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Predictive Model of Anxiety and Depression Perception in Multiple Sclerosis Patients: Possible Implications for Clinical Treatment
No full textAbstract: Multiple Sclerosis (MS) is a neurodegenerative disease characterized by motor and nonmotor symptoms, including emotional distress, anxiety, and depression. These emotional symptoms currently have a pharmacological treatment with limited effectiveness; therefore, it is necessary to delve into their relationship with other psychological, functional, or prefrontal alterations. Additionally, exploring non-pharmacological therapeutic alternatives that have shown benefits in addressing emotional distress in MS patients is essential. Aim: To establish a predictive model for the presence of anxiety and depression in MS patients, based on variables such as psychological well-being, functional activity, and prefrontal symptoms. Additionally, this study aimed to propose non pharmacological therapeutic alternatives based on this model. Materials and Methods: A descriptive, observational, and cross-sectional study was conducted with a sample of 64 diagnosed MS patients who underwent functional and cognitive assessments using the following questionnaires and scales: Functional Activities Questionnaire (FAQ), Acceptance and Action Questionnaire (AAQ-II), Experiences Questionnaire (EQ), Self-Compassion Scale Short Form (SCS-SF), Beck Depression Inventory II (BDI-II), State-Trait Anxiety Inventory (STAI), and Prefrontal Symptoms Inventory (PSI). Results: The model showed an excellent fit to the data and indicated that psychological well-being was the most significant predictor of the criteria (β = −0.83), followed by functional activity (β = −0.18) and prefrontal symptoms (β = 0.15). The latter two are negatively related to psychological well-being (β = −0.16 and β = −0.75, respectively). Conclusions: Low psychological well-being is the variable that most significantly
predicts the presence of anxiety and depression in MS patients, followed by functional activity and prefrontal alterations. Interventions based on mindfulness and acceptance are recommended, along with nutritional interventions such as antioxidant-enriched ketogenic diets and moderate group physical exercise.Catholic University Foundation San Vicente Mártir, for the research project The Impact of Triglycerides on Multiple Sclerosis (Promotion code 2018-203-001)4.6 Q2 JCR 20220.627 Q3 SJR 2023No data IDR 2023UE
Personal and family factors for emotional distress in adolescents with chronic disease
No full textIntroduction: Physical and psychological comorbidity is a challenge for public health, especially in the adolescent stage due to the difficulties of this age. The salutogenic perspective emphasizes general psychological resources such as self-esteem but also highlights the role of contextual factors such as family members in promoting health. From this perspective, the objective of this study was to analyze the joint influence of demographic factors (sex, age and type of chronic disease), personal factors (self-esteem and perception of threat of the disease) and family factors (affection and communication, psychological and behavioral control) of risk of emotional distress (anxiety-depressive symptoms) in chronically ill adolescents. Methods: The study is a cross-sectional design with 495 adolescents with chronic disease aged 12–16 years. In order to obtain the results, a linear methodology was used to compare means and perform regressions to predict belonging to the anxiety and depression typologies. Four typologies were constructed: typology I (high anxiety and depression scores); typology II (high anxiety and low depression scores); typology III (low anxiety and high depression scores) and typology IV (low anxiety and depression scores). Results: The results were consistent with the salutugenic theory. Potential mediating or moderating roles of age, sex, self-esteem, perceived threat and psychological and behavioral control marked the differences between the typologies. Discussion: This population could benefit from interventions focused on family flexibility.Generalitat Valencia, Conselleria d’Educació, Universitats i Empleo (CIGE21-119)3.8 Q1 JCR 20220.891 Q2 SJR 2022No data IDR 2022UE
Small Extracellular Vesicles and Oxidative Pathophysiological Mechanisms in Retinal Degenerative Diseases
No full textThis review focuses on the role of small extracellular vesicles in the pathophysiological mechanisms of retinal degenerative diseases. Many of these mechanisms are related to or modulated by the oxidative burden of retinal cells. It has been recently demonstrated that cellular communication in the retina involves extracellular vesicles and that their rate of release and cargo features might be affected by the cellular environment, and in some instances, they might also be mediated by autophagy. The fate of these vesicles is diverse: they could end up in circulation being used as markers, or target neighbor cells modulating gene and protein expression, or eventually, in angiogenesis. Neovascularization in the retina promotes vision loss in diseases such as diabetic retinopathy and age-related macular degeneration. The importance of micro RNAs, either as small extracellular vesicles’ cargo or free circulating, in the regulation of retinal angiogenesis is also discussed.‘Consolidación de Indicadores’ (CEU-UCH 2022- 2023)‘Proyectos Puente y en Consolidación’ (CEU FUSP 2022-2023)Agencia Estatal de Investigación (AEI) (PID2020-117875GB-I00/AEI/10.13039/501100011033)Instituto de Salud Carlos III (ISCIII) (PI21/00083)5.6 Q1 JCR 20221.154 Q1 SJR 2022No data IDR 2022UE
Corporate Social Responsibility and Environmental Management
No full textFast fashion, a prominent sector in global business, has come under scrutiny for its substantial clothing production and the resulting social and environmental impacts. A social and sustainable orientation in fast fashion is gaining traction with increased consumer awareness, prompting a shift in manufacturing practices. This paper, using a combination of qualitative (content analysis) and quantitative (survey) approaches, focuses on Zara and applies Stakeholder theory to confirm the positive impact of adopting social and sustainable initiatives on clients' purchase intentions. Our findings also underscore the significance of keeping stakeholders informed about the sustainable and corporate social responsibility initiatives undertaken by a brand.Sin financiación9.8 Q1 JCR 20222.201 Q1 SJR 2023No data IDR 2022UE
The Influence of High-Intensity Work on the Record Power Profile of Under-23, Pro Team, and World Tour Cyclists
No full textBackground: Durability (ie, the ability to attenuate the decline in performance after accumulated work) has been identified as a performance determinant in elite cyclists. The aim of the present study was to compare durability in elite cyclists of various performance levels, particularly after high-intensity work, referred to as "high-intensity durability."
Methods: Forty-nine (N = 49) male road cyclists were categorized as either under 23 years of age (U23) (N = 11), Pro Team (N = 13), or World Tour (N = 24). The participants' critical power (CP) was assessed during the preseason. Thereafter, the participants' maximum mean power (MMP) values were determined for efforts of different durations (from 5 s to 30 min) after different levels of accumulated work above CP (from 0 to 7.5 kJ·kg-1).
Results: U23 cyclists showed a significant reduction of all relative MMP values for durations ≥1 minute after ≥5 kJ·kg-1 above CP compared with the "fresh" state (0 kJ·kg-1), whereas in Pro Team and World Tour cyclists, a significant reduction was not observed until 7.5 kJ·kg-1 above CP. In the "fresh" state, both Pro Team and particularly World Tour cyclists attained higher MMP values for efforts ≥10 minutes than U23 riders. However, more differences emerged with greater previous work levels, and indeed after 7.5 kJ·kg-1 above CP World Tour cyclists attained higher MMP values than both U23 and Pro Team cyclists for most efforts (≥30 s).
Conclusion: Pro Team and particularly World Tour cyclists tolerate greater levels of accumulated work at high intensity, which might support the importance of high-intensity durability for performance.Sin financiación3.3 Q2 JCR 20221.388 Q1 SJR 2023No data IDR 2022UE
Systemic and local effect of oxidative stress on recurrent aphthous stomatitis: systematic review
No full textRecurrent aphthous stomatitis (RAS) is a chronic and recurrent inflammatory disease of the mouth. It is characterised by the
appearance of painful ulcers in the oral mucosa. RAS is believed to be a multifactorial disease with genetic predisposition,
environmental factors and alterations in the immune system. Oxidative stress, caused by an imbalance between free radicals
and the antioxidant system, also appears to be involved in the pathogenesis of RAS. Several risk factors, such as smoking,
iron and vitamin deficiency and anxiety, may contribute to the development of the disease. Understanding the underlying
mechanisms may help in the prevention and treatment of RAS. We searched PubMed, Scopus and Web of Science databases
for articles on oxidative stress in patients with RAS from 2000 to 2023. Studies analysing oxidant and antioxidant levels
in the blood and saliva of RAS patients and healthy controls were selected. Of 170 potentially eligible articles, 24 met the
inclusion criteria: 11 studies on blood samples, 6 on salivary samples and 7 on both blood and salivary samples. Multiple
oxidative and antioxidant markers were assessed in blood and saliva samples. Overall, statistically significant differences
were found between RAS patients and healthy controls for most markers. In addition, increased oxidative DNA damage was
observed in patients with RAS. Patients with RAS show elevated levels of oxidative stress compared to healthy controls, with
a significant increase in oxidative markers and a significant decrease in antioxidant defences in saliva and blood samples.Sin financiación4.7 Q1 JCR 20221.422 Q1 SJR 2023No data IDR 2022UE
¿Cuándo se debe plantear no realizar recambio electivo de generador de un desfibrilador automático implantable?
No full textSin financiación5.9 Q1 JCR 20221.1991 Q1 SJR 2023No data IDR 2022UE
Taller de pensamiento 1. Pensamientos sobre el origen y causas del delito
No full textPensamiento sobre las causas y orígenes del delito, atendiendo a las múltiples formas por las que alguien puede terminar delinquiendo.Sin financiaciónSPI 2022UE
La historia del docente y los entornos virtuales: tendencias de mejora en las competencias digitales
No full textEn los últimos tiempos y en plena era de globalización, es una de las vocaciones que más transformación ha tenido y experimentado. En plena sociedad de la información y comunicación, se han abierto nuevos escenarios tecnológicos que han impactado de manera práctica en la organización y gestión de la enseñanza educativa.
Por este motivo, se hace necesario revisar los enfoques y perspectivas que se han ido involucrando entorno a la formación profesional del docente y el significado que ha cogido en los últimos años esta profesión.
Cuando conversamos sobre la formación del docente, en verdad no podemos dejar atrás la evolución de los entornos tecnológicos multimediales, su propio impacto en la educación y el surgimiento de internet como parte central en nuestras vidas, ha impactado de manera significativa en los roles tradicionales atribuidos a los docentes.Sin financiaciónSPI 2022UE