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Effect of an interdisciplinary inpatient program for patients with CRPS in reducing disease activity -a single center prospective cohort study.
Get PDFOBJECTIVE
The aim of this study was to evaluate the benefit of inpatient treatment in reducing disease activity in patients with CRPS who have exhausted outpatient options. Furthermore, the study sought to identify patient-related outcome variables that predict a reduction in disease activity.
METHODS
The primary outcome was disease severity (CRPS Severity Score, range 0-16 points)). Secondary outcomes included depression, anxiety, physical function, pain interference, fatigue, sleep disturbance, and ability to participate in social roles and activities, all of which were assessed using the Promis-29. Furthermore, pain catastrophizing, neuropathic pain, quality of life, pain self-efficacy, medication intake, and the patient's global impression of change were examined in accordance with current international agreed recommendations, assessed at discharge, three-month and six-month post-discharge. Mixed-effects models were conducted to identify baseline variables associated with CRPS severity.
RESULTS
Twenty-five patients completed the program (mean age 49.28 (SD 11.23) years, 92% females, mean symptom duration 8.5 (SD 6.5) months). Results showed a significant reduction between baseline and discharge of disease activity (CSS -2.36, p < 0.0001), pain (PROMIS-29 pain -0.88, p = 0.005) and emotional function (PROMIS-29 depression -5.05, p < 0.001; fatigue -4.63, p = 0.002). Moderate evidence for a reduction between baseline and discharge could be observed for pain interference (+2.27, p = 0.05), social participation (PROMIS-29 +1.93, p = 0.05), anxiety (PROMIS-29 -3.32, p = 0.02) and physical function (PROMIS-29 +1.3, p = 0.03). On discharge, 92% of patients (23 of 25) reported improvement in their overall condition. In the follow-up period, medication intake could be reduced after 3 (MQS -8.22, p = 0.002) and 6 months (MQS -8.69, p = 0.001), and there was further improvement in social participation after 3 months (PROMIS-29 +1.72, 0.03) and sleep after 6 months (PROMIS-29 +2.38, 0.008). In the mixed models, it was demonstrated that patients experiencing less pain at baseline also exhibited lower disease activity.
CONCLUSION
The results of this study confirm that inpatient interdisciplinary treatment of CRPS patients improves disease activity, pain, physical function, emotional function, and social participation. Most improvements were maintained for up six months after discharge. The majority of patients reported that their overall condition had improved during the study period
Gott wahrnehmen und lieben. Christologie und Nächstenliebe zwischen Johannesevangelium und 1. Johannesbrief
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Until death do us part: A multidisciplinary study on joint human-animal burials from the Late Iron Age necropolis of Seminario Vescovile (Verona, Northern Italy)
No full textThe Displaying of Dead Bodies in Italian Catholicism (c.1750-1950)
No full textSince the latter half of the 18th century, the concept of sanctity in Catholicism underwent significant changes in both its canonical and devotional aspects. Alongside these changes, there was a notable increase in the occurrence of extraordinary phenomena involving the corpses of Catholic heroes, such as incorruption, flexible limbs, and fragrances. Public displays of the dead bodies in churches, crypts, and convents often accompanied these events. While these remarkable occurrences recurred throughout the history of the Church since its origin, the sheer quantity of them, in conjunction with the complexity of the period, makes these cases uniquely intriguing. My doctoral project aims to hermeneutically investigate this phenomenon, addressing questions such as: to whom do dead bodies belong? Are they saints, blessed, servants of God, or none of those above? What were the attitudes of the Church, political authorities, and scientists? Are there recurring figures, such as martyrs, members of religious orders, or mystics? I approach these questions in my thesis by focusing on the Italian context, where most cases are located. I employ a comparative methodology, examining various political and religious contexts, and adopt a long-term perspective to trace both continuities and discontinuities. During my presentation, I will provide an overview of the current state of research, focusing on introducing the phenomenon’s statistical overview, summarizing interpretative approaches, discussing research methodologies and sources employed, and highlighting potential future directions and unresolved questions
Co-creating knowledge in transdisciplinary art and climate science collaborations: Exploring epistemic justice in applied methods and procedures
No full textTransdisciplinary collaborations between art and climate science aim to co-create knowledge to strive for climate and ecological justice. This research explores developed and applied methods and procedures that promote epistemic justice between artists, climate scientists, societal actors, and the more-than-human to avoid marginalising knowledge and contribute to social justice. That means collaborations strive to co-create knowledge to increase climate and ecological justice, but the co-creation processes are not necessarily practised just and on eye level. Thus, the main research question concerns how to reach epistemic justice in terms of knowledge co-creation regarding the climate crisis between artists, climate scientists, society, and the more-than-human in art and climate science transdisciplinary collaborations through uncovering underlying assumptions and dynamics and investigating just, participatory, and pluralistic methodologies, practices, and processes. The research aims to answer this based on the three interdependent types of knowledge in transdisciplinary research. System knowledge describes the current state of the problem, followed by the target knowledge referring to the desired future scenario development based on values, norms, and system knowledge, and finally, transformation knowledge deals with initiating the actual change and how to turn system and target knowledge into practice (Buser & Schneider, 2021). Combining the concepts of ecological art, transdisciplinarity, and climate and ecological justice provides the research framework. Drawing on qualitative and transdisciplinary research methods by applying participatory interviews, participant observation, focus group discussions, actor constellation, and storywall in the context of Switzerland, I will suggest emerging challenges, issues, and inspirations in transdisciplinary collaboration processes. The case studies will provide examples from which priorities of some practices over others through reflection can be observed, which can help conduct future art and climate science transdisciplinary research projects. Recognising present power dimensions in collaborations and inter- and intrapersonal dynamics is crucial in the context of art, ecology, the environment, and marginalised knowledge on a societal, political, and scientific level
Russian Foreign Policy Debates and the Conflicts in Georgia (1991–2008). Between Multilateralism and Unilateralism
No full textRussian Foreign Policy Debates and the Conflicts in Georgia (1991–2008): Between Multilateralism and Unilateralism discusses the conflicts and crises in the former Soviet space from a historical perspective and reconstructs the often-contradictory approaches of public actors in Russia on how to deal with them. Notably, it inquires whether the actions suggested follow a “multilateral” approach—one based on pluralist decisions and international law—or, on the opposite, a “unilateral” one—concentrating exclusively on Russia’s own national interests, to the detriment of commonly agreed-on international rules. The case of Georgia, from the disintegration of the Soviet Union in 1991 to the “Five-Day War” in August 2008, serves as an example illustrating Russian approaches to conflict management. Richly illustrated with empirical data, the three parts of this book show how foreign and security policy debates in Moscow and their outcomes on the ground evolved from a chaotic policy of ad hoc interventions in the 1990s to a coherent, geopolitically informed strategy of coercion and persuasion in the 2000s. About a decade and a half before the large-scale invasion of Ukraine, Moscow had already shown its willingness to go quite far in defending its interests in the former Soviet space
Die Zukunft der Theologie oder die Theologie der Zukunft? Vortrag im Rahmen der Feierlichkeiten "150 Jahre Christkatholische Theologie an der Universität Bern"
No full textEpidemiological and clinical insights into the enterovirus D68 upsurge in Europe 2021/22 and the emergence of novel B3-derived lineages, ENPEN multicentre study.
Get PDFEnterovirus D68 (EV-D68) infections are associated with severe respiratory disease and acute flaccid myelitis (AFM). The European Non-Polio Enterovirus Network (ENPEN) aimed to investigate the epidemiological and genetic characteristics of EV-D68 and its clinical impact during the fall-winter season of 2021/22. From 19 European countries, 58 institutes reported 10,481 (6.8%) EV-positive samples of which 1,004 (9.6%) were identified as EV-D68 (852 respiratory samples). Clinical data was reported for 969 cases. 78.9% of infections were reported in children (0-5 years); 37.9% of cases were hospitalised. Acute respiratory distress was commonly noted (93.1%) followed by fever (49.4%). Neurological problems were observed in 6.4% of cases with six reported with AFM. Phylodynamic/Nextstrain and phylogenetic analyses based on 694 sequences showed the emergence of two novel B3-derived lineages, with no regional clustering. In conclusion, we describe a large-scale EV-D68 European upsurge with severe clinical impact and the emergence of B3-derived lineages
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