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BAP, Kehadiran dan Nilai Mahasiswa, PTI, Ganjil TA 2023-2024
Get PDFBAP, Kehadiran dan Nilai Mahasiswa, PTI, Ganjil TA 2023-202
The Effect of Manager's Commitment, Training, and Sustainable Improvement on Construction Project Performance in the Pandemic Era
Get PDFThe purpose of this study was to determine The Effect of Manager Commitment, Training, and Continuous Improvement on PT Harvest City Construction Project Performance in the Pandemic Era. The method used in this study is a quantitative method with primary data types. The sampling technique used was purposive sampling with a sample of 218 construction workers with 126 respondents. The techniques employed for data management and analysis include external model analysis (measurement model) and internal model analysis (structural model) utilizing the SmartPLS 3 Multivariate Structural Equation Model (SEM) approach. Partially the results of this study indicate that the manager's commitment has a P-value of 0.106 > 0.05, so it can be interpreted that the manager's commitment does not affect project performance, training has a P-value of 0.029 < 0.05, so it can be interpreted that training effect on project performance and continuous improvement has a P-Value of 0.005 < 0.05, so it can be interpreted that continuous improvement has an effect on project performance. Concurrently, this investigation achieved an R-Square (R2) value of 0.81, equivalent to 81%. This indicates that the project performance variable is influenced by manager commitment, training, and continuous improvement to the extent of 81%
An Investigation of Atorvastatin Calcium Loaded Transethosomes for Transdermal Delivery and Validation of HPLC Methods
Get PDFAtorvastatin calcium is an antihyperlipidemic agent with low
bioavailability due to the first-pass metabolism after oral administration.
To overcome the limitation, an alternative method for delivering drug
molecules to the systemic circulation is needed, such as transethosomes
produced for transdermal delivery. Therefore, this study aimed to produce
atorvastatin calcium transethosomes with characteristics suitable for
transdermal delivery using validated analytical method. Transethosomes
formulations were prepared with different concentrations of soy lecithin
and ethanol. All formulations were evaluated for particle size, zeta
potential, polydispersity index (PDI), drug content, and deformability
index. Validation of the analytical method of atorvastatin calcium was
carried out using system suitability, selectivity, linearity, limit of detection
(LOD), limit of quantification (LOQ), precision, accuracy, and robustness.
The result showed that transethosomes had a small particle size of 123.90
nm-165.10 nm, high zeta potential values, acceptable PDI, the highest
atorvastatin calcium content, and good deformability index. In addition,
the system suitability test results were acceptable and there was no
interference in the atorvastatin calcium area. Linearity showed r =0.9999
with LOD and LOQ values of 0.388 µg/mL and 1.176 µg/mL, respectively.
The % RSD in the precision was < 2 and the recovery in the accuracy was
98.76%-101.04%. The method proved to be robust with respect to mobile
phase pH changes. Based on the results, atorvastatin calcium-loaded
transethosomes were suitable for transdermal delivery and could be
effectively produced with a 3% soy lecithin and 30% ethanol
concentration. The analytical method for determining drug content of
atorvastatin calcium-loaded transethosomes could be effectively applied
(Buku) - Pengantar Sistem Informasi [2024-08-06]
No full textSistem informasi adalah inti dari transformasi digital yang melanda dunia saat ini. Di tengah percepatan teknologi, sistem informasi telah menjadi alat yang tak tergantikan dalam menghubungkan manusia, data, dan proses untuk menciptakan nilai yang lebih besar. Buku ini hadir untuk memberikan wawasan mendalam tentang bagaimana teknologi dan informasi bekerja bersama-sama untuk mendukung keberlanjutan, inovasi, dan keunggulan kompetitif dalam berbagai konteks.
Sebagai salah satu bidang yang terus berkembang, sistem informasi tak hanya berbicara tentang teknologi, tetapi juga mencakup cara manusia dan organisasi beradaptasi dengan perubahan. Buku ini menempatkan sistem informasi sebagai katalisator yang mengubah cara kerja, pola pikir, dan pengambilan keputusan di berbagai sektor. Melalui pendekatan yang menyeluruh, pembaca diajak untuk memahami tidak hanya aspek teknis, tetapi juga dampak strategis, sosial, dan etis dari penerapan sistem informasi.
Dengan gaya penulisan yang mudah dipahami dan relevan dengan tantangan dunia nyata, buku ini memberikan landasan yang kuat bagi siapa saja yang ingin memperluas wawasan mereka tentang peran sistem informasi di era modern. Baik Anda seorang pelajar, profesional, atau penggemar teknologi, buku ini akan membuka perspektif baru tentang bagaimana sistem informasi menjadi kunci untuk menghadapi masa depan yang terus berubah