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O-antigen serotyping and MALDI-TOF, potentially useful toolsfor optimizing semi-empiric antipseudomonal treatmentsthrough the early detection of high-risk clones
No full textAbstractThe increasing prevalence of extensively drug-resistant (XDR) Pseudomonas aeruginosa infections is due to theglobal spread of defined high-risk clones (HRC). Among them, ST175 is particularly frequent in Spain and France.Here, we evaluated O-antigen serotyping and MALDI-TOF as typing methods for the early identification of ST175.O-antigen (O4) serotyping and MALDI-TOF biomarker peak-based recognition models were tested in several straincollections, including 206 non-duplicated P. aeruginosa clinical isolates collected in 2016. Resistance profiles weredetermined by broth microdilution and clonal epidemiology by pulsed-field gel electrophoresis (PFGE) andmultilocus sequence typing (MLST). Up to 24.3% of the isolates were XDR and 28.2% non-susceptible tomeropenem, while resistance to ceftolozane/tazobactam (2.9%) and colistin (0.5%) was infrequent. Half of allXDR isolates belonged to ST175 and most of them were only susceptible to ceftolozane/tazobactam and colistin.A model based on the detection of one MALDI-TOF biomarker peak yielded negative and positive predicted values(NPV/PPV) for the detection of ST175 of 100%/51.9%, whereas NPV/PPV for a model based on two biomarkerpeaks were 99.4%/87.1% and for O4 serotyping, 99.4%/84.1%. Both, O4 serotyping and MALDI-TOF biomarkerpeak analysis, proved to be sensitive and specific methods that could be easily incorporated in the routine workflowfor the early detection of ST175 HCR. Since ST175 is associated with defined XDR profiles, with most isolates onlybeing susceptible to colistin and ceftolozane/tazobactam, these simple techniques could be useful for optimizingsemi-empiric antipseudomonal treatments in areas where this HRC is prevalent.Keywords Pseudomonas aeruginosa . High-risk clones . Antibiotic resistance . Ceftolozane-tazobactam . ST17
Effects of Cyanobacterial Secondary Metabolites on Phytoplankton Community Succession
No full textAllelopathic effects are one of the factors potentially influencing the succession ofphytoplankton communities; however, their influence has often been neglected.This is especially true for cyanobacteria that often outcompete other phytoplanktonspecies and form blooms causing severe problems. Allelopathic effects ofcyanobacteria can play an important role for phytoplankton succession. In thischapter, we introduce the different ways how aquatic organisms are influenced bycyanobacterial allelochemicals; the mechanisms of their interaction from the aspects of chemical intermediates, target reaction, and target signals; and interferingfactors and the ecological consequences of this process.Cyanobacteria produce and excrete a variety of allelopathic compounds thataffect other Cyanophyta, eukaryotic algae, bacteria, zooplankton, higher plants,and fish and mammalian cells. These effects are regulated by various abiotic andbiotic conditions, such as nutrient availability, temperature, and light intensity butalso cell density and growth phase of the source cyanobacterial community. Thebioactive metabolites include cyclic peptides, alkaloids, terpenoids, and otherswhich can have a variety of inhibitory effects on the different target organisms.Ecological consequences such as declines in biodiversity and accumulation oftoxins in the food chain have been shown. However, most of these compoundshave not yet been fully tested regarding their full range of effects on naturalphytoplankton communities. A detailed elucidation of the influence ofcyanobacterial allelochemicals is of key importance for understanding and managingthe succession of natural phytoplankton communities
Pengaruh kualitas laporan keuangan terhadap Decision Usefulness laporan keuangan pada pemerintah daerah se-Lampung [Tesis]
No full textBibliografi halaman 74-79xvi, 73 halaman : ilustrasi ; 28 cm
Augmented Reality Budaya Lampung Sebagai Media Pembelajaran Berbasis Android [CD-Skripsi] / Aditya Riyaldie Pratama
No full textPanduan Praktis Belajar Diagnosis Anemia bagi Mahasiswa Pendidikan Dokter
No full textviii, 68 hlm, : il. ; 21 x 29,5 cm
Perancangan Tata Letak Keyboard Aksara Lampung Rataya [CD-Skripsi] /Fahreza Apriyoga Arizal
No full textSubyek : KEYBOAR
Strategi Pengembangan Kelembagaan Pengelolaan Sampaj aaerah permukiman Kumuh Kota Palembang :Studi Kasus Kelurahan Kemang Agung Kecamatan Kertaati Dan Kelurahan 11 Ulu Kecamatan Seberang Ulu II Kota Palembang [Tesis] / Agung Bahari xv, 62 halaman : ilustaris ; 28 cm.--Lamp. (11 lembar)
No full textSubyek : PERMASALAHAN LINGKUNGAN KUMU
Karakteristik Penduga Empirical Bayes Pada Pendugaan Area Kecil Dengan Model Beta-Bernoulli [Skripsi] / Margaretha Siburian
No full textDekripsi : xiv, 24 halaman : ilustrasi ; 28 cm.--Lamp. (4 lembar) Subyek : MATEMATIKA STATISTIKAL DESKRIPTI
Akuntabilitas Kepala Kampung Dalam Pengelolaan Anggaran Pendapatan Dan Belanja Kampung : (Studi Kasus Kampung Sangga Buana Kecamatan Way Seputih Kabupaten Lampung Tengah) [Skripsi] /Ni Kadek Poniasih
No full textDesk. : 104 halaman : ilustrasi ; 28 cm.--Lamp. (75 lembar
Proses Pemberian Katil/Jajulang Pada Acara Tradisi Pernikahan Adat Lampung Saibatin Di Desa Banjar Negeri Kecamatan Gunung Alip Kabupaten Tanggamus [Skripsi ]/ Dita Puspita Sari
No full textSubyek : ADAT ISTIADAT PERNIKAHAN DAN PERKAWINAN--LAMPUNGxx, 99 halaman : ilustrasi ; 28 cm