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Sustainable Packaging Trends in the Consumer Packaged Goods Market
No full textThis paper explores sustainable packaging trends in the consumer packaged goods (CPG) market, highlighting the environmental challenges posed by plastic waste, resource scarcity, and recycling inefficiencies. It delves into innovative solutions such as biodegradable materials, technological integration with AI and blockchain, and circular economy models, emphasizing their potential to reduce the environmental footprint of packaging. The study also provides actionable recommendations for enhancing sustainability and fostering consumer engagement through transparent communication and storytelling.The increasing global awareness of environmental challenges, including plastic pollution and resource scarcity, has amplified the demand for sustainable packaging in the consumer packaged goods (CPG) sector. This paper examines sustainable packaging trends and their application within the CPG industry, which significantly contributes to environmental issues due to high usage of non-recyclable and single-use materials. The analysis explores advancements in material innovation, such as biodegradable and compostable packaging, technological integration, including AI and blockchain for supply chain transparency, and circular economy models like reusable packaging. The study highlights the environmental, regulatory, and consumer pressures driving these innovations and provides actionable recommendations for enhancing sustainability, including dematerialization, smart packaging, and stakeholder collaboration. By adopting these strategies, the CPG sector can reduce its ecological footprint, align with consumer preferences, and contribute to global sustainability goals, serving as a benchmark for other industries.Author's Origina
Programs, Origins, and Niches of Immunomodulatory Myeloid Cells in Gliomas
No full textABSTRACTGliomas are incurable malignancies notable for an immunosuppressive microenvironment with abundant myeloid cells whose immunomodulatory properties remain poorly defined. Here, utilizing scRNA-seq data for 183,062 myeloid cells from 85 human tumors, we discover that nearly all glioma-associated myeloid cells express at least one of four immunomodulatory activity programs: Scavenger Immunosuppressive, C1Q Immunosuppressive, CXCR4 Inflammatory, and IL1B Inflammatory. All four programs are present in IDH1 mutant and wild-type gliomas and are expressed in macrophages, monocytes, and microglia whether of blood or resident myeloid cell origins. Integrating our scRNA-seq data with mitochondrial DNA-based lineage tracing, spatial transcriptomics, and organoid explant systems that model peripheral monocyte infiltration, we show that these programs are driven by microenvironmental cues and therapies rather than myeloid cell type, origin, or mutation status. The C1Q Immunosuppressive program is driven by routinely administered dexamethasone. The Scavenger Immunosuppressive program includes ligands with established roles in T-cell suppression, is induced in hypoxic regions, and is associated with immunotherapy resistance. Both immunosuppressive programs are less prevalent in lower-grade gliomas, which are instead enriched for the CXCR4 Inflammatory program. Our study provides a framework to understand immunomodulatory myeloid cells in glioma, and a foundation to develop more effective immunotherapies.Author's Origina
Physician's Casebook, Boston 1832: An American Auscultation-Percussion Discussion
No full textAuthor's Origina
Benefits and Challenges of Hiring Refugee Employees: U.S. Employers’ Perspective
No full textThis thesis examines the viewpoint of U.S. employers who employ refugees revealing the advantages and obstacles encountered by enterprises seeking to hire, train, and retain employees from this group. Exploratory research was conducted, focusing on several specific questions. Interviews were conducted with business leaders and managers, and Reflexive Thematic Analysis (RTA) was used to analyze data gathered from discussions. Findings reveal that refugees possess qualities and characteristics that appeal to employers. However, the lack of English proficiency often masks these attributes. Employers who successfully integrate refugees adopt practices to assist the process. The Office of Refugee Resettlement (ORR), as well as related agencies and organizations, can leverage these findings to encourage other employers to consider refugee labor and to develop procedures that assist businesses in overcoming these and other relevant obstacles
An increased copy number of glycine decarboxylase (GLDC) associated with psychosis reduces extracellular glycine and impairs NMDA receptor function
No full textKeeps timing out so here is the complete list of Authors: Maltesh Kambali, Yan Li, Petr Unichenko, Jessica Feria Pliego, Rachita Yadav, Jing Liu, Patrick McGuinness, Johanna Cobb, Muxiao Wang, Rajasekar Nagarajan, Jinrui Lyu, Vanessa Vongsouthi, Colin Jackson, Elif Engin, Joseph T. Coyle, Jaeweon Shin, Nathaniel Hodgson, Takao Hensch, Michael Talkowski, Gregg Homanics, Vadim Bolshakov, Christian Henneberger and Uwe Rudolph
Manuscript Number: 2023MP002124RMolecular and Cellular BiologyAccepted Manuscrip
The Death of Qassem Soleimani and its Effects on Iran’s National Strategy
No full textThis thesis seeks to answer the question of how Qassem Soleimani’s death in 2020 affected Iran’s national strategy. Soleimani’s death at the hands of the U.S. was an important moment in U.S.-Iran relations, and it was a monumental loss for Iran which leaned so heavily on this one man to implement the country’s strategy throughout the Middle East. To understand Iran today and the role Soleimani played, one must understand general Iranian history and the role Shi’ism has within it, to include Ayatollah Khomeini’s implementation of velayat-e faqih during the 1979 revolution. This thesis seeks to give the reader the essential knowledge in these areas while consistently addressing the research question throughout. The research primarily used a qualitative approach in its methodology and made inferences based on scholarly books and articles, interviews with Iran experts, and primary sources such as the IRGC’s constitution. There was a distinct gap in literature on the importance of Soleimani’s death and how it is distinctly tied to Iranian history and its current strategy. Soleimani’s death not only negatively affected Iran’s primary means of deterrence through proxy warfare without its leader who navigated the complex relationships that held it together, but it forced Iran to reevaluate its other alternatives in deterring the west. Iran has looked east to Russia and China for greater support and relationships while also strongly considering the ultimate deterrent of a nuclear weapon; the effect of one man’s death may seem surprising to westerners, but Soleimani’s unique role in Iran caused his loss to be strategic one for Iran
Opportunities in nanoscale probing of laser-driven phase transitions
No full textOther Research UnitAccepted Manuscrip
The Right to Education
No full textAbstract
This chapter examines the right to education of refugees. International human rights instruments, including the International Covenant on Economic, Social and Cultural Rights (ICESCR) and the Refugee Convention, provide a framework for the right to education for refugees. As a social right, and as reflected in the ICESCR, the right to education is to be progressively realized and requires positive action and allocation of funding. Like all human rights, it is dependent on action by government, the availability of public resources, and enforcement mechanisms. The devolution of responsibility for the education of refugees to States through recent policy further entrenches the role of the State in respecting, protecting, and fulfilling refugees' right to education. The chapter then explores the intersection of global and national frameworks for the right to education for refugees and its realization in the form of access to schools. Despite the widely embraced global articulation of the right to education for all refugee children, the realization of the right to education is highly variable, being largely dependent upon their State of asylum.Accepted Manuscrip
Ms. Kaekin - an Original Script
No full textDaniel Coppinger has been a prisoner at the Wilkes Correctional Facility for almost thirty years; he was incarcerated in 1978 for the murder of a teacher and a classmate in his freshman year of high school. He claims he was framed, and that it was a demented substitute tutor who killed them all: Ms. Kaekin, though no one has heard of this woman before. For the last three decades, Daniel has been pleading not guilty, and no one will believe him… until Attorney Afeen Wan steps in with a bizarre connection to the case that might be able to finally set Daniel free
Education for Refugees: Building Durable Futures?
No full textAbstract
Education is one of the key tools of nation-building, as it aims to create future citizens. Yet what happens in seemingly 'futureless' contexts where refugees cannot access even social membership, let alone legal citizenship? In this introduction to our special issue on education for refugees, we explore the aspirations and conceptions of possible futures that students, teachers, governments, international non-governmental organizations (INGOs), and funders have when they promote and pursue education as the solution to the liminal position that refugees in protracted refugee situations find themselves in. Based on insights from the articles, we analyse disconnects between aspirations for education and realities of access to quality education and to opportunities after completing education. We argue that to address these disconnects requires us to move beyond temporal and spatial binaries—present vs. future, here vs. there—that are so common in refugee education discourse and policy. Our suggestion is to draw on and support stakeholders' work, powerfully exemplified in this special issue, to contribute to improved conditions through pedagogies, practices, and policies that address these binaries.Accepted Manuscrip