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C21 Editions Interview with Martin Paul Eve
Get PDFThis research is part of the C21 Editions project (c21editions.org), a three-year international collaboration jointly funded by the Arts & Humanities Research Council (AH/W001489/1) and Irish Research Council (IRC/W001489/1)
Round the red lamp: being facts and fancies of medical life
No full textBook synopsis: An often overlooked collection in Arthur Conan Doyle’s career, these tales actually track the vital moment in his life when he decided to shift careers from provincial medic to celebrated London author
Detailed introduction, notes and scholarly apparatus
Appendixes that collect extra medical tales, Conan Doyle’s early contributions to the medical press and the two one-act plays that he produced from two of the stories, including one of his greatest successes for the stage, Waterloo
Introduction provides the medical context to help understand its place in Conan Doyle’s career
This is a scholarly edition of Arthur Conan Doyle’s controversial collection of medical tales, first published in 1894 in the first flush of his fame. Conan Doyle had trained in medicine at Edinburgh University in the 1870s, and then spent eight years as a General Practitioner in Southsea, before deciding to become a professional author in 1890. The stories he collected in Round the Red Lamp are gathered from his medical training and incidents in his life as a provincial GP. Some of the stories are daring – dealing explicitly with child birth, sexually transmitted diseases and malpractice. Some are sentimental or comic vignettes. Some are Gothic horrors. On publication the shades of dark and light bewildered some of his readers and the medical realism outraged others. Round the Red Lamp is a vital collection in understanding Conan Doyle’s shift of profession from medic to author
Salient sounds distort time perception and production
Get PDFThe auditory world is often cacophonous, with some sounds capturing attention and distracting us from our goals. Despite the universality of this experience, many questions remain about how and why sound captures attention, how rapidly behavior is disrupted, and how long this interference lasts. Here we use a novel measure of behavioral disruption to test predictions made by models of auditory salience. Models predict that goal-directed behavior is disrupted immediately after points in time that feature a high degree of spectrotemporal change. We find that behavioral disruption is precisely time-locked to the onset of distracting sound events: participants who tap to a metronome temporarily increase their tapping speed 750 ms after the onset of distractors. Moreover, this response is greater for more salient sounds (larger amplitude) and sound changes (greater pitch shift). We find that the time course of behavioral disruption is highly similar after acoustically disparate sound events: both sound onsets and pitch shifts of continuous background sounds speed responses at 750 ms, with these effects dying out by 1750 ms. These temporal distortions can be observed using only data from the first trial across participants. A potential mechanism underlying these results is that arousal increases after distracting sound events, leading to an expansion of time perception, and causing participants to misjudge when their next movement should begin
Hymnal
Get PDFBook synopsis: Late in the 1960s, before Bell was born, her father and mother visited Aberaeron, a small fishing town on the west coast of Wales. Here, her father heard a voice – which he knew to be God – directing him to minister to the Welsh. Six months after she was born in the early 1970s, they moved to Aberaeron where he took up his first curateship. Over the next eighteen years they would move to various parishes within a forty mile radius: first to Llangeler a predominantly Welsh-speaking parish in the Teifi valley, then back to Aberaeron where Bell’s father became vicar, and then to a larger and more Evangelical church in Aberystwyth.
This unique memoir in verse offers a series of snapshots about religion and sexuality. In verse because it’s how Bell remembers: snapshots in words strung along a line, which somehow constitute a life. Snapshots of another time from now, but from a time which tells us about how Bell got here. Not the whole story, but her story. Of an English family on a mission from God, of signs and wonders in the Welsh countryside, of difference, and of faith and its loss
Reconceptualising knowledge exchange and higher education institutions: broadening our understanding of motivations, channels, and stakeholders
Get PDFThis Special Issue represents an effort to go beyond a narrow notion of knowledge exchange (KE) and explicitly address broader questions related to the measurement of and incentives towards KE in Higher education institutions (HEI). Specifically, we bring attention to a number of under-researched topics in the literature. These relate to: (i) The participation of a diverse set of academic actors in KE activities - in particular, academics in emerging economies and women academics - whose role in KE is insufficiently investigated in the extant literature; (ii) academics’ engagement with under-explored KE stakeholders, specifically policymakers and the public sector; and (iii) the tensions and tradeoffs that are implicit, but often unacknowledged, in the relationship between HEIs’ traditional teaching and research activities, and KE as a third institutional mission
Development of a facile method to compute collagen network pathological anisotropy using AFM imaging
Get PDFType I collagen, a fundamental extracellular matrix (ECM) component, is pivotal in maintaining tissue
integrity and strength. It is also the most prevalent fbrous biopolymer within the ECM, ubiquitous in
mammalian organisms. This structural protein provides essential mechanical stability and resilience to
various tissues, including tendons, ligaments, skin, bone, and dentin. Collagen has been structurally
investigated for several decades, and variation to its ultrastructure by histology has been associated
with several pathological conditions. The current study addresses a critical challenge in the feld
of collagen research by providing a novel method for studying collagen fbril morphology at the
nanoscale. It ofers a computational approach to quantifying collagen properties, enabling a deeper
understanding of how collagen type I can be afected by pathological conditions. The application of
Fast Fourier Transform (FFT) coupled with Atomic Force Microscope (AFM) imaging distinguishes not
only healthy and diseased skin but also holds potential for automated diagnosis of connective tissue
disorders (CTDs), contributing to both clinical diagnostics and fundamental research in this area. Here
we studied the changes in the structural parameters of collagen fbrils in Ehlers Danlos Syndrome
(EDS). We have used skin extracted from genetically mutant mice that exhibit EDS phenotype as our
model system (Col1a1Jrt/+
mice). The collagen fbrils were analyzed by AFM based descriptive-structural
parameters, coupled with a 2D Fast Fourier Transform(2D-FFT) approach that automated the analysis
of AFM images. In addition, each sample was characterized based on its FFT and power spectral
density. Our qualitative data showed morphological diferences in collagen fbril clarity (clearness
of the collagen fbril edge with their neighbouring fbri), D-banding, orientation, and linearity. We
have also demonstrated that FFT could be a new tool for distinguishing healthy from tissues with
CTDs by measuring the disorganization of fbrils in the matrix. We have also employed FFT to reveal
the orientations of the collagen fbrils, providing clinically relevant phenotypic information on their
organization and anisotropy. The result of this study can be used to develop a new automated tool for
better diagnosis of CTD
Le pain et le cirque : le pouvoir symbolique des bienfaits
No full textBook synopsis: L’œuvre de Paul Veyne est iconoclaste et profondément novatrice. De l’archéologie à l’histoire de l’art, du pouvoir de l’empereur au métier d’historien, du paganisme à la sexualité, les études réunies ici entendent restituer tous ses champs d’investigation et explorer toute la richesse de ce « roman vrai » qu’est l’histoire. Paul Veyne aimait susciter le débat ; discuter de son œuvre est un moyen de lui emboîter le pas
Psychosocial care for cancer survivors: a global review of national cancer control plans
No full textObjective: National Cancer Control Plans (NCCPs) are high-level policy documents that prioritise actions to be taken to improve cancer control activities. As the number of cancer survivors grows globally, there is an urgent need to assess whether and how psychosocial care across the cancer care continuum is included in NCCPs. This review aimed to ascertain the extent to which NCCPs referenced psycho-oncology care for cancer survivors in the post-treatment phase.
Methods: NCCPs were obtained from the International Cancer Control Partnership (ICCP) portal (in November 2021) and reviewed in two phases. In Phase 1, all available NCCPs were screened to determine whether they mentioned psycho-oncology or survivorship. In Phase 2, reviewers extracted data from the NCCPs identified in Phase 1 on the degree that each plan articulated objectives/goals to improve psychosocial care in the post-treatment survivorship phase.
Results: We screened 237 NCCPs. Of these, initial potential reference to psycho-oncology and survivorship content were identified in 97 plans (41%). In Phase 1, 57/97 (59%) had reference to psycho-oncology or survivorship content within defined criteria. In Phase 2, 27/97 (28%) had little mention of psycho-oncology specifically in survivorship, 47/97 (48%) had some (general or brief) mention, and the remaining 23/97 (24%) had substantial content/specific sections and clearly articulated goals and/or objectives. Common goals for improving psychosocial care in the post-treatment period included building capacity of healthcare professionals, implementing rehabilitation models, and increasing the utilisation of community services.
Conclusions: Most NCCPs did not reference psycho-oncology and only one-quarter contained clear objectives specifically in the post-treatment survivorship phase
Fault lines after COVID-19: global economic challenges and opportunities
No full textThe book contains contributions by world renowned economists and historians on many of the big issues of our time. These range from the split between democracies and autocratic regimes to the effects of negative supply shocks to the growth prospects of China to the conflict in Ukraine to financial market issues to global warming. The book should be of interest to academics, policy makers, journalists, and the enlightened public.
Here are the some of the issues addressed: There is the effects of multitude of shocks on our fragile systems;; the split between democracies and autocratic countries and its causes; the future growth prospects of China; the future of global financial integration; how to cope with international monetary instability and the effects of rising US interest rates and inflation on world capital markets; the challenges faced by central banks in the post-covid world; policies intended to tackle global warming; the threat to democracy caused by populism; the economic effects of public debt; the role of the US as a lender of last resort in the world economy; the fragility of the cross-border payment system; the crisis in Ukraine and the economic effects of a renewed arms race
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