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Million-year lag times in a post-orogenic sediment conveyor
Get PDFUnderstanding how sediment transport and storage will delay, attenuate, and even erase the erosional signal of tectonic and climatic forcings has bearing on our ability to read and interpret the geologic record effectively. Here, we estimate sediment transit times in Australia’s largest river system, the Murray-Darling basin, by measuring downstream changes in cosmogenic 26Al/10Be/14C ratios in modern river sediment. Results show that the sediments have experienced multiple episodes of burial and reexposure, with cumulative lag times exceeding 1 Ma in the downstream reaches of the Murray and Darling rivers. Combined with low sediment supply rates and old sediment blanketing the landscape, we posit that sediment recycling in the Murray-Darling is an important and ongoing process that will substantially delay and alter signals of external environmental forcing transmitted from the sediment’s hinterland. Copyright © 2020 The Author
Pyrochlore glass‐ceramics fabricated via both sintering and hot isostatic pressing for minor actinide immobilization
No full textPyrochlore glass‐ceramics (GCs) have been investigated with samples fabricated via both sintering and hot isostatic pressing (HIPing) of a mixed oxide precursor. It has been demonstrated that sintering at 1200°C in air is necessary to obtain well‐crystallized pyrochlore crystals in a sodium aluminoborosilicate glass through a one‐step controlled cooling. The crystallization, structure, and microstructure of Eu2Ti2O7 pyrochlore as the major phases in residual glass were confirmed with X‐ray diffraction (XRD), scanning electron microscopy‐energy dispersive spectroscopy, transmission electron microscopy, and Raman spectroscopy. The structures of major Eu2Ti2O7 pyrochlore and minor [Eu4.67O(SiO4)3] apatite in both sintered and HIPed samples were refined using synchrotron XRD data. While the processing atmosphere did not appear to affect the cell parameter of the main pyrochlore phase, very small volume expansion (~0.3%) was observed for the minor apatite phase in the HIPed sample. In addition, static leaching of the HIPed sample confirmed that pyrochlore GCs are chemically durable. Overall, pyrochlore GCs prepared via both sintering and HIPing with the Eu partitioning factor of ~23 between ceramics and the residual glass are suitable waste forms for minor actinides with processing chemicals. © 1999-2020 John Wiley & Sons, Inc
Geological evidence for the destruction of Shinmachi, Hawaii, by the 1946 Aleutian and 1960 Chile Tsunamis?
No full textThe Japanese community of Shinmachi, established on low-lying land between downtown Hilo and Waiakea, Hawaii, was obliterated by the 1946 Aleutian tsunami but was rebuilt, only to be destroyed again by the 1960 Chilean tsunami. The aim of this study was to find out if any geological evidence of these well documented events had been preserved in the sedimentary record in Wailoa River State Park, which replaced Shinmachi after the 1960 tsunami. This was achieved by collecting cores in the park and performing sedimentological, chronological and geochemical analyses, the latter also processed by principal component analysis. Sediment transport modelling was carried out for both tsunamis, to infer the source of the sediment and areas of deposition on land. The field survey revealed two distinct units within peat and soil, a thin lower unit composed of weathered basalt fragments within mud (Unit 1) and an upper unit dominated by fine volcanic sand within fine silt exhibiting subtle upward fining and coarsening (Unit 2, consisting of Unit 2A and Unit 2B), although these two anomalous units only occur on the western shore of Waiakea Mill Pond. Analysis with an ITRAX core scanner shows that Unit 1 is characterised by high Mn, Fe, Rb, La and Ce counts, combined with elevated magnetic susceptibility. Based on its chemical and sedimentological characteristics, Unit 1 is attributed to a flood event in Wailoa River that occurred around 1520–1660 CE, most probably as a result of a tropical storm. The sharp lower contact of Unit 2 coincides with the appearance of arsenic, contemporaneous with an increase in Ca, Sr, Si, Ti, K, Zr, Mn, Fe, La and Ce. In this study, As is used as a chronological and source material marker, as it is known to have been released into Wailoa River Estuary and Waiakea Mill Pond by the Canec factory between 1932 and 1963. Thus, not only the chemical and sedimentological evidence but also sediment transport modelling, corroborating the historical record, suggest that Unit 2A was deposited by the 1946 tsunami, and the sediment most likely originated from Wailoa River Estuary, beach and nearshore seafloor. The upper part of this unit, Unit 2B, is believed to have been deposited by the 1960 tsunami, as suggested by sediment transport modelling, although limited accommodation space is likely to have resulted in the thin deposit (3 cm thickness) present at that site. Limited accommodation space on the island of Hawaii has led to only rare locations where tsunami deposits are preserved, despite the repeated occurrence of tsunamis affecting the island. © 2020 Elsevier B.
Determining flow patterns and emplacement dynamics from tsunami deposits with no visible sedimentary structure
No full textIn the absence of eyewitness reports or clear sedimentary structures, it can be difficult to interpret tsunami deposits or reconstruct tsunami inundation patterns. The emplacement dynamics of two historical tsunami deposits were investigated at seven transects in Okains Bay, New Zealand, using a combined geospatial, geomagnetic and sedimentological approach. The tsunami deposits are present as layers of sand and silt intercalated between soils and become finer and thinner with distance inland. The deposits are attributed to the 1960 and possibly the 1868 tsunamis, based on radiometric dating and correlation with historical records. Measurements of Magnetic Fabric (MF: Anisotropy of Magnetic Susceptibility) and particle size were used to reconstruct the evolution of flow dynamics laterally and vertically. A combination of statistical methods, including spatial autocorrelation testing, Spearman's rank order correlation, Principal Component Analysis (PCA) and K-means cluster analysis, was applied to examine relationships between MF parameters and sediment texture, and infer depositional hydrodynamics. Flow patterns deduced from MF show the estuary channel acted as a conduit for inundation, with flow commonly aligned sub-perpendicular to the estuary bed. MF and sediment data suggest deposition occurred from settling during laminar flow. Evidence of both uprush and backwash deposition, as well as wave reflection from infrastructure, was found. Statistical analysis of data showed significant relationships between grain size parameters and MF parameters associated with flow speed and magnetic fabric type. PCA and cluster analysis differentiated samples into two primary hydrodynamic groups: (1) samples deposited from laminar flow; and (2) samples deposited close to the limit of inundation, which includes samples deposited further inland, those affected by flow convergence, and those in the upper part of tsunami deposits. This approach has potential as a tool for reconstructing hydrodynamic conditions for palaeotsunamis and by combining spatial and statistical analyses, large-scale investigations can be more easily performed. Copyright © 2016 John Wiley & Sons, Ltd
Archaeological investigations into the origins of bel trading groups around the madang coast, Northeast New Guinea
No full textThis article presents archaeological data critical to our understanding of the pre-colonial past along the northeast coast of New Guinea. Two archaeological sites from coastal and offshore Madang, Papua New Guinea, were excavated to establish the timing of colonization by Bel (Austronesian) speakers, and the subsequent emergence of their trade and exchange networks along the coast leading up to ethnographic accounts. These sites include Nunguri on Bilbil Island, formerly the center of the expansive Madang (Bilbil) pottery exchange network, and Tilu, Malmal village, a pottery consumption area along the coast. Both excavations suggest that initial occupation at these sites by the Bel-speaking groups occurred very recently in the last millennium before present (c. 550–650 cal BP), which is broadly in line with oral history and linguistic evidence. From the start, this occupation involved local red-slipped pottery production and distribution, the exchange of obsidian and sedimentary lithics, and the consumption of nearshore marine resources along with key domesticated animals. In-depth descriptions of these investigations and the archaeological material are presented here. © Taylor & Francis Grou
Intrinsic synergistic-topological mechanism versus synergistic-topological matrix in microtubule self-organization
Get PDFBackground
In this body of work we investigate the synergistic-topological relationship during self-organization of the microtubule fiber in vitro, which is composed of straight, axially shifted and non-shifted, acentrosomal microtubules under crowded conditions.
Methods
We used electron microscopy to observe morphological details of ordered straight microtubules. This included the observation of the differences in length distribution between microtubules in ordered and non-ordered phases followed by the observation of the formation of interface gaps between axially shifted and ordered microtubules. We performed calculations to confirm that the principle of summation of pairwise electrostatic forces act between neighboring microtubules all their entire length.
Results
We have shown that the self-organization of a microtubule fiber imposes a variety of topological restrictions onto its constituting components: (a) tips of axially shifted neighboring microtubules are not in direct contact but rather create an ‘interface gap’; (b) fibers are always composed of a restricted number of microtubules at given solution conditions; (c) the average length of microtubules that constitute a fiber is always shorter than that of microtubules outside a fiber; (d) the length distribution of microtubules that constitute a fiber is narrower than that of microtubules outside a fiber and this effect is more pronounced at higher GTP-tubulin concentrations; (e) a cooperative motion of fiber microtubules due to actualization of the summation principle of pairwise electrostatic forces; (f) appearance of local GTP-tubulin depletion immediately in front of the tips of fiber microtubules.
Conclusion
Overall our data indicate that under crowded conditions in vitro, the self-organization of a microtubule fiber is governed by an intrinsic synergistic-topological mechanism, which in conjunction with the topological changes, GTP-tubulin depletion, and cooperative motion of fiber constituting microtubules, may generate and maintain a ‘synergistic-topological matrix’. Failure of the mechanism to form biologically feasible microtubule synergistic-topological matrix may, per se, precondition tumorigenesis. © 2014 BioMed Central Lt
The synthesis and fluorescence profile of novel thalidomide analogues
No full textHerein we describe the synthesis of various simple N-alkyl thalidomide derivatives in order to determine their fluorescence excitation and emission profile. Following this, a series of more complex fragments were attached through a Huisgen 1,3-dipolar cycloaddition providing a more diverse fluorescence profile. A thalidomide azide derivative was also found to be particularly reactive in a copper-free click reaction with two known cyclooctynes. © 2015 Elsevier Ltd
Novel fluorinated 8-hydroxyquinoline based metal Ionophores for exploring the metal hypothesis of alzheimer’s disease
No full textZinc, copper, and iron ions are involved in amyloid-beta (Aβ) deposition and stabilization in Alzheimer’s disease (AD). Consequently, metal binding agents that prevent metal-Aβ interaction and lead to the dissolution of Aβ deposits have become well sought therapeutic and diagnostic targets. However, direct intervention between diseases and metal abnormalities has been challenging and is partially attributed to the lack of a suitable agent to determine and modify metal concentration and distribution in vivo. In the search of metal ionophores, we have identified several promising chemical entities by strategic fluorination of 8-hydroxyquinoline drugs, clioquinol, and PBT2. Compounds 15–17 and 28–30 showed exceptional metal ionophore ability (6–40-fold increase of copper uptake and >2-fold increase of zinc uptake) and inhibition of zinc induced Aβ oligomerization (EC50s < ∼5 μM). These compounds are suitable for further development as drug candidates and/or positron emission tomography (PET) biomarkers if radiolabeled with 18F. © 2015 American Chemical Societ
The 18 kDa translocator protein, microglia and neuroinflammation
Get PDFThe 18 kDa translocator protein (TSPO), previously known as the peripheral benzodiazepine receptor, is expressed in the injured brain. It has become known as an imaging marker of “neuroinflammation” indicating active disease, and is best interpreted as a nondiagnostic biomarker and disease staging tool that refers to histopathology rather than disease etiology. The therapeutic potential of TSPO as a drug target is mostly based on the understanding that it is an outer mitochondrial membrane protein required for the translocation of cholesterol, which thus regulates the rate of steroid synthesis. This pivotal role together with the evolutionary conservation of TSPO has underpinned the belief that any loss or mutation of TSPO should be associated with significant physiological deficits or be outright incompatible with life. However, against prediction, full Tspo knockout mice are viable and across their lifespan do not show the phenotype expected if cholesterol transport and steroid synthesis were significantly impaired. Thus, the “translocation” function of TSPO remains to be better substantiated. Here, we discuss the literature before and after the introduction of the new nomenclature for TSPO and review some of the newer findings. In light of the controversy surrounding the function of TSPO, we emphasize the continued importance of identifying compounds with confirmed selectivity and suggest that TSPO expression is analyzed within specific disease contexts rather than merely equated with the reified concept of “neuroinflammation.” © 2014 The Authors© 2014 The Authors. Brain Pathology published by John Wiley & Sons Ltd on behalf of International Society of Neuropathology.
This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited
An early onset of ENSO influence in the extra-tropics of the southwest Pacific inferred from a 14, 600 year high resolution multi-proxy record from Paddy's Lake, northwest Tasmania
No full textTropical El Niño Southern Oscillation (ENSO) is an important influence on natural systems and cultural change across the Pacific Ocean basin. El Niño events result in negative moisture anomalies in the southwest Pacific and are implicated in droughts and catastrophic wildfires across eastern Australia. An amplification of tropical El Niño activity is reported in the east Pacific after ca. 6.7 ka; however, proxy data for ENSO-driven environmental change in Australia suggest an initial influence only after ca. 5 ka. Here, we reconstruct changes in vegetation, fire activity and catchment dynamics (e.g. erosion) over the last 14.6 ka from part of the southwest Pacific in which ENSO is the main control of interannual hydroclimatic variability: Paddy's Lake, in northwest Tasmania (1065 masl), Australia. Our multi-proxy approach includes analyses of charcoal, pollen, geochemistry and radioactive isotopes. Our results reveal a high sensitivity of the local and regional vegetation to climatic change, with an increase of non-arboreal pollen between ca. 14.6–13.3 ka synchronous with the Antarctic Cold Reversal, and a sensitivity of the local vegetation and fire activity to ENSO variability recorded in the tropical east Pacific through the Holocene. We detect local-scale shifts in vegetation, fire and sediment geochemistry at ca. 6.3, 4.8 and 3.4 ka, simultaneous with increases in El Niño activity in the tropical Pacific. Finally, we observe a fire-driven shift in vegetation from a pyrophobic association dominated by rainforest elements to a pyrogenic association dominated by sclerophyllous taxa following a prolonged (>1 ka) phase of tropical ENSO-amplification and a major local fire event at ca. 3.4 ka. Our results reveal the following key insights: (1) that ENSO has been a persistent modulator of southwest Pacific climate and fire activity through the Holocene; (2) that the climate of northwest Tasmania is sensitive to long-term shifts in tropical ENSO variability; and (3) that there has been possible stationarity in the spatial influence of ENSO over this region through the Holocene. © 2016 Elsevier Ltd