participants persist in applying an inferred rule despite negative feedback, and set-loss errors, were participants cease applying an inferred rule despite positive feedback. The two types of error are known to dissociate. In this paper we apply an existing model of the WCST – the model of Bishara et al. (2010) – to a novel dataset, focussing specifically on the distribution of the two types of error over the duration of the task. Using Maximum Likelihood Estimation to fit the model to the data, we argue that the model provides a good account of the performance of some participants, but a poor account of individual differences. It is argued that this is because the model is essentially a competence model which fails to incorporate performance factors, and that accounting for the different types of error, and in particular the error distribution during the task, requires incorporating performance factors into the model. Some consequences of this for the broader enterprise of developing normative competence models are discussed
Lack of backups threatens the scholarly record
No full textA quarter of online journal articles are not digitally archived, warns Martin Ev
Graveyard Gothic
No full textBook synopsis: Graveyard Gothic is the first sustained consideration of the graveyard as a key Gothic locale. This volume examines various iterations of the Gothic graveyard (and other burial sites) from the eighteenth century to the twenty-first, as expressed in numerous forms of culture and media including poetry, fiction, TV, film and video games. The volume also extends its geographic scope beyond British traditions to accommodate multiple cultural perspectives, including those from the US, Mexico, Japan, Australia, India and Eastern Europe. The seventeen chapters from key international Gothic scholars engage a range of theoretical frameworks, including the historical, material, colonial, political and religious. With a critical introduction offering a platform for further scholarship and a coda mapping potential future critical and cultural developments, Graveyard Gothic is a landmark volume defining a new area of Gothic studies
Introduction: Graveyard gothic
Get PDFThis introductory chapter theorises the graveyard’s persistent appeal to Gothic writers, identifying it as a heterotopic space of intergenerational confrontation replete with supernatural potential. Readings of key texts from Gothic’s first wave establish the centrality of burial spaces to the emerging Gothic mode, from the funerary sculptures and tombside denouement of Horace Walpole’s The Castle of Otranto (1764) to the double-coded graveyards found in Gothic spoofs and satires. The accumulated layers of meaning that the graveyard accrues marks it as an example of what Michel Foucault, in ‘Of Other Spaces’ (1967), calls a heterotopia’: a space that is discursively ‘other’ due to its disturbing and transformative qualities. Here, the authors argue that the graveyard is a heterotopia characterised by temporal accumulation and discontinuity in which ideologies compete, become distorted, are repressed and re-emerge, transformed in and by different cultures and new media. It is this seemingly endless flexibility and relevance that have given the graveyard its enduring position as a key Gothic locale, and which necessitates both the cross-media and international approach that characterises this volume
Cryo-EM structure and B-factor refinement with ensemble representation
Get PDFCryo-EM experiments produce images of macromolecular assemblies that are combined to produce three-dimensional density maps. Typically, atomic models of the constituent molecules are fitted into these maps, followed by a density-guided refinement. We introduce TEMPy-ReFF, a method for atomic structure refinement in cryo-EM density maps. Our method represents atomic positions as components of a Gaussian mixture model, utilising their variances as B-factors, which are used to derive an ensemble description. Extensively tested on a substantial dataset of 229 cryo-EM maps from EMDB ranging in resolution from 2.1-4.9 Å with corresponding PDB and CERES atomic models, our results demonstrate that TEMPy-ReFF ensembles provide a superior representation of cryo-EM maps. On a single-model basis, it performs similarly to the CERES re-refinement protocol, although there are cases where it provides a better fit to the map. Furthermore, our method enables the creation of composite maps free of boundary artefacts. TEMPy-ReFF is useful for better interpretation of flexible structures, such as those involving RNA, DNA or ligands
Financial education(s). Developments and manifestations of financial literacy in EU law and policy
No full textThe recently adopted new Consumer Credit Directive has attracted large interest from academics ever since its original proposal was first unveiled by the European Commission two years ago. Commenting already on that proposal, scholars have noted, among other things, its continuity with the inspiration of the Mortgage Credit Directive and that the new instrument pays more attention to digitalisation. This contribution focuses on an only seemingly minor aspect of the CCD II, namely its reference to financial education. It takes this as an opportunity to reflect on developments in EU law regarding the promotion of consumers’ financial literacy, in an attempt to uncover what is the model of financial education which underpins EU law
More than 2 million research papers have disappeared from the Internet
No full textAn analysis of DOIs suggests that digital preservation is not keeping up with burgeoning scholarly knowledge
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