31325 research outputs found
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Future Contingents, Bivalence, and the Excluded Middle in Aristotle
No full textThe principle of bivalence (PB) states that every declarative sentence is either true or false, and the principle of excluded middle (PEM) states that one member of any contradictory pair must be true. According to the standard interpretation of Int. 9, PB fails for future contingents. Moreover, some standardists believe that PEM fails for pairs of contradictory future contingents, whereas other standardists attempt to rescue PEM by applying the method of supervaluations. I argue that PB and PEM are not suspended and that the method of supervaluations fails to explain how PEM holds. I propose an interpretation of Int. 9 according to which neither PB nor PEM fails
Demonstratives in heritage Greek, Russian, and Turkish in Germany and the United States
No full textAims and Objectives: This study investigates the use of definite noun phrases involving demonstratives in adolescent and adult monolingually raised and heritage speakers of Greek, Russian, and Turkish with the following research questions: (1) Do heritage speakers of Greek, Russian, and Turkish align with monolingually raised speakers regarding the production of demonstratives? and (2) Do mode and register affect the use of demonstratives? Methodology: We conducted a corpus study on production data of heritage speakers of Greek, Russian, and Turkish residing in the United States and Germany and the respective monolingually raised speakers in Greece, Russia, and Turkey. The majority languages of the heritage speakers were German or English, respectively. Data were elicited in two distinct registers (formal vs informal) and in two distinct modes (spoken vs written). Participants were asked to narrate what happened in a short video showing a fictional minor car accident. Analysis: Oral and written narrations were annotated and analyzed using generalized linear mixed-effects regression modeling on the use of demonstratives by heritage and monolingually raised speakers accounting for individual variation, country of elicitation, mode, and register. Findings: The results show that heritage and monolingually raised speakers of Greek, Russian, and Turkish converge in their use of demonstratives. Also, mode and/or register significantly affect the production of definite noun phrases with demonstratives across all speaker groups. Originality: This is the first cross-linguistically comparable large-scale corpus study with ecologically valid production data of definite noun phrases with demonstratives in bilinguals. Significance: The study contributes to understanding the use of demonstratives in heritage and monolingual Greek, Russian, and Turkish. It provides insights into the use of demonstratives in languages with different determiner systems and the impact of mode and/or register, which seems to be pronounced roughly similarly across these languages.Deutsche Forschungsgemeinschaft https://doi.org/10.13039/501100001659Peer Reviewe
One-Pot Synthesis of High-Capacity Sulfur Cathodes via In-Situ Polymerization of a Porous Imine-Based Polymer
No full textLithium-ion batteries, essential for electronics and electric vehicles, predominantly use cathodes made from critical materials like cobalt. Sulfur-based cathodes, offering a high theoretical capacity of 1675 mAh g−1 and environmental advantages due to sulfur's abundance and lower toxicity, present a more sustainable alternative. However, state-of-the-art sulfur-based electrodes do not reach the theoretical capacities, mainly because conventional electrode production relies on mixing of components into weakly coordinated slurries. Consequently, sulfur‘s mobility leads to battery degradation—an effect known as the “sulfur-shuttle”. This study introduces a solution by developing a microporous, covalently-bonded, imine-based polymer network grown in situ around sulfur particles on the current collector. The polymer network (i) enables selective transport of electrolyte and Li-ions through pores of defined size, and (ii) acts as a robust host to retain the active component of the electrode (sulfur species). The resulting cathode has superior rate performance from 0.1 C (1360 mAh g−1) to 3 C (807 mAh g−1). Demonstrating a high-performance, sustainable sulfur cathode produced via a simple one-pot process, our research underlines the potential of microporous polymers in addressing sulfur diffusion issues, paving the way for sulfur electrodes as viable alternatives to traditional metal-based cathodes.Peer Reviewe
Thermal tolerance in an extremophile fish from Mexico is not affected by environmental hypoxia
No full textThe thermal ecology of ectotherm animals has gained considerable attention in the face of human-induced climate change. Particularly in aquatic species, the experimental assessment of critical thermal limits (CTmin and CTmax) may help to predict possible effects of global warming on habitat suitability and ultimately species survival. Here we present data on the thermal limits of two endemic and endangered extremophile fish species, inhabiting a geothermally heated and sulfur-rich spring system in southern Mexico: The sulfur molly (Poecilia sulphuraria) and the widemouth gambusia (Gambusia eurystoma). Besides physiological challenges induced by toxic hydrogen sulfide and related severe hypoxia during the day, water temperatures have been previously reported to exceed those of nearby clearwater streams. We now present temperature data for various locations and years in the sulfur spring complex and conducted laboratory thermal tolerance tests (CTmin and CTmax) both under normoxic and severe hypoxic conditions in both species. Average CTmax limits did not differ between species when dissolved oxygen was present. However, critical temperature (CTmax=43.2°C) in P. sulphuraria did not change when tested under hypoxic conditions, while G. eurystoma on average had a lower CTmax when oxygen was absent. Based on this data we calculated both species' thermal safety margins and used a TDT (thermal death time) model framework to relate our experimental data to observed temperatures in the natural habitat. Our findings suggest that both species live near their thermal limits during the annual dry season and are locally already exposed to temperatures above their critical thermal limits. We discuss these findings in the light of possible physiological adaptions of the sulfur-adapted fish species and the anthropogenic threats for this unique system.Peer Reviewe
preon: Fast and accurate entity normalization for drug names and cancer types in precision oncology
No full textMotivation: In precision oncology (PO), clinicians aim to find the best treatment for any patient based on their molecular characterization. A major bottleneck is the manual annotation and evaluation of individual variants, for which usually a range of knowledge bases are screened. To incorporate and integrate the vast information of different databases, fast and accurate methods for harmonizing databases with different types of information are necessary. An essential step for harmonization in PO includes the normalization of tumor entities as well as therapy options for patients. Summary: preon is a fast and accurate library for the normalization of drug names and cancer types in large-scale data integration. Availability and implementation: preon is implemented in Python and freely available via the PyPI repository. Source code and the data underlying this article are available in GitHub at https://github.com/ermshaua/preon/.Peer Reviewe
Does EU-internal migration fuel public concerns about immigration?
No full textThe free movement of people is a fundamental principle of the European Union (EU) that has led to an increase in EU-internal migration. This study investigates the impact of increased immigration to Germany resulting from the 2004 and 2007 eastern enlargement of the EU on concerns about immigration within the German population. By merging 20 years of annual migration statistics with panel data on individual attitudes and exploiting exogenous variation in the gradual enlargement of the free movement policy, we examine the causal effects of EU-internal migration on immigration concerns. Our findings suggest that the influx of immigrants from new member states did not have a clear average effect on concerns about immigration, but increased concerns among German natives with materialist-survival values. The study provides insights into the societal division caused by opposition to immigration as part of the European integration process.Peer Reviewe
Dissection of the synthesis of polyunsaturated fatty acids in nematodes and Collembola of the soil fauna
No full textIt is becoming increasingly clear that not only unicellular, photoautotrophic eukaryotes, plants, and fungi, but also invertebrates are capable of synthesizing ω3 long-chain polyunsaturated fatty acids (LC-PUFA) de novo. However, the distribution of this anabolic capacity among different invertebrate groups and its implementation at the gene and protein level are often still unknown. This study investigated the PUFA pathways in common soil fauna, i.e. two nematode and two Collembola species. Of these, one species each (Panagrellus redivivus, Folsomia candida) was assumed to produce ω3 LC-PUFA de novo, while the others (Acrobeloides bodenheimeri, Isotoma caerulea) were supposed to be unable to do so. A highly labeled oleic acid (99 % 13C) was supplemented and the isotopic signal was used to trace its metabolic path. All species followed the main pathway of lipid biosynthesis. However, in A. bodenheimeri this terminated at arachidonic acid (ω6 PUFA), whereas the other three species continued the pathway to eicosapentaenoic acid (ω3 PUFA), including I. caerulea. For the nematode P. redivivus the identification and functional characterization of four new fatty acid desaturase (FAD) genes was performed. These genes encode the FAD activities Δ9, Δ6, and Δ5, respectively. Additionally, the Δ12 desaturase was analyzed, yet the observed activity of an ω3 FAD could not be attributed to a coding gene. In the Collembola F. candida, 11 potential first desaturases (Δ9) and 13 front-end desaturases (Δ6 or Δ5 FADs) have been found. Further sequence analysis indicates the presence of omega FADs, specifically Δ12, which are likely derived from Δ9 FADs
Gut microbiota dysbiosis is associated with altered tryptophan metabolism and dysregulated inflammatory response in COVID-19
No full textThe clinical course of COVID-19 is variable and often unpredictable. To test the hypothesis that disease progression and inflammatory responses associate with alterations in the microbiome and metabolome, we analyzed metagenome, metabolome, cytokine, and transcriptome profiles of repeated samples from hospitalized COVID-19 patients and uninfected controls, and leveraged clinical information and post-hoc confounder analysis. Severe COVID-19 was associated with a depletion of beneficial intestinal microbes, whereas oropharyngeal microbiota disturbance was mainly linked to antibiotic use. COVID-19 severity was also associated with enhanced plasma concentrations of kynurenine and reduced levels of several other tryptophan metabolites, lysophosphatidylcholines, and secondary bile acids. Moreover, reduced concentrations of various tryptophan metabolites were associated with depletion of Faecalibacterium , and tryptophan decrease and kynurenine increase were linked to enhanced production of inflammatory cytokines. Collectively, our study identifies correlated microbiome and metabolome alterations as a potential contributor to inflammatory dysregulation in severe COVID-19.Peer Reviewe
Migration as good, bad and necessary: examining impacts of migration on staying Himalayan communities affected by climate change
No full textWithin the migration system, the seminal Foresight report highlighted that climate change can have significant implications for staying populations. Yet research on this remains limited. This study aims to fill this gap by assessing the impacts of sustained outmigration on staying farmer communities in the Indian Himalayan Region, affected by incremental climate change. Employing an empirical qualitative approach, new data is collected through semi-structured interviews ( n = 72). Staying communities describe migration as good, bad, and necessary with the majority (46%) noting negative impacts such as fewer people to do agriculture, abandoned assets, more tasks for women, loss of community, disrupted household structures, mental health implications for the elderly, and disinvestment in public services. While remittances from migration have positive impacts, they are primarily used for meeting everyday needs (81%) and not invested in climate change adaptation. In addition to migration impacts, changing weather patterns, agricultural shifts, and societal transformations further exacerbate the vulnerabilities of staying populations. Without policy support to address these vulnerabilities, the benefits of migration may not effectively contribute to climate change adaptation. The findings here are likely applicable to staying populations in other mountain areas, facing similar pressures from migration and climate change, underscoring the need for targeted interventions to build long-term adaptive capacity.Peer Reviewe
Correlations between local geoclimatic variables and hatchling body size in the sea turtles Caretta caretta and Chelonia mydas
No full textIt has been widely demonstrated that air and sand temperatures influence the anatomy of sea turtle hatchlings. We examined the impact of precipitation during the nesting season on the hatchling body size of loggerhead and green turtles from 37 beaches worldwide. Longitudinal data collected between 2012 and 2018 from Florida (US) and from a sample on Bõa Vista Island (Cabo Verde) carried out in 2019 showed that loggerhead body size at hatching was negatively correlated with precipitation, while precipitation was not correlated with hatchling body size in green turtles. A meta-analysis revealed that precipitation is positively correlated with hatchling mass in loggerhead turtles, while it is positively correlated with straight carapace length and width in green turtle hatchlings. The strongest influence of precipitation was found in the middle of the incubation period of loggerhead turtles in Cabo Verde, and we posit that this is due to an increase in the uptake of water for embryonic growth. These findings highlight the great importance of understanding the correlated effects of regional environmental variables, such as precipitation, on the development of sea turtle hatchlings and will have an impact on the evaluation of ongoing conservation and climate change discussions.Open Access funding enabled and organized by Projekt DEAL.Deutsche Forschungsgemeinschafthttp://dx.doi.org/10.13039/501100001659Senckenberg Gesellschaft für Naturforschung (SGN) (3507)Peer Reviewe