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"I really can't exhibit it". Omosessualità, autobiografia e (auto)censura in The Picture of Dorian Gray (1890-91) di Oscar Wilde
No full textIn alternativa alle correnti interpretazioni di 'Dorian Gray' come romanzo sul doppio, il saggio rilegge il capolavoro wildiano alla luce delle dinamiche censorie dell'epoca, delle leggi sull'omosessualità e del rapporto autore/testo. La riluttanza del pittore ad esporre il ritratto di Dorian viene dunque riletta come proiezione dei dubbi dell'autore stesso riguardo alla pubblicabiltà della sua opera. Tale tesi è suffragata, oltre che da una serrata analisi del testo, anche dal confronto con una serie di metatesti (in particolare, le lettere di Wilde) e dalla ricostruzione delle autocensure autorali nelle tre principali versioni del romanzo
Libertà religiosa ed eguaglianza. Casi di discriminazione in Europa e nel contesto internazionale
No full textComputational approaches from polymer physics to investigate chromatin folding
No full textMicroscopy and sequencing-based technologies are providing increasing insights into chromatin architecture. Nevertheless, a full comprehension of chromosome folding and its link with vital cell functions is far from accomplished at the molecular level. Recent theoretical and computational approaches are providing important support to experiments to dissect the three-dimensional structure of chromosomes and its organizational mechanisms. Here, we review, in particular, the String&Binders polymer model of chromatin that describes the textbook scenario where contacts between distal DNA sites are established by cognate binders. It has been shown to recapitulate key features of chromosome folding and to be able at predicting how phenotypes causing structural variants rewire the interactions between genes and regulators
Saggi di Procedura penale europea
No full textNel volume sono raccolti studi incentrati, in varie modulazioni e con diverso metodo, su temi di procedura penale che testimoniano i condizionamenti, sempre più penetranti, della integrazione tra diritto interno e diritto sovranazionale sul processo, sulle regole che lo disciplinano, sui diritti che ne sono coinvolti
Validation of University Entrance Tests Through Rasch Analysis
No full textInitial preparation of first year university students is often assessed by means of an entrance examination, which tests their knowledge of mathematics and science as well as their reading skills. The present study illustrates how we used Rasch analysis to: (i) investigate the reliability and construct validity of a typical university entrance test administered in Italy; (ii) explore the extent to which mathematics, science and reading items differ in their difficulty. Two studies were set up. In study 1, we analyzed the psychometric quality of an 80-item test administered in 2016 to N=2435 science and engineering freshmen. In study 2, we analyzed the responses of N=1223 students to a 100-item entrance test administered in 2017, 2018 and 2019 to an extended population of students. Results of both studies show that the analyzed entrance tests do not match unidimensional requirement, as proficiency in mathematics, science and reading capability correspond to distinct latent traits. Moreover, items on different scientific topics have significantly different difficulty. The study shows a need for revising the analyzed tests to meet unidimensionality requirements. Moreover, the analysis of items’ difficulty suggests balancing in a more suitable way the difficulty of the different content areas
The Role of Mobile Health Technologies in Allergy Care: an EAACI Position Paper
No full textMobile Health (mHealth) uses mobile communication devices such as smartphones and tablet computers to support and improve health-related services, data flow and information, patient self-management, surveillance, and disease management from the moment of first diagnosis to an optimized treatment. The European Academy of Allergy and Clinical Immunology created a task force to assess the state of the art and future potential of mHealth in allergology. The task force endorsed the "Be He@lthy, Be Mobile" WHO initiative and debated the quality, usability, efficiency, advantages, limitations, and risks of mobile solutions for allergic diseases. The results are summarized in this position paper, analyzing also the regulatory background with regard to the "General Data Protection Regulation" and Medical Directives of the European Community. The task force assessed the design, user engagement, content, potential of inducing behavioral change, credibility/accountability, and privacy policies of mHealth products. The perspectives of health care professionals and allergic patients are discussed, underlining the need of thorough investigation for an effective design of mHealth technologies as auxiliary tools to improve quality of care. Within the context of precision medicine, these could facilitate the change in perspective from clinician- to patient-centered care. The current and future potential of mHealth is then examined for specific areas of allergology, including allergic rhinitis, aerobiology, allergen immunotherapy, asthma, dermatological diseases, food allergies, anaphylaxis, insect venom, and drug allergy. The impact of mobile technologies and associated big data sets are outlined. Facts, recommendations, and an action plan for future mHealth initiatives within EAACI are listed. This article is protected by copyright. All rights reserved
Cellulose absorbable barrier for prevention of de-novo adhesion formation at the time of laparoscopic myomectomy: A systematic review and meta-analysis of randomized controlled trials
No full textOBJECTIVE:
Myomectomy is the standard surgical treatment for symptomatic uterine leiomyomas, especially for patients wishing to preserve their fertility. However, this procedure is associated with adhesion formation. Several strategies have been proposed to reduce them. Cellulose absorbable barrier is widely used. We aimed to assess its effectiveness in the prevention of de-novo adhesion formation after laparoscopic myomectomy.
STUDY DESIGN:
A systematic review and meta-analysis was performed by searching electronic databases (i.e. MEDLINE, Scopus, ClinicalTrials.gov, EMBASE, Sciencedirect, the Cochrane Library at the CENTRAL Register of Controlled Trials, Scielo) from their inception until May 2019. We included all randomized clinical trials (RCT) comparing use of cellulose absorbable barrier (i.e. intervention group) with either placebo or no treatment (i.e. control group) in the prevention of de-novo adhesion formation at the time of laparoscopic myomectomy. Primary and secondary outcomes were defined before data extraction. The primary outcome was the incidence of adhesions at second-look laparoscopy. The secondary outcome was the operative time.
RESULTS:
Three RCT, including 366 participants, were included. All trials evaluated women undergoing laparoscopic myomectomy who were randomized to intervention (either oxidized regenerated cellulose or carboxymethylcellulose powder adhesion barrier) or no treatment (control group). Women who received treatment had significantly lower incidence of adhesions at the second look laparoscopy (RR 0.63, 95 % CI 0.40-0.99). Interventions with use of cellulose absorbable barrier were 4 min longer (MD 4 min, 95 % CI 2.82-5.18).
CONCLUSION:
Use of cellulose absorbable barrier at the time of laparoscopic myomectomy reduces the risk of postoperative adhesions
