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A global effort toward standards for data sharing in biomedical imaging:Developing Consensus and Infrastructure for Global Data Interoperability
No full textThe role of Transformative Action Research in territorial peace building: Insights for New Area Studies
No full textWar and peace have been extensively researched in Colombia over the past decades. However, little is said about the role that research can play as a driver of change in the transition from war to peace when research is carried out with those who have been part of the dynamics of the conflict or have found themselves in the middle of the crossfire. In this article, we discuss the experience of the "School, Territory and Post-Conflict: Grounding a Local Peace Culture in South Tolima, Colombia" project working with eight community organisations between 2018 and 2022 studying their experiences building peace during the armed conflict between the Revolution Armed Force of Colombia (FARC) and the Colombian government, and after the 2016 peace agreement. We discuss the transdisciplinary journey of the project and of transformations we have witnessed as a result with the hope that the lessons learned can inform ongoing discussions about how to widen further the research and methodological frontiers of New Areas Studies and beyond
Digital biopsy and network Analysis of dynamic [68Ga]Ga-FAPI-46 data in patients with malignant and benign pancreatic lesions
No full textPurposePathologies like pancreatic ductal adenocarcinomas (PDAC), inflammatory lesions of the pancreas (ILP), postpancreatectomy reactive tissue (PRT) and recurrent-PDAC (RPDAC) all express Fibroblast Activation protein (FAP) and are hardly distinguishable by static PET using [68Ga]Ga-labeled fibroblast activation protein inhibitors combined with CT ([68Ga]-Ga-FAPI-PET/CT). Dynamic imaging allows full [68Ga]-Ga-FAPI kinetic profile analysis, highlighting differences between these pathologies. Here, we applied a voxel-level digital biopsy (DB) approach combined with network analysis and clustering to characterize healthy, non-malignant pathological and malignant pathological kinetic signatures.<br/
Parental mediation of very young children’s early experiences with digital media at home
No full textDigital devices are now found in the majority of homes, including the homes of very young children, and may be said to be a “dominant force” in their lives. This highlights the critical role parents play in mediating their very young children's access to, ownership and use of digital technology in the family home. One of the greatest challenges that parents experience is managing the tension between enhancing their children's digital opportunities and safeguarding them from its potential harms. Referred to as parental digital mediation practices, there is a body of work that both conceptualises these practices and explores their daily lived reality. While there has been a great deal of research around digital technology and parental mediation practices with older children, a stronger research base regarding very young children is needed; not least because there is a growing concern to ensure both digital inclusion and digital safety and privacy. Drawing on findings from a UK-wide study that explored digital ownership, use and parental attitudes and practices, in relation to very young children aged 0–36 months, this paper focuses on parents' perceptions of their mediation practices. The findings suggest that parents proactively mediate their children's use of digital technology using complex, fluid, nuanced and interrelated approaches and strategies. We suggest a new paradigm for capturing this complexity. We end by exploring the implications for research and practice. The study was funded by the Economic and Social Research Council (Grant Reference ES/W001020/1).</p
The life and death of old-age social security in late-colonial Kenya
No full textThe last decade of colonial rule in Kenya witnessed a widespread debate about social security for African workers. The government sought to create a stable, permanent workforce, while workers wanted secure and improved conditions. Old-age security was central to these discussions, deemed necessary for the transition from the traditional security of rural land-owning to a ‘detribalised’ existence. This paper revisits the largely forgotten 1954–5 Social Security Committee, a key moment in the history of social welfare in East Africa. Formed at the intersection of colonial labour policy, humanitarian impulses, and African trade union activism, the Committee represented a rare instance of African participation in colonial social policymaking. Its deliberations on different models of social security – pensions versus provident funds, contributory versus non-contributory models, and inclusion of women, domestic workers, and peasants – exposed competing visions of race, labour, and welfare. The Committee’s recommendation for a comprehensive pension scheme echoed principles of universal social rights and risk pooling associated with the British postwar welfare state. Fiscal caution and intra-official tensions ensured it was not implemented. Kenya was left with a limited, contributory scheme that continues to frustrate many. This lost model illuminates both the ambitions and constraints shaping postcolonial welfare trajectories.<br/
What do general adult psychiatry patients think we should call borderline personality disorder?:A cross-sectional study to find the most acceptable diagnostic term
No full textAIMS AND METHOD: To determine the most acceptable term for borderline personality disorder (BPD). We conducted a cross-sectional study of patients who know what it feels like to be diagnosed with a mental disorder. The main outcome measures were the proportion of participants offended and confused by alternative terms for BPD.RESULTS: Seventy-two people participated in the study. Being diagnosed with a condition was more offensive than being diagnosed with a disorder ( χ 2 = 41.18, d.f. = 1, P < 0.01). Fluxithymia offended the fewest participants (13%), but was the most confusing term (31%). Emotionally unstable personality disorder was the most offensive term (63%). After fluxithymia, emotional intensity disorder was the least offensive term, and not especially confusing (11%). Changing BPD to emotional intensity disorder would avoid an offensive event every 3.6 diagnostic announcements. CLINICAL IMPLICATIONS: The diagnostic term BPD should be replaced with emotional intensity disorder, because this term provides a balance of clarity and inoffensiveness.</p
Effective Transcriptional Induction of the CARMN/miR-143/145 Complex Locus in Smooth Muscle Cells Using CRISPR Activation
No full textA cause and protective treatment for acute and progressive disability and grey matter atrophy
Get PDFCollaborative learning in older age and the role of familiarity:Evidence from the map task
No full textAs we age, learning new knowledge and skills becomes more difficult due to age-related changes to cognition. Learning collaboratively could counteract these changes, and perhaps more so when working with someone familiar. This study examined whether collaborative learning is affected by age and partner familiarity. Forty-eight participants (younger n = 24, older n = 24) completed the Map Task with a familiar and unfamiliar same-age partner. Participants became more efficient at completing the Map Task over time, regardless of age and partner familiarity. There was no age difference in immediate or 1-hour recall, but younger adults recalled more after 7 days than older adults. Overall, results suggest that collaborative learning outcomes are unaffected by age or partner familiarity and that collaborative learning has short-term protective effects on memory, with age-related declines only emerging after 7 days
‘A Deep, Empathetic, Wondrous Connection’:Autistic adults’ definitions and experiences of nature connection
Get PDF1. Connection to nature is an important concept for understanding human-nature relationships, interests in nature, and pro-environmental behaviours. However, conceptualisations of this relationship thus far have excluded autistic perspectives.2. Through this reflexive thematic analysis of survey responses from 108 autistic participants in the UK, we sought to understand how autistic people define and experience connection to nature. 3. Towards this aim, we developed three themes: ‘feeling that you benefit nature and nature benefits you’; ‘connecting with something ancient to which I nevertheless belong’; and ‘it makes me a little sad tbh.’ Across many participants in this sample, nature was not something they saw as separate from themselves (or from humans more generally), and so connection to nature was not a simple, unidirectional relationship nor a clear-cut binary. 4. Through this work, we hope to contribute towards the effort to imbue ecopsychology and related fields with the influences of critical disability studies
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