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    CXCR4 involvement in neurodegenerative diseases

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    Ultrafast modification of the polarity at LaAlO3/SrTiO3 interfaces

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    Oxide growth with semiconductorlike accuracy has led to atomically precise thin films and interfaces that exhibit a plethora of phases and functionalities not found in the oxide bulk material. This has yielded spectacular discoveries such as the conducting, magnetic, and even superconducting LaAlO3/SrTiO3 interfaces separating two prototypical insulating perovskite materials. All these investigations, however, consider the static state at the interface, although studies on fast oxide interface dynamics would introduce a powerful degree of freedom to understanding the nature of the LaAlO3/SrTiO3 interface state. Here, we show that the polarization state at the LaAlO3/SrTiO3 interface can be optically enhanced or attenuated within picoseconds. Our observations are explained by a model based on charge propagation effects in the interfacial vicinity and transient polarization buildup at the interface

    Armonie intellegibili. Il dorico di Paestum alla luce della tecnologia di rilievo integrato SAPR e TLS

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    Questo lavoro descrive gli esiti di una campagna di rilevamento recentemente completata all'interno del perimetro del Parco Archeologico di Paestum. Le indagini strumentali sono state effettuate sui tre templi dorici che connotano il sito e nel loro ambiente circostante, abbinando due diverse metodologie hi-tech, il Unmanned Aerial Vehicle (UAV) e il Terrestrial Laser Scanner (TLS). L’obiettivo delle attività è stato quello di acquisire dati da utilizzare per una conoscenza dettagliata dell'ordine dorico che regola le strutture templari. I primi riferimenti generali della ricerca sono state le teorie vitruviane e, tra i saggi più recenti e influenti incentrati sugli ordini architettonici, in particolare quello di C. Thoenes 1998. Un'analisi critica del punto di vista ottocentesco sui tre Templi dorici è stata inoltre condotta utilizzando altri studi recenti (J. Raspi Serra 1990, R. Florio 2004). L'high level e l'insieme delle tecnologie utilizzate che offrono elevate prestazioni basate su algoritmi di structure from motion hanno permesso di scoprire e comprendere a fondo le relazioni armoniche delle architetture studiate, aprendo nuove prospettive al presente. In questo modo si è inteso offrire un focus metodologico non solo sulla natura fisica dell'architettura ma sulle sue proporzioni armoniche, al fine di rendere comprensibile e chiaro il significato nel presente di queste antiche architetture. L'obiettivo principale di questo lavoro è quello di introdurre un approccio nuovo e completamente diverso dalle precedenti tecniche di rilevamento tradizionali, prevalentemente indirizzate a descrivere le architetture templari. Le possibilità offerte dai big data a disposizione consentono di comparare le informazioni ottenendo una complessa e più approfondita conoscenza dei Templi Dorici

    Outcomes of hematopoietic stem cell transplantation from unmanipulated haploidentical versus matched sibling donor in patients with acute myeloid leukemia in first complete remission with intermediate or high-risk cytogenetics: A study from the acute leukemia working party of the european society for blood and marrow transplantation

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    Allogeneic hematopoietic stem cell transplantation is the optimal care for patients with high-risk or intermediate -acute myeloid leukemia. In patients lacking matched sibling donor, haploidentical donors are an option. We compared outcomes of unmanipulated (Haplo) to matched sibling donor transplant in acute myeloid leukemia patients in first complete remission. Included were intermediate and high-risk acute myeloid leukemia in first complete remission undergoing Haplo and matched sibling donor transplant from 2007-2015, and reported to the ALWP of the EBMT. A propensity score technique was used to confirm results of main analysis: 2 matched sibling donors were matched with 1 Haplo. We identified 2654 pts (Haplo =185; matched sibling donor =2469), 2010 with intermediate acute myeloid leukemia (Haplo=122; matched sibling donor =1888) and 644 with high-risk acute myeloid leukemia (Haplo =63; matched sibling donor =581). Median follow up was 30 (range 1-116) months. In multivariate analysis, in intermediate -acute myeloid leukemia patients, Haplo resulted in lower leukemia-free survival (Hazard Ratio 1.74; P<0.01), overall-survival (HR 1.80; P<0.01) and GvHD-free-relapse-free survival (Hazard Ratio 1.32; P<0.05) and higher graft-versu s-host disease (GvHD) non-relapse mortality (Hazard Ratio 3.03; P<0.01) as compared to matched sibling donor. In high-risk acute myeloid leukemia, no differences were found in leukemia-free survival, overall-survival, and GvHD-free-relapse-free survival according to donor type. Higher grade II-IV acute GvHD was observed for Haplo in both high-risk (Hazard Ratio 2.20; P<0.01) and intermediate risk (Hazard Ratio 1.84; P<0.01). A trend for a lower Relapse-Incidence was observed in Haplo among high-risk acute myeloid leukemia (Hazard Ratio 0.56; P=0.06). The propensity score analysis confirmed results. Our results underline that matched sibling donor is the first choice for acute myeloid leukemia patients in first complete remission. On the other hand, results of Haplo transplants are similar to matched sibling donor transplants in acute myeloid leukemia patients with high risk cytogenetics

    Immagini del processo nelle declamazioni pseudo-quintilianee

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    Analisi delle tecniche e vicende processuali che si possono individuare nelle Declamazioni maggiori pseudo-quintilianee, comparazione con le fonti cd. giuridich

    Developing a Fire Propagation System for a Massively Multiplayer Online Game

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    Die Popularität und der Umfang von Massively Multiplayer Online Games (MMOGs) steigt. Einer der Gründe dafür ist, dass die Interaktion mit einem menschlichen Gegenüber in einem Spiel als sehr viel reizvoller wahrgenommen wird als mit einer künstlichen Intelligenz. Obwohl die visuelle Qualität von Computerspiel-Welten im Laufe der letzten Jahre zugenommen hat erreicht sie oft nicht dieselbe Qualität in Bezug auf Verhalten und Interaktivität. Dies gilt besonders für Computerspiel-Welten in MMOGs. Ein Fire Propagation System, welches die Art und Weise, wie sich Feuer in der Computerspiel-Welt ausbreitet, definiert, ist eine Möglichkeit um eine solche Welt lebendiger wirken zu lassen. Singleplayer Spiele wie Far Cry 2 und The Legend of Zelda: Breath of the Wild können bereits die Implementierung eines solches Systems vorweisen. Nach dem Kenntnisstand des Autors wurde jedoch noch kein MMOG mit solch einem System veröffentlicht. Diese Arbeit zeigt zwei Ansätze für ein solches System in einem MMOG mit einer Client-Server Architektur. Das System wurde mit der Game Engine Snowdrop umgesetzt. Beide hier vorgestellten Ansätze dienen als Basis für ein Fire Propagation System und können an projektspezifische Bedürfnisse angepasst werden.Massively Multiplayer Online Games (MMOGs) are increasing in both popularity and scale. One of the reasons for this is that interacting with human counterparts is typically considered much more interesting than playing against an Artificial Intelligence. Although the visual quality of game worlds has increased over the past years,they often fall short in providing consistency with regard to behavior and interactivity. This is especially true for the game worlds of MMOGs. One way of making a game world feel more alive is to implement a Fire Propagation System that defines show fire spreads in the game world. Singleplayer games like Far Cry 2 and The Legend of Zelda: Breath of the Wild already feature implementations of such a system. As far as the author of this thesis knows, however, noMMOGwith an implemented Fire Propagation System has been released yet. This work introduces two approaches for developing such a system for a MMOG with a client-server architecture. It was implemented using the proprietary game engine Snowdrop. The approaches presented in this thesis can be used as a basis for developing a Fire Propagation System and can be adjusted easily to fit the needs of a specific project

    Tiergestützte Intervention – Analyse eines möglichen Mehrwertes von Hunden in öffentlichen Bibliotheken

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    Gegenstand der hier vorgestellten Arbeit ist die Analyse eines möglichen Mehrwertes der Tiergestützten Intervention mit Hund in öffentlichen Bibliotheken. Inhalte sind die Vorstellung der wissenschaftlichen Grundlagen der Mensch-Tier-Beziehung, wie beispielsweise die Biophilie, Bindungstheorie und Du-Evidenz. Teil davon ist außerdem die Wirkung von Tieren auf Menschen. Außerdem soll die Tiergestützte Intervention in ihrer Entstehung und mitsamt den begrifflichen Abgrenzungen definiert werden. Dies beinhaltet auch Voraussetzungen für Mensch und Tier, sowie das Risikomanagement mit Hygienemanagement und die rechtlichen Rahmenbedingungen. Anschließend sollen die theoretischen Aspekte in die bibliothekarische Praxis eingebunden und anhand von Praxisbeispielen dargelegt werden. Die durchgeführte Umfrage zum Interesse und Erfahrungen in öffentlichen Bibliotheken soll abschließend präsentiert, ausgewertet und analytisch diskutiert werden.Subject of this work is the analysis of a possible value of an animal-assisted dog intervention in public libraries. After the presentation of the scientific basis of the human-animal relationship, the Animal Assisted Intervention should be defined in its genesis and with the conceptual delimitation. This also includes requirements for humans and animals, as well as risk management including hygiene management and the legal framework. Subsequently, the theoretical aspects should be integrated into the practice of the library and presented on the basis of a practical example. The survey on interest and experiences in public libraries will then be presented, evaluated and analytically discussed

    Salivary glands abnormalities in oculo-auriculo-vertebral spectrum

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    Feeding and swallowing impairment are present in up to 80% of oculo-auriculo-vertebral spectrum (OAVS) patients. Salivary gland abnormalities have been reported in OAVS patients but their rate, features, and relationship with phenotype severity have yet to be defined

    De Martino - Cirese. Percorsi di studio, assetti accademici e ri-fondazione delle discipline demoetnoantropologiche

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    Il rapporto tra Cirese e De Martino è stato prima di collaborazione e poi di conflitto. Nel saggio vengono ripercorse le tappe di una relazione che ha fortemente inciso sugli discipline antropologiche italiane del secondo dopoguerra

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