Pharmaceutical Sciences and Research (PSR)
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GAMBARAN PELAKSANAAN STANDAR PELAYANAN FARMASI DI APOTEK DKI JAKARTA TAHUN 2003
Get PDFThe service orientation of clinical pharmacy and community have been changed from focusing only managing the medicine as commodity to comprehensive service based on pharmaceutical care. Refer to that basic, ISFI with the cooperation of Ministry of Health establish Standard of Pharmaceutical Service in Pharmacy. The standard is aimed to ensure the service quality and shall be implemented in all Pharmacies. The purpose of the study is to have an implementation overview Standard of Pharmaceutical Service in Pharmacy and the results may used for establishing the phase of implementation Standard of Pharmaceutical Service in Pharmacy. This study is a descriptive study, the data were compiled by using a questionnaire, as respondents. Compiled data consist of pharmacy's basic data, pharmacist's basic data, implementation of non prescription drug's service (section I), KIE's service (section II), prescription drug's service (section III) and management of medicine (section IV). The average score of implementation of section I is 60.18 (not good), section II is 31.84 (worse), section III is 64.22 (not good) , section IV 87.84 (good) and the overall average from section I to IV is 61.02 (not good
PETUNJUK PELAKSANAAN VALIDASI METODE DAN CARA PERHITUNGANNYA
Get PDFEach analysis method by some reason, must be validated. The parameters are selectivity, accuracy, precision, linearity, LOD, LOQ, ruggedness, and robustness. The parameters need to be calculated by assay methods. This paper try to give some information above these methods base on some literatures (USP 23rd, WHO, journal, etc). Key words : Validation method, Parameter, Assay and calculation methods
VAKSIN DNA: VAKSIN GENERASI KEEMPAT
Get PDFoai:ojs.psr.ui.ac.id:article/3433Vaccines have been developed for a range of different infectious diseases. The complex-ity of microbial infections requires novel approaches to vaccine design. The first-generation of vaccines were live attenuated pathogens. Because of safety concerns, the second-generation of vaccines, chemically or physically inactivated pathogens werelater developed. Purified or synthetic proteins represent a third generation, and recent advances in molecular biology and genetic engineering have led to the development ofthe fourth vaccine generation, which includes DNA and virus vector-based vaccines.This review discusses on the genetic elements and construction of DNA vaccines, comparison of DNA vaccines and conventional vaccines, the benefits and limitations of DNA vaccines, and the advances of genetic vaccine development over the last decade.Keywords: DNA vaccines, conventional vaccines
VALIDASI METODE ANALISIS CILOSTAZOL DALAM PLASMA IN VITRO SECARA KROMATOGRAFI CAIR KINERJA TINGGI
Get PDFCilostazol is an antiplatelet agent with the mechanism of action by inhibiting phos-phodiesterase III (PDE III). Referred to Food and Drug Administration(FDA),cilostazol is a drug recommended to be bioequivalence (BE) studied. A high-perfor-mance liquid chromatographic (HPLC) method with ultraviolet detector for in vitro determination of cilostazol in human plasma had been developed and validated.Cilostazol and pioglitazone as internal standard were extracted from human plasma by protein precipitation method using methanol. The mobile phase consisting of ac-etonitrile-potassium di-hydrogen phosphate buffer 50 mM (40:60) was used at the flow rate of 1.5 mL/min on reversed phase C18 column (SunfireTM, 5 µm, 250x4.6 mm), and was detected at wavelength of 257 nm. Linearity was established withinconcentration range of 20-2000 ng/mL with coefficient correlation (r) was 0,9999.Accuracy (% diff) of this method was -14.67% up to 8.84% with precision (CV) being 0.98% to 4.93%, and absolute recovery was established to be 82.26% to 119.85%.Cilostazol in plasma was stable for 30 days in -200C storage.Keyword: Validation, HPLC, cilostazol, pioglitazone, plasma in vitro
EVALUASI PENGGUNAAN SEDIAAN FARMASI INTRAVENA UNTUK PENYAKIT INFEKSI PADA SALAH SATU RUMAH SAKIT SWASTA DI KOTA BANDUNG
Get PDFAn usage evaluation of intravenous pharmaceutical dosage form for infectious dis-eases at one of the private hospitals in Bandung by retrospective method on October to December 2005 had been done based on the rationality of drug used according to the certain criteria. The result of the evaluation from 1170 prescriptions found that the combination of two or more drugs was 7.78%, no drug dose improper, no duplication of drug used, nor interaction with another drugs were found. The preparation of intravenous pharmaceutical dosage form had been well done, but the aseptic tech-nique still less of attention.Key words: usage evaluation, intravenous pharmaceutical dosage form, infectiousdisease
EKSPLORASI PELAYANAN INFORMASI YANG DIBUTUHKAN KONSUMEN APOTEK DAN KESIAPAN APOTEKER MEMBERI INFORMASI TERUTAMA UNTUK PENYAKIT KRONIK DAN DEGENERATIF
Get PDFCurrently, the prevalence of degenerative diseases in Indonesia is increased. The degenerative and chronic diseases need life-long treatment as well as changes in life style. On the other hand, long-life treatment using drugs will develop risks of adverse drug reactions or the possibilities of drug-drug interactions. In these circumstances, the role of a pharmacist is important to providing drug information and counselling, and patient education. However, there is evidence that pharmaceutical care in almost all pharmacies (drug dispensaries) in Indonesia is still “drug-oriented”. Drug information is not adequate and is provided by pharmacy assistants (technicians). In order to implement pharmaceutical care practice that meets the “Standard Competence for Pharmacy Practice” as well as consumer’s expectation, we need to know what is the exactly consumer’s expect in pharmaceutical care, particularly in drug information, and how is the commitment of the pharmacists to provide drug information of degenerative and chronic diseases in pharmaceutical care. For those reasons, a field survey has been carried out in Jakarta, Yogyakarta and Makassar to explore the consumer/patient’s opinions and needs for pharmaceutical care. A focus group discussion has also been done to explore the pharmacist commitment to provide drug information in pharmaceutical care practice. As a result, there is an indication of a discrepancy between the consumer/patient’s need for drug information and the commitment of pharmacists to provide drug information. Consumers have need for more drug information for all aspects including adverse drug reactions, drug interaction, what to do if adverse reaction occurred, duration of any treatments etc., not only drug indication and administration. On the other hand, pharmacists still need more knowledge and continuing education, particularly in pharmacotherapy and pharmacology of drugs used for degenerative and chronic diseases. Key words : pharmacy, pharmacist, pharmaceutical care
PENGARUH KANDUNGAN PATI SINGKONG TERPREGELATINASI TERHADAP KARAKTERISTIK FISIK TABLET LEPAS TERKONTROL TEOFILIN
Get PDFIn order to make use of pregelatinized Manihot starch in controlled release tablet, the research was done by heating the starch suspension up to its gelatinized temperatur, then dried. The particle size of pregelatinized Manihot starch used were (100-150 mesh) : (150-250 mesh) : smaller than 200 mesh = 3,5 : 1 : 1. The effect of pregelatinized Manihot starch on physical characteristic of Theophyllin controlled relase tablet was known by using 4 formulas containing variety of pregelatinized starch as follows: 30%, 40%, 50%, and 60%. Evaluation on the tablet results including tablet mass and size uniformity, hardness and friability. The result showed that pregelatinized Manihot starch in variable content on these tablet formulas fulfilled the requirement of tablet physical characteristics. Key words : Pregelatinized Manihot starch, controlled release, Theophyllin
PEMBUATAN NIOSOM BERBASIS MALTODEKSTRIN DE 5-10 DARI PATI SINGKONG (Manihot Utilissima)
Get PDFNiosomes are non ionic surfactant vesicles that have potential application in the delivery of hydrophobic or amphilic drugs. We developed proniosomes, a dry formulation using a maltodextrin as a carrier coated with non ionic surfactant, which can be used to produce niosomes within a minutes by addition of hot water followed by agitation. A novel method is reported here for rapid preparation of proniosomes with wide range of surfactant loading. Maltodextrin DE 5-10 was hidrolyzed from tapioca starch using Thermamyl L 120 da Novo at 85o C. The result from SEM analyses shown that proniosomes appear very similar to the maltodextrin, but the surface was more smooth. Niosome suspensions which was observed under the optical microscopy and particle size analyzer were evaluated as drug carrier using ibuprofen as a model. The result provide an indication of maltodextrin DE 5-10 from tapioca starch are potentialy carrier in the proniosome preparation which can be used for producing niosomes
UJI AKTIVITAS ANTIMIKROBA DAN UJI SITOTOKSIK EKSTRAK ETANOL AKAR TANAMAN AKAR KUCING (ACALYPHA INDICA LINN), DAGING BUAH MAHKOTA DEWA (PHALERIA MACROCARPA (SHEFF) BOERL) DAN SARI BUAH MERAH (PANDANUS CONOIDEUS LAM)
Get PDFThe antimicrobial activity and cytotoxic effect of ethanol extract of Acalypha indica Linn, Phaleria macrocarpa (Sheff) Boerl and Pandanus conoideus Lam, had been carried out. The results of the research showed that those ethanol extracts had antimi-crobial activities against Staphylococcus aureus ATCC 25923, Escherichia coli ATCC 25922, Pseudomonas aeruginosae ATCC 27853 and Candida albicans. The determi-nation of cytotoxic effects of those ethanol extracts by brine shrimp lethality test (BSLT) using Artemia salina Leach showed that LC50 of Acalypha indica Linn, Phaleria macrocarpa (Sheff) Boerl and Pandanus conoideus Lam were 1,279 ug/ml, 0.123 ug/ml and 0.054 ug/ml respectively.Key Words: Acalypha indica, Phaleria macrocarpa, Pandanus conoideus, antimi-crobial, BSLT
KEMAMPUAN PETUGAS MENGGUNAKAN PEDOMAN EVALUASI PENGELOLAAN DAN PEMBIAYAAN OBAT
Get PDFOne important aspect of district public health service is the management and budgeting of drugs. Up to this time no indicators can be used yet as guidelines for evaluating drug management and budgeting effectiveness in a district in Indonesia. The objective of this study is to determine the effect of training managing drug staff on the evaluation capability increase and their knowledge. Training has been conducted twice in 2 provinces, 4 districts ex HP IV each, covering Dinas Kesehatan, GFK, 5 PHCs per district and 300 outpatients. There are 7 groups of indicator which include a total of 29 indicators. Training involved computation of indicators of drug management and budgeting in a district. Tests were carried out before training and after the first and second training. Data were analyzed using paired t-test for the effect of training on the increase of knowledge and capability of managing drug staff in indicator computation for the evaluation of drug management and budgeting as well as linear regression for the relation between education and working experience of the staff and unpaired t-test for the difference in the increase in knowledge of pharmacy assistant and non pharmacy assistant. Results from the study on 54 managing drug staff in 8 district shows that knowledge increase significantly after the first and second training, whilst the latter increase is greater than the former one and that the increase in knowledge of pharmacy assistant exceeds that of non pharmacy assistant. Key word: capability, drug management, budgetin