155155 research outputs found
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Safety and efficacy of modern concurrent radiochemotherapy with Cisplatin and Gemcitabine
No full textSalvage Radiotherapy after Failure of Primary Focal Therapy for prostate cancer:A Systematic Review
No full textGeometry-Preserving MR-based Synthetic CT Generation via Diffusion Schrödinger Bridge Models
No full textBeyond Voxel-Based Methods: Continuous Motion Modeling for Enhanced Deformable Image Registration
No full textCopyright Levies in Digital Ecosystems – a Tool for Contributing to Sustainable Innovation?
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The future politics must be more intersectional and decolonial
Get PDFThe aim of the project is to tell and reflect the different histories of feminist theory. To this end, conversations are held with protagonists who had and have a formative influence on feminist theories. In engaging with these scholars, we wish to delve deeper not only into the ideas and concepts that form the key basis of these theories but also to explore the historical contexts, collective thinking, political practices and historical controversies that enabled them at the time. The conversations bring forth exigent questions around power, inequality and violence, intersectionality, the relation of sex, gender and sexuality, or the critique of binary thinking. We discuss the contributions of feminism to analyzing and challenging significant differences other than gender, such as race, class, nationality, religion, and caste. The project is rooted in oral history and philosophical exchange. It has value for those of us interested in the history of feminist theory and in feminism as a resourceful way of challenging dominant knowledges and creating different ones
Spinal anesthesia in ambulatory patients.
Get PDFPURPOSE OF THIS REVIEW
To assess current practice in the use of spinal anesthesia in major ambulatory surgery, highlighting its advantages over general anesthesia and identifying potential areas for improvement to facilitate a transition to a sustainable healthcare system.
RECENT FINDINGS
Spinal anesthesia might be preferred in selected populations when compared to general anesthesia providing the highest standards of healthcare quality.The use of local anesthetics with short half-life has proven to be efficient in achieving high anesthesia success rates. Spinal anesthesia does not increase perioperative complications; instead, it has shown a reduction in postoperative nausea and vomiting, an improvement in patient comfort, and a favorable economic impact when compared to general anesthesia.
SUMMARY
Spinal anesthesia is an appropriate method for anesthesia in ambulatory patients, offering advantages over general anesthesia in selected populations.The use of spinal anesthesia is expanding to meet surgical needs. Therefore, it is crucial to plan ahead and anticipate organizational failures in the ambulatory setting to maintain safety and efficiency during outpatient procedures and surgeries
Exploring the thermally-controlled fentanyl transdermal therapy to provide constant drug delivery by physics-based digital twins.
Get PDFTransdermal drug delivery is suitable for low-molecular-weight drugs with specific lipophilicity, like fentanyl, which is widely used for cancer-induced pain management. However, fentanyl's transdermal therapy displays high intra-individual variability. Factors like skin characteristics at application sites and ambient temperature contribute to this variation. In this study, we developed a physics-based digital twin of the human body to cope with this variability and propose better adapted setups. This twin includes an in-silico skin model for drug penetration, a pharmacokinetic model, and a pharmacodynamic model. Based on the results of our simulations, applying the patch on the flank (side abdominal area) showed a 15.3% higher maximum fentanyl concentration in the plasma than on the chest. Additionally, the time to reach this maximum concentration when delivered through the flank was 19.8 h, which was 10.3 h earlier than via the upper arm. Finally, this variation led to an 18% lower minimum pain intensity for delivery via the flank than the chest. Moreover, the impact of seasonal changes on ambient temperature and skin temperature by considering the activity level was investigated. Based on our result, the fentanyl uptake flux by capillaries increased by up to 11.8% from an inactive state in winter to an active state in summer. We also evaluated the effect of controlling fentanyl delivery by adjusting the temperature of the patch to alleviate the pain to reach a mild pain intensity (rated three on the VAS scale). By implementing this strategy, the average pain intensity decreased by 1.1 points, and the standard deviation for fentanyl concentration in plasma and average pain intensity reduced by 37.5% and 33.3%, respectively. Therefore, our digital twin demonstrated the efficacy of controlled drug release through temperature regulation, ensuring the therapy toward the intended target outcome and reducing therapy outcome variability. This holds promise as a potentially useful tool for physicians
Development of narcissism across the life span: A meta-analytic review of longitudinal studies.
Get PDFThis meta-analytic review investigated the development of narcissism across the life span, by synthesizing the available longitudinal data on mean-level change and rank-order stability. Three factors of narcissism were examined: agentic, antagonistic, and neurotic narcissism. Analyses were based on data from 51 samples, including 37,247 participants. As effect size measures, we used the standardized mean change d per year and test-retest correlations that were corrected for attenuation due to measurement error. The results suggested that narcissism typically decreases from age 8 to 77 years (i.e., the observed age range), with aggregated changes of d = -0.28 for agentic narcissism, d = -0.41 for antagonistic narcissism, and d = -0.55 for neurotic narcissism. Rank-order stability of narcissism was high, with average values of .73 (agentic), .68 (antagonistic), and .60 (neurotic), based on an average time lag of 11.42 years. Rank-order stability did not vary as a function of age. However, rank-order stability declined as a function of time lag, asymptotically approaching values of .62 (agentic), .52 (antagonistic), and .33 (neurotic) across long time lags. Moderator analyses indicated that the findings on mean-level change and rank-order stability held across gender and birth cohort. The meta-analytic data set included mostly Western and White/European samples, pointing to the need of conducting more research with non-Western and ethnically diverse samples. In sum, the findings suggest that agentic, antagonistic, and neurotic narcissism show normative declines across the life span and that individual differences in these factors are moderately (neurotic) to highly (agentic, antagonistic) stable over time. (PsycInfo Database Record (c) 2024 APA, all rights reserved)
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