JURNAL AGROTEKNOLOGI
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DyNeuMo Mk-1: Design and pilot validation of an investigational motion-adaptive neurostimulator with integrated chronotherapy.
No full textThere is growing interest in using adaptive neuromodulation to provide a more personalized therapy experience that might improve patient outcomes. Current implant technology, however, can be limited in its adaptive algorithm capability. To enable exploration of adaptive algorithms with chronic implants, we designed and validated the ‘Picostim DyNeuMo Mk-1’ (DyNeuMo Mk-1 for short), a fully-implantable, adaptive research stimulator that titrates stimulation based on circadian rhythms (e.g. sleep, wake) and the patient's movement state (e.g. posture, activity, shock, free-fall). The design leverages off-the-shelf consumer technology that provides inertial sensing with low-power, high reliability, and relatively modest cost. The DyNeuMo Mk-1 system was designed, manufactured and verified using ISO 13485 design controls, including ISO 14971 risk management techniques to ensure patient safety, while enabling novel algorithms. The system was validated for an intended use case in movement disorders under an emergency-device authorization from the Medicines and Healthcare Products Regulatory Agency (MHRA). The algorithm configurability and expanded stimulation parameter space allows for a number of applications to be explored in both central and peripheral applications. Intended applications include adaptive stimulation for movement disorders, synchronizing stimulation with circadian patterns, and reacting to transient inertial events such as posture changes, general activity, and walking. With appropriate design controls in place, first-in-human research trials are now being prepared to explore the utility of automated motion-adaptive algorithms
The effect of mindfulness-based programmes on elite athlete mental health: A systematic review and meta-analysis
No full textMeta-analysis. Data extracted from primary papers, or requested from authors of paper if not available in the manuscript
The politics of data visualisation and policy making
No full textData visualisation has become ubiquitous in everyday life, from seeing images in news media to tracking individual health indicators. While the effects of data visualisation on society and people have been explored within a range of literature, there has been far less attention paid to the interconnectedness of data visualisation and policy making. In this special issue, we explore how data visualisation matters for policy priorities, processes and outcomes; how it reflects the demands and constraints posed by specific policy problems; and finally, what data visualisations reveal about broader political, social, and cultural shifts and the implications for policy
Community engagement for malaria elimination in the Greater Mekong Sub-region: a qualitative study among malaria researchers and policymakers
No full textBackground
Community engagement has increasingly received attention in malaria research and programme interventions, particularly as countries aim for malaria elimination. Although community engagement strategies and activities are constantly developing, little is known about how those who implement research or programmes view community engagement. This article explores the perspectives of researchers and policy makers in the Greater Mekong Sub-region (GMS) on community engagement for malaria control and elimination.
Methods
Semi-structured interviews were conducted among 17 policymakers and 15 senior researchers working in the field of malaria. All interviews were audio-recorded and transcribed in English. Transcribed data were analysed using deductive and inductive approaches in QSR NVivo. Themes and sub-themes were generated.
Results
Researchers and policymakers emphasized the importance of community engagement in promoting participation in malaria research and interventions. Building trust with the community was seen as crucial. Respondents emphasized involving authority/leadership structures and highlighted the need for intense and participatory engagement. Geographic remoteness, social, cultural, and linguistic diversity were identified as barriers to meaningful engagement. Local staff were described as an essential ‘connect’ between researchers or policymakers and prospective participants. Sharing information with community members, using various strategies including creative and participatory methods were highlighted.
Conclusions
Policymakers and researchers involved in malaria prevention and control in the GMS viewed community engagement as crucial for promoting participation in research or programmatic interventions. Given the difficulties of the ‘last mile’ to elimination, sustained investment in community engagement is needed in isolated areas of the GMS where malaria transmission continues. Involving community-based malaria workers is ever more critical to ensure the elimination efforts engage hard-to-reach populations in remote areas of GMS
Integrating palliative care and heart failure: a protocol for a realist synthesis (PalliatHeartSynthesis)
No full textIntroduction Heart failure affects over 26 million people worldwide with prevalence expected to grow due to an ageing global population. Palliative care can address the holistic needs of patients with heart failure, and integrated palliative care in heart failure management has been indicated to improve outcomes for patients. Despite known benefits for integrated palliative care in heart failure management, implementation is poor across the majority of global health services. Recent systematic reviews have identified the benefits of integrating palliative care into heart failure management and highlighted barriers to implementation. However, there was heterogeneity in terms of countries, healthcare settings, delivery by differing staff across multidisciplinary teams, modes of delivery and different intervention components.
Methods and analysis The aim of this study is to identify how integrated palliative care and heart failure interventions produce desired outcomes, in which contexts, and for which patients. We will undertake a realist synthesis to identify this, using Pawson’s five iterative steps. We will recruit an international stakeholder group comprised of healthcare providers and patients with heart failure to advise and provide feedback throughout the review. Our initial realist programme theory sets out the necessary steps needed to accomplish the final intended outcome(s) from the implementation of integrated palliative care and heart failure. This initial programme theory will be shaped through an iterative process of testing and refinement.
Ethics and dissemination Ethical approval is not required for this study. With our stakeholder group, we will coproduce a user guide that outlines practical advice to optimise, tailor and implement interventions designed to integrate palliative care and heart failure, taking into consideration local context, alongside user-friendly summaries of the synthesis findings using short animations to convey complex findings. We will draw on the expertise within the stakeholder group to identify key stakeholders for disseminating to relevant audiences, ensuring outputs are tailored for their respective needs.
PROSPERO registration number CRD42021240185
Longitudinal changes of early motor and cognitive symptoms in progressive supranuclear palsy: the OxQUIP study
No full textBackground Progressive supranuclear palsy (PSP) is a rare neurodegenerative condition characterised by a range of motor and cognitive symptoms. Very little is known about the longitudinal change in these symptoms over time. Moreover, the effectiveness of clinical scales to detect early changes in PSP is still a matter of debate.
Objective We aimed to determine longitudinal changes in PSP features using multiple closely spaced follow-up time points over a period of 2 years.
Methods
28 healthy control and 28 PSP participants, with average time since onset of symptoms of 1.9 years, were prospectively studied every 3 months for up to 24 months. Changes from baseline scores were calculated at each follow-up time point using multiple clinical scales to identify longitudinal progression of motor and cognitive symptoms.
Results The Montreal Cognitive Assessment, but not the Mini-Mental State Examination, detected cognitive decline at baseline. Both scales revealed poor longitudinal sensitivity to clinical change in global cognitive symptoms. Conversely, the Movement Disorders Society Unified Parkinson’s disease Rating Scale – part III and the PSP Rating Scale (PSPRS) reliably detected motor decline less than 2 years after disease onset. The ‘Gait/Midline’ PSPRS subscore consistently declined over time, with the earliest change being observed 6 months after baseline assessment.
Conclusion While better cognitive screening tools are still needed to monitor cognitive decline in PSP, motor decline is consistently captured by clinical rating scales. These results support the inclusion of multiple follow-up time points in longitudinal studies in the early stages of PSP
Metabolomics data for: Altered glycolysis triggers impaired mitochondrial metabolism and mTORC1 activation in diabetic β-cells
No full textThese data support the paper "Altered glycolysis triggers impaired mitochondrial metabolism and mTORC1 activation in diabetic β-cells". We have investigated the mechanism(s) by which chronic hyperglycaemia and diabetes lead to impaired β-cell metabolism and if this is linked to activation of mTORC1. We show that a glycolytic metabolite downstream of glucokinase and upstream of GAPDH mediates the effects of diabetes and chronic hyperglycemia on β-cell metabolism. This occurs, in part, through marked upregulation of mTORC1, which leads to changes in metabolic gene expression, oxidative phosphorylation and insulin secretion. AMPK is concomitantly downregulated. In addition, diabetes dramatically inhibits the activity of GAPDH and PDH, which impairs both glycolytic metabolism and entry into the TCA cycle. Our results support the idea that progressive impairment of β-cell metabolism, induced by increasing hyperglycaemia, speeds T2D development, and suggest that reducing glycolysis at the level of glucokinase may slow this progression.
These data were produced from liquid chromatography-mass spectrometry analysis of: control and diabetic islets stimulated with 2 mM or 20 mM glucose (Fig. 3a,b & Suppl. Fig. 2), INS-1 (832/13) cells cultured for 48h with or without 5 μM koningic acid and subsequently stimulated with 2 mM or 20 mM glucose in the absence of koningic acid (Fig. 4a,b), and INS-1 cells cultured in 2 mM or 20 mM glucose (Suppl. Fig. 2). Anion-exchange chromatography-mass spectrometry (IC-MS) data were acquired on a Dionex IC-5000+ ion chromatography system hyphenated to a Thermo Fisher Scientific Q Exactive.
Data are .zip compressed to reduce file size. Data files are in .raw format and require Thermo Fisher Scientific Xcalibur software to analyse
KARAKTERISTIK ORGANOLEPTIK, KIMIA, DAN TOTAL MIKROBA PINDANG IKAN TONGKOL TERAWETKAN GARAM DAN SERBUK BIJI PICUNG (Pangium edule Reinw) SELAMA PENYIMPANAN
Full text linkPicung (Pangium edule Reinw) seeds had been used as fresh fish preservatives for a long time, there had not been reported about the boiled salted tuna using picung seeds. The aim of this research was to determine the chemical organoleptic properties and total microbe of boiled salted tuna with the addition of salt and picung seed powder during storage. This research consisted of 2 factors, those were variations of the salt concentration which consisted of G1 (the use of 10% of salt), G2 (the use of 15% of salt), and G3 (the use of 20% of salt) and the variations of picung seeds powder which consisted of P1 by adding 1% of picung seeds powder (150-200 g of the fish weight), P2 by adding 3%, and P3 by adding 5%. It was done three times. The organoleptic, chemical, and total plate count (TPC) of boiled salted tuna observation was done during 0, 3, 6, and 9 days of storage. The organoleptic test of boiled salted tuna by using 20 persons of the untrained panelists (permanent respondents). The organoleptic observation parameters consisted of appearance, aroma, taste, and mucous. The result of boiled salted tuna which used 15% (G15) and 20% (G20) of salt and added 3% (P3) and 5% (P5) of picung seeds powder could be still accepted by the panelist until in day-9. In addition, it was also able to maintain chemical properties up to day-6 of storage including parameters of free fatty acid and TVBN (total volatile basic nitrogen) content. The use of salt and powdered picung seeds with a ratio of 15%:5% (G15P5) and 20%:5% (G20P5) was able to maintain the amount of TPC until the day-6 of storage not to exceed the specified threshold.
Keywords: boiled salted tuna, organoleptic, TPC, TVB
KARAKTERISTIK FISIKOKIMIA TEPUNG CAMPOLAY (Pouteria campechiana) TERMODIFIKASI SECARA FISIK DAN BIOLOGI
Full text linkFlour modifications can be conducted to expand its utilization into processed products. This research aimed to study the effect of physical and biological modification on the physicochemical properties of canistel (Pouteria campechiana) flour. The research method included making canistel flour unmodified (native), physical modification using heat moisture treatment (HMT) method, and biological modification by fermentation. Physical properties analysis included color and morphology of starch granules, while chemical analysis included water content, total sugar content, starch content, amylose content, and amylopectin content. The data were analyzed statistically using One Way ANOVA and continued with the Duncan post hoc test. Statistical analysis showed that modification of canistel flour could decrease brightness and increase a value and decrease b value. Native, HMT-modified, and fermented-modified canistel flour had colors of incarnation, rose pink, and fresh plaster, respectively. In addition, the fermented modified canistel flour tends to have higher total sugar content, although the HMT modified flour tends to decrease compared to the native canistel flour. Modified canistel flour tends to have lower starch, amylose, and amylopectin content than native flour. Morphologically, modifications to canistel flour have no effect on flour morphology.
Keywords: fermentation, heat moisture treatment, modified flour, Pouteria campechian