62463 research outputs found
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Dataset for Global carbon viability of glass retrofits
No full textThis dataset was generated to support the open-access publication “Global carbon viability of glass retrofits.”© the author</p
හදිසි ආපදාවන්ට මුහුණ දීමට සහ ඒවා කළමනාකරණය කර ගැනීමට ශ්රී ලංකාව තවදුරටත් ශක්තිමත් කරගත යුතු ක්ෂේත්ර මොනවා ද?
No full textEnglish title: What areas does Sri Lanka need to strengthen further to face and manage sudden disasters?© BBC, reshared with permission</p
A human factors approach to design an information interface model for a Digital Twin
No full textA Digital Twin requires a user interface to deliver information relevant to its users, hence a model is required to represent the information required by the interface. The objective of this research is to develop a transdisciplinary human factors approach to information gathering and modelling to design Digital Twin information interfaces. Existing approaches to interface modelling either do not consider human factors or those that do provide a high-level view of information insufficient to capture the complexities required for an information interface for a Digital Twin. The approach presented here consists of capturing the information interface requirements using Cognitive Work Analysis to analyse the human-information interaction and structuring this information via Unified Modelling Language (UML) models. To understand human information requirements when interacting with a Digital Twin interface, personas are used to guide the CWA. To illustrate this approach a Digital Twin of an Industrial Gearbox Product-Service is considered. Validation was conducted through a case study with a research and technology organisation. The approach was found to be clear and able to provide information customised to user needs and the level of detail required. The research described creates a more effective approach to creating a Digital Twin information interface model through reducing the number of iterations required to gather information. By specifically considering human interactions the transdisciplinary approach advanced here will augment the development of software systems.</p
A postcode lottery of SEND provision? Analysing and explaining variability in the education of children with SEND since the Children and Families Act: Data Management Plan
No full textProject descriptionThere is a lack of systematic research about the spatial variability in SEND provision and its drivers, leaving debates about the effectiveness of the current policy uninformed. This project addresses this evidence gap by investigating the extent, drivers, and implications of the postcode lottery for the education of children with SEND. Using a new harmonised dataset and spatial and non-spatial statistical and multilevel econometric methods, the project will characterise recent trends and spatial variability in SEND provision and outcomes in England pre- and post- the 2014 Children and Families Act.© the authors</p
Chiral Eu(III) probes for selective sensing of organic monophosphates through circularly polarised luminescence
No full textChiral Eu(III) probes for selective sensing of organic monophosphates through circularly polarised luminescence</p
Daily maximum and minimum dry-bulb air temperatures measured inside homes, work places and other public spaces in Accra and Tamale, Ghana
No full textDaily maximum and minimum dry-bulb air temperatures measured inside homes, work places and other public spaces in Accra and Tamale, Ghana.Principal Investigator: Professor Katherine V. Gough, Loughborough UniversityCo-Investigators: Professor Paula Griffiths, Loughborough University; Professor Robert Wilby, Loughborough University; Professor Samuel Nii Ardey Codjoe, University of Ghana; Professor Paul William Kojo Yankson, University of Ghana; Dr Sam Kayaga, Loughborough University; Dr Raymond Kasei, University for Development Studies© the authors</p
Agile antipatterns
No full textThe challenges faced by project managers, while identical, are sometimes strikingly different, especially based on geographical attributes. However, most of the research churning out from academia is focused on environments where there are technological and knowledge advantages. Technology has made the world a global village but has not done much in solving inherent foundational biases, infrastructural and political issues as well as policies that affect project management. This paper aims to identify some of the gaps that exist in antipattern classifications. In this paper, we look at the adoption of agile based methodologies and antipatterns experienced by regional practitioners and its reaching effects in practice. We discovered that most known antipatterns in co-located teams are exacerbated in remote teams and their occurrences may require different refactored approaches than those used in co-located environments, especially for regional practitioners. We also discovered that human elements are the primary cause of most Agile development antipatterns. To illustrate more clearly the gaps that exist in current agile development antipattern coverage in regional practice and how it affects other autonomous subsystems, we introduce potential additional antipatterns using Tacoee Consults, an Agile practicing software development company in Africa.</p
Randomised controlled trials (RCTs) in rehabilitation: Looking backwards, looking forwards [Editorial]
No full textRandomised controlled trials (RCTs) in rehabilitation: Looking backwards, looking forwards [Editorial]</p
Rapamycin exerts Its geroprotective effects in the ageing human immune system by enhancing resilience against DNA damage
No full textmTOR inhibitors such as rapamycin are among the most robust life‐extending interventions known, yet the mechanisms underlying their geroprotective effects in humans remain incompletely understood. At non‐immunosuppressive doses, these drugs are senomorphic, that is, they mitigate cellular senescence, but whether they protect genome stability itself has been unclear. Given that DNA damage is a major driver of immune ageing, and immune decline accelerates whole‐organism ageing, we tested whether mTOR inhibition enhances genome stability. In human T cells exposed to acute genotoxic stress, we found that rapamycin and other mTOR inhibitors suppressed senescence not by slowing protein synthesis, halting cell division, or stimulating autophagy, but by directly reducing DNA lesional burden and improving cell survival. Ex vivo analysis of aged immune cells from healthy donors revealed a stark enrichment of markers for DNA damage, senescence, and mTORC hyperactivation, suggesting that human immune ageing may be amenable to intervention by low‐dose mTOR inhibition. To test this in vivo, we conducted a placebo‐controlled experimental medicine study in older adults administered with low‐dose rapamycin. p21, a marker of DNA damage‐induced senescence, was significantly reduced in immune cells from the rapamycin compared to placebo group. These findings reveal a previously unrecognised role for mTOR inhibition: direct genoprotection. This mechanism may help explain rapamycin's exceptional geroprotective profile and opens new avenues for its use in contexts where genome instability drives pathology, ranging from healthy ageing, clinical radiation exposure and even the hazards of cosmic radiation in space travel.</p
SPRINT: Line-rate In-band Network Telemetry recovery for application optimization
No full textIn-band Network Telemetry (INT) has enabled efficient, real-time network monitoring and analysis by embedding telemetry data directly into live traffic. However, INT packet loss is inevitable due to network limitations (e.g., congestion, buffer overflow), which compromises the accuracy and effectiveness of INT-based applications. Existing INT recovery solutions cannot operate on the data plane, making them impractical for latency-sensitive in-network computing (INC) applications (e.g., RHA), which rely on accurate INT for decisions. To address this gap, this paper introduces SPRINT, the first forward-error-correction (FEC) INT recovery mechanism that runs entirely at line-rate within the programmable data plane. SPRINT leverages a novel, hardware-friendly shift powered XOR encoding with nested grouping to minimize redundant state and maximize throughput, thereby providing robust fault tolerance. We have implemented a testbed prototype of SPRINT on P4 hardware (Intel Tofino ASIC) and the BMv2 software switch. Our evaluation shows that SPRINT uses under 10% of on-chip SRAM, achieves a minimum recovery latency of approximately 21 μs, delivers a 99% recovery rate, and maintains strong reliability for INT-based applications, e.g., HPCC and RHA.</p