Journal of Mathematical and Fundamental Sciences
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Isolation and Antibacterial Properties of Phenyl Acrylic Acid Derivatives from Balanophora elongata Blume
Full text linkBalanophora elongata (Balanophoraceae) is a tropical parasitic flowering plant 9 cm in height. Four known phenyl acrylic acid derivatives, methyl caffeate (1), caffeic acid (2), 1,6-di-O-caffeoyl-β-D-glucopyranose (3), and coniferin (4), were isolated from this plant. Structural elucidation of the isolated compounds was determined by IR, LC-ESI-MS, 1D and 2D NMR. Extracts and isolated compounds were tested toward some standard human pathogenic bacteria using the agar disk diffusion method. Their inhibition zones were compared to that of chloramphenicol as positive control. Compound 1 showed inhibition toward Streptococcus mutans, while compound 3 and 4 inhibited Staphylococcus aureus
Coefficient Estimates for Bi-univalent Functions Defined by (P, Q) Analogue of the Salagean Differential Operator Related to the Chebyshev Polynomials
Full text linkIn the present investigation we use the Jackson (p,q)-differential operator to introduce the extended Salagean operator denoted by Rkp,q. Certain bi-univalent function classes based on operator Rkp,q related to the Chebyshev polynomials are introduced. First, two coefficient bounds and Fekete-Szego inequalities for the function classes are established. A number of corollaries are developed by varying parameters involved
Fibroin and Spidroin Thin Film to Support the Attachment and Spread of Human Dermal Fibroblast: The Potency of Skin Tissue Engineering
Full text linkThis study aimed to determine the characteristics of scaffolds made of fibroin from Bombyx mori and spidroin from Argiope appensa in supporting the attachment and proliferation of HDF cells on the scaffolds. Thin-film scaffolds were made using the solvent casting technique, where the scaffold is an amalgamation of fibroin, spidroin, PVA, and glycerol. HDF cells were grown on DMEM medium with 10% FBS and 1% antibiotic-antimicotic. Characterization of the scaffolds was performed by using ATR-FTIR, swelling test, contact angle measurement, tensile test, biodegradation, MTT and SEM. The results of the ATR-FTIR analysis showed that the scaffolds contained fibroin, spidroin, PVA, and glycerol. Swelling and contact angle tests showed that all scaffold combinations were hydrophilic. Mechanical properties and in vitro biodegradation tests showed no significant difference among the scaffold combinations. MTT testing showed that all scaffolds could facilitate the attachment of fibroblasts and showed increased viability from day 1, 3, and 5. Scanning electron microscopy showed that the cells in the 70% fibroin and 10% spidroin scaffold had the best cell morphology and the best combination for potential application in skin tissue engineering
Glycosaminoglycans Content and Type II Collagen Localization in Chondrogenic Differentiation of Adipose-Derived Mesenchymal Stem Cells Induced by L-Ascorbic Acid 2-Phosphate
Full text linkL-ascorbic acid 2-phosphate (LAA) is known to induce chondrocyte differentiation. The objective of this study was to analyze the potency of LAA in chondrogenic differentiation of adipose-derived mesenchymal stem cells (ADSC) by analyzing the glycosaminoglycans (GAG) content and type II collagen (Coll2) localization. ADSC was characterized using flow cytometry and cultured in media containing various concentrations of LAA (0, 25, 50, 100 μg/mL) for 2, 3 and 4 weeks. Coll2 localization was analyzed by immunocytochemistry (ICC) using a confocal microscope. The quantification of GAG was performed by Alcian Blue staining and calcium deposition by Alizarin Red S staining. The results showed that ADSC was positive for mesenchymal stem cell (MSC) markers. Coll2 was localized in the cytoplasm and showed increasing abundance along with the increase of the LAA concentration. The highest intensity of Coll2 localization was shown in LAA 100 μg/mL. ADSC in LAA induction medium showed higher GAG content compared to the control group (LAA 0 μg/mL) (p < 0.05). The highest calcium deposit was shown by LAA 25 μg/mL after 4 weeks of culture (p < 0.05) and it decreased at higher concentrations. In conclusion, LAA 100 μg/mL is considered the optimum LAA concentration for chondrogenic differentiation
Preliminary Studies of Cassava Leavesâ Ability to Remove Dyes from Water
Full text linkLow-cost adsorbents from cassava leaves (CLP) were prepared by simply washing the leaf powder with deionized water. The adsorption of methylene blue (MB) from the aqueous solution was measured in order to examine the adsorbent performance. The effect of the pH of the solution was studied by varying pH from 2 to 10. The kinetics of MB adsorption onto CLP followed the pseudo-second-order kinetic model with a k-value of 0.087907 g mg-1 min-1 and 0.094081 g mg-1 min-1 for CLP before and after washing, respectively. The adsorption isotherm for both adsorbents followed the Langmuir isotherm model with qm values of 178.5 mg g-1 and 243.9 mg g-1. The existence of disturber ions was investigated by adding NaCl into the MB solutions at a variety of concentrations
Synthesis of Oligosuccinimide and Evaluation of Its Corrosion Inhibition Performance on Carbon Steel in CO2-Saturated 1% NaCl Solution
Full text linkOligosuccinimide (OSI) is an oligomer with several repeating units of succinimide. In this study, OSI was synthesized by thermal condensation between maleic anhydride and ammonium carbonate. The chemical structure of the synthesized compound was confirmed by FTIR and NMR spectroscopy as well as LC-MS characterization. Evaluation of its performance as corrosion inhibitor and the adsorption mechanism on a carbon steel surface in CO2-saturated 1% (w/v) NaCl solution was performed using electrochemical techniques (electrochemical impedance spectroscopy (EIS) and potentiodynamic polarization) and weight-loss methods. These tests were simultaneously carried out for all fractions without separation. The EIS results showed that the inhibition efficiency (IE) of the OSI increased with increasing concentration but decreased at higher temperatures. The potentiodynamic polarization data indicated that the OSI acted as a mixed inhibitor. Adsorption of OSI on the carbon steel generally obeys the Langmuir adsorption isotherm according to curve linearity, which relates the degree of surface coverage to the inhibitor concentration. The standard Gibbs free energy of the adsorption values (∆G° ads) were negative within the range of -33.14 to -38.73 kJ.mol-1, which indicates the spontaneity of the adsorption process on the carbon steel surface and that OSI molecules interacted with the carbon steel through semi-physisorption
Rational Design, Synthesis and Cytotoxic Activity of N-(Phenylcarbamoyl)Benzamide on HeLa Cell Lines
No full textUrea derivatives are extensively used in the pharmaceutical industry. However, the unsatisfactory level of their membrane penetration requires further modification of the structures with stronger lipophillic properties. Phenylurea has a phenyl group that enables easier membrane penetration as a result of stronger pharmacological activity. Activity prediction was conducted by docking experiments and molecular dynamics, performed with Molegro Virtual Docker 5.5 using checkpoint kinase 1 (CHK1) enzyme with ID PDB: 2YWP. ADMET prediction was applied to collect data using the pkCSM tool. N-(phenyl carbamyol)benzamide compounds, modified by the Schotten Baumann method, were synthesized from benzoil chloride reacting with N-phenylurea. For evaluating anticancer activity, the MTT assay method on HeLa cells was used. Derived from the docking experiments, the compound rerank score of the N-(phenylcarbamoyl)benzamide was 72.0603 kcal/mol, lower than that of hydroxyurea, -32.1514 kcal/mol, causing better inhibitory activities against HeLA cell lines due to higher cytotoxic effects. ADMET Predictor was employed, indicating satisfactory compound distribution with a low, favorable metabolism, possessing good excretion and non-toxicity. The synthesized compound was 82% N-(phenyl carbamoyl)benzamide with 0.8 mM IC80, higher than that of hydroxyurea, 4.3 mM. In conclusion, successfully synthesized N-(phenylcarbamoyl)benzamide was proved to have higher cytotoxic effects. The satisfactory values of these compounds indicate that they are promising anticancer drug candidates
On Size Bipartite and Tripartite Ramsey Numbers for The Star Forest and Path on 3 Vertices
Full text linkFor simple graphs G and H the size multipartite Ramsey number mj(G,H) is the smallest natural number t such that any arbitrary red-blue coloring on the edges of Kjxt contains a red G or a blue H as a subgraph. We studied the size tripartite Ramsey numbers m3(G,H) where G=mK1,n and H=P3. In this paper, we generalize this result. We determine m3(G,H) where G is a star forest, namely a disjoint union of heterogeneous stars, and H=P3. Moreover, we also determine m2(G,H) for this pair of graphs G and H