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Sexuality in Islamic Traditions
No full textIn this chapter I give an overview of the most relevant aspects related to sexuality in Islamic traditions, looking at how, especially in pre-modern societies, different normative systems co-existed beside each other. The chapter looks at discourses on sexuality in the Qur’an, the Sunna, Islamic jurisprudence (fiqh), medicine, and books on bāh (coitus). I focused on those aspects of sexuality that were considered legitimate, and then on those sexual practices that were debated, such as masturbation, or considered completely illegitimate from the perspective of Islamic jurisprudence, such as same-sex relations. At the end of the chapter I present a brief discussion of how traditional ideas have been reinterpreted and/or challenged by feminist approaches to Islam
Efficacy and Safety of Alirocumab and Evolocumab as Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9) Inhibitors in Familial Hypercholesterolemia: A Systematic Review and Meta-Analysis.
No full textBACKGROUND
Familial hypercholesterolemia (FH) is a prevalent and potentially fatal illness that causes a substantial elevation in low-density lipoprotein cholesterol (LDL-C).
OBJECTIVE
The aim of this study was to investigate the effects of monoclonal antibodies alirocumab and evolocumab on LDL-C and other lipid parameters, as well as their safety in familial hypercholesterolemia patients.
METHODS
A comprehensive search was done on PubMed/MEDLINE, EMBASE, Web of Science (WOS/ ISI), Scopus, ClinicalTrials (www.
CLINICALTRIALS
gov), and conferences/ congress research papers. Random effect models were used to calculate mean differences (%) and risk ratios (RRs), and confidence intervals (95%).
RESULTS
Ten studies (n=1489 patients) were included in this study. PCSK9 inhibitors decreased the levels of LDL-C by -49.59% (95%CI -55.5%, -43.67%) as compared to placebo. They also didn't alter the Treatment-Emergent Adverse Event (TEAE) and neuronal events by RR 0.92 (0.75, 1.13) and 1.31 (0.66, 2.59), respectively. PCSK9 inhibitors were effective and safe in treating patients with FH.
CONCLUSION
There was high-quality evidence showing that monoclonal antibodies (alirocumab & evolocumab) lower LDL-C (GRADE: high), lipoprotein (a) (GRADE: High), triglycerides (TG) (GRADE: High), total cholesterol (GRADE: High), non-high-density lipoprotein cholesterol (nonHDL-C) (GRADE: Moderate), and apolipoprotein B (GRADE: High), and increase the HDL-C (GRADE: High) as well as apolipoprotein A1 (GRADE: High). Comparing PCSK9 inhibitors against placebo, neither TEAE (GRADE: high) nor neuronal events (GRADE: moderate) were changed. Registration number PROSPERO-CRD42022334035
Scan accuracy and time efficiency of different implant-supported fixed partial denture situations depending on the intraoral scanner and scanned area: An in vitro study.
Get PDFSTATEMENT OF PROBLEM
The type of intraoral scanner (IOS), region of the implant, and extent of the scanned area have been reported to affect scan accuracy. However, knowledge of the accuracy of IOSs is scarce when digitizing different partially edentulous situations either with complete- or partial-arch scans.
PURPOSE
The purpose of this in vitro study was to investigate the scan accuracy and time efficiency of complete- and partial-arch scans of different partially edentulous situations with 2 implants and 2 different IOSs.
MATERIAL AND METHODS
Three maxillary models with implant spaces at the lateral incisor sites (anterior 4-unit), right first premolar and right first molar sites (posterior 3-unit), or right canine and right first molar sites (posterior 4-unit) were fabricated. After placing implants (Straumann S RN) and scan bodies (CARES Mono Scanbody), models were digitized by using an optical scanner (ATOS Capsule 200MV120) to generate reference standard tessellation language (STL) files. Complete- or partial-arch scans (test scans) of each model were then performed by using 2 IOSs (Primescan [PS] and TRIOS 3 [T3]) (n=14). The duration of the scans and the time needed to postprocess the STL file until the design could be started were also recorded. A metrology-grade analysis software program (GOM Inspect 2018) was used to superimpose test scan STLs over the reference STL to calculate 3D distance, interimplant distance, and angular (mesiodistal and buccopalatal) deviations. Nonparametric 2-way analysis of variance followed by Mann-Whitney tests with Holm correction were used for trueness, precision, and time efficiency analyses (α=.05).
RESULTS
The interaction between IOSs and scanned area only affected the precision of the scans when angular deviation data were considered (P≤.002). Trueness of the scans was affected by IOSs when 3D distance, interimplant distance, and mesiodistal angular deviations were considered. The scanned area affected only 3D distance deviations (P≤.006). IOSs and scanned area significantly affected the precision of scans when 3D distance, interimplant distance, and mesiodistal angular deviations were considered, while only IOSs significantly affected buccopalatal angular deviations (P≤.040). Scans from PS had higher accuracy when 3D distance deviations were considered for the anterior 4-unit and posterior 3-unit models (P≤.030), when interimplant distance deviations were considered for complete-arch scans of the posterior 3-unit model (P≤.048), and when mesiodistal angular deviations were considered in the posterior 3-unit model (P≤.050). Partial-arch scans had higher accuracy when 3D distance deviations of the posterior 3-unit model were considered (P≤.002). PS had higher time efficiency regardless of the model and scanned area (P≤.010), while partial-arch scans had higher time efficiency when scanning the posterior 3-unit and posterior 4-unit models with PS and the posterior 3-unit model with T3 (P≤.050).
CONCLUSIONS
Partial-arch scans with PS had similar or better accuracy and time efficiency than other tested scanned area-scanner pairs in tested partial edentulism situations
Historische Kontinuitäten von Veränderung und emanzipatorischer Allianzbildung von Frauen* im Theaterbetrieb
No full text
Impact of template-based synoptic reporting on completeness of surgical pathology reports.
Get PDFSynoptic reporting increases completeness and standardization of surgical pathology reports and thereby contributes to an increased quality of clinical cancer care. Nevertheless, its widespread practical implementation remains a challenge, which is in part related to the effort required for setup and maintenance of database structures. This prompted us to assess the effect of a simple template-based, database-free system for synoptic reporting on completeness of surgical pathology reports. For this purpose, we analyzed 200 synoptic reports (100 colon and 100 lung cancer resections each) for completeness as required by the pertinent College of American Pathologists (CAP) protocols and compared these to a control dataset of 200 narrative reports. Introduction of template-based synoptic reporting resulted in improved completeness (98% of mandatory data elements) as compared to narrative reports (77%). Narrative reports showed a high degree of completeness for data elements covered by previously existing dictation templates. In conclusion, template-based synoptic reporting without underlying database structure can be a useful transitory phase in the implementation of synoptic reporting. It can result in a similar degree of completeness as reported in the literature for database solutions and provides other benefits of synoptic reporting while facilitating its implementation
Influence of print orientation on the accuracy (trueness and precision) of diagnostic casts manufactured with a daylight polymer printer.
No full textSTATEMENT OF PROBLEM
Print orientation may affect the manufacturing accuracy of vat-polymerized diagnostic casts. However, its influence should be analyzed based on the manufacturing trinomial (technology, printer, and material) and printing protocol used to manufacture the casts.
PURPOSE
The purpose of this in vitro study was to measure the influence of different print orientations on the manufacturing accuracy of vat-polymerized polymer diagnostic casts.
MATERIAL AND METHODS
A standard tessellation language (STL) reference file containing a maxillary virtual cast was used to manufacture all specimens using a vat-polymerization daylight polymer printer (Photon mono SE. LCD 2K) and a model resin (Phrozen Aqua Gray 4K). All specimens were manufactured using the same printing parameters, except for print orientation. Five groups were created depending on the print orientation: 0, 22.5, 45, 67.5, and 90 degrees (n=10). Each specimen was digitized using a desktop scanner. The discrepancy between the reference file and each of the digitized printed casts was measured using the Euclidean measurements and root mean square (RMS) error (Geomagic Wrap v.2017). Independent (unpaired) sample t tests and multiple pairwise comparisons using the Bonferroni test were used to analyze the trueness of the Euclidean distances and RMS data. Precision was assessed using the Levene test (α=.05).
RESULTS
In terms of Euclidean measurements, significant differences in trueness and precision values were found among the groups tested (P<.001). The 22.5- and 45-degree groups resulted in the best trueness values, and the 67.5-degree group had the lowest trueness value. The 0- and 90-degree groups led to the best precision values, while the 22.5-, 45-, and 67.5-degree groups showed the lowest precision values. Analyzing the RMS error calculations, significant differences in trueness and precision values were found among the groups tested (P<.001). The 22.5-degree group had the best trueness value, and the 90-degree group resulted in the lowest trueness value among the groups. The 67.5-degree group led to the best precision value, and the 90-degree group to the lowest precision value among the groups.
CONCLUSIONS
Print orientation influenced the accuracy of diagnostic casts fabricated by using the selected printer and material. However, all specimens had clinically acceptable manufacturing accuracy ranging between 92 μm and 131 μm
Effect of Seclusion on Mental Health Status in Hospitalized Psychiatric Populations: A Trial Emulation using Observational Data.
Get PDFThe use of coercive practices, i.e., interventions against a person's will, is controversial. Recent observational studies highlighted their potential detrimental effects on patients' mental health, but this topic remains understudied. This study investigated the effect of a common coercive practice, seclusion (i.e., being locked in a closed room), on mental health using a trial emulation of observational data to allow causal inference. We used data from 1200 psychiatric inpatients, classified as being either secluded or non-secluded during their hospital stay. Inverse probability of treatment weighting was used to emulate the random assignment to the intervention. The primary outcome was the Health of the Nations Outcome Scales (HoNOS). The secondary outcome was the first item of the HoNOS, which focuses on overactive, aggressive, disruptive, or agitated behavior. Both outcomes were assessed at hospital discharge. There was a significant effect of seclusion with increases in both total HoNOS score (p = .002) and item 1 of the HoNOS (p = .01). Seclusion may have a negative causal effect of patients' mental health status and should therefore be avoided in mental health care settings. Training efforts should raise the awareness of the medical staff about potential adverse effects instead of therapeutic benefits
Exploring group differences in the response to a sexual risk reduction intervention to prevent hepatitis C virus reinfection in HIV-infected MSM: a mixed-methods study.
No full textTo prevent hepatitis C virus (HCV) reinfection, within the Swiss HCVree Trial, a preventive risk reduction intervention was implemented alongside curative treatment. Formative qualitative research identified three response patterns to the intervention. This mixed-methods study's aim was to cross-validate group differences in (a) the content of sexual risk reduction goals set during intervention and (b) the extent of their behavioural change in condomless anal intercourse with non-steady partners (nsCAI), sexualised and intravenous drug use at start and six-month post-intervention. Qualitative thematic analysis was used to summarise goal setting domains. Quantitative descriptive analysis was used to evaluate group differences based on assumptions of the group descriptions. Results largely confirmed assumptions on inter-group response differences in goal setting and behaviour: as expected group 1 Avoid risks showed the lowest HCV risk profile with changes in nsCAI. Group 2 Minimize-risks and Group 3 Accept-risks showed unchanged nsCAI. Group 3 had the highest HCV risk profile. Differences in their goal preferences (1: condom use; 2 reduction blood exposure; 3 safer dating) highlight diversity in attitudes to behavioural change. Our results improve understanding of variability in intervention responses such as changes in attitudes and behaviour. This provides evidence for intervention tailoring and outcome measurement
Risk factors for thromboembolic complications in isolated severe head injury.
Get PDFPURPOSE
Patients with traumatic brain injury (TBI) are at high risk for venous thromboembolism (VTE). The aim of the present study is to identify factors independently associated with VTE events. Specifically, we hypothesized that the mechanism of penetrating head trauma might be an independent factor associated with increased VTE events when compared with blunt head trauma.
METHODS
The ACS-TQIP database (2013-2019) was queried for all patients with isolated severe head injuries (AIS 3-5) who received VTE prophylaxis with either unfractionated heparin or low-molecular-weight heparin. Transfers, patients who died within 72 h and those with a hospital length of stay < 48 h were excluded. Multivariable analysis was used as the primary analysis to identify independent risk factors for VTE in isolated severe TBI.
RESULTS
A total of 75,570 patients were included in the study, 71,593 (94.7%) with blunt and 3977 (5.3%) with penetrating isolated TBI. Penetrating trauma mechanism (OR 1.49, CI 95% 1.26-1.77), increasing age (age 16-45: reference; age > 45-65: OR 1.65, CI 95% 1.48-1.85; age > 65-75: OR 1.71, CI 95% 1.45-2.02; age > 75: OR 1.73, CI 95% 1.44-2.07), male gender (OR 1.53, CI 95% 1.36-1.72), obesity (OR 1.35, CI 95% 1.22-1.51), tachycardia (OR 1.31, CI 95% 1.13-1.51), increasing head AIS (AIS 3: reference; AIS 4: OR 1.52, CI 95% 1.35-1.72; AIS 5: OR 1.76, CI 95% 1.54-2.01), associated moderate injuries (AIS = 2) of the abdomen (OR 1.31, CI 95% 1.04-1.66), spine (OR 1.35, CI 95% 1.19-1.53), upper extremity (OR 1.16, CI 95% 1.02-1.31), lower extremity (OR 1.46, CI 95% 1.26-1.68), craniectomy/craniotomy or ICP monitoring (OR 2.96, CI 95% 2.65-3.31) and pre-existing hypertension (OR 1.18, CI 95% 1.05-1.32) were identified as independent risk factors for VTE complications in isolated severe head injury. Increasing GCS (OR 0.93, CI 95% 0.92-0.94), early VTE prophylaxis (OR 0.48, CI 95% 0.39-0.60) and LMWH compared to heparin (OR 0.74, CI 95% 0.68-0.82) were identified as protective factors for VTE complications.
CONCLUSION
The identified factors independently associated with VTE events in isolated severe TBI need to be considered in VTE prevention measures. In penetrating TBI, an even more aggressive VTE prophylaxis management may be justified as compared to that in blunt
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