155155 research outputs found
Sort by
Selenium Supplementation in Patients with Hashimoto Thyroiditis - A Systematic Review and Meta-Analysis of Randomized Clinical Trials.
Get PDFBACKGROUND
Hashimoto thyroiditis (HT) is the most common cause of hypothyroidism in iodine-sufficient areas. Selenium is an essential trace element required for thyroid hormone synthesis and exerts antioxidant effects. Therefore, it may be of relevance in the management of HT.
METHODS
We conducted a systematic review and meta-analysis of randomized controlled trials (RCTs) to evaluate the effect of selenium supplementation on thyroid function (thyroid-stimulating hormones [TSH], free and total thyroxine [fT4, T4], free and total triiodothyronine [fT3, T3]), thyroid antibodies (thyroid peroxidase [TPOAb], thyroglobulin [TGAb], thyrotropin receptor [TRAb]), ultrasound findings (echogenicity, thyroid volume), immune markers, patient-reported outcomes, and adverse events in HT. The study protocol was registered on PROSPERO (CRD42022308377). We systematically searched MEDLINE, Embase, CINHAL, Web of Science, Google Scholar, and the Cochrane CENTRAL Register of Trials from inception to January 2023 and searched citations of eligible studies. Two independent authors reviewed and coded the identified literature. The primary outcome was TSH in patients without thyroid hormone replacement therapy (THRT); the others were considered secondary outcomes. We synthesized the results as standardized mean differences (SMD) or odds ratio (OR), assessed risk of bias using the Cochrane RoB2 tool, and rated the evidence using the GRADE approach.
RESULTS
We screened 687 records and included 35 unique studies. Our meta-analysis found that selenium supplementation decreased TSH in patients without THRT (SMD -0.21 [95% CI -0.43, -0.02]; 7 cohorts, 869 participants; I2 = 0%). Additionally, TPOAb (SMD -0.96 [95% CI -1.36, -0.56]; 29 cohorts; 2358 participants; I2 = 90%) and malondialdehyde (SMD -1.16 [95% CI -2.29, -0.02]; 3 cohorts; 248 participants; I2 = 85%) decreased in patients with and without THRT. Adverse effects were comparable between the intervention and control groups (OR 0.89 [95% CI 0.46, 1.75]; 16 cohorts; 1339 participants; I2 = 0%). No significant changes were observed in fT4, T4, fT3, T3, TGAb, thyroid volume, interleukin-2, and interleukin-10. Overall, certainty of evidence was moderate.
CONCLUSIONS
In people with HT without THRT, selenium was effective and safe in lowering TSH, TPOAb, and malondialdehyde levels. Indications for lowering TPOAb were found independent of THRT
Adaptation of the Concept of Brain Reserve for the Prediction of Stroke Outcome: Proxies, Neural Mechanisms, and Significance for Research
Get PDFDigitale Sammlungen: Anforderungen an das digitalisierte Kulturerbe
No full textWie kann der Öffentlichkeit ein digitaler Zugang zu Sammlungen visuellen Kulturerbes ermöglicht werden? Diese Frage beschäftigt viele Museen, Archive und Bibliotheken, allerdings fehlen entsprechende Erhebungen, die bei der Umsetzung helfen könnten. Im Auftrag der Stiftung für Kunst, Kultur und Geschichte (SKKG) in Winterthur widmet sich Sonja Gasser dieser Leerstelle und analysiert in einer Umfrage die Anforderungen zur digitalen Repräsentation von Sammlungen. Die Ergebnisse bieten Museen und anderen Kulturinstitutionen Orientierung und Inspiration - beispielsweise bei der Entwicklung oder Erweiterung eines digitalen Angebots und der Abstimmung digitaler Sammlungen auf die Bedürfnisse der Nutzenden
Connecting the DOTs: a novel imaging sign on flat-panel detector CT indicating distal vessel occlusions after thrombectomy.
Get PDFBACKGROUND
Immediate non-contrast post-interventional flat-panel detector CT (FPDCT) has been suggested as an imaging tool to assess complications after endovascular therapy (EVT). We systematically investigated a new imaging finding of focal hyperdensities correlating with remaining distal vessel occlusion after EVT.
METHODS
A single-center retrospective analysis was conducted for all acute ischemic stroke patients admitted between July 2020 and December 2022 who underwent EVT and immediate post-interventional FPDCT. A blinded core lab performed reperfusion grading on post-interventional digital subtraction angiography (DSA) images and evaluated focal hyperdensities on FPDCT (here called the distal occlusion tracker (DOT) sign). DOT sign was defined as a tubular or punctiform, vessel confined, hyperdense signal within the initial occlusion target territory. We assessed sensitivity and specificity of the DOT sign when compared with DSA findings.
RESULTS
The median age of the cohort (n=215) was 74 years (IQR 63-82) and 58.6% were male. The DOT sign was positive in half of the cohort (51%, 110/215). The DOT sign had high specificity (85%, 95% CI 72% to 93%), but only moderate sensitivity (63%, 95% CI 55% to 70%) for detection of residual vessel occlusions. In comparison to the core lab, operators overestimated complete reperfusion in a quarter of the entire cohort (25%, 53/215). In more than half of these cases (53%, 28/53) there was a positive DOT sign, which could have mitigated this overestimation.
CONCLUSION
The DOT sign appears to be a frequent finding on immediate post-interventional FPDCT. It correlates strongly with incomplete reperfusion and indicates residual distal vessel occlusions. In the future, it may be used to complement grading of reperfusion success and may help mitigating overestimation of reperfusion in the acute setting
The Young European Resuscitation Council Resuscitation Science Masterclass - Concept and implementation.
Get PDFNurturing the development of the next generation of resuscitation scientists is essential for creating a vibrant and enabled community equipped with the necessary knowledge, attitudes, and skills to transform resuscitation practice and improve outcomes. In this concept paper we will describe the development and implementation of the first Young European Resuscitation Council Resuscitation Science Masterclass. The masterclass aims to connect, inspire, and support the growth of the next generation of resuscitation scientists through education, networking, and joint scientific work. The masterclass provides 20 international, multi-professional early career resuscitation scientists with the opportunity to expand their knowledge and network as well as conduct joint scientific work over the course of one year. This is achieved by interactive webinars, innovative online workshops, engaging online journal clubs as well as an educational in-person event to conclude the masterclass. The Young European Resuscitation Council Resuscitation Science Masterclass aims to strengthen the global resuscitation community and next generation of resuscitation scientists by facilitating opportunities of broader international initiatives and collaboration for early career resuscitation scientists, potentially leading to accelerated recruitment of future resuscitation leaders. Ultimately, this masterclass may enable early career researchers to produce high impact research that can shape the future of resuscitation science and improve cardiac arrest patient care globally
The Precious Summary: A History of the Mongols from Chinggis Khan to the Qing Dynasty By Sagang Sechen
No full textPeri-transplant flow-MRD assessment of cells with leukemic stem cells (LSC) associated phenotype in AML patients undergoing allogeneic stem cell transplantation in CR.
No full textModern RP and the (re)creation of social distinction
No full textWhile the loss of regional distinctiveness across the southeastern UK is well studied and largely undisputed, there is less consensus about class-based divisions. This paper investigates this question through an updated analysis of the variety emblematic of Britain’s upper class: Received Pronunciation (RP). While previous studies have suggested levelling in RP to a broader standard southeastern norm, our findings indicate that the most recent advances in the variety show it (re)differentiating itself from other varieties in the region. Investigating both individual vowel movements and broader system-wide properties, we argue that the changes observed in RP today result from speakers adopting a particular articulatory setting (lax voice), which has subsequent ramifications on vowel realisations. We suggest that speakers make strategic use of this articulatory setting as a way of embodying an elite persona in the British context, an interpretation that resonates with the social distributions of similar changes in other varieties
The ILO, the Politics of Statistics, and Changing Perceptions of Informal Work, 1970-Present
No full textThe influence of cardiac arrhythmias on the detection of heartbeats in the photoplethysmogram: benchmarking open-source algorithms.
Get PDFCardiac arrhythmias are a leading cause of mortality worldwide. Wearable devices based on photoplethysmography give the opportunity to screen large populations, hence allowing for an earlier detection of pathological rhythms that might reduce the risks of complications and medical costs. While most of beat detection algorithms have been evaluated on normal sinus rhythm or atrial fibrillation recordings, the performance of these algorithms in patients with other cardiac arrhythmias, such as ventricular tachycardia or bigeminy, remain unknown to date. 
The PPG-beats open-source framework, developed by Charlton and colleagues, evaluates the performance of the beat detectors named QPPG, MSPTD and ABD among others. We applied the PPG-beats framework on two newly acquired datasets, one containing seven different types of cardiac arrhythmia in hospital settings, and another dataset including two cardiac arrhythmias in ambulatory settings.
In a clinical setting, the QPPG beat detector performed best on atrial fibrillation (with a median F1 score of 94.4%), atrial flutter (95.2%), atrial tachycardia (87.0%), sinus rhythm (97.7%), ventricular tachycardia (83.9%) and was ranked 2nd for bigeminy (75.7%) behind ABD detector (76.1%). In an ambulatory setting, the MSPTD beat detector performed best on normal sinus rhythm (94.6%), and the QPPG detector on atrial fibrillation (91.6%) and bigeminy (80.0%).
Overall, the PPG beat detectors QPPG, MSPTD and ABD consistently stand out from other detectors with high performances. However, the detection of beats from wrist-PPG signals is compromised in presence of bigeminy or ventricular tachycardia
Data sources:
BORIS Portal Bern Open Repository and I...BAF-Online: Proceedings of the Berner Al...HASBonline – Hefte zur Archäologie des M...Informationswissenschaft: Theorie, Metho...Jahrbuch Diakonie SchweizJournal of Eye Movement ResearchJournal of Radiation Oncology Informatic...BOP SerialsVersants. Revista suiza de literaturas r...BORIS ThesesAccess Repository Dashboard
Do you manage Bern Open Repository and Information System (BORIS)? Access insider analytics, issue reports and manage access to outputs from your repository in the CORE Repository Dashboard!