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Vascular leaking, a pivotal and early pathogenetic event in systemic sclerosis: Should the door be closed?
No full textThe early phase of systemic sclerosis (SSc) presents edema as one of the main features: this is clinically evident in the digital swelling (puffy fingers) as well as in the edematous skin infiltration of the early active diffuse subset. Other organs could be affected by this same disease process, such as the lung (with the appearance of ground glass opacities) and the heart (with edematous changes on cardiac magnetic resonance imaging). The genesis of tissue edema is tightly linked to pathological changes in the endothelium: various reports demonstrated the effect of transforming growth factor β, vascular endothelial growth factor and hypoxia-reperfusion damage with reactive oxygen species generation in altering vascular permeability and extravasation, in particular in SSc. This condition has an alteration in the glycocalyx thickness, reducing the protection of the vessel wall and causing non-fibrotic interstitial edema, a marker of vascular leak. Moreover, changes in the junctional adhesion molecule family and other adhesion molecules, such as ICAM and VCAM, are associated with an increased myeloid cells' extravasation in the skin and increased myofibroblasts transformation with further vascular leak and cellular migration. This mini-review examines current knowledge on determinants of vascular leak in SSc, shedding light on the role of vascular protection. This could enhance further studies in the light of drug development for early treatment, suggesting that the control of vascular leakage should be considered in the same way that vasodilation and inflammation reduction, as potential therapeutic targets
Peroxisome proliferator activated receptor and cannabinoids
No full textCannabinoids are a complex group of molecules that comprise phytocannabinoids, endocannabinoids and synthetic cannabinoids. Cannabinoids were initially identified by its ability to bind and activate the classical cannabinoid receptors CB1 and CB2. However, cannabinoids are pleiotropic in nature and also activate other type of receptors such as transient receptor potential cation channels, ligand-gated ion channels, deorphanized G protein-coupled receptors and peroxisome proliferator activated receptors such as PPAR. Thus, cannabinoids may exert their biological activities through CB1/CB2-dependent and –independent mechanisms, or a combination of both, which is especially relevant in the case of botanical drugs containing mixtures of phytocannabinoids. PPAR exert a wide variety of physiological functions and its pharmacological manipulation has been exploited for the treatment of diabetes. In addition, PPAR is recognized as a major target for the development of novel therapies aimed to manage chronic inflammatory and neurodegenerative diseases. Herein we review the published literature on cannabinoids and PPAR and discuss their potential therapeutic implications
L'istruzione degli adulti nei CPIA in Campania. Rapporto preliminare del Centro Regionale di Ricerca, Sperimentazione e Sviluppo
No full textLe contraddizioni tra le ragioni del mercato, proiettato verso la competizione tra
gli attori, e i diritti/bisogni dei cittadini, irrinunciabili in un’ottica di democrazia ed
equità, si riflettono inevitabilmente sulle politiche di lifelong learning, sottolineando
la necessità di offrire modelli capaci di interpretare le traiettorie di inclusione/esclusione
senza prescindere dal riconoscimento reale delle “voci” di coloro che apprendono.
Voci che emergono con chiarezza dalle evidenze empiriche di questo
primo Rapporto di ricerca, esito del processo di valutazione partecipata del Sistema
di istruzione degli adulti messo in campo dal Centro Regionale di Ricerca, Sperimentazione
e Sviluppo istituito dal MIUR in Campania. Lo studio è il risultato di
una curiosità sostantiva relativa ai meccanismi e ai processi che hanno orientato
l’agire sociale delle istituzioni nel percorso verso la definizione del sistema regionale
campano di apprendimento permanente, al ruolo dei diversi attori, e alle caratteristiche
che presentano la domanda e l’offerta di istruzione degli adulti nei
diversi contesti nei quali sono state implementate le politiche
Introducción al monográfico Sistema, codificación e interpretación. Aproximaciones al análisis de la lengua y su didáctica en una perspectiva metaoperacional.
No full textLa supuesta no concordancia de los tiempos verbales en textos narrativos orales como estrategia discursiva
No full textDue to the use of a resource that is, in this particular case, the temporal agreement or what is here defined as an “apparent non-temporal agreement” with respect to oral narrative texts, the organization that the speaker / enunciator plans as a means to achieve given communicative purposes may be seen as a discursive strategy. “Apparent” because, indeed, what seems to break the rules of the classic Consecutio Temporum, actually follows some rules of their own that, when they are not respected, lead to a communicative sanction. In this paper, we will try to show that verbal forms do not always convey purely temporal
information, but they are often used to achieve a pragmatic goal, thanks to the implementation of discursive strategies
Giovanni Attuario. L'eccellente trattato sulle urine di Avicenna
No full textEdizione critica con introduzione e note di commento di un testo di uroscopia di origine araba, finora inedito ma molto diffuso nel quattordicesimo secolo
La sépulture des non catholiques à Naples entre XVIIIe et XIXe siècle : règles et exceptions de l'intolérance
No full textLes dynamiques de rencontre et d’affrontement entre cultures différentes font l’objet de l’intérêt des sciences humaines depuis longtemps. Le décès des personnes de confession différente de celle de la communauté d’accueil c’est un problème constant au cours de l’Ancien Régime européen. Dans ce contexte, le cas de la ville de Naples est particulièrement intéressant. Le rôle important de cette ville méditerranéenne dans les trafics commerciaux déterminait une présence constante d’étrangers. Frontière physique et culturelle de l’Europe occidentale, Naples développe au cours du XVIIIe siècle une florissante culture des lumières. Cependant, la condition d’état confessionnel ne permettait pas d’établir un régime de tolérance. Par conséquent, parallèlement aux règles rigides de la ségrégation sociale sur base religieuse, une série de compromis a été expérimentée pour ne pas compromettre les rapports avec les rapports économiques avec les communautés étrangères