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Minute by minute:The problem of officials in official history
Get PDFThis article explores a persistent dilemma in official history: whether officials should be protected from the loss of anonymity when their confidential advice is published. Since FOI (2000) the problem has recurrd,from its interwar precedent with the publication of British Documents on the Origins of the War (1926–38). Its most controversial voice was that of Sir Eyre Crowe, whose minutes were later used by German revisionists to claim that British ministers were ‘prisoner’ to Germanophobic Foreign Office officials. Crowe’s case illustrates how publishing private advice can distort intentions and implicate officials in enduring political and historiographical battles about 1914.</p
EdFoil: an open-source software enabling faster geometrical modelling of composite blades
No full textSetting up a numerical model is often the most time-consuming stage of any analysis. Preparing the geometry, applying material definitions, and defining boundary conditions can take considerably longer than running the simulation itself. This user guide introduces the \EdFoil framework designed to accelerate the modelling process for composite blades. By automating the generation of airfoils, stations, and laminate sections, the tool aims to reduce setup time and ensure consistency across different models. In addition, it takes advantage of modern computing hardware, allowing engineers and researchers to start modelling full three-dimensional composite blades more efficiently than with traditional two-dimensional workflows. EdFoil is built with Qt, the C++ framework for software development
Whole genome DNA methylation of undifferentiated spermatogonia of postnatal day 14 (P14) wild-type and Spocd1-K464A (does not interact with TPR) homozygous mutant mice
No full textIn the male mouse germline, PIWI-interacting RNAs (piRNAs), bound by the PIWI protein MIWI2 (PIWIL4), guide the DNA methylation of young active transposable elements (TEs) through SPOCD1. We find that SPOCD1 interacts with the nuclear pore protein TPR, and that this interaction is required to prevent SPOCD1 and its known binding partners SPIN1 and C19ORF84 from being incorporated into constitutive heterochromatin. We perform enzymatic methylation sequencing of undifferentiated spermatogonia from wild-type mice and mice carrying the K464A mutation in SPOCD1, which prevents interaction with TPR. The mutant mice display a stochastic failure of young LINE1 methylation.Tamoghna Chowdhury, Donal O'Carroll & Xinyu Xiang (2025). Whole genome DNA methylation of undifferentiated spermatogonia of postnatal day 14 (P14) wild-type and Spocd1-K464A (does not interact with TPR) homozygous mutant mice. BioStudies, E-MTAB-14862. Retrieved from https://www.ebi.ac.uk/biostudies/ArrayExpress/studies/E-MTAB-1486
La restauración de Inside Downtown (2001), entre la pintura y el cine
Get PDFThis essay focuses on Inside Downtown (2001), the only and final film made in Miami by Cuban filmmaker Nicolás Guillén Landrián, in collaboration with Jorge Egusquiza. Taking this documentary as a starting point, we will explore the intermedial “dialogue” (Schmid 2019) between Landrián’s visual and cinematic work. This dialogue allows us to see continuity where critics previously perceived a silence in his film work. This encounter between cinema and painting also elaborates a kind of conceptual space for considering the intervention of time, a complex concentration of past and future, which implies restoration as a ritual of collective and individual memory
Suppos þat þai be nocht bot fabill:Medieval Film and Robert the Bruce
Get PDFThis article focusses on three films about Robert the Bruce: The Bruce (1996), Outlaw King (2018) and Robert the Bruce (2019). By exploring connections between historians and film-makers views of the past, and how these are expressed through cinematic conventions, it goes beyond assessments of ‘accuracy’ to enable more nuanced assessments of these films as creative works of art
Hygiene behaviours are critical for addressing neglected tropical diseases
No full textNeglected tropical diseases affect more than a billion people worldwide, cause ill health and perpetuate cycles of poverty. Behavioural change can help, particularly through hygiene. But to achieve this we first need to understand the complex circumstances that mean hygiene is not always prioritized.</p
AccentBox:Towards high-fidelity zero-shot accent generation
No full textWhile recent Zero-Shot Text-to-Speech (ZS-TTS) models have achieved high naturalness and speaker similarity, they fall short in accent fidelity and control. To address this issue, we propose zero-shot accent generation that unifies Foreign Accent Conversion (FAC), accented TTS, and ZS-TTS, with a novel two-stage pipeline. In the first stage, we achieve state-of-the-art (SOTA) on Accent Identification (AID) with 0.56 f1 score on unseen speakers. In the second stage, we condition a ZS-TTS system on the pretrained speaker-agnostic accent embeddings extracted by the AID model. The proposed system achieves higher accent fidelity on inherent/cross accent generation, and enables unseen accent generation
Cholangiocarcinoma 2025: Status Quo, unmet needs and priorities
No full textCholangiocarcinoma (CCA) is a cancer that originates within the bile ducts. Traditionally considered a rare neoplasm, increased awareness of CCA along with advancements in diagnosis and the rising prevalence of certain risk factors, have contributed to a global increase in incidence and mortality rates. CCAs are highly heterogeneous from clinical, histomorphological, and molecular perspectives, but they commonly share a poor prognosis. These tumours usually develop and progress silently; by the time they are detected, it is often too late for curative surgical intervention. In such cases, current therapeutic approaches offer modest survival improvements and are generally considered185 palliative. While well-known risk factors predispose individuals to develop CCA, the majority of cases are considered sporadic, occurring without any identifiable underlying condition. Over the past decade, substantial collaborative efforts have been made to understand the etiopathogenesis of these tumours better, aiming to identify novel biomarkers and therapeutic targets for developing more effective treatments. The ultimate goal is to improve patient outcomes and overall well-being. However, significant gaps of the molecular mechanisms driving cholangiocarcinogenesis remain to be understood. In this International Expert Consensus Statement, endorsed by the European Network for the Study of Cholangiocarcinoma (ENSCCA), we provide a critical review of the latest advancements in the field of CCA. We highlight the key aspects on CCA etiopathogenesis and clinical management and provide insights into promising new treatments for CCA. Further, the document includes a set of consensus recommendations and future research priorities for CCA, based on a Delphi Panel questionnaire involving international experts
Decolonising primary teacher education through embodied and sensory approaches in STEAM education
No full textDecolonisation in Higher Education has become an increasing concern, spurring reviews across curricula, policy, and research practices. In teacher education, this calls for reaffirmation of the ability of students to act as their own subjects, with the capacity to attend to diverse ways of knowing and to speak back to the overt system of modernity that obliterates, categorises, and divides humans from more-than-humans. Set in Scotland, a country with recent openings towards decolonial perspectives, this paper explores a two-day teaching experience involving 41 students enrolled in an Initial Teacher Education programme. Moving from traditional workshops to STEAM ateliers, students were invited into a series of arts-based inquiries, including soil painting, body portraits, and a final exhibition. Drawing on the decolonial methodology of palimpsest, data points to approaches to knowing that recentre the body through encounters with materiality, transgress centralising discourses, and open possibilities for crafting new narratives in teacher education
Shifting to online and telephone bereavement support provision during the COVID-19 pandemic:A mixed methods study of bereavement service provider perspectives and lessons learnt
No full textBackground: Provision of remote (online/telephone) bereavement support accelerated during the COVID-19 pandemic. However, the extent and impact of this change and lessons learnt are unknown. Aim: To determine the extent to which UK voluntary and community sector bereavement services moved to remote support provision during the pandemic, explore providers’ perspectives on this shift, and consider implications. Design: Mixed methods explanatory sequential study, conducted spring 2021: (1) Online survey of UK bereavement services; (2) Qualitative interviews with staff and volunteers. Setting/participants: 147 services participated in the survey; 44.5% hospice/palliative care services; 15.1% national charities/organisations; 11.6% local charities/ organisations. 24 interviews were conducted across 14 services. Results: Pre-pandemic, remote support was offered by <10% of bereavement organisations. By spring 2021, there had been increases in online: peer group meetings (3.4% pre-pandemic to 33% during, OR 13.8), facilitated group meetings (4.1% to 56%, OR 30.48), 1:1 support (8.8% to 83%, OR 50.3), and specialist intervention (3.4% to 36%, OR 16.01). Telephone bereavement support was also more widely available. The appropriateness and acceptability of these changes differed by client group. Adaptations presented organisational/logistical challenges, and difficulties for support providers working from home. Smaller organisations with fewer resources found these harder to accommodate. Hybrid working and new technologies were reported to increase service efficiency and costeffectiveness. Conclusions: Remote delivery of bereavement support increased support capacity and can potentially reduce inequities in access. However, it needs to be carefully tailored, and is not appropriate for everyone. Staff and volunteers providing remote services require training and support
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