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Deep Electrical Resistivity Tomography for a 3D picture of the most active sector of Campi Flegrei caldera
No full textThe central sector of the Campi Flegrei volcano, including the Solfatara maar and Pisciarelli fumarole field, is currently the most active area of the caldera as regards seismicity and gaseous emissions and it plays a significant role in the ongoing unrest. However, a general volcano-tectonic reconstruction of the entire sector is still missing. This work aims to depict, for the first time, the architecture of the area through the application of deep Electrical Resistivity Tomography. We reconstructed a threedimensional resistivity model for the entire sector. Results provide useful elements to understand the present state of the system and the possible evolution of the volcanic activity and shed solid bases for any attempt to develop physical-mathematical models investigating the ongoing phenomena
Prolegomena to a critical theory of the global order
No full textWe start from, and expand on, a basic insight in negative dialectic, namely, that our main concern should be with the absolute worst in political life. We then consider how this might have an impact on the way we understand the role and grounds of moral equality. Subsequently, we move on to explain the importance of decency in political morality. Finally, we take a closer look to basic data about global poverty and inequality and what these might tell us in light of our analysis of the foundations of moral equality and its relationship to social cruelty
Epigenetic and Metabolism: Glucose and Homeotic Transcription Factor PREP1 VRP Suggested Epigenetics and Metabolism
No full textL-2-critical NLS on noncompact metric graphs with localized nonlinearity: topological and metric features
No full textCarrying on the discussion initiated in Dovetta and Tentarelli (Ground states of the L2-critical NLS equation with localized nonlinearity on a tadpole graph, 2018. arXiv:1804.11107 [math.AP]), we investigate the existence of ground states of prescribed mass for the L2-critical NonLinear Schrodinger Equation on noncompact metric graphs with localized nonlinearity. Precisely, we show that the existence (or nonexistence) of ground states mainly depends on a parameter called reduced critical mass, and then we discuss how the topological and metric features of the graphs affect such a parameter, establishing some relevant differences with respect to the case of the extended nonlinearity studied by Adami et al. (Commun Math Phys 352(1):387-406, 2017). Our results rely on a thorough analysis of the optimal constant of a suitable variant of the L2-critical Gagliardo-Nirenberg inequality
OPTIMIZATION OF THE HYDROALCOHOLIC EXTRACT OF EPILOBIUM ANGUSTIFOLIUM L. AND CHEMICAL CHARACTERIZATION THROUGH UHPLCMS/ MS ANALYSIS
No full textEpilobium angustifolium L. is a plant used in traditional medicine for the treatment of many disorders
and ailments. In vitro and in vivo studies have demonstrated that the extracts obtained from the aerial
parts of E. angustifolium possess a broad range of pharmacological and therapeutic effects,
including antioxidant, anti-proliferative, anti-inflammatory and antimicrobial properties, mainly
ascribed to flavonoids and ellagitannins (i.e oenothein B). The present study aimed to optimize the
extraction method to obtain a hydroalcoholic extract rich in polyphenols through a systematic method
consisting in the Design of Experiments (DoE). In addition, the second aim of this investigation was
to determine the metabolic profile of the optimized E. angustifolium hydroalcoholic extract by using
the latest generation of chromatography involving the use of Ultra-High-Performance Liquid
Chromatography (UHPLC) coupled with a Quadrupole orbitrap Linear Trap (LTQ orbitrap), which
allows for the detection of the compounds of interest at very low concentrations. This study led to
the determination of the best extraction conditions with the identification of the effect of solvent,
temperature, pH and duration on extraction process. The analysis of the optimized hydroalcoholic
extract led to the identification of 43 compounds, including sugars, organic acids, non-flavonoids and
flavonoids, both aglycones and glycosylated compounds
QUESTIONI DI LIBERTÀ, FELICITÀ E BONHEUR NEL XVII SECOLO. UNA PREMESSA SPINOZIANA PER BERNARD DE FONTENELLE
No full textIl "Du Bonheur" di Fontenelle rappresenta senz’altro il punto di svolta dell’idea principe della morale sei-settecentesca, su cui centinaia e centinaia di menti, di diversa provenienza e obiettivi, si erano concentrate. Il filosofo francese assume Spinoza come punto di riferimento, per quanto si tratti di uno Spinoza piegato a esigenze esclusivamente pratiche, come tipico di una intera tradizione del libero pensiero
Effectiveness and safety of secukinumab in Italian patients with psoriasis: an 84 week, multicenter, retrospective real-world study
No full textBackground: Long term data on the real-life use of secukinumab are scant. The aim of this study was to investigate the real-life effectiveness, safety and treatment persistence of secukinumab in patients with moderate-to-severe psoriasis. Research design and methods: This 84-week, multicenter (n = 7) retrospective study analyzed data from patients who initiated and received at least 6 months of secukinumab treatment between June 2016 and June 2018 in the Campania region of Italy. Patient demographic and treatment characteristics, duration of treatment and reasons for discontinuation as well as Psoriasis Area and Severity Index (PASI), Body Surface Area (BSA), and Dermatology Life Quality Index (DLQI) scores were assessed. Results: 324 patients (63% male, mean age 50.2 years) were enrolled and received a mean 11.7 months of secukinumab treatment. Overall, 9.5% discontinued secukinumab, including 5.2% who discontinued due to secondary inefficacy and 1.8% due to adverse events. PASI, BSA and DLQI scores were significantly improved from baseline at every follow-up visit (p < 0.001) and mean PASI decreased from 15.3 ± 6.3 at baseline to 0.5 ± 1.0 at week 84. Secukinumab had comparable effectiveness in biologic naïve and non-naïve patients. Conclusions: This study confirmed the effectiveness and safety of secukinumab in real-world patients with psoriasis
Posttransplant cyclophosphamide vs antithymocyte globulin in HLA-mismatched unrelated donor transplantation
No full textThe use of anti-thymocyte globulin (ATG) has represented the standard of care in graft-versus-host disease (GVHD) prophylaxis in patients undergoing a mismatched unrelated donor (MMUD) transplant. The safety and feasibility of posttransplant cyclophosphamide (PTCY) in this setting have been reported recently, but no study has compared the outcomes of PTCY vs ATG in 9/10 MMUD transplants. Using the registry data of the Acute Leukemia Working Party of the European Society for Blood and Marrow Transplantation, we performed a matched-pair analysis comparing those 2 strategies in a 9/10 MMUD setting. Ninety-three patients receiving PTCY were matched with 179 patients receiving ATG. A significantly lower incidence of severe acute GVHD was observed with PTCY compared with ATG. Recipients of the former also showed higher leukemia-free survival and GVHD/relapse-free survival (GRFS). When performing a subgroup analysis including patients receiving peripheral blood stem cells, being in complete remission, or receiving the same associated immunosuppressive agents, superiority of PTCY over ATG was confirmed. Similar to the haploidentical setting, use of PTCY is an effective anti-GVHD prophylaxis in the 9/10 MMUD transplant. Use of PTCY may also provide better outcomes in long-term disease control. These results need confirmation in large prospective randomized trials