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Interaction between gut microbiota metabolites and dietary components in lipid metabolism and metabolic diseases
Get PDFGut microbiota composition has caused perplexity in developing precision therapy to cure metabolic disorders. However, recent research has focused on using daily diet and natural bioactive compounds to correct gut microbiota dysbiosis and regulate host metabolism. Complex interactions between the gut microbiota and dietary compounds disrupt or integrate the gut barrier and lipid metabolism. In this review, we investigate the role of diet and bioactive natural compounds in gut microbiota dysbiosis and also the modulation of lipid metabolism by their metabolites. Recent studies have revealed that diet, natural compounds and phytochemicals impact significantly on lipid metabolism in animals and humans. These findings suggest that dietary components or natural bioactive compounds have a significant impact on microbial dysbiosis linked to metabolic diseases. The interaction between dietary components or natural bioactive compounds and gut microbiota metabolites can regulate lipid metabolism. Additionally, natural products can shape the gut microbiota and improve barrier integrity by interacting with gut metabolites and their precursors, even in unfavourable conditions, potentially contributing to the alignment of host physiology
The tangible and intangible: dance and the safeguarding of intangible cultural heritage
Get PDFThis article returns to issues raised in the pages of Dance Research regarding dance in the context of UNESCO’s 2003 adoption of the Convention for the Safeguarding of the Intangible Cultural Heritage. Bakka and Karoblis’ article published in 2021 refuted the proposal made by Iacono and Brown in 2016 to replace the Convention’s term ‘Intangible Cultural Heritage’ (ICH) with the concept of ‘living cultural heritage’. However, Bakka and Karoblis’ response was written in the spirit of ‘a discursive unity’ and, sharing in this spirit, I aim to consider both articles with the aim of highlighting how the discourses surrounding safeguarding ICH and those that consider dance as a significant part of culture might inform one another
Barriers and facilitators to genetic testing for breast and ovarian cancer amongst Black African women in Luton (UK)
Get PDFEvidence suggests that although Black African women have the lowest incidence of breast and ovarian cancer, they have the highest mortality rate and low rates of uptake for cancer screening services for these conditions in the United Kingdom (UK). This study aimed to explore the perceived barriers and facilitators to genetic testing for breast and ovarian cancer amongst Black African women in Luton (UK). We conducted a qualitative study that included one face-to-face and five telephone focus group discussions. Consistent with the health belief model, a focus group discussion guide was developed. A total of 24 participants, aged 23-57 who self-identified as Black African women and who were English speakers residing in Luton, took part in the focus group discussions. Purposive and snowballing sampling were used to recruit the participants for this study. The focus group discussions were recorded, transcribed per verbatim, coded and analyzed using an inductive thematic analysis approach, and the findings were classified. Nine themes emerged from the narratives obtained including six barriers and three facilitators. Barriers to genetic testing included (1) Cost and affordability, (2) Lack of knowledge, awareness, and family health history knowledge, (3) Language barrier, immigration, and distrust in western healthcare services, (4) Fear, (5) Cultural, religious, and intergenerational views and perceptions, and (6) Eligibility for genetic testing for the BRCA1/2 pathogenic variants and a lack of referral to specialist genetic clinics. Facilitators to genetic testing included (7) Availability of tests cost-free under the National Health Service (NHS) (8) Family members' health and (9) Awareness and education on genetic testing. The barriers and facilitators identified could enable policy makers and healthcare services alike to gain a better understanding of the factors influencing Black African women's decision-making process toward genetic testing. Ultimately, this work can inform interventions aiming to increase the uptake of genetic testing among this group
Evaluating step-down, intermediate care programme in Buckinghamshire, UK:a mixed methods study
Get PDFIntermediate care (IC) services are models of care that aim to bridge the gap between hospital and home, enabling continuity of care and the transition to the community. The purpose of this study was to explore patient experience with a step-down, intermediate care unit in Buckinghamshire, UK. A mixed-methods study design was used. Twenty-eight responses to a patient feedback questionnaire were analysed and seven qualitative semi-structured interviews were conducted. The eligible participants were patients who had been admitted to the step-down IC unit. Interview transcripts were analysed using thematic analysis. Our interview data generated five core themes: (1) "Being uninformed", (2) "Caring relationships with health practitioners", (3) "Experiencing good intermediate care", (4) "Rehabilitation" and (5) "Discussing the care plan". When comparing the quantitative to the qualitative data, these themes are consistent. Overall, the patients reported that the admission to the step-down care facility was positive. Patients highlighted the supportive relationship they formed with healthcare professionals in the IC and that the rehabilitation that was offered in the IC service was important in increasing mobility and regaining their independence. In addition, patients reported that they were largely unaware about their transfer to the IC unit before this occurred and they were also unaware of their discharge package of care. These findings will inform the evolving patient-centred journey for service development within intermediate care
The critical factors in producing high quality and policy-relevant research: insights from international behavioural science units
Get PDFBackground There has been a rapid increase in the number of, and demand for, organisations offering behavioural science advice to government over the last 10 years. Yet we know little of the state of science and the experiences of these evidence providers. Aims and objectives To identify current practice in this emerging field and the factors that impact on the production of high quality and policy-relevant research. Methods A qualitative study using one-to-one interviews with representatives from a purposeful sample of 15 units in the vanguard of international behavioural science research in policy. The data were analysed thematically. Findings Relationships with policymakers were important in the inception of units, research conduct, implementation and dissemination of findings. Knowledge exchange facilitated a shared understanding of policy issues/context, and of behavioural science. Sufficient funding was crucial to maintain critical capacity in the units’ workforces, build a research portfolio beneficial to policymakers and the units, and to ensure full and transparent dissemination. Discussion and conclusion Findings highlight the positive impact of strong evidence-provider/user relationships and the importance of governments commitment to co-produced research programmes to address policy problems and transparency in the dissemination of methods and findings. From the findings we have created a framework ‘STEPS’ (Sharing, Transparency, Engagement, Partnership, Strong relationships) of five recommendations for units working with policymakers. These findings will be of value to all researchers conducting research on behalf of government
Experience and views of healthcare professionals towards people who use new psychoactive substances: evidence from statutory, non-statutory, and private mental health and addiction healthcare services
Get PDFIt is unclear how healthcare professionals (HCPs) experience and view the challenges of working with people who use New Psychoactive Substances (PWUNPS), in different healthcare services (HCS). The aim of the study was to explore HCPs' experiences of working with individuals who use NPS across statutory, non-statutory, and private mental health and addiction HCSs. HCPs completed in-depth semi-structured interviews. Audio recordings were transcribed verbatim with a mean duration of 30 min 55 s. Data were analysed through thematic analysis. A purposive sample of 14 HCPs (6 men, 8 women) with a mean age of 42.5 years were interviewed in 2019. Organisational issues, including funding, impacted the treatment for PWUNPS and HCPs perceived a lack of support dependent on their qualifications. They reported a lack of assessment, policy, harm reduction, and awareness of NPS-related symptoms including mental health problems and stigma faced by PWUNPS. HCPs need better training, education, and assessment processes to manage acute NPS intoxications and address the stigma associated with PWUNPS. There is a need for policy-making opportunities across different HCSs to ensure better healthcare outcomes for PWUNPS
Playing by white rules of racial equality: student athlete experiences of racism in British university sport
Get PDFInequalities related to racial identity are consistently reported across social institutions, not least education, and sport. These inequalities consistently challenge ‘post-race’ narratives that rationalise racism down to individual prejudices and poor decision-making. This paper presents part of the findings from a wider a twelve-month research project commissioned by British University and Colleges Sport (BUCS) to explore race equality. This wider research privileged the voices of non-White students and staff in an exploration of race and equality in British UK university sport. ‘Non-white’ was chosen as a race identifier to focus on Whiteness, the normalised, raceless power that reproduces itself both knowingly and unknowingly, to ensure racial ‘others’ remain subordinate. This paper presents the findings of the student voices. In this study a research team of academic and student researchers explored the experiences of 38 students across five universities. Generating case studies from each university, the data was analysed from an Intersectional and Critical Race Theory perspective. Two core themes relating to negotiating Whiteness were developed from the data analysis which reflected experiences of university sport as predominantly White spaces; ‘Play by the Rules’ and ‘Keep You Guessing’. Racial abuse was subtle, camouflaged in comments and actions that happened momentarily and hence were implausible to capture and evidence. For incidents to be addressed, evidence had to meet a ‘beyond doubt’ standard. Students were required to consciously negotiate racial bias and abuse to ensure they did not provide a justification for abuse. Navigating racialisation and stereotypes, plus White denial, was additional emotional labour for students. This mechanism of silencing the victim served to normalise racism for both the abused and perpetrator. The conclusion explores potential ways of disrupting these mechanisms of Whiteness in placing students’ welfare at the heart of university sport
Institutions and macroeconomic indicators: entrepreneurial activities across the world
Get PDFPurpose: Entrepreneurial activity is a phenomenon that boosts the economic growth of countries and improves social welfare. The levels of economic development in countries have significant effects on these entrepreneurial activities. This research examines which institutional and macroeconomic variables explain early-stage entrepreneurial activities in developed and developing economies. Methodology: We conducted panel data analysis on data from the Global Entrepreneurship Monitor and International Monetary Fund surveys covering 2009–2018. Findings: To begin with, our results reveal that cognitive, normative, and regulatory institutions, as well as macroeconomic factors, have differential effects on early-stage entrepreneurial activity in developed and developing countries. Moreover, our findings indicate a stronger positive impact of cognitive, normative, and regulatory institutions on early-stage entrepreneurship in developed countries compared to developing countries. Finally, our results suggest that macroeconomic factors play a more significant role in early-stage entrepreneurial activity in developing countries than in developed countries. These findings have important implications for institutional theory, macroeconomics, and the entrepreneurship literature. Originality: This study provides a better understanding of the components that help explain the differences in entrepreneurship between developed and developing countries regarding institutions and macroeconomic factors. In this way, it contributes to developing entrepreneurship literature with the theoretical achievements of combining institutional theory and macroeconomic indicators with entrepreneurship literature
Competition, scandal, or ideology? a congruence analysis of Australian political finance reforms (1980–2020)
Get PDFAlthough studies into political finance reform have become commonplace, many questions remain unanswered in this area. Studies into links between scandals and political finance reform have provided conflicting findings, while little is known about why incumbents force through self-serving reforms in some instances, but cooperate with rivals in others. The ‘General Theory of Campaign Finance Reform’ reconciles inconsistencies by situating reform processes within the context of party competition. Observing that this framework has not yet been empirically tested, this study undertakes a Congruence Analysis to apply the model to a 40-year period of Australian political finance reform. Hansard is used to document inter-party interactions, in conjunction with quantitative indicators of party competition, organization, and ideology, which outline the changing contexts of reform. Findings indicate that party competition, scandals, and changes in incumbency are influential drivers of reform, while ideological factors play an inconsistent role. Providing insights into causal processes of reform, this article bridges the gap between theoretical and empirical literature on political finance
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