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Evaluation of measured and calculated small dense low-density lipoprotein in capillary blood and association with the metabolic syndrome
No full textBackground and aims: Small-dense-low-density-lipoprotein cholesterol (sdLDL-C) is proatherogenic and not commonly measured. The aims were to evaluate capillary blood and its stability for sdLDL-C measurement and measure sdLDL-C in patients with metabolic syndrome (MS).
Methods: 182 patients were studied (49 with MS). sdLDL-C was measured by electrophoresis (LipoPrint®), direct measurement (Roche Diagnostics) and Sampson equation. Intima-media thickness (IMT) and presence of atheroma was evaluated. sdLDL-C was compared in paired venous and capillary blood according to CLSI-EP09c (n = 40). sdLDL-C stability was studied after 24 h at room temperature (RT).
Results: sdLDL-C in capillary blood and venous blood showed agreement with the direct measurement (bias: 4.17 mg/dL, LOA 95 %:-5.66; 13.99) and estimation (bias:8.12 mg/dL, LOA 95 %:-8.59; 24.82). sdLDL-C is stable in capillary blood for 24 h at RT. The electrophoretic method yielded lower (p < 0.05) sdLDL-C than the equation or direct measurement. Patients with MS had (p < 0.05) higher sdLDL-C (%) than patients without MS. Patients with atheroma plaques had higher sdLDL-C (p < 0.05). Estimated sdLDL-C correlated with IMT (r = 0.259, p < 0.001).
Conclusions: Capillary blood is an alternative to venous blood for sdLDL-C measurement and is stable for 24 h after collection. Estimated and directly measured sdLDL-C associate with the MS being accessible tools for cardiovascular risk assessment
Nursing interventions to promote self-care in non hospitalized patients with digestive ostomies: a literature review
No full textIntroduction: Patients with digestive ostomies face numerous challenges, including changes
in their daily lives and well-being, impacting physical, psychological, and social aspects. Yet,
there's no standard nursing care protocol to assist in their adjustment and encourage
self-management.
Aim of the study: To know which nursing interventions are most beneficial for promoting
self-care in individuals with digestive ostomies and who are at home.
Methods: A literature review was conducted in PubMed and CINAHL databases between
October and December 2023.
Results: Two types of nursing interventions were identified: home care via a mobile app and
virtual platforms; and the Ostomy Self-Management Program (OSMT). It was found that
technologies were beneficial in promoting self-care, but the OSMT program could not
demonstrate statistically significant benefits.
Conclusions: Online follow-up care can effectively improve self-care in ostomy patients.
However, further research is needed to find more effective intervention.Introducción: Pacientes con ostomías digestivas enfrentan numerosos retos, incluyendo
alteraciones en su vida cotidiana y bienestar, impactando lo físico, lo psicológico y lo social.
Aún así, no hay un protocolo estándar de cuidados de enfermería para facilitar su adaptación y
fomentar el autocuidado.
Objetivo: Conocer cuáles son las intervenciones de enfermería más beneficiosas para
promover el autocuidado en individuos con ostomías digestivas que se encuentran en su
hogar.
Metodología: Se realizó una revisión de la literatura en las bases de datos PubMed y
CINAHL entre octubre y diciembre de 2023.
Resultados: Se identificaron dos tipos de intervenciones de enfermería: seguimiento
domiciliario a través de una aplicación móvil y plataformas virtuales; y el Programa de
Autogestión de la Ostomía (OST). Se encontró que las tecnologías eran beneficiosas para
promover el autocuidado, pero el programa OSMT no pudo mostrar beneficios
estadísticamente significativos.
Conclusiones: El seguimiento domiciliario online puede mejorar eficazmente el autocuidado
en pacientes con ostomía. Sin embargo, se necesitan más investigaciones para encontrar más
intervenciones efectivas
Los programas de prevención del consumo de sustancias culturalmente sensibles benefician a los jóvenes
No full textEl consumo de sustancias por parte de los jóvenes tiene una serie de consecuencias negativas, que incluyen la toma de decisiones inapropiadas, prácticas sexuales de riesgo y resultados psicosociales deficientes. Los jóvenes de 2º de Bachillerato que informaron haber consumido alcohol, marihuana o tabaco antes de los 12 años, también manifestaron tener menos interés en el colegio y ser más propensos a faltar a clases.
Instituto Cultura y Sociedad (ICS), Universidad de Navarra, ha traducido y adaptado el documento de HEDCO Institute “Day, E., Golfen, J., & Shimmel, L. (2023). Culturally Sensitive Substance Use Prevention Programs Benefit Youth. HEDCO Institute for Evidence-Based Educational Practice, University of Oregon. (Recuperado de https://hedcoinstitute.uoregon.edu/reports/culturally-sensitivesubstance-use-prevention). Material elaborado en el marco del proyecto de investigación orientado a la transferencia del conocimiento, “Revisión y valoración de políticas de prevención e intervención en salud mental infanto-juvenil en centros educativos” (IP, Martiño Rodríguez-González, ICS-UNAV) desarrollado por la Universidad de Navarra en colaboración con la Universidad Internacional de La Rioja UNIR- ITEI
Química Farmacéutica I. Antibióticos. Parte 1, reacción 2: Síntesis de la quinolina. Aislamiento
No full textTemas de la Asignatura Química Farmacéutica I de 3º de Farmacia
Fichas de buenas prácticas para la atención a problemas de salud mental en Educación Primaria. Una herramienta de ayuda para los centros educativos. Ficha individual: Miedos
No full textMaterial elaborado en el marco del proyecto de investigación orientado a la transferencia del conocimiento,
"Revisión y valoración de políticas de prevención e intervención en salud mental infanto-juvenil
en centros educativos” (IP, Martiño Rodríguez-González, ICS-UNAV) desarrollado por la Universidad
de Navarra en colaboración con la Universidad Internacional de La Rioja UNIR- ITEI. Esta guía pretende proporcionar al profesorado un marco de comprensión sencillo acerca de los problemas de salud mental en la etapa de primaria, así como identificar señales de alarma y ofrecer pautas para un primer abordaje con los estudiantes que puedan estar experimentando tales problemas. La guía busca promover y prevenir la salud mental, pero en ningún diagnosticar u orientar sobre la forma de intervenir. El objetivo de este documento es prevenir y detectar los problemas de salud mental, además de planificar el acompañamiento, cuidado y, en caso necesario, derivación a los servicios especializados de salud mental. Ayudar al alumno es, en gran medida, conseguir coordinarse y colaborar con las familias y otros profesionales externos al centro educativo. Para cada una de las fichas incluidas en este documento, se sigue la misma estructura: primero, una introducción sobre el problema de salud mental o el trastorno en cuestión; segundo, se detallan las principales señales de alarma que pueden ser observadas por el docente en diferentes espacios y situaciones escolares; finalmente, se proporcionan sugerencias sobre su abordaje, ¿qué puede hacer el maestro o profesor ante esto
Preparation of multifunctional superhydro- and hydro-oleophobic coatings with self-cleaning capacities for construction materials
No full textVersatile coatings were developed to protect mortar surfaces across a broad range of applications, from preserving architectural heritage to modern civil engineering projects. These coatings utilize super-hydrophobic (SPHB) and hydro-oleophobic (OHB) materials, incorporating a nanostructured photocatalyst (Bi2O3-ZnO 8/92). To prevent the aggregation of the nanophotocatalyst, non-ionic dispersants such as Brij35, TritonX-100, and Tween20 were added. The coatings were applied to lime and limecement mortar substrates, and their properties¿such as hydro- and oleo-repellence, photocatalytic activity (through NOx abatement studies), and self-cleaning performance (dye degradation studies)¿were evaluated. Generally, mortars with SPHB coatings exhibited higher photocatalytic activity compared to those with OHB coatings. To simulate real-world conditions, the samples underwent artificial climate aging to assess their durability. Microstructural examination by SEM was addressed to evaluate the alteration degree of the coatings. Their retained effective hydrophobic properties, photocatalytic activity, and self-cleaning performance even after accelerated weathering tests. Future studies aim to apply these coatings to earthen mortars and earthen building materials, in particular by improving the hydrophobicity of the materials
Prospective multicenter study to identify optimal target population for motorized spiral enteroscopy
No full textMotorized spiral enteroscopy (MSE) enhances small bowel exploration, but the optimal target population for this technique is unknown. We aimed to identify the target population for MSE by evaluating its efficacy and safety, as well as detecting predictors of efficacy. A prospective multicenter observational study was conducted at 9 tertiary hospitals in Spain, enrolling patients between June 2020–2022. Analyzed data included demographics, indications for the procedure, exploration time, depth of maximum insertion (DMI), technical success, diagnostic yield, interventional yield, and adverse events (AE) up to 14 days from enteroscopy. Patients with prior gastrointestinal surgery, unsuccessful balloon enteroscopy and small bowel strictures were analyzed. A total of 326 enteroscopies (66.6% oral route) were performed in 294 patients (55.1% males, 65 years ± 21). Prior abdominal surgery was present in 50% of procedures (13.5% gastrointestinal surgery). Lower DMI (162 vs 275 cm, p = 0.037) and diagnostic yield (47.7 vs 67.5%, p = 0.016) were observed in patients with prior gastrointestinal surgery. MSE showed 92.2% technical success and 56.9% diagnostic yield after unsuccessful balloon enteroscopy (n = 51). In suspected small bowel strictures (n = 49), the finding was confirmed in 23 procedures (46.9%). The total AE rate was 10.7% (1.8% classified as major events) with no differences related to prior gastrointestinal/abdominal surgery, unsuccessful enteroscopy, or suspected small bowel strictures. The study demonstrates that MSE has a lower diagnostic yield and DMI in patients with prior gastrointestinal surgery but is feasible after unsuccessful balloon-enteroscopy and in suspected small bowel strictures without safety concerns
Wear study of additively manufactured repair material for R260 grade rails.
No full textAdditive Manufacturing (AM) has been considered as a promising method for repairing rails and extending their service life. In this work, the wear rates of twin-disc specimens produced through laser additive manufacturing against ER7 material are studied applying creepages from 0.4 % to 2.6 %. The approved E11018-G electrode material is atomised and fully cladded into twin-disc rail specimens by Laser Powder Directed Energy Deposition. After the weight loss tests at 1400 MPa, experimental results are fitted with the theoretical adhesion curve modifying FASTSIM coefficients. This adhesion curve is employed to numerically calculate the slip contact area of each test. A non-linear correlation has been found and defined between wear and the slip area including the non-linear zone. This relationship is identified for tribochemical wear for low creepages and delaminative wear for middle and high creepages by surface and metallographic characterisation. The obtained results allow to predict the wear of the additively manufactured E11018-G repair material under wheel-rail contact conditions when the slip area is known
The impact of counterfeits and fake copies in the luxury brand perception
No full textThe primary objective of this thesis is to critically assess the role of counterfeit products in
altering the traditional concept of luxury. The research investigates how the increasing
acceptance of counterfeit luxury goods influences brand perception and consumer
behaviour. Additionally, the study seeks to identify the strategic discussions luxury brands
must adopt to counteract these challenges and preserve their market position.
The study employs a quantitative research approach, utilising a structured questionnaire to
collect data from a diverse sample of luxury / counterfeits consumers. The questionnaire
targets various aspects, including consumer awareness of counterfeits, purchasing
behaviours, and perceptions of luxury brands. Data analysis involves statistical techniques
to examine the relationships between these variables and test the proposed hypotheses.
Key findings reveal that a significant portion of younger consumers, particularly Millennials
and Generation Z, knowingly purchase counterfeit luxury goods. This trend is driven by a
combination of economic factors, digital access, and shifting values towards experiential
and value-conscious consumption. Counterfeit goods negatively impact the perceived
exclusivity and quality of luxury brands. Consumers increasingly find it challenging to
distinguish between authentic and fake products, leading to a dilution of brand value. The
prevalence of counterfeits erodes consumer trust and brand loyalty, as buyers become
skeptical about the authenticity of luxury items. This skepticism is particularly pronounced
among younger consumers who are more digitally astute and exposed to online counterfeit
markets. The study underscores the necessity for luxury brands to innovate in their
approaches to authentication, consumer education, and marketing. Embracing digital
solutions such as blockchain for supply chain transparency, enhancing anti-counterfeiting
measures, and creating personalised consumer experiences are essential strategies.
In conclusion, the luxury market is at a critical juncture, facing significant challenges from
the rise of high-quality counterfeits and changing consumer values. To sustain their
relevance and desirability, luxury brands must adapt by reinforcing their traditional values
of authenticity and exclusivity while aligning with contemporary consumer expectations of
sustainability and ethical practices. The study highlights the importance of strategic
innovation in preserving brand equity in an increasingly complex market environment