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INCREASED ABSORPTION OF CURCUMIN AND RESVERATROL IN A CHOCOLATE MATRIX IN A HUMAN IMMORTALIZED KERATINOCYTE IN VITRO MODEL SYSTEM
No full textSeismic response of a geological, historical and architectural site: the Gerace cliff (southern Italy)
No full textAccommodation, slip inversion, and fault segmentation in a province-scale shear zone from high-resolution, densely spaced wide-aperture seismic profiling, Centennial Valley, MT, USA
No full textWe acquired a ~9-km long, high-resolution reflection seismic profile in the Centennial Valley, Montana, to better understand the kinematics of basin bounding faults and their role in accommodating proposed right-lateral shear in the Northern Basin and Range adjacent to the Yellowstone hotspot. In pursuing these goals, our findings have also shed light on the development of hanging wall stratigraphy and seismic hazards for this part of the SW Montana seismic belt. Here we present the profile and a working interpretation that identifies fault inversion, and an oblique, anticlinal accommodation zone linking the Centennial and Lima Reservoir faults in the Centennial Valley. These interpretations are consistent with seismicity and GPS-geodetically observed right-lateral shear aligned with the Centennial Valley north of the Yellowstone hotspot. Data were acquired using dense, wide-aperture arrays and illuminate the subsurface stratigraphy and faults down to ~1200 m, showing that the basin is a half-graben with a southern depocenter driven by the listric geometry of the north-dipping Centennial fault. Reflectors onlap basement highs with growth geometry against these faults. Our interpretation of a bright basal reflection as the Timber Hill Basalt (~6 Ma) or related flow, is consistent with a late Miocene - Pliocene inception of the basin proposed by other research. We also note a small inversion structure that we interpret as local evidence of transpression in the shear zone. This transpression is part of the accommodation zone and seismogenic faults including the Lima Reservoir fault that has well-expressed Holocene surface ruptures a few kilometres west of the seismic line along the northern edge of the Centennial basin
Riflettendo su MIfid2La attuazione della Product governance e la sovrapposizione di fonti normative
No full textLa relazione ha ripercorso la disciplina introdotta prima dalla Mifid e poi dalla Mifid2 a tutela degli investitori dopo le crisi finanziarie. Le nuove norme del settore mobiliareanche se predispongono nuovi e penetranti controlli sui prodotti finanziari rischiano di sovrapporsi a norme introdotte dalle Direttiva BRRD che richiedono l'emissione di titoli altamente rischiosi (MREl)per prevenire l'incidenza di fattori di rischio, e che sono poco indicati per i risparmiatori retail
Application of numerical simulation for the estimation of die life after repeated hot forging work cycles
No full textDie life estimation in hot forging processes is a compelling challenge, due to the number of factors, mainly wear and plastic deformation induced by thermal effects (tempering). The extent of the heating-cooling cycle and the steady state die temperature are known only after hundredth of work cycles. In the paper a realistic work sequence of repeated forging is simulated by the Finite Elements Method on a symmetrical workpiece geometry, for ease of calculation. Tool wear and tempering-induced deformation are estimated along the complete die life cycle, with the help of Neural Network Regression
Geomorphology of coastal marine environments and their evolution
No full textDescrizione dei principali processi geomorfici e dinamico-evolutivi delle coste basse clastiche ed in particolare delle spiagge urbane, in relazione a cambiamenti climatici, oscillazioni del livello marino, moti verticali del suolo ed attività antropiche, con esempi di numerosi casi studio in zone a clima di tipo mediterraneo
Education in England and Continental Europe in the Early Modern Period, in Comparative Legal History: Methodology and Legal Sources, Institutions and Codifications
No full textThe European legal tradition has handed down to us the cliché of a marked contrast between common law, assumed to be an oral and exclusively case-law, and civil law, seen as a written and doctrinal law rationalized and formalized through codification. According to this view, common law would have developed, since the 12th century, in continuity with the past and the ancient customs of the country, through the stratification of judicial precedents; while civil law would have developed through the doctrinal interpretation and elaboration of the roman-canon law texts on behalf of the doctores of the Continental Universities.
One of the consequences of the presumed dichotomy between the two “systems” of common and civil law – dichotomy destined to take deep root in the European legal consciousness and not challenged until very recently - has been the juxtaposition between the English and Continental systems of legal education. It has been highlighted, infact, that while in England during the Early Modern Period law students were educated in the Inns of Courts through an oral and practical training, on the Continent legal education, held by the Universities spread all over Europe, had a much more theoretical and doctrinal character.
The essay challenges the assumption of a marked contrast between the English and Continental systems of legal education during the period under examination. Focusing on the characters of the lecturae and disputationes held at the Italian Universities and the readings and moots practiced at the English Inns of Court, the essay stresses the existence of many similarities between them, showing how the traditional paradigm of the contraposition between common law and civil law cannot be applied tout court to legal education in Europe between the Middle Ages and the Early Modern Period
A novel homozygous KCNQ3 loss-of-function variant causes non-syndromic intellectual disability and neonatal-onset pharmacodependent epilepsy
No full textOBJECTIVE:
Heterozygous variants in KCNQ2 or, more rarely, KCNQ3 genes are responsible for early-onset developmental/epileptic disorders characterized by heterogeneous clinical presentation and course, genetic transmission, and prognosis. While familial forms mostly include benign epilepsies with seizures starting in the neonatal or early-infantile period, de novo variants in KCNQ2 or KCNQ3 have been described in sporadic cases of early-onset encephalopathy (EOEE) with pharmacoresistant seizures, various age-related pathological EEG patterns, and moderate/severe developmental impairment. All pathogenic variants in KCNQ2 or KCNQ3 occur in heterozygosity. The aim of this work was to report the clinical, molecular, and functional properties of a new KCNQ3 variant found in homozygous configuration in a 9-year-old girl with pharmacodependent neonatal-onset epilepsy and non-syndromic intellectual disability.
METHODS:
Exome sequencing was used for genetic investigation. KCNQ3 transcript and subunit expression in fibroblasts was analyzed with quantitative real-time PCR and Western blotting or immunofluorescence, respectively. Whole-cell patch-clamp electrophysiology was used for functional characterization of mutant subunits.
RESULTS:
A novel single-base duplication in exon 12 of KCNQ3 (NM_004519.3:c.1599dup) was found in homozygous configuration in the proband born to consanguineous healthy parents; this frameshift variant introduced a premature termination codon (PTC), thus deleting a large part of the C-terminal region. Mutant KCNQ3 transcript and protein abundance was markedly reduced in primary fibroblasts from the proband, consistent with nonsense-mediated mRNA decay. The variant fully abolished the ability of KCNQ3 subunits to assemble into functional homomeric or heteromeric channels with KCNQ2 subunits.
SIGNIFICANCE:
The present results indicate that a homozygous KCNQ3 loss-of-function variant is responsible for a severe phenotype characterized by neonatal-onset pharmacodependent seizures, with developmental delay and intellectual disability. They also reveal difference in genetic and pathogenetic mechanisms between KCNQ2- and KCNQ3-related epilepsies, a crucial observation for patients affected with EOEE and/or developmental disabilities
La Cassazione e l’usura... per fatto del debitore (“Aberrazioni” giurisprudenziali in tema interessi di mora e usura)
No full textCon l’ordinanza del 30 ottobre 2018 n. 27442 la Cassazione propone, per la prima volta, un articolato
tentativo di spiegazione dell’orientamento secondo cui anche gli interessi convenzionali di mora
sarebbero suscettibili di essere qualificati come usurari, ove fissati in una misura superiore alla soglia
usura della categoria di operazioni di finanziamento cui accede. L’Autore esprime un fermo dissenso
rispetto a tale impostazione, sottolineando non solo le contraddizioni interne al ragionamento della Corte
e l’infondatezza dell’argomento basato sulla pretesa identità di funzione degli interessi moratori e
corrispettivi, ma anche l’irragionevolezza complessiva dell’impostazione, che finisce per far dipendere
la concreta connotazione usuraria del finanziamento dalla scelta del debitore di rendersi inadempiente
all’obbligo di restituzione della somma alla scadenza. In realtà il problema sotteso all’ordinanza - ossia il
rischio che, non applicandosi il limite della soglia agli interessi convenzionali moratori, questi possano
essere pattuiti anche inmisura eccessivamente elevata - trova già una risposta nell’ordinamento, senza
bisogno di evocare la disciplina antiusura, nelle norme che consentono al giudice di sindacare l’equità
della clausola penale