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Integrated analysis of the Neogene–Quaternary Valdera-Volterra Basin (Northern Apennines). Evidence for composite development of hinterland basins
Get PDFThe Neogene and Quaternary hinterland basins of the Northern Apennine have been the subject of different tectonic interpretations. Several studies considered these basins as the result of polyphase normal faulting framed in a continuous crustal extensional regime since the middle Miocene. On the contrary, geophysical and geological studies provided evidence of the important role played by out-of-sequence thrusts and backthrusts in the evolution of these basins during a prolongated and intense period of shortening. Here we present an integrated analysis of 2D stacked seismic reflection profiles, stratigraphic and geophysical data from deep exploration wells, gravity data, and published geological and biostratigraphic data for the Valdera-Volterra basin (central Tuscany, Italy). The results support a polyphase and composite evolution of the basin, subdivided into three main phases. During the late Tortonian?Zanclean, the growth of major thrust-related anticlines controlled the evolution of the sedimentary basin. The growth of a syncline determined the creation of accommodation space for the sediments. This main compressional deformation occurred during the Messinian and ended during the Late Zanclean. NE migration of the depocentre during the Early Zanclean was identified, likely possibly due to a differential activity growth between the bordering anticlines. During the Piacenzian, an extensional phase has been recognised, superposed to the previous compressive phase. During the Latest Piacenzian?Early Pleistocene (?), a final compressional phase took place resulting in the positive inversion of the Piacenzian WSW dipping main border fault
At the Crossroads: Developing local strategies to support pathways into employment for young people:Phase 2 Report on the Cross-Sectoral Project run by Royal Holloway University of London seeking to improve employment outcomes in our regional area
Get PDFRitual, Tableau, Ecosystem: Composing with Non-Linear Musical Objects:A portfolio of compositions and commentary
Get PDFThis thesis consists of a portfolio of twelve compositions, a written commentary, and recordings of ten of the submitted works. The music within was written for a range of forces, from solo pieces to work for symphony orchestra. The way we listen to music involves bounding the flow of sound; as we hear and grasp music, we objectify it, creating a space between us, the subject, and it, the object. Certain types of musical object can be characterised as non-linear, in the way that they unfold in time without direction or recourse to causal relationships between materials. In the compositions within this portfolio I consider the ramifications of composing with non-linear musical objects, exploring one principal research question:- How can musical material be presented as a musical object, and what possibilities for expressive outcomes exist when working with musical objects?This key area of examination is filtered through two secondary research questions:a) How do different approaches to structural openness affect the sense of time and rhythm of a musical object?b) How can microtonality and muted timbres be employed in the creation of musical objects?The project as a whole makes reference to a number of composers: John Cage, Frank Denyer, Morton Feldman, Cassandra Miller, James Weeks, amongst others; as well as writers on a range of subjects: Pierre Schaeffer, Tim Ingold, Marius Kozak, Vincent Meelberg, Bob Snyder, Junichirō Tanizaki, et al. The work of these figures, both canonical and modern, is discussed as a means to shed light on my own music, and as a source of inspiration. Concepts drawn from narrativity, semiotics and psychoacoustics lightly colour both my approach to composing and the subsequent analysis found in this commentary. In the course of this thesis, various approaches to structuring combinations of objects lead to insight into the dialogue between strict and intuitive compositional & notational approaches, and degrees of performer agency; microtones create a space in which pitch is inflected, and the boundary between melody, harmony and timbre is blurred to create an elusive, subjective musical experience; and the model of performer-object-listener is explored as an index for musical meaning
Coupling Artificial Intelligence Capability and Strategic Agility for Enhanced Product and Service Creativity
Get PDFCreativity is key for organizations’ ability to remain relevant in today’s disruptive world. In this article, we identify new ways in which organizations can use artificial intelligence (AI) more effectively for creativity. Drawing on the resource-based view as a background mechanism, we developed and empirically tested a new integrative model. We collected the research data via a large survey of managers distributed to 600 organizations in China. Our findings show that coupling AI capability with strategic agility can directly support creativity. It also mediates the effects of ambidexterity, customer orientation, and competitor orientation on organizations’ creativity and performance when developing new products and services. In addition, our findings show that coupling AI capability and strategic agility can significantly improve firms’ new product creativity and new service development performance when there is a high level of government institutional support. Our findings provide theoretical and practical implications for academics and practitioners, who are interested in managing AI for organizational creativity
Developing a Tanshinone IIA Memetic by Targeting MIOS to Regulate mTORC1 and Autophagy in Glioblastoma
Get PDFTanshinone IIA (T2A) is a bioactive compound that provides promise in the treatment of Glioblastoma multiforme (GBM), with a range of molecular mechanisms including inhibition of the mechanistic target of rapamycin complex 1 (mTORC1) and the induction of autophagy. Recently, T2A has been demonstrated to function through sestrin 2 (SESN) to inhibit mTORC1 activity, but this pathway has not been investigated regarding autophagy. Here we employed the model system Dictyostelium discoideum and GBM cell lines to investigate the role of T2A in autophagy induction, focusing on the regulation of SESN via a GATOR2 component MIOS, to mTORC1. We show that in D. discoideum, T2A treatment induces autophagy, and both this effect and mTORC1 inhibition is lost upon ablation of either SESN (sesn-) or MIOS (mios-). We then investigated targeting MIOS to reproduce this effect of T2A. Here, computational analysis identified 25 novel compounds predicted to strongly bind the human MIOS protein, and one compound (MIOS inhibitor 3; Mi3) that reduced cell proliferation in two GBM cell lines. Furthermore, Mi3 specificity was demonstrated through the reduction of D. discoideum cell proliferation and induced autophagy, dependent upon MIOS. These effects were also confirmed in GBM cells, where Mi3 treatment also inhibited mTORC1 activity and induced autophagy. Thus, we identify a potential T2A mimetic with demonstrated effects on inhibition of mTORC1 and induction of autophagy in GBM cells
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