155155 research outputs found
Sort by
Noninvasive assessment of liver segmental volumes and its relationship with 5-year prognostication
No full textPurpose: This study aimed to analyze the predictive value of liver segmental
volume and attenuation ratio (LSVR/LSVAR), and caudate to right lobe ratio
(CRL-R) for chronic liver disease (CLD) on routine abdominal CT scans and
to predict the 5-year probability of transplant-free survival and first hepatic
decompensation.
Material and Methods: This retrospective study included 108 patients without
CLD (noCLD-group; n=108), as well as 98 patients with biopsy-proven CLD.
All patients underwent abdominal CT scans between 03/2015 and 08/2017.
Patients with CLD were divided into three groups: early CLD (F0–F2; eCLD;
n=40), advanced CLD (F3–F4; aCLD; n=20), and aCLD with clinically significant portal hypertension according to the BAVENO VII consensus (aCLDPH;
n=38). CRL-R, LSVR, and LSVAR were compared between the groups using
Kruskal–Wallis test and receiver operating characteristic (ROC) analysis to
determine cutoff values. The 5-year transplant-free survival and first hepatic
decompensation were assessed by Kaplan–Meier curve analysis.
Results: CRL-R, LSVR and LSVAR differed significantly between all the
groups (p0.93 predicted aCLD with a sensitivity of 69% and a specificity of 78%, while LSVR >0.37 had a sensitivity
of 68% and a specificity of 80%. Patients with both CRL-R >0.99 and LSVR
>0.37 had the lowest probability of 5-year transplant-free survival (46%) and
the lowest probability of a decompensation-free 5-year course (75%), which
was significantly different (p<0.001) from patients with both CRL-R <0.99 and
LSVR <0.37 (86%; 98%).
Conclusion: LSVR/LSVAR and CRL-R on routine abdominal CT scans showed
a high predictive value for CLD and 5-year outcome prognostication
Investigating migraine phenotype and dynamics in women with endometriosis: an observational pilot study.
Get PDFINTRODUCTION
Migraine and endometriosis are chronic disabling pain conditions. There is evidence for a shared genetic background. Migraine phenotype and course in patients with the comorbidity are insufficient investigated. Both conditions can be treated with progestins.
METHODS
For this observational study we included women with migraine and endometriosis, visiting our clinic from 2015 to 2021. We collected available information from charts and complemented these data by a structured phone interview to collect more specific information on migraine and the course of both diseases.
RESULTS
From 344 patients fulfilling the inclusion criteria, 94 suffered from both, endometriosis and migraine. Migraine with aura was reported by 41% of the patients and was associated with earlier onset of migraine (age < 17 years (OR 6.54) and with a history of medication overuse headache (OR 9.9, CI 1.6-59.4). Present monthly migraine frequency (1.5 ± 2.6) was significantly lower than five years before the interview (2.9 ± 4.64). There was a correlation between medication overuse headache and use of analgesics more than 3 days/months for dysmenorrhoea (p < 0.03). ASRM endometriosis score was not associated with migraine characteristics.
CONCLUSIONS
We conclude that the comorbidity of endometriosis is highly linked to migraine with aura. Migraine onset in these patients was earlier. Further studies are needed to explore, if the observed decrease in migraine frequency can be attributed to recent endometriosis surgery and to understand if early diagnosis and treatment of both conditions may contribute to improve the course of both conditions. Trial registration BASEC Nr. 2021-00285
A Leadless Ventricular Pacemaker Providing Atrioventricular Synchronous Pacing in the Real-World Setting: 12-Month Results from the Micra AV Post-Approval Registry.
Get PDFBACKGROUND
Advances in leadless pacemaker technology have enabled accelerometer-based atrioventricular (AV) synchronous pacing by sensing atrial mechanical contraction.
OBJECTIVES
To report performance of the Micra AV leadless pacemaker from the worldwide Micra AV post-approval registry (PAR) through 12-months.
METHODS
The Micra AV PAR is a prospective single-arm observational registry designed to assess safety and effectiveness of Micra AV in a real-world setting. For the present interim analysis, major complications and system revisions through 12-months were summarized and compared to a historical cohort of 2,667 transvenous dual-chamber pacing patients.
RESULTS
The device was successfully implanted in 796 of 801 patients (99.4%) at 97 centers in 19 countries. Micra AV patients were older (74.1 vs. 71.1 years, P90%.
CONCLUSIONS
The Micra AV leadless pacemaker was implanted with a high rate of success in patients with multiple co-morbidities, with a significantly lower rate of complications and system revisions through 12-months compared to a historical cohort of patients with transvenous dual-chamber pacemakers
Promoting sleep health during pregnancy for enhancing women's health: a longitudinal randomized controlled trial combining biological, physiological and psychological measures, Maternal Outcome after THERapy for Sleep (MOTHERS).
Get PDFBACKGROUND
Sleep is vital for maintaining individuals' physical and mental health and is particularly challenged during pregnancy. More than 70% of women during the gestational period report insomnia symptoms. Sleep dysfunction in the peripartum increases the risk for a cascade of negative health outcomes during late pregnancy, birth, and postpartum. While psychological interventions are considered the first line treatment for sleep difficulties, they are still scarcely offered during pregnancy and there is a lack of longitudinal research combining psychological and physiological indices.
METHODS
The present protocol outlines a randomized controlled trial aimed at testing the long-term effectiveness of an automatized digitalized psychoeducational intervention for insomnia for expectant mothers complaining insomnia symptoms without comorbidity. Outcomes include physiological, hormonal, and subjective indices of maternal psychopathology, stress, and emotional processes, and sleep and wellbeing of the family system. The trial is part of a longitudinal study evaluating expectant mothers from early pregnancy (within the 15th gestational week) to 6-months postpartum through 6 observational phases: baseline (BSL), 6- and 12-weeks from BSL (FU1-FU2), 2-to-4 weeks after delivery (FU3), and 3- and 6-months after delivery (FU4-5). We plan to recruit 38 women without sleep difficulties (Group A) and 76 women with sleep difficulties (Group B). Group B will be randomly assigned to digital psychological control intervention (B1) or experimental psychoeducational intervention targeting insomnia (B2). At 3 time points, an ecological-momentary-assessment (EMA) design will be used to collect data on sleep and emotions (diaries), sleep-wake parameters (actigraphy) and stress reactivity (salivary cortisol). We will also test the DNA methylation of genes involved in the stress response as biomarkers of prenatal poor sleep. Information on partner's insomnia symptoms and new-borns' sleep will be collected at each stage.
DISCUSSION
The proposed protocol aims at testing an easily accessible evidence-based psychoeducational intervention for expectant mothers to help them improving sleep, health, and wellbeing in the peripartum. The results could improve the understanding and management of sleep difficulties and peripartum depression.
TRIAL REGISTRATION
The study protocol has been registered on 22 April 2024 with ClinicalTrials.gov Protocol Registration and Results System (PRS), ID: NCT06379074.
PROTOCOL VERSION
April 23, 2024
Die blinde ‹Wut des Spiels›. Schillers Tell-Schauspiel als Musterfall agonaler Aushandlung in Dramatik und Politik
No full textAngiotensin II in the treatment of distributive shock: a systematic-review and meta-analysis.
Get PDFBACKGROUND
While non-norepinephrine vasopressors are increasingly used as a rescue therapy in cases of norepinephrine-refractory shock, data on their efficacy are limited. This systematic review and meta-analysis aims to synthesize existing literature on the efficacy of Angiotensin II (ATII) in distributive shock.
METHODS
We pre-registered our meta-analysis with PROSPERO (CRD42023456136). We searched PubMed, Scopus, and gray literature for studies presenting outcomes on ATII use in distributive shock. The primary outcome of the meta-analysis was all-cause mortality. We used a random effects model to calculate pooled risk ratio (RR) and 95% confidence intervals (CI).
RESULTS
By incorporating data from 1555 patients included in 10 studies, we found that however all-cause mortality was similar among patients receiving ATII and controls (RR 1.02, 95% CI 0.89 to 1.16, p = 0.81), the reduction in norepinephrine or norepinephrine-equivalent dose at 3 h after treatment initiation was greater among patients receiving ATII (MD -0.06, 95% CI -0.11 to -0.02, p = 0.008), while there were no higher rates of adverse events reported among ATII patients.
CONCLUSIONS
While ATII did not reduce mortality among distributive shock patients, it allowed for significant adjunctive vasopressor reduction at 3 h without an increase in reported adverse events, deeming it a viable alternative for the increasingly adopted multimodal vasopressor for minimizing catecholamine exposure and its adverse events
Suicidality after the genocide against the Yazidi in Iraq in 2014.
No full textOBJECTIVE
To explore the relationship between psychological stress and suicidality in Yazidi refugee camps in Iraq.
METHOD
At the time of the investigation, the Yazidi survivors of the 2014 genocide by Islamic State of Iraq and Syria had been living in refugee camps in Iraq for 9 years. The aim of this study was to investigate the relationship between psychological stress and suicidality in Yazidi refugee camps in Iraq. In total, 425 participants took part in the study and participated in interviews using standard scales to measure general physical and mental health and suicidality.
RESULTS
The results demonstrate that suicidality and psychological stress are higher among the Yazidis survivors of genocide than in the other Yazidi and Non-Yazidi participants.
CONCLUSIONS
Genocide, flight, and life in refugee camps without any prospect of being able to live in peace again increases suicidal thoughts, which should also be considered in the psychosocial care and therapy of this population. (PsycInfo Database Record (c) 2024 APA, all rights reserved)
Prevalence of Critical Errors and Insufficient Peak Inspiratory Flow in Patients Hospitalized with COPD in a Department of General Internal Medicine: A Cross-Sectional Study.
No full textBACKGROUND
The suboptimal use of inhalers in the treatment of patients with chronic obstructive pulmonary disease (COPD) is probably a major but poorly documented problem in hospitalized patients. We aimed to describe the prevalence of misused inhalers among patients hospitalized with COPD in a department of general internal medicine.
METHODS
We conducted a monocentric cross-sectional study in consecutive patients with a diagnosis of COPD and hospitalized between August 2022 and April 2023 in the internal medicine division of Fribourg Hospital, Switzerland. Patients underwent an assessment of their inhaler technique and peak inspiratory flow (PIF) using the In-Check Dial G16®. The primary outcome was the prevalence of misused inhalers, defined as an inhaler used with a critical error and/or insufficient PIF. Secondary outcomes included the prevalence of inhaler unsuitable to patient characteristics and of patients using at least one misused inhaler.
RESULTS
The study included 96 patients and 160 inhalers were assessed at admission. Among these inhalers, 111 (69.4%; 95% confidence interval [CI] 61.6-76.4) were misused; 105 (65.6%; 95% CI 57.7-72.9) due to the presence of a critical error in the inhalation technique and 22 (13.8%; 95% CI 8.8-20.1) due to insufficient PIF. Concerning the secondary outcome, 27 inhalers (16.9%) were unsuitable and 79 patients (82.3%) used at least one misused inhaler.
CONCLUSION
Among patients hospitalized with a diagnosis of COPD, two-thirds of inhalers were misused. Suboptimal use was mainly due to the presence of critical errors, but also to the presence of an insufficient PIF and unsuitable inhalers
Die Welt des Islams. International Journal for the Study of Modern Islam, 64(2-3).
No full textDie Welt des Islams focuses on the history, religion and culture of Muslim societies across the world from the eighteenth century to the present. The peer-reviewed journal welcomes contributions in English, French and German from all relevant academic disciplines. Research articles and extensive book reviews offer a broad scholarly view of the field of Islam; in-depth thematic issues are devoted to relevant historical and contemporary problems.
Originally established in 1913, Die Welt des Islams is found in the world’s major research libraries. By the breadth of its geographical as well as thematic perspectives, the journal is unrivalled in its field and an essential resource for those who wish to stay on top of their discipline
Data sources:
BORIS Portal Bern Open Repository and I...BAF-Online: Proceedings of the Berner Al...HASBonline – Hefte zur Archäologie des M...Informationswissenschaft: Theorie, Metho...Jahrbuch Diakonie SchweizJournal of Eye Movement ResearchJournal of Radiation Oncology Informatic...BOP SerialsVersants. Revista suiza de literaturas r...BORIS ThesesAccess Repository Dashboard
Do you manage Bern Open Repository and Information System (BORIS)? Access insider analytics, issue reports and manage access to outputs from your repository in the CORE Repository Dashboard!