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Guide to NMR Spectral Interpretation
No full textThis book is designed to provide undergraduate and graduate students with practical strategies, methods and explanations to unravel the intriguing combinations of chemical shift, integration, and multiplicity of NMR signals. In particular, it is organized in a way that basic 1H- and 13C-NMR concepts are introduced and immediately applied in a number of problems, solved and discussed in a step-by-step fashion. It contains almost exclusively real NMR data and it describes how to interpret the chemical shift, intensity and splitting pattern of the proton and carbon NMR signals (Chapters 1-5), paying attention to the effects of the magnetically non-equivalent nuclei (Chapter 4). The role of the solvent is also explained (Chapter 6), and a description of the interpretation of the most common two-dimensional NMR experiments is reported in Chapter 7. Chapter 8 is dedicated to the strategy for structural elucidation, while Chapter 9 contains exclusively summary problems with increasing levels of difficulty.
The entire learning path is aimed to provide practical tools to determine the chemical structures of small organic molecules from their 1D and 2D NMR spectra
Centro Interdipartimentale Vincenzo Arangio-Ruiz di Studi storici e giuridici sul mondo antico
No full text
Multi-modal Morphing Wing Flaps for Next Generation Green Regional Aircraft: the Clean Sky Challenge
No full textRegional aviation is an innovation-driven sector of paramount importance for the European Union economy.
Large resources and efforts are currently spent through the CleanSky program for the development of an efficient air transport system characterized by a lower environmental impact and unequaled capabilities of ensuring safe and seamless mobility while complying with very demanding technological requirements. The Green Regional Aircraft (GRA) panel, active from 2006, aims to mature, validate and demonstrate green aeronautical technologies best fitting the regional aircraft that will fly from 2020 onwards with reference to specific and challenging domains: from advanced low-weight and high performance structures up to all-electric systems and bleed-less engine architectures, from low noise/high efficiency aerodynamic up to environmentally optimized missions and trajectories management.
The development of such technologies addresses two different aircraft concepts, identified by two seat classes, 90-pax with Turboprop (TP) engine and 130-pax, in combination with advanced propulsion solutions, namely, the Geared Turbofan (GTF), the Advanced Turbofan (ATF) and the Open Rotor (OR) configuration.
Within the framework of the Clean Sky program, and along nearly 10 years of research, the design and technological demonstration of a novel wing flap architecture was addressed. Research activities aimed at demonstrating the industrial feasibility of a morphing architecture enabling flap camber variation in compliance with the demanding safety requirements applicable to the next generation GRA in both open rotor and turboprop configurations. The driving motivation was found in the opportunity to replace a conventional double slotted flap with a single slotted morphing flap assuring improved high lift performances -in terms of maximum attainable lift coefficient and stall angle- while lowering emitted noise, fuel-burnt and deployment system complexity. Additional functionalities for load control and alleviation were then considered and enabled by a smart architecture allowing for an independent shape-control of the flap tip region during cruise.
The entire process moving from concept definition up to the experimental qualification of true scale prototypes, characterized by global and multi-zone differential morphing capabilities, is here described with specific emphasis on the adopted design philosophy and implemented technological solutions. Paths to improvements are finally outlined in perspective of a low-term item certification and series production
A high-content screening of anticancer compounds suggests the multiple tyrosine kinase inhibitor ponatinib for repurposing in neuroblastoma therapy
No full textNovel druggable targets have been discovered in neuroblastoma (NB), paving the way for more effective treatments. However, children with high-risk NB still show high mortality rates prompting for a search of novel therapeutic options. Here, we aimed at repurposing FDA-approved drugs for NB treatment by performing a high-content screening of a 349 anticancer compounds library. In the primary screening, we employed three NB cell lines, grown as three-dimensional (3D) multicellular spheroids, which were treated with 10 μmol/L of the library compounds for 72 hours. The viability of 3D spheroids was evaluated using a high-content imaging approach, resulting in a primary hit list of 193 compounds. We selected 60 FDA-approved molecules and prioritized drugs with multi-target activity, discarding those already in use for NB treatment or enrolled in NB clinical trials. Hence, 20 drugs were further tested for their efficacy in inhibiting NB cell viability, both in two-dimensional and 3D models. Dose-response curves were then supplemented with the data on side effects, therapeutic index, and molecular targets, suggesting two multiple tyrosine kinase inhibitors, ponatinib and axitinib, as promising candidates for repositioning in NB. Indeed, both drugs showed induction of cell-cycle block and apoptosis, as well as inhibition of colony formation. However, only ponatinib consistently affected migration and inhibited invasion of NB cells. Finally, ponatinib also proved effective inhibition of tumor growth in orthotopic NB mice, providing the rationale for its repurposing in NB therapy. Mol Cancer Ther; 17(7); 1405-15. ©2018 AACR
Phytochemistry of compounds isolated from the leaf-surface extract of Psiadia punctulata (DC.) Vatke growing in Saudi Arabia
No full textThe surface extract of an accession of Psiadia punctulata (DC.) Vatke (Asteraceae) growing in Saudi Arabia was investigated for its phytochemical composition. A bio-guided investigation of the extract led to the isolation of thirteen ent-kaurane and trachylobane diterpenes and seventeen compounds previously described, including nine flavonoids and eight diterpenes. Three flavonoids and one ent-kaurane diterpene showed antimicrobial activity with MIC100 values ranging from 25 to 150 μg/ml. The extract showed antibacterial activity against Staphylococcus aureus (MIC100 = 180 μg/ml) and antifungal activity against Candida albicans (MIC0 = 130 μg/ml). The isolated 3',4',5,7-tetramethoxyflavone, at a concentration of 40 μg/ml, displayed the ability to reduce biofilm formation of S. aureus and C. albicans by 50% and 90% respectively
Studying Local Antiquities in the Kingdom of Naples. Giovanni Pontano, Francesco Soderini, and the Varronianum of Fondi
No full textAfter being exiled from Rome in 1517 for taking part in Cardinal Petrucci’s plot to assassinate Pope Leo X, the Florentine cardinal Francesco Soderini found refuge at Fondi, in the Kingdom of Naples, in what is now southern Lazio, where he was hosted by the powerful baron Prospero Colonna.
During his sojourn at Fondi, Soderini restored a long Roman wall in opus reticulatum still visible today and part of an ancient monumental area used by the cardinal as his suburban residence. This area was locally known as the Varronianum, since it was believed to be the remains of an ancient villa belonging to Marcus Terentius Varro. Two inscriptions, today lost, bearing the coats of arms respectively of Soderini and Colonna, celebrated the restoration. Albeit only modestly investigated, this episode in itself is not totally unknown; yet it has never been pointed out that the area, before Soderini’s intervention, is referred to in the dialogue Aegidius, written by the humanist Giovanni Gioviano Pontano between 1501
and 1503. The article analyses the episode in the light of this source, underscoring how this dialogue encouraged the growth of the ‘myth of Varro’ at Fondi, and that the trait d’union between Pontano and Soderini was the humanist Francesco Peto of Fondi, who was one of the personae in Pontano’s dialogue and was a member of Prospero Colonna’s close entourage. It thus appears that Francesco Peto acted both as a source for Pontano and, later, as an antiquarian consultant for Soderini’s restoring of the Varronianum
Das Phänomen Comic und Öffentliche Bibliotheken - Eine Analyse der Potenziale zur Vermittlung von Lesekompetenz
Get PDFMit der vorliegenden Bachelorarbeit wird primär versucht zwei Fragen zu beantworten.
Zum einen soll die heutige Grundeinstellung Öffentlicher Bibliotheken gegenüber dem Medium Comic dargelegt werden und zum anderen soll die Thesis analysieren, ob die
sequenzielle Kunst sich als Leseförderungsinstrument eignen kann.
Um die unterschiedlichen Dimensionen dieses Mediums besser verstehen zu können, wird der Begriff „Comic“definiert.
Des Weiteren wird erklärt, welche Wichtigkeit das Lesen darstellt und welche Einflussfaktoren die Lesegewohnheit maßgeblich beeinträchtigen.
Wesentlicher Input,der zu neuen Erkenntnissen in diesem Bereich geführt hat, wurde gewonnen durch die Auswertung von Fragebögen.
Diese richteten sich an Großstadt-Bibliotheken, die
ekz, den Deutschen Jugendliteraturpreis und zentrale Akteure.The bachelor thesis mainly tries to answer two questions. On the one hand, the basic attitude of public libraries nowadays towards the medium of comic should be explained
and on the other hand it should be analyzed whether sequential art is suitable as a readingpromotion tool.
To better understand the different dimensions of this medium, the word “comic” will be defined. Furthermore, the importance of reading and which factors significantly influence the reading habits will be explained. Substantial input, which has led to new findings in this area, was generated through the evaluation of questionnaires.
They were addressed to public libraries, the ekz, the German Children's Literature
Award and key actors