JURNAL AGROTEKNOLOGI
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Alcohol drinking and risks of liver cancer and non-neoplastic chronic liver diseases in China: a 10-year prospective study of 0.5 million adults
No full textBackground
Alcohol consumption is an important risk factor for hepatic neoplastic and non-neoplastic diseases. Questions remain, however, about the relevance to disease risk of drinking patterns and alcohol tolerability, which differ appreciably between Chinese and Western populations.
Methods
The prospective China Kadoorie Biobank included 512,715 adults (41% men) aged 30–79 years recruited from ten areas during 2004–2008, recording alcohol intake, drinking patterns, and other characteristics. After median 10 years’ follow-up, 2531 incident liver cancer, 2040 liver cirrhosis, 260 alcoholic liver disease (ALD), and 1262 non-alcoholic fatty liver disease (NAFLD) cases were recorded among 492,643 participants without prior cancer or chronic liver disease at baseline. Cox regression was used to estimate adjusted hazard ratios (HR) relating alcohol intake and drinking patterns to each disease.
Results
Overall, 33% of men and 2% of women drank alcohol regularly (i.e. at least weekly) at baseline. Among male current regular drinkers, alcohol consumption showed positive dose-response associations with risks of several major chronic liver diseases, with HRs per 280 g/week (i.e. around four drinks/day) higher usual alcohol intake of 1.44 (95% CI 1.23–1.69) for liver cancer (n = 547), 1.83 (1.60–2.09) for liver cirrhosis (n = 388), 2.01 (1.77–2.28) for ALD (n = 200), 1.71 (1.35–2.16) for NAFLD (n = 198), and 1.52 (1.40–1.64) for total liver disease (n = 1775). The association with ALD appeared stronger among men reporting flushing (i.e., with low alcohol tolerance). After adjustment for the total amount of weekly alcohol consumption, daily drinkers had significantly increased risk of ALD (2.15, 1.40–3.31) compared with non-daily drinkers, and drinking without meals was associated with significantly greater risks of liver cancer (1.32, 1.01–1.72), liver cirrhosis (1.37, 1.02–1.85), and ALD (1.60, 1.09–2.33) compared with drinking with meals. Female current regular drinkers had significantly higher risk of ALD, but not other liver diseases, than female abstainers.
Conclusions
In Chinese men, alcohol intake was associated with significantly increased risks of several major chronic liver diseases, and certain drinking patterns (e.g. drinking daily, drinking without meals) may further exacerbate the disease risks
Synergistic effect between 3′-terminal noncoding and adjacent coding regions of the influenza A virus hemagglutinin segment on template preference
No full textThe influenza A virus genome is comprised of eight single-stranded negative-sense viral RNA (vRNA) segments. Each of the eight vRNA segments contains segment-specific nonconserved noncoding regions (NCRs) of similar sequence and length in different influenza A virus strains. However, in the subtype-determinant segments, encoding hemagglutinin (HA) and neuraminidase (NA), the segment-specific noncoding regions are subtype specific, varying significantly in sequence and length at both the 3′ and 5′ termini among different subtypes. The significance of these subtype-specific noncoding regions (ssNCR) in the influenza virus replication cycle is not fully understood. In this study, we show that truncations of the 3′-end H1-subtype-specific noncoding region (H1-ssNCR) resulted in recombinant viruses with decreased HA vRNA replication and attenuated growth phenotype, although the vRNA replication was not affected in single-template RNP reconstitution assays. The attenuated viruses were unstable, and point mutations at nucleotide position 76 or 56 in the adjacent coding region of HA vRNA were found after serial passage. The mutations restored the HA vRNA replication and reversed the attenuated virus growth phenotype. We propose that the terminal noncoding and adjacent coding regions act synergistically to ensure optimal levels of HA vRNA replication in a multisegment environment. These results provide novel insights into the role of the 3′-end nonconserved noncoding regions and adjacent coding regions on template preference in multiple-segmented negative-strand RNA viruses
Association between current medication use and progression of radiographic knee osteoarthritis: data from the Osteoarthritis Initiative
No full textObjective
Use of specific medications may accelerate the progression of radiographic knee osteoarthritis (RKOA). Our aim was to examine the effect of medication use on the progression of RKOA.
Methods
We used longitudinal data from the Osteoarthritis Initiative (OAI); an observational study of risk factors for knee OA. At baseline, we selected participants with RKOA (KL grade ≥2) and excluded those with a history of knee-related injury/surgery and other musculoskeletal disorders. Current medication use (use/non-use in the previous 30 days) and radiographic medial minimum joint space width (mJSW) data were available at baseline and annually up to 96-months follow-up. We used random-effects, panel-regression to assess the association between current medication use (non-users as reference group) and change in mJSW.
Results
Of 2,054 eligible participants, 2,003 participants with baseline mJSW data were included (55.7% female, mean age 63.3 (SD 8.98) years). Of 7 medication classes, at baseline non-steroidal anti-inflammatory drugs (NSAIDs) were the most frequently used analgesia (14.7%), anti-histamine (10.4%) use were frequent and, the following comorbidity medications were used most frequently; i) statins (27.4%), ii) anti-hypertensives (up to 15.0%), iii) anti-depressant/anxiolytics/psychotropics (14.0%), iv) osteoporosis-related medication (10.9%) and v) diabetes-related medication (6.9%). Compared with current non-users, current use of NSAIDs was associated with a loss of mJSW (b = -0.042, 95% CI -0.08 to -0.0004). No other associations were observed.
Conclusions
In current users of NSAIDs, mJSW loss was increased compared with current non-users in participants with RKOA. Clinical trials are required to assess the potential disease-modifying effects of these medications
The challenges for England’s post-conviction review body: deference to Juries, the Principle of Finality and the Court of Appeal
No full textSince 1997, the Criminal Cases Review Commission of England, Wales and Northern Ireland has served as a state-funded post-conviction body to consider claims of wrongful conviction for those who have exhausted their rights to appeal. A meticulous organisation that has over its lifetime referred over 700 cases back to the Court of Appeal, with over sixty percent of those applicants having their convictions quashed, it is nonetheless restricted in its response to cases by its own legislation. This shapes its decision-making in reviewing cases, causing it to be somewhat deferential to the original jury, to the principle of finality and, most importantly, to the Court of Appeal, the only institution that can overturn a wrongful conviction. In mandating such deference, the legislation causes the Commission to have one eye on the Court’s evolving jurisprudence but leaves room for institutional and individual discretion, evidenced in some variability in responses across the Commission. While considerable variability would be difficult to defend, some inconsistency raises the prospects for a shift towards a less deferential referral culture. This article draws on original research by the author to consider the impact of institutional deference on the work of the Criminal Cases Review Commission and argues for a slightly bolder approach in its work
The Independent Volcanic Eruption Source Parameter Archive (IVESPA, version 1.0): a new observational database to support explosive eruptive column model validation and development
No full textEruptive column models are powerful tools for investigating the transport of volcanic gas and ash, reconstructing past explosive eruptions, and simulating future hazards. However, the evaluation of these models is challenging as it requires independent estimates of the main model inputs (e.g. mass eruption rate) and outputs (e.g. column height). There exists no database of independently estimated eruption source parameters (ESPs) that is extensive, standardized, maintained, and consensus-based. This paper introduces the Independent Volcanic Eruption Source Parameter Archive (IVESPA, ivespa.co.uk), a community effort endorsed by the International Association of Volcanology and Chemistry of the Earth's Interior (IAVCEI) Commission on Tephra Hazard Modelling. We compiled data for 134 explosive eruptive events, spanning the 1902-2016 period, with independent estimates of: i) total erupted mass of fall deposits; ii) duration; iii) eruption column height; and iv) atmospheric conditions. Crucially, we distinguish plume top versus umbrella spreading height, and the height of ash versus sulphur dioxide injection. All parameter values provided have been vetted independently by at least two experts. Uncertainties are quantified systematically, including flags to describe the degree of interpretation of the literature required for each estimate. IVESPA also includes a range of additional parameters such as total grain size distribution, eruption style, morphology of the plume (weak versus strong), and mass contribution from pyroclastic density currents, where available. We discuss the future developments and potential applications of IVESPA and make recommendations for reporting ESPs to maximize their usability across different applications. IVESPA covers an unprecedented range of ESPs and can therefore be used to evaluate and develop eruptive column models across a wide range of conditions using a standardized dataset
Morphology of active deformable 3D droplets
No full textWe numerically investigate the morphology and disclination line dynamics of active nematic droplets in three dimensions. Although our model incorporates only the simplest possible form of achiral active stress, active nematic droplets display an unprecedented range of complex morphologies. For extensile activity, fingerlike protrusions grow at points where disclination lines intersect the droplet surface. For contractile activity, however, the activity field drives cup-shaped droplet invagination, run-and-tumble motion, or the formation of surface wrinkles. This diversity of behavior is explained in terms of an interplay between active anchoring, active flows, and the dynamics of the motile disclination lines. We discuss our findings in the light of biological processes such as morphogenesis, collective cancer invasion, and the shape control of biomembranes, suggesting that some biological systems may share the same underlying mechanisms as active nematic droplets
The famous stone: the alchemical tropes of George Herbert’s “The Elixir” in their late Renaissance context
No full textEuropean Resuscitation Council Guidelines 2021: newborn resuscitation and support of transition of infants at birth
No full textThe European Resuscitation Council has produced these newborn life support guidelines, which are based on the International Liaison Committee on Resuscitation (ILCOR) 2020 Consensus on Science and Treatment Recommendations (CoSTR) for Neonatal Life Support. The guidelines cover the management of the term and preterm infant. The topics covered include an algorithm to aid a logical approach to resuscitation of the newborn, factors before delivery, training and education, thermal control, management of the umbilical cord after birth, initial assessment and categorisation of the newborn infant, airway and breathing and circulation support, communication with parents, considerations when withholding and discontinuing support
Home-Based Intervention to Test and Start (HITS): a community-randomized controlled trial to increase HIV testing uptake among men in rural South Africa
No full textIntroduction
The uptake of HIV testing and linkage to care remains low among men, contributing to high HIV incidence in women in South Africa. We conducted the “Home-Based Intervention to Test and Start” (HITS) in a 2x2 factorial cluster randomized controlled trial in one of the World’s largest ongoing HIV cohorts in rural South Africa aimed at enhancing both intrinsic and extrinsic motivations for HIV testing.
Methods
Between February and December 2018, in the uMkhanyakude district of KwaZulu-Natal, we randomly assigned 45 communities (clusters) (n = 13,838 residents) to one of the four arms: (i) financial incentives for home-based HIV testing and linkage to care (R50 [$3] food voucher each); (ii) male-targeted HIV-specific decision support application, called EPIC-HIV; (iii) both financial incentives and male-targeted HIV-specific decision support application and (iv) standard of care (SoC). EPIC-HIV was developed to encourage and serve as an intrinsic motivator for HIV testing and linkage to care, and individually offered to men via a tablet device. Financial incentives were offered to both men and women. Here we report the effect of the interventions on uptake of home-based HIV testing among men. Intention-to-treat (ITT) analysis was performed using modified Poisson regression with adjustment for clustering of standard errors at the cluster levels.
Results
Among all 13,838 men ≥ 15 years living in the 45 communities, the overall population coverage during a single round of home-based HIV testing was 20.7%. The uptake of HIV testing was 27.5% (683/2481) in the financial incentives arm, 17.1% (433/2534) in the EPIC-HIV arm, 26.8% (568/2120) in the arm receiving both interventions and 17.8% in the SoC arm. The probability of HIV testing increased substantially by 55% in the financial incentives arm (risk ratio (RR)=1.55, 95% CI: 1.31 to 1.82, p < 0.001) and 51% in the arm receiving both interventions (RR = 1.51, 95% CI: 1.21 to 1.87 p < 0.001), compared to men in the SoC arm. The probability of HIV testing did not significantly differ in the EPIC-HIV arm (RR = 0.96, 95% CI: 0.76 to 1.20, p = 0.70).
Conclusions
The provision of a small financial incentive acted as a powerful extrinsic motivator substantially increasing the uptake of home-based HIV testing among men in rural South Africa. In contrast, the counselling and testing application which was designed to encourage and serve as an intrinsic motivator to test for HIV did not increase the uptake of home-based testing
Cross-correlating radio continuum surveys and CMB lensing: constraining redshift distributions, galaxy bias and cosmology
No full textWe measure the harmonic-space auto-power spectrum of the galaxy overdensity in the LOFAR Two-metre Sky Survey (LoTSS) First Data Release and its cross correlation with the map of the lensing convergence of the cosmic microwave background (CMB) from the Planck collaboration. We report a ∼5σ detection of the cross-correlation. We show that the combination of the clustering power spectrum and CMB lensing cross-correlation allows us to place constraints on the high-redshift tail of the redshift distribution, one of the largest sources of uncertainty in the use of continuum surveys for cosmology. Our analysis shows a preference for a broader redshift tail than that predicted by the photometric redshifts contained in the LoTSS value added catalog, as expected, and more compatible with predictions from simulations and spectroscopic data. Although the ability of CMB lensing to constrain the width and tail of the redshift distribution could also be valuable for the analysis of current and future photometric weak lensing surveys, we show that its performance relies strongly on the redshift evolution of the galaxy bias. Assuming the redshift distribution predicted by the Square Kilometre Array Design simulations, we use our measurements to place constraints on the linear bias of radio galaxies and the amplitude of matter inhomogeneities σ8, finding σ8=0.69+0.14−0.21 assuming the galaxy bias scales with the inverse of the linear growth factor, and σ8=0.79+0.17−0.32 assuming a constant bias